GREMLIN Database
YKWC - Uncharacterized oxidoreductase YkwC
UniProt: O34948 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 288 (276)
Sequences: 11457 (7413)
Seq/√Len: 446.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
149_M153_S3.5871.00
73_E105_K3.3131.00
142_K146_E3.2571.00
29_L49_K3.0421.00
4_T27_P2.8921.00
116_F144_A2.8601.00
42_L48_W2.7661.00
116_F147_A2.6801.00
19_S44_K2.6541.00
236_K276_N2.2091.00
39_E43_Q2.2061.00
50_D54_D2.2021.00
146_E149_M2.1531.00
110_A115_L2.1381.00
38_A48_W2.1371.00
91_Y148_C2.0501.00
6_G55_L2.0051.00
213_G218_S1.9891.00
22_L46_A1.9841.00
15_K40_S1.9491.00
26_H154_L1.9211.00
199_E202_N1.9011.00
142_K161_Y1.8791.00
83_I110_A1.8681.00
51_T54_D1.8621.00
107_A165_A1.8391.00
64_T92_L1.8341.00
116_F141_E1.8131.00
101_S251_L1.7981.00
248_E251_L1.7781.00
4_T29_L1.7711.00
27_P47_I1.7711.00
20_H23_N1.7501.00
34_T37_K1.7351.00
24_D154_L1.7021.00
87_K90_A1.6961.00
36_E39_E1.6691.00
111_K141_E1.6491.00
76_Y92_L1.6441.00
141_E144_A1.6391.00
35_K39_E1.6391.00
136_I155_M1.6371.00
193_A203_V1.6281.00
108_E112_E1.5901.00
65_M95_M1.5891.00
30_V46_A1.5731.00
91_Y144_A1.5721.00
236_K270_A1.5711.00
109_A112_E1.5691.00
118_L140_G1.5581.00
136_I156_G1.5401.00
274_E277_S1.5331.00
86_A90_A1.5201.00
107_A111_K1.5201.00
105_K109_A1.4851.00
120_A136_I1.4831.00
118_L148_C1.4621.00
145_F149_M1.4611.00
55_L59_A1.4541.00
145_F161_Y1.4501.00
20_H132_G1.4421.00
63_I95_M1.4321.00
29_L47_I1.4241.00
68_Y71_D1.4141.00
222_P226_Q1.4101.00
53_K57_K1.3991.00
126_D130_Q1.3971.00
39_E42_L1.3931.00
201_E205_K1.3901.00
127_I131_N1.3801.00
69_P102_L1.3681.00
181_A185_G1.3661.00
53_K85_N1.3631.00
35_K50_D1.3611.00
173_M244_I1.3481.00
260_S264_S1.3471.00
29_L58_E1.3321.00
263_K267_D1.3311.00
162_Q171_T1.3231.00
208_T218_S1.3221.00
91_Y147_A1.3061.00
23_N44_K1.2991.00
194_Q200_P1.2941.00
103_A117_A1.2901.00
235_V269_L1.2821.00
60_D87_K1.2791.00
110_A117_A1.2761.00
19_S130_Q1.2621.00
133_T157_E1.2581.00
58_E87_K1.2561.00
261_L264_S1.2471.00
118_L145_F1.2451.00
93_I148_C1.2421.00
70_S74_E1.2401.00
16_S130_Q1.2381.00
65_M122_V1.2291.00
236_K275_E1.2261.00
239_I270_A1.2191.00
61_V91_Y1.2171.00
6_G59_A1.2171.00
81_G84_E1.2131.00
83_I113_K1.2041.00
52_V85_N1.2031.00
250_E260_S1.2011.00
23_N130_Q1.1981.00
191_A195_K1.1951.00
148_C152_F1.1821.00
196_S252_M1.1761.00
247_E251_L1.1751.00
90_A115_L1.1651.00
41_I46_A1.1621.00
18_A28_V1.1571.00
141_E164_P1.1571.00
84_E113_K1.1551.00
104_K170_H1.1541.00
249_A256_M1.1481.00
95_M136_I1.1461.00
7_F17_M1.1381.00
180_A242_M1.1361.00
86_A115_L1.1351.00
40_S43_Q1.1281.00
109_A113_K1.1231.00
73_E109_A1.1191.00
99_K102_L1.1171.00
7_F63_I1.1091.00
56_S85_N1.1091.00
66_V75_V1.1071.00
104_K165_A1.1021.00
19_S23_N1.1011.00
4_T60_D1.1011.00
7_F18_A1.1001.00
61_V151_I1.0941.00
49_K55_L1.0931.00
255_E260_S1.0881.00
264_S267_D1.0821.00
180_A238_F1.0791.00
161_Y164_P1.0781.00
12_V126_D1.0691.00
73_E102_L1.0681.00
233_F237_H1.0581.00
29_L59_A1.0571.00
69_P99_K1.0511.00
104_K108_E1.0491.00
239_I267_D1.0461.00
138_V145_F1.0431.00
164_P167_S1.0421.00
246_L260_S1.0381.00
32_T37_K1.0371.00
92_L110_A1.0351.00
95_M155_M1.0321.00
243_G263_K1.0281.00
234_Y237_H1.0271.00
63_I151_I1.0051.00
108_E111_K1.0021.00
107_A141_E1.0011.00
22_L45_G0.9971.00
178_A189_A0.9941.00
202_N205_K0.9911.00
80_N84_E0.9661.00
247_E250_E0.9661.00
80_N109_A0.9631.00
118_L138_V0.9621.00
40_S44_K0.9591.00
86_A92_L0.9531.00
49_K54_D0.9531.00
53_K81_G0.9511.00
119_D166_G0.9491.00
174_C193_A0.9481.00
35_K48_W0.9481.00
63_I93_I0.9431.00
235_V270_A0.9431.00
267_D271_A0.9361.00
190_M204_L0.9341.00
153_S159_I0.9301.00
72_V98_S0.9261.00
174_C189_A0.9211.00
208_T217_L0.9181.00
129_A134_L0.9181.00
71_D74_E0.9051.00
99_K247_E0.9021.00
140_G145_F0.9021.00
76_Y110_A0.9021.00
162_Q167_S0.9011.00
33_R71_D0.9001.00
10_L41_I0.9001.00
243_G247_E0.8991.00
181_A258_G0.8981.00
220_L223_R0.8981.00
88_E114_A0.8971.00
76_Y82_I0.8961.00
123_S175_N0.8961.00
20_H155_M0.8931.00
221_A225_L0.8921.00
123_S137_M0.8781.00
15_K19_S0.8771.00
102_L105_K0.8771.00
137_M206_S0.8771.00
52_V56_S0.8741.00
36_E40_S0.8731.00
73_E106_I0.8671.00
170_H196_S0.8661.00
195_K254_E0.8641.00
4_T57_K0.8621.00
7_F28_V0.8571.00
54_D57_K0.8561.00
103_A169_Q0.8551.00
170_H248_E0.8541.00
215_W219_N0.8511.00
61_V147_A0.8501.00
146_E161_Y0.8461.00
239_I263_K0.8451.00
91_Y116_F0.8431.00
243_G267_D0.8431.00
10_L30_V0.8331.00
270_A275_E0.8301.00
269_L281_S0.8281.00
98_S102_L0.8221.00
17_M155_M0.8201.00
37_K40_S0.8181.00
221_A224_M0.8171.00
5_I26_H0.8161.00
144_A147_A0.8161.00
105_K108_E0.8151.00
21_I63_I0.8141.00
62_I82_I0.8141.00
93_I120_A0.8141.00
277_S281_S0.8101.00
171_T198_L0.8091.00
204_L208_T0.8041.00
182_G214_S0.8041.00
150_P153_S0.8031.00
208_T213_G0.8011.00
184_I258_G0.7951.00
119_D168_G0.7951.00
258_G262_A0.7941.00
162_Q206_S0.7911.00
67_G71_D0.7901.00
268_K271_A0.7841.00
204_L221_A0.7841.00
201_E226_Q0.7831.00
142_K164_P0.7811.00
29_L55_L0.7801.00
182_G186_V0.7781.00
64_T72_V0.7771.00
177_I259_L0.7721.00
187_A282_I0.7701.00
101_S104_K0.7691.00
230_E277_S0.7671.00
220_L224_M0.7651.00
139_G168_G0.7581.00
144_A148_C0.7561.00
30_V38_A0.7511.00
17_M134_L0.7441.00
268_K272_Q0.7421.00
61_V93_I0.7421.00
178_A186_V0.7411.00
17_M95_M0.7411.00
118_L144_A0.7401.00
104_K166_G0.7401.00
195_K252_M0.7381.00
66_V71_D0.7381.00
94_D117_A0.7371.00
116_F143_E0.7341.00
201_E225_L0.7341.00
15_K44_K0.7331.00
248_E252_M0.7331.00
8_I52_V0.7301.00
193_A198_L0.7261.00
264_S268_K0.7261.00
22_L44_K0.7211.00
97_T244_I0.7191.00
234_Y276_N0.7191.00
125_G128_G0.7181.00
5_I21_I0.7141.00
177_I245_A0.7131.00
33_R37_K0.7111.00
26_H151_I0.7061.00
7_F65_M0.7051.00
21_I28_V0.7031.00
8_I31_Y0.7021.00
64_T76_Y0.7001.00
52_V55_L0.6981.00
145_F159_I0.6961.00
106_I117_A0.6941.00
160_Q206_S0.6931.00
149_M159_I0.6921.00
5_I151_I0.6921.00
83_I115_L0.6911.00
83_I109_A0.6901.00
186_V217_L0.6871.00
152_F159_I0.6851.00
102_L106_I0.6831.00
191_A194_Q0.6821.00
17_M65_M0.6791.00
117_A165_A0.6781.00
38_A42_L0.6741.00
4_T58_E0.6701.00
250_E263_K0.6631.00
53_K56_S0.6631.00
234_Y238_F0.6621.00
246_L263_K0.6621.00
72_V96_T0.6601.00
219_N223_R0.6571.00
15_K41_I0.6551.00
120_A138_V0.6541.00
182_G216_S0.6531.00
54_D58_E0.6511.00
174_C192_Y0.6501.00
35_K38_A0.6481.00
178_A185_G0.6470.99
158_N209_T0.6470.99
235_V281_S0.6430.99
22_L28_V0.6380.99
171_T203_V0.6330.99
198_L203_V0.6310.99
143_E146_E0.6290.99
138_V152_F0.6280.99
88_E113_K0.6280.99
66_V72_V0.6280.99
215_W218_S0.6270.99
178_A182_G0.6270.99
74_E81_G0.6250.99
62_I86_A0.6250.99
99_K244_I0.6240.99
173_M245_A0.6220.99
183_M279_T0.6220.99
158_N205_K0.6180.99
192_Y256_M0.6160.99
170_H198_L0.6140.99
18_A30_V0.6130.99
72_V102_L0.6120.99
47_I58_E0.6120.99
239_I243_G0.6110.99
228_N231_P0.6110.99
39_E48_W0.6100.99
128_G133_T0.6100.99
70_S73_E0.6100.99
178_A207_I0.6090.99
181_A262_A0.6070.99
152_F156_G0.6070.99
82_I86_A0.6060.99
204_L207_I0.6060.99
72_V94_D0.6060.99
233_F238_F0.6050.99
59_A62_I0.6030.99
98_S169_Q0.6020.99
223_R228_N0.6010.99
32_T35_K0.6010.99
53_K84_E0.6000.99
98_S103_A0.5990.99
74_E80_N0.5950.99
187_A224_M0.5940.99
243_G250_E0.5940.99
138_V159_I0.5930.99
149_M161_Y0.5910.99
120_A152_F0.5910.99
139_G161_Y0.5910.99
19_S22_L0.5900.99
57_K85_N0.5900.99
269_L274_E0.5860.99
75_V81_G0.5810.99
10_L18_A0.5810.99
55_L58_E0.5800.99
13_M17_M0.5800.99
246_L250_E0.5790.99
255_E271_A0.5780.99
53_K80_N0.5770.99
16_S126_D0.5770.99
62_I90_A0.5750.99
32_T71_D0.5740.99
204_L225_L0.5730.99
142_K145_F0.5720.99
11_G67_G0.5710.99
64_T94_D0.5700.99
103_A165_A0.5700.99
128_G131_N0.5680.99
207_I212_A0.5650.99
61_V148_C0.5650.99
191_A254_E0.5620.99
200_P225_L0.5550.98
19_S40_S0.5510.98
8_I55_L0.5500.98
100_P170_H0.5490.98
72_V106_I0.5470.98
93_I152_F0.5440.98
162_Q202_N0.5390.98
255_E268_K0.5390.98
20_H24_D0.5360.98
143_E147_A0.5360.98
76_Y106_I0.5360.98
150_P154_L0.5350.98
48_W52_V0.5350.98
151_I154_L0.5350.98
87_K115_L0.5340.98
38_A41_I0.5320.98
177_I192_Y0.5300.98
179_I216_S0.5300.98
63_I155_M0.5270.98
31_Y52_V0.5250.98
4_T59_A0.5240.98
258_G261_L0.5210.98
101_S105_K0.5210.98
60_D90_A0.5200.98
33_R74_E0.5170.98
142_K149_M0.5160.98
233_F236_K0.5140.97
63_I152_F0.5120.97
160_Q163_G0.5120.97
16_S132_G0.5100.97
160_Q209_T0.5090.97
157_E209_T0.5080.97
147_A150_P0.5040.97
167_S170_H0.5020.97
94_D103_A0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vpdA 1 0.9931 100 0.342 Contact Map
3pduA 4 0.9965 100 0.345 Contact Map
3ckyA 4 0.9965 100 0.346 Contact Map
3pefA 5 0.9965 100 0.348 Contact Map
3dojA 3 1 100 0.35 Contact Map
3g0oA 3 0.9826 100 0.353 Contact Map
3obbA 4 0.9931 100 0.356 Contact Map
2uyyA 3 1 100 0.356 Contact Map
4gbjA 2 0.9931 100 0.359 Contact Map
3ws7A 2 0.9757 100 0.364 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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