GREMLIN Database
BCER - Sensory transduction protein BceR
UniProt: O34951 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 231 (210)
Sequences: 76114 (55175)
Seq/√Len: 3807.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
14_F30_G3.8231.00
14_F32_Q3.3671.00
18_K30_G3.2761.00
7_I37_V2.8781.00
38_L66_L2.7331.00
35_S57_K2.6611.00
29_Y46_P2.5871.00
34_F58_F2.5451.00
33_D57_K2.4711.00
58_F66_L2.4631.00
42_A70_R2.4461.00
3_K29_Y2.2241.00
20_R105_F2.0941.00
3_K27_D2.0881.00
18_K22_T2.0811.00
31_I40_E2.0531.00
24_W109_I1.9781.00
87_M107_V1.9561.00
54_Q81_R1.9491.00
51_I63_W1.9481.00
32_Q36_Q1.9471.00
64_C75_I1.9091.00
191_N194_T1.8481.00
77_F90_S1.7891.00
77_F95_A1.7711.00
33_D36_Q1.7621.00
29_Y40_E1.7571.00
68_R96_D1.7321.00
156_N159_F1.7171.00
5_L31_I1.7031.00
84_P104_H1.6991.00
66_L70_R1.6811.00
58_F62_H1.6531.00
97_D111_K1.6521.00
29_Y44_V1.6201.00
40_E44_V1.6181.00
34_F63_W1.5971.00
59_D62_H1.5681.00
162_K166_E1.5301.00
163_Q180_S1.5251.00
81_R86_D1.5131.00
40_E43_A1.5121.00
131_T136_A1.5121.00
174_R194_T1.5081.00
66_L69_S1.5021.00
41_F67_I1.5001.00
196_N199_R1.4931.00
21_L112_I1.4881.00
49_V73_V1.4611.00
64_C77_F1.4611.00
65_R93_L1.4451.00
35_S58_F1.4401.00
62_H65_R1.4251.00
38_L63_W1.4121.00
48_C112_I1.3961.00
172_V180_S1.3791.00
173_S176_E1.3781.00
53_V61_F1.3701.00
76_L115_M1.3331.00
96_D118_R1.3281.00
8_E14_F1.3221.00
40_E46_P1.3031.00
11_E32_Q1.3011.00
53_V77_F1.2901.00
51_I64_C1.2881.00
163_Q167_Q1.2771.00
7_I55_L1.2661.00
9_D52_D1.2631.00
39_Q43_A1.2611.00
134_G147_D1.2471.00
38_L58_F1.2471.00
96_D115_M1.2331.00
143_L150_S1.2291.00
36_Q39_Q1.2231.00
136_A145_S1.2201.00
3_K44_V1.2151.00
26_Y113_Q1.2141.00
36_Q40_E1.2081.00
31_I37_V1.2041.00
83_H86_D1.1931.00
197_V201_R1.1881.00
138_D141_Q1.1871.00
35_S39_Q1.1831.00
5_L46_P1.1781.00
61_F90_S1.1731.00
61_F89_M1.1551.00
109_I113_Q1.1501.00
176_E180_S1.1281.00
5_L37_V1.1171.00
4_L26_Y1.1121.00
84_P88_V1.1121.00
157_E203_K1.0931.00
37_V63_W1.0741.00
92_Q113_Q1.0731.00
5_L40_E1.0721.00
25_S113_Q1.0711.00
88_V92_Q1.0691.00
163_Q172_V1.0641.00
195_V198_N1.0631.00
24_W113_Q1.0611.00
159_F162_K1.0541.00
107_V110_A1.0521.00
89_M93_L1.0511.00
48_C116_F1.0451.00
139_A162_K1.0421.00
85_A89_M1.0411.00
65_R89_M1.0391.00
38_L42_A1.0291.00
41_F71_S1.0251.00
206_A215_T1.0111.00
110_A114_A1.0101.00
15_H30_G1.0091.00
31_I36_Q1.0091.00
6_L17_I1.0031.00
137_V165_I0.9921.00
61_F93_L0.9911.00
5_L41_F0.9861.00
37_V41_F0.9851.00
192_T196_N0.9831.00
175_E190_D0.9711.00
51_I75_I0.9701.00
84_P87_M0.9681.00
7_I49_V0.9671.00
12_S16_E0.9661.00
142_N219_Q0.9641.00
87_M100_Q0.9601.00
53_V59_D0.9591.00
64_C95_A0.9571.00
18_K28_V0.9561.00
49_V67_I0.9561.00
17_I78_L0.9561.00
137_V158_M0.9451.00
11_E15_H0.9391.00
158_M162_K0.9361.00
7_I31_I0.9351.00
62_H66_L0.9291.00
49_V75_I0.9241.00
50_I108_L0.9031.00
172_V176_E0.9011.00
55_L63_W0.8931.00
39_Q42_A0.8911.00
51_I77_F0.8891.00
64_C93_L0.8881.00
191_N195_V0.8841.00
6_L28_V0.8831.00
11_E14_F0.8821.00
115_M118_R0.8771.00
15_H18_K0.8731.00
74_P96_D0.8701.00
155_K159_F0.8701.00
145_S150_S0.8691.00
82_D100_Q0.8681.00
89_M92_Q0.8671.00
191_N198_N0.8571.00
3_K46_P0.8561.00
199_R202_K0.8451.00
76_L111_K0.8421.00
26_Y109_I0.8401.00
19_D23_G0.8371.00
107_V111_K0.8361.00
88_V106_D0.8321.00
163_Q177_L0.8311.00
53_V86_D0.8301.00
53_V81_R0.8301.00
198_N202_K0.8271.00
65_R69_S0.8241.00
207_L210_G0.8231.00
129_I136_A0.8221.00
142_N159_F0.8161.00
45_N71_S0.8131.00
50_I78_L0.8001.00
58_F63_W0.7961.00
105_F109_I0.7911.00
41_F73_V0.7881.00
54_Q80_S0.7821.00
17_I108_L0.7761.00
63_W67_I0.7731.00
41_F46_P0.7721.00
104_H107_V0.7701.00
206_A211_A0.7661.00
85_A106_D0.7611.00
91_M111_K0.7531.00
215_T219_Q0.7511.00
86_D89_M0.7501.00
103_F108_L0.7461.00
175_E179_R0.7451.00
7_I63_W0.7431.00
3_K47_D0.7411.00
42_A71_S0.7391.00
38_L41_F0.7381.00
97_D114_A0.7351.00
34_F38_L0.7341.00
205_D211_A0.7301.00
78_L103_F0.7271.00
190_D194_T0.7191.00
207_L211_A0.7161.00
154_T203_K0.7161.00
200_L203_K0.7111.00
114_A117_R0.7101.00
67_I75_I0.7081.00
114_A119_V0.7051.00
15_H19_D0.7031.00
90_S95_A0.6941.00
145_S148_K0.6931.00
34_F57_K0.6901.00
176_E179_R0.6871.00
16_E20_R0.6861.00
116_F119_V0.6841.00
41_F49_V0.6821.00
92_Q110_A0.6801.00
13_L103_F0.6781.00
171_I219_Q0.6771.00
163_Q166_E0.6761.00
6_L30_G0.6721.00
76_L97_D0.6721.00
42_A66_L0.6661.00
195_V199_R0.6641.00
166_E180_S0.6601.00
84_P106_D0.6551.00
111_K115_M0.6531.00
72_N122_Y0.6521.00
14_F18_K0.6511.00
6_L18_K0.6491.00
132_W135_A0.6491.00
8_E55_L0.6471.00
106_D110_A0.6401.00
50_I112_I0.6391.00
10_D13_L0.6391.00
208_Q211_A0.6381.00
68_R73_V0.6371.00
53_V90_S0.6351.00
160_I164_L0.6341.00
50_I76_L0.6341.00
74_P122_Y0.6301.00
142_N158_M0.6281.00
38_L70_R0.6251.00
119_V123_N0.6211.00
85_A88_V0.6211.00
74_P116_F0.6161.00
20_R109_I0.6161.00
61_F86_D0.6151.00
201_R206_A0.6131.00
137_V162_K0.6131.00
79_S87_M0.6121.00
34_F55_L0.6071.00
64_C68_R0.6071.00
166_E172_V0.6071.00
74_P118_R0.6061.00
22_T28_V0.6041.00
67_I73_V0.6021.00
87_M104_H0.6001.00
211_A214_E0.5981.00
52_D101_K0.5961.00
72_N121_H0.5951.00
139_A166_E0.5931.00
68_R74_P0.5921.00
10_D80_S0.5911.00
192_T197_V0.5871.00
210_G213_I0.5871.00
4_L48_C0.5861.00
103_F107_V0.5851.00
137_V144_V0.5841.00
51_I55_L0.5801.00
159_F163_Q0.5771.00
41_F63_W0.5771.00
164_L197_V0.5761.00
174_R190_D0.5741.00
4_L21_L0.5731.00
197_V200_L0.5701.00
21_L26_Y0.5681.00
13_L16_E0.5671.00
133_C136_A0.5661.00
80_S102_P0.5601.00
36_Q57_K0.5571.00
194_T197_V0.5561.00
134_G146_N0.5511.00
9_D79_S0.5511.00
90_S98_F0.5461.00
146_N149_G0.5451.00
20_R24_W0.5441.00
150_S215_T0.5441.00
135_A146_N0.5431.00
146_N206_A0.5421.00
138_D143_L0.5421.00
26_Y116_F0.5401.00
79_S101_K0.5361.00
110_A113_Q0.5331.00
205_D210_G0.5321.00
113_Q117_R0.5301.00
22_T27_D0.5301.00
210_G214_E0.5291.00
129_I133_C0.5281.00
74_P119_V0.5271.00
6_L14_F0.5271.00
188_V193_L0.5251.00
131_T134_G0.5241.00
41_F70_R0.5231.00
97_D115_M0.5221.00
198_N201_R0.5201.00
189_S192_T0.5201.00
4_L112_I0.5181.00
205_D212_Y0.5171.00
19_D22_T0.5161.00
128_T140_E0.5141.00
112_I116_F0.5121.00
146_N207_L0.5121.00
188_V192_T0.5091.00
205_D208_Q0.5091.00
155_K219_Q0.5081.00
146_N205_D0.5071.00
156_N196_N0.5061.00
48_C115_M0.5051.00
130_K133_C0.5051.00
82_D102_P0.5001.00
9_D55_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ys7A 2 0.974 100 0.208 Contact Map
3r0jA 2 0.9481 100 0.221 Contact Map
2oqrA 2 0.9697 100 0.226 Contact Map
2gwrA 1 0.9567 100 0.228 Contact Map
4kfcA 2 0.9654 100 0.228 Contact Map
1kgsA 1 0.9437 100 0.234 Contact Map
4b09A 2 0.9264 100 0.242 Contact Map
1p2fA 1 0.9264 100 0.264 Contact Map
2hqrA 2 0.9524 100 0.269 Contact Map
3q9sA 1 0.9091 100 0.27 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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