GREMLIN Database
YODH - Uncharacterized methyltransferase YodH
UniProt: O34954 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 233 (188)
Sequences: 18009 (13196)
Seq/√Len: 962.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
38_P59_P3.1361.00
67_P88_Q2.7071.00
123_S175_F2.5321.00
44_C62_V2.5041.00
121_E124_R2.3671.00
50_A60_V2.3111.00
61_T101_F2.3111.00
70_L86_A2.2551.00
116_T172_S2.2531.00
122_I132_L2.2331.00
63_V89_A2.2321.00
73_A86_A2.1421.00
37_Q103_C2.1001.00
70_L74_K2.0931.00
40_L101_F2.0911.00
102_S127_K2.0611.00
55_H80_E2.0471.00
61_T87_Y2.0431.00
104_V122_I2.0171.00
96_F101_F2.0151.00
59_P85_P1.9921.00
70_L88_Q1.9151.00
42_A122_I1.9061.00
34_S37_Q1.8441.00
104_V126_L1.8361.00
72_K75_K1.8161.00
51_A77_F1.8101.00
67_P71_E1.7891.00
116_T120_Q1.7271.00
39_I53_L1.6961.00
108_S112_F1.6931.00
126_L130_G1.6791.00
51_A76_R1.6671.00
121_E125_V1.6541.00
77_F86_A1.6351.00
8_L11_F1.6171.00
116_T169_L1.6051.00
38_P61_T1.5671.00
162_E165_E1.5401.00
44_C50_A1.5341.00
126_L132_L1.5161.00
64_D70_L1.5081.00
42_A91_L1.4981.00
38_P127_K1.4911.00
61_T85_P1.4811.00
109_V113_S1.4721.00
115_L169_L1.4561.00
25_K52_Y1.4361.00
50_A62_V1.4241.00
68_I71_E1.4081.00
114_R117_S1.3971.00
89_A95_P1.3911.00
167_H171_R1.3681.00
126_L175_F1.3531.00
110_L113_S1.3361.00
152_M156_G1.3171.00
109_V112_F1.2891.00
75_K79_N1.2871.00
77_F82_L1.2781.00
90_E93_H1.2771.00
5_L68_I1.2651.00
52_Y55_H1.2641.00
5_L66_D1.2521.00
62_V86_A1.2481.00
52_Y56_L1.2231.00
97_S100_S1.2111.00
117_S120_Q1.1931.00
25_K29_Q1.1891.00
38_P101_F1.1781.00
39_I103_C1.1771.00
33_P37_Q1.1751.00
119_L170_L1.1711.00
98_S124_R1.1671.00
167_H180_A1.1661.00
77_F84_I1.1611.00
65_K90_E1.1611.00
38_P102_S1.1581.00
71_E74_K1.1471.00
63_V94_L1.1361.00
51_A80_E1.1331.00
87_Y96_F1.1261.00
43_G106_S1.1261.00
40_L104_V1.1261.00
108_S111_S1.1241.00
25_K56_L1.1181.00
168_K172_S1.1131.00
152_M155_Y1.1061.00
76_R79_N1.1031.00
168_K171_R1.0921.00
94_L121_E1.0901.00
95_P121_E1.0841.00
118_S122_I1.0831.00
78_A83_A1.0701.00
154_F157_F1.0621.00
116_T173_Y1.0491.00
26_A29_Q1.0411.00
123_S173_Y1.0391.00
75_K78_A1.0371.00
46_T69_M1.0291.00
62_V73_A1.0271.00
43_G108_S1.0221.00
26_A181_M1.0201.00
44_C73_A1.0121.00
104_V125_V1.0081.00
112_F118_S1.0071.00
51_A55_H1.0041.00
15_G18_P1.0011.00
27_V133_I0.9831.00
30_K179_E0.9811.00
47_G73_A0.9781.00
153_D157_F0.9741.00
37_Q58_Y0.9701.00
94_L125_V0.9671.00
38_P100_S0.9591.00
74_K78_A0.9461.00
39_I105_L0.9431.00
122_I126_L0.9411.00
43_G109_V0.9361.00
30_K181_M0.9361.00
153_D156_G0.9301.00
64_D69_M0.9231.00
53_L105_L0.9181.00
107_E110_L0.9161.00
26_A30_K0.9031.00
36_D58_Y0.9001.00
117_S121_E0.8981.00
163_E182_S0.8871.00
20_G23_F0.8861.00
106_S109_V0.8821.00
49_T105_L0.8811.00
50_A86_A0.8811.00
151_M154_F0.8801.00
72_K76_R0.8701.00
61_T96_F0.8691.00
107_E112_F0.8661.00
50_A84_I0.8651.00
66_D69_M0.8611.00
76_R80_E0.8541.00
29_Q56_L0.8521.00
16_A20_G0.8341.00
120_Q173_Y0.8231.00
143_M148_K0.8201.00
63_V87_Y0.8191.00
107_E111_S0.8151.00
71_E75_K0.8151.00
5_L8_L0.8131.00
44_C64_D0.8101.00
37_Q102_S0.8051.00
41_D62_V0.8031.00
100_S127_K0.7991.00
48_Q52_Y0.7921.00
54_G84_I0.7911.00
107_E135_I0.7901.00
151_M156_G0.7891.00
41_D60_V0.7851.00
89_A94_L0.7751.00
146_A149_K0.7711.00
148_K151_M0.7661.00
19_G23_F0.7571.00
147_E150_Q0.7551.00
8_L12_G0.7531.00
108_S113_S0.7471.00
47_G86_A0.7471.00
177_K180_A0.7461.00
165_E168_K0.7401.00
28_L53_L0.7351.00
40_L125_V0.7341.00
110_L136_E0.7321.00
163_E180_A0.7291.00
146_A150_Q0.7231.00
39_I60_V0.7221.00
33_P36_D0.7201.00
144_P150_Q0.7161.00
144_P147_E0.7141.00
42_A104_V0.7081.00
28_L56_L0.7071.00
55_H82_L0.7041.00
92_E114_R0.7021.00
4_Y7_M0.7001.00
17_H20_G0.6991.00
103_C131_M0.6991.00
51_A54_G0.6951.00
136_E166_W0.6921.00
16_A19_G0.6911.00
96_F125_V0.6891.00
98_S125_V0.6881.00
17_H21_L0.6881.00
152_M157_F0.6871.00
119_L173_Y0.6851.00
74_K85_P0.6851.00
21_L25_K0.6821.00
109_V136_E0.6821.00
148_K153_D0.6821.00
21_L24_S0.6771.00
14_A22_A0.6761.00
68_I72_K0.6691.00
151_M155_Y0.6641.00
123_S174_G0.6621.00
22_A25_K0.6611.00
147_E151_M0.6601.00
119_L169_L0.6601.00
74_K86_A0.6601.00
103_C130_G0.6591.00
46_T76_R0.6591.00
62_V84_I0.6551.00
120_Q124_R0.6551.00
49_T53_L0.6511.00
92_E113_S0.6491.00
39_I58_Y0.6471.00
150_Q153_D0.6461.00
12_G16_A0.6441.00
148_K152_M0.6411.00
67_P74_K0.6391.00
41_D44_C0.6391.00
100_S125_V0.6351.00
32_A131_M0.6351.00
18_P21_L0.6321.00
164_S168_K0.6301.00
54_G82_L0.6261.00
163_E167_H0.6251.00
169_L173_Y0.6161.00
4_Y8_L0.6141.00
51_A82_L0.6081.00
165_E169_L0.6071.00
150_Q155_Y0.6061.00
11_F14_A0.6051.00
33_P58_Y0.6041.00
98_S121_E0.6031.00
143_M147_E0.6021.00
108_S135_I0.6011.00
65_K88_Q0.6011.00
132_L175_F0.6001.00
24_S49_T0.5991.00
94_L101_F0.5981.00
101_F125_V0.5971.00
42_A63_V0.5961.00
145_P149_K0.5931.00
145_P148_K0.5901.00
77_F81_G0.5891.00
132_L170_L0.5891.00
119_L166_W0.5871.00
131_M134_G0.5851.00
18_P22_A0.5821.00
107_E113_S0.5811.00
96_F100_S0.5791.00
149_K153_D0.5761.00
9_S72_K0.5701.00
14_A20_G0.5621.00
41_D105_L0.5571.00
38_P99_E0.5521.00
170_L173_Y0.5511.00
20_G24_S0.5501.00
51_A86_A0.5481.00
93_H117_S0.5461.00
31_A133_I0.5451.00
138_A141_K0.5441.00
42_A118_S0.5431.00
16_A24_S0.5411.00
48_Q76_R0.5401.00
147_E152_M0.5401.00
44_C70_L0.5391.00
95_P125_V0.5361.00
113_S118_S0.5321.00
43_G65_K0.5311.00
92_E118_S0.5301.00
93_H121_E0.5301.00
14_A18_P0.5291.00
50_A54_G0.5251.00
92_E117_S0.5231.00
110_L118_S0.5191.00
9_S75_K0.5181.00
49_T52_Y0.5161.00
37_Q131_M0.5131.00
115_L161_H0.5121.00
41_D63_V0.5121.00
28_L57_L0.5121.00
38_P58_Y0.5121.00
171_R177_K0.5071.00
145_P151_M0.5061.00
91_L118_S0.5041.00
36_D102_S0.5031.00
169_L172_S0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pneA 2 0.9914 100 0.381 Contact Map
3kkzA 2 0.9871 100 0.39 Contact Map
2o57A 2 1 100 0.393 Contact Map
3busA 1 0.9442 100 0.395 Contact Map
5bp7A 3 0.9914 100 0.401 Contact Map
2fk8A 1 0.9614 100 0.413 Contact Map
3f4kA 2 0.9871 100 0.414 Contact Map
3vc1A 5 0.9571 100 0.419 Contact Map
1vl5A 1 0.9142 100 0.419 Contact Map
2yqzA 1 0.9914 100 0.42 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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