GREMLIN Database
YOAZ - Uncharacterized protease YoaZ
UniProt: O34947 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 210 (176)
Sequences: 14962 (9886)
Seq/√Len: 745.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
155_S177_K2.9291.00
5_K40_K2.9201.00
7_Y73_Q2.8011.00
50_M60_K2.7941.00
7_Y44_V2.6301.00
173_E176_K2.5271.00
42_V73_Q2.4071.00
125_R157_E2.4011.00
5_K42_V2.2981.00
125_R156_D2.2751.00
123_N144_G2.2501.00
122_L127_H2.1801.00
42_V63_I2.1331.00
181_F185_T2.0071.00
155_S173_E1.9691.00
25_E175_L1.9671.00
100_L158_N1.8281.00
14_M53_T1.8221.00
125_R159_L1.7721.00
23_I27_N1.7301.00
152_P169_E1.7211.00
29_G175_L1.7011.00
45_G48_K1.6671.00
50_M58_S1.6661.00
100_L106_I1.6641.00
176_K181_F1.6601.00
126_K148_Y1.5951.00
126_K156_D1.5901.00
99_A104_T1.5841.00
52_T58_S1.5771.00
108_A161_T1.5761.00
46_V89_H1.5581.00
105_T177_K1.5291.00
155_S160_V1.5251.00
183_P186_L1.5191.00
93_L97_G1.4771.00
64_S67_E1.4701.00
125_R158_N1.4281.00
179_D183_P1.4141.00
39_L178_L1.4041.00
107_A174_V1.4011.00
138_V147_F1.4001.00
126_K147_F1.3911.00
8_L23_I1.3701.00
16_D20_G1.3621.00
8_L77_I1.3581.00
94_K98_D1.3581.00
66_D91_P1.3451.00
75_L105_T1.3421.00
58_S62_D1.3371.00
98_D102_L1.3241.00
95_K99_A1.3231.00
160_V177_K1.3151.00
6_V75_L1.3111.00
173_E177_K1.3071.00
10_V43_T1.3011.00
108_A116_L1.3011.00
12_H52_T1.2941.00
94_K97_G1.2791.00
90_Q94_K1.2771.00
25_E191_K1.2731.00
100_L159_L1.2461.00
100_L121_Y1.2341.00
107_A170_F1.2331.00
63_I67_E1.2271.00
117_A145_E1.2251.00
127_H145_E1.2221.00
14_M19_Y1.1971.00
139_C149_E1.1821.00
39_L179_D1.1771.00
26_L171_A1.1741.00
103_G106_I1.1731.00
126_K146_T1.1661.00
180_V183_P1.1571.00
23_I43_T1.1481.00
103_G158_N1.1421.00
48_K64_S1.1341.00
155_S158_N1.1291.00
136_N141_N1.1291.00
93_L119_E1.1251.00
120_G123_N1.1241.00
114_L136_N1.1241.00
91_P94_K1.1041.00
9_Y92_I1.1041.00
126_K149_E1.1021.00
19_Y43_T1.0971.00
16_D57_L1.0951.00
105_T178_L1.0891.00
17_W21_Y1.0751.00
126_K154_V1.0741.00
77_I170_F1.0731.00
74_D104_T1.0701.00
24_A28_S1.0621.00
21_Y168_L1.0491.00
10_V19_Y1.0361.00
14_M59_I1.0261.00
153_A173_E1.0131.00
126_K151_G1.0121.00
21_Y24_A0.9991.00
8_L41_V0.9941.00
88_I118_N0.9881.00
100_L103_G0.9851.00
111_G133_D0.9801.00
46_V91_P0.9791.00
97_G101_K0.9751.00
130_N164_G0.9751.00
21_Y171_A0.9741.00
98_D101_K0.9731.00
118_N141_N0.9731.00
44_V63_I0.9701.00
78_L96_V0.9691.00
184_D188_S0.9681.00
39_L175_L0.9551.00
151_G169_E0.9501.00
134_Y142_Y0.9461.00
50_M61_P0.9361.00
76_I99_A0.9211.00
113_T129_S0.9151.00
105_T158_N0.9141.00
70_L98_D0.9021.00
162_A170_F0.9011.00
24_A27_N0.8981.00
45_G61_P0.8921.00
142_Y145_E0.8901.00
128_T154_V0.8891.00
42_V62_D0.8881.00
99_A102_L0.8871.00
160_V170_F0.8811.00
25_E171_A0.8811.00
44_V68_C0.8801.00
185_T189_W0.8761.00
182_A186_L0.8751.00
160_V174_V0.8671.00
108_A113_T0.8611.00
46_V65_L0.8601.00
75_L178_L0.8591.00
22_L77_I0.8501.00
10_V14_M0.8481.00
63_I68_C0.8411.00
87_D118_N0.8291.00
97_G119_E0.8241.00
77_I107_A0.8221.00
132_L190_Y0.8211.00
78_L112_A0.8211.00
105_T160_V0.8201.00
21_Y167_P0.8151.00
149_E154_V0.8151.00
83_T86_E0.8101.00
12_H47_N0.8091.00
6_V39_L0.7991.00
16_D55_G0.7981.00
93_L118_N0.7961.00
73_Q99_A0.7951.00
7_Y68_C0.7851.00
38_S179_D0.7691.00
160_V173_E0.7651.00
109_I167_P0.7651.00
141_N146_T0.7641.00
6_V26_L0.7581.00
16_D53_T0.7561.00
93_L96_V0.7541.00
19_Y23_I0.7521.00
134_Y149_E0.7521.00
175_L187_R0.7501.00
176_K184_D0.7501.00
118_N142_Y0.7491.00
95_K98_D0.7381.00
136_N140_P0.7301.00
123_N145_E0.7241.00
165_I191_K0.7241.00
22_L167_P0.7231.00
23_I41_V0.7151.00
167_P171_A0.7121.00
8_L22_L0.7111.00
78_L115_G0.7081.00
8_L19_Y0.7071.00
89_H92_I0.7071.00
48_K61_P0.7021.00
134_Y139_C0.7011.00
69_T98_D0.6931.00
100_L125_R0.6921.00
172_V188_S0.6921.00
75_L107_A0.6901.00
70_L102_L0.6891.00
28_S191_K0.6851.00
14_M79_P0.6681.00
135_M140_P0.6661.00
168_L172_V0.6611.00
106_I158_N0.6571.00
63_I69_T0.6531.00
78_L92_I0.6521.00
49_E61_P0.6511.00
25_E28_S0.6501.00
39_L75_L0.6501.00
9_Y76_I0.6471.00
96_V115_G0.6461.00
133_D136_N0.6441.00
26_L174_V0.6381.00
186_L190_Y0.6331.00
131_D164_G0.6321.00
182_A185_T0.6291.00
117_A122_L0.6271.00
5_K74_D0.6191.00
108_A112_A0.6191.00
75_L174_V0.6191.00
48_K67_E0.6101.00
26_L39_L0.6101.00
15_S24_A0.6091.00
138_V142_Y0.6091.00
73_Q76_I0.6041.00
7_Y42_V0.6021.00
105_T174_V0.5981.00
28_S190_Y0.5931.00
23_I57_L0.5911.00
93_L115_G0.5911.00
27_N41_V0.5841.00
116_L119_E0.5821.00
97_G121_Y0.5791.00
148_Y151_G0.5761.00
129_S148_Y0.5751.00
49_E60_K0.5731.00
44_V73_Q0.5621.00
96_V121_Y0.5621.00
183_P187_R0.5611.00
25_E172_V0.5601.00
68_C73_Q0.5511.00
90_Q93_L0.5481.00
10_V51_I0.5461.00
122_L161_T0.5451.00
127_H146_T0.5411.00
109_I170_F0.5401.00
88_I93_L0.5391.00
38_S183_P0.5361.00
147_F150_K0.5351.00
114_L133_D0.5291.00
9_Y44_V0.5291.00
39_L74_D0.5291.00
169_E172_V0.5261.00
106_I121_Y0.5251.00
152_P163_S0.5231.00
13_T52_T0.5231.00
96_V119_E0.5231.00
82_N85_G0.5211.00
106_I159_L0.5191.00
130_N165_I0.5181.00
151_G154_V0.5181.00
107_A160_V0.5171.00
22_L26_L0.5141.00
90_Q97_G0.5101.00
106_I116_L0.5091.00
7_Y95_K0.5081.00
25_E29_G0.5081.00
82_N86_E0.5081.00
29_G183_P0.5081.00
52_T56_G0.5071.00
124_S144_G0.5061.00
68_C95_K0.5051.00
15_S54_L0.5041.00
22_L171_A0.5021.00
18_E80_G0.5021.00
25_E168_L0.5011.00
76_I95_K0.5011.00
158_N177_K0.5001.00
117_A143_K0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3efeA 2 0.9762 100 0.183 Contact Map
3er6A 2 0.919 100 0.191 Contact Map
3mgkA 2 0.9429 100 0.194 Contact Map
3graA 2 0.8762 100 0.2 Contact Map
2rk3A 2 0.8667 100 0.238 Contact Map
3ewnA 2 0.9429 100 0.239 Contact Map
3noqA 2 0.9333 100 0.245 Contact Map
3bhnA 2 0.9143 100 0.255 Contact Map
4e08A 2 0.8667 100 0.255 Contact Map
3fseA 2 0.9333 100 0.27 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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