GREMLIN Database
PEPVL - Putative dipeptidase YtjP
UniProt: O34944 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 463 (404)
Sequences: 5715 (4241)
Seq/√Len: 211.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
397_E403_K5.2801.00
96_T439_D4.0081.00
98_D101_S3.3911.00
42_G45_A3.3171.00
51_L55_E3.2281.00
394_K460_E3.2071.00
107_G445_D3.1941.00
398_G456_Q3.1361.00
52_E56_K2.9161.00
194_P341_G2.9071.00
101_S112_R2.8111.00
398_G460_E2.7461.00
22_L111_A2.7401.00
414_Y419_K2.6301.00
108_R441_Y2.6151.00
182_A408_S2.5611.00
48_T52_E2.5151.00
20_E49_S2.4921.00
361_D365_S2.4731.00
54_G71_I2.3691.00
81_G167_P2.3471.00
358_V362_T2.2911.00
72_E143_R2.2581.00
192_L341_G2.2531.00
44_N48_T2.2481.00
230_K233_E2.2101.00
97_S105_R2.1771.00
52_E55_E2.1581.00
19_Q23_R2.1371.00
49_S53_L2.1131.00
414_Y418_L2.0381.00
20_E23_R2.0201.00
74_G141_R2.0001.00
74_G77_D1.9841.00
50_L86_V1.9731.00
21_F46_S1.9591.00
103_E112_R1.9231.00
104_I444_I1.9081.00
192_L370_E1.8811.00
442_I447_L1.8731.00
23_R101_S1.8731.00
227_E366_A1.8491.00
25_N42_G1.8301.00
78_D168_T1.8051.00
192_L372_G1.8051.00
79_I141_R1.8001.00
244_T358_V1.8001.00
394_K398_G1.7751.00
456_Q459_Y1.7551.00
218_V322_E1.7371.00
138_L459_Y1.7271.00
268_H272_P1.7171.00
192_L343_E1.7121.00
129_K133_D1.7091.00
49_S52_E1.7071.00
193_I369_F1.6881.00
194_P370_E1.6731.00
19_Q102_A1.6731.00
60_T72_E1.6731.00
104_I107_G1.6301.00
62_K164_E1.6291.00
59_F71_I1.6191.00
51_L69_G1.6041.00
190_S372_G1.5791.00
392_L457_A1.5761.00
423_A426_P1.5761.00
385_D390_K1.5721.00
393_Q403_K1.5611.00
395_V460_E1.5571.00
107_G443_E1.5461.00
283_C286_L1.5441.00
41_E45_A1.5421.00
271_E274_N1.5211.00
96_T105_R1.5171.00
16_R20_E1.5151.00
16_R19_Q1.5091.00
269_A272_P1.5081.00
94_G97_S1.5081.00
254_E257_Q1.4921.00
12_E16_R1.4861.00
253_I257_Q1.4761.00
399_Q456_Q1.4751.00
190_S343_E1.4721.00
393_Q406_L1.4641.00
53_L56_K1.4611.00
361_D364_E1.4601.00
386_H420_A1.4581.00
80_I458_I1.4461.00
22_L102_A1.4451.00
253_I256_G1.4331.00
456_Q460_E1.4301.00
169_M388_L1.4231.00
51_L61_T1.4121.00
48_T51_L1.3991.00
86_V146_I1.3871.00
26_S46_S1.3851.00
222_A225_V1.3791.00
270_M274_N1.3741.00
51_L63_N1.3661.00
208_S225_V1.3611.00
390_K393_Q1.3601.00
23_R102_A1.3531.00
22_L26_S1.3491.00
268_H271_E1.3431.00
230_K235_L1.3341.00
84_C121_T1.3321.00
194_P368_E1.3301.00
57_E125_F1.3291.00
159_H163_H1.3271.00
13_D16_R1.3191.00
149_D155_R1.3171.00
448_L452_A1.3121.00
130_I134_M1.3111.00
263_Y266_S1.3061.00
394_K397_E1.3021.00
189_A363_F1.2991.00
65_D161_F1.2981.00
249_G252_A1.2781.00
111_A114_A1.2721.00
283_C287_Q1.2711.00
284_E287_Q1.2681.00
357_K361_D1.2651.00
57_E132_K1.2621.00
24_I49_S1.2601.00
395_V399_Q1.2591.00
91_P100_F1.2561.00
97_S103_E1.2551.00
47_L69_G1.2521.00
395_V456_Q1.2521.00
246_D353_T1.2371.00
288_Q291_L1.2371.00
104_I109_I1.2321.00
355_E358_V1.2291.00
22_L114_A1.2281.00
251_A254_E1.2231.00
267_C272_P1.2201.00
59_F144_M1.2201.00
130_I455_A1.2171.00
267_C270_M1.2151.00
259_I262_M1.2121.00
44_N63_N1.2011.00
116_D120_P1.1981.00
360_R364_E1.1961.00
262_M265_L1.1941.00
255_N258_L1.1931.00
355_E378_K1.1871.00
266_S270_M1.1801.00
287_Q290_E1.1801.00
282_L285_F1.1781.00
258_L264_G1.1771.00
258_L261_R1.1751.00
47_L63_N1.1731.00
265_L268_H1.1621.00
239_K366_A1.1581.00
252_A255_N1.1581.00
218_V320_E1.1571.00
128_L144_M1.1541.00
116_D125_F1.1511.00
20_E53_L1.1461.00
248_K253_I1.1451.00
116_D119_G1.1421.00
46_S86_V1.1411.00
253_I258_L1.1401.00
105_R110_Y1.1401.00
392_L422_V1.1391.00
70_H143_R1.1381.00
250_E253_I1.1381.00
171_F424_F1.1371.00
116_D121_T1.1321.00
445_D449_R1.1281.00
24_I46_S1.1271.00
225_V317_I1.1261.00
399_Q452_A1.1251.00
59_F73_W1.1211.00
17_D126_Y1.1211.00
360_R373_E1.1181.00
356_S378_K1.1181.00
262_M266_S1.1161.00
221_A342_G1.0991.00
393_Q397_E1.0981.00
260_L263_Y1.0961.00
420_A423_A1.0911.00
241_M245_T1.0861.00
235_L239_K1.0751.00
285_F290_E1.0731.00
356_S376_D1.0651.00
57_E129_K1.0621.00
19_Q104_I1.0611.00
47_L86_V1.0601.00
187_I360_R1.0581.00
267_C271_E1.0571.00
284_E288_Q1.0571.00
421_G426_P1.0521.00
54_G125_F1.0471.00
15_I19_Q1.0431.00
53_L57_E1.0411.00
285_F288_Q1.0391.00
358_V361_D1.0381.00
410_G413_T1.0351.00
248_K251_A1.0321.00
86_V148_T1.0281.00
190_S345_G1.0261.00
62_K65_D1.0211.00
14_L451_T1.0201.00
72_E141_R1.0191.00
321_D343_E1.0151.00
416_R419_K1.0131.00
126_Y129_K1.0121.00
283_C290_E1.0101.00
263_Y267_C1.0071.00
420_A426_P1.0051.00
282_L290_E1.0051.00
432_P435_A1.0051.00
175_A180_I1.0031.00
414_Y417_S1.0031.00
399_Q453_L0.9981.00
180_I407_I0.9951.00
324_S330_N0.9931.00
431_R443_E0.9911.00
180_I409_I0.9881.00
265_L270_M0.9871.00
239_K243_R0.9861.00
282_L286_L0.9851.00
391_T395_V0.9791.00
258_L265_L0.9791.00
258_L262_M0.9791.00
27_V100_F0.9771.00
19_Q101_S0.9721.00
99_P102_A0.9721.00
190_S374_F0.9711.00
29_D149_D0.9711.00
73_W128_L0.9711.00
287_Q291_L0.9671.00
103_E110_Y0.9551.00
48_T63_N0.9511.00
17_D57_E0.9501.00
117_D120_P0.9501.00
267_C273_N0.9491.00
421_G424_F0.9491.00
151_E436_H0.9480.99
149_D156_C0.9480.99
239_K242_L0.9470.99
93_D113_G0.9440.99
264_G268_H0.9430.99
397_E402_K0.9430.99
236_S239_K0.9420.99
45_A48_T0.9410.99
73_W132_K0.9380.99
268_H273_N0.9350.99
252_A257_Q0.9350.99
79_I143_R0.9330.99
266_S272_P0.9330.99
152_S155_R0.9280.99
320_E326_E0.9240.99
257_Q260_L0.9230.99
286_L290_E0.9230.99
181_N384_A0.9210.99
117_D121_T0.9210.99
254_E259_I0.9190.99
106_N445_D0.9160.99
390_K394_K0.9150.99
16_R23_R0.9140.99
17_D53_L0.9140.99
315_L348_I0.9130.99
66_G148_T0.9090.99
64_L70_H0.9070.99
15_I104_I0.9070.99
269_A273_N0.9040.99
249_G253_I0.9040.99
191_L346_I0.9030.99
324_S408_S0.9020.99
261_R264_G0.8980.99
444_I448_L0.8970.99
119_G125_F0.8960.99
250_E254_E0.8920.99
431_R446_D0.8900.99
397_E404_A0.8900.99
170_G421_G0.8840.99
15_I444_I0.8820.99
54_G59_F0.8810.99
264_G272_P0.8780.99
285_F289_T0.8740.99
212_G219_P0.8720.99
14_L122_M0.8680.99
393_Q404_A0.8670.99
29_D152_S0.8640.99
269_A274_N0.8590.99
106_N110_Y0.8590.99
354_A359_I0.8580.99
391_T460_E0.8540.99
195_H217_M0.8540.99
252_A256_G0.8540.99
240_D243_R0.8520.99
443_E446_D0.8490.99
415_A419_K0.8480.99
189_A371_L0.8470.99
150_E436_H0.8450.99
121_T125_F0.8440.99
191_L371_L0.8420.99
313_K318_D0.8400.99
268_H274_N0.8360.99
409_I412_G0.8330.99
159_H162_K0.8250.99
248_K252_A0.8240.99
138_L142_V0.8230.99
250_E257_Q0.8220.99
255_N259_I0.8200.99
396_Y453_L0.8200.99
364_E373_E0.8190.99
420_A424_F0.8180.99
362_T366_A0.8170.99
85_H116_D0.8150.98
183_E413_T0.8130.98
21_F50_L0.8120.98
116_D123_A0.8100.98
28_M152_S0.8100.98
265_L269_A0.8090.98
348_I363_F0.8080.98
223_E231_N0.8050.98
179_I404_A0.8040.98
27_V30_E0.8040.98
318_D321_D0.8020.98
79_I165_E0.8020.98
283_C291_L0.8020.98
70_H164_E0.8000.98
71_I144_M0.7970.98
75_E137_P0.7950.98
457_A461_L0.7950.98
314_K317_I0.7940.98
127_A144_M0.7920.98
14_L447_L0.7900.98
286_L291_L0.7890.98
236_S240_D0.7870.98
116_D122_M0.7850.98
24_I45_A0.7850.98
102_A109_I0.7820.98
432_P441_Y0.7720.98
189_A373_E0.7710.98
19_Q109_I0.7700.98
409_I413_T0.7700.98
215_L220_D0.7700.98
54_G61_T0.7690.98
27_V91_P0.7670.98
156_C159_H0.7660.98
252_A258_L0.7660.98
282_L287_Q0.7590.98
281_L284_E0.7560.98
258_L263_Y0.7550.98
364_E371_L0.7550.98
25_N100_F0.7540.97
206_L226_I0.7540.97
17_D129_K0.7530.97
237_S240_D0.7530.97
446_D449_R0.7520.97
368_E371_L0.7470.97
254_E258_L0.7470.97
257_Q264_G0.7470.97
115_I119_G0.7470.97
259_I265_L0.7440.97
61_T72_E0.7440.97
128_L142_V0.7430.97
179_I393_Q0.7420.97
48_T55_E0.7410.97
21_F49_S0.7400.97
260_L265_L0.7400.97
17_D49_S0.7380.97
222_A226_I0.7370.97
17_D20_E0.7360.97
283_C288_Q0.7360.97
362_T365_S0.7350.97
122_M125_F0.7320.97
415_A418_L0.7310.97
115_I122_M0.7280.97
117_D125_F0.7280.97
218_V222_A0.7250.97
191_L369_F0.7240.97
179_I392_L0.7220.97
348_I359_I0.7210.97
263_Y272_P0.7210.97
118_K123_A0.7180.97
267_C274_N0.7130.96
261_R265_L0.7110.96
188_D347_N0.7110.96
262_M270_M0.7080.96
79_I168_T0.7070.96
84_C120_P0.7060.96
128_L132_K0.7020.96
186_I377_S0.7010.96
433_D441_Y0.7010.96
396_Y400_L0.7000.96
198_N205_V0.7000.96
426_P429_P0.6980.96
387_P391_T0.6970.96
373_E376_D0.6960.96
115_I120_P0.6950.96
102_A111_A0.6950.96
18_T22_L0.6950.96
283_C289_T0.6940.96
259_I263_Y0.6940.96
357_K360_R0.6930.96
206_L221_A0.6930.96
122_M126_Y0.6920.96
119_G122_M0.6920.96
282_L288_Q0.6900.96
176_D402_K0.6900.96
115_I118_K0.6890.96
158_E162_K0.6880.96
321_D325_G0.6880.96
325_G330_N0.6870.96
260_L269_A0.6860.96
256_G259_I0.6850.96
50_L146_I0.6840.96
82_V458_I0.6830.96
316_D319_C0.6830.96
108_R443_E0.6820.95
116_D130_I0.6760.95
118_K122_M0.6730.95
186_I412_G0.6690.95
13_D132_K0.6650.95
50_L121_T0.6610.95
221_A344_L0.6610.95
260_L270_M0.6600.95
331_V344_L0.6590.95
391_T461_L0.6590.95
234_I237_S0.6590.95
116_D150_E0.6590.95
391_T394_K0.6580.95
265_L272_P0.6580.95
141_R165_E0.6560.94
389_V422_V0.6550.94
251_A258_L0.6540.94
350_Y376_D0.6540.94
61_T65_D0.6520.94
72_E166_M0.6520.94
247_Q250_E0.6510.94
98_D103_E0.6500.94
117_D123_A0.6490.94
118_K121_T0.6480.94
354_A358_V0.6470.94
206_L211_S0.6470.94
28_M155_R0.6450.94
62_K70_H0.6440.94
448_L451_T0.6440.94
47_L51_L0.6430.94
262_M267_C0.6430.94
88_V100_F0.6430.94
26_S118_K0.6420.94
68_A160_Y0.6410.94
408_S413_T0.6410.94
260_L264_G0.6400.94
158_E417_S0.6390.94
264_G270_M0.6390.94
80_I169_M0.6380.94
120_P124_A0.6380.94
97_S102_A0.6370.94
204_A340_Q0.6350.93
395_V453_L0.6350.93
95_W98_D0.6350.93
27_V88_V0.6340.93
108_R433_D0.6320.93
222_A317_I0.6300.93
266_S269_A0.6280.93
110_Y441_Y0.6270.93
50_L71_I0.6270.93
19_Q22_L0.6260.93
131_V459_Y0.6220.93
451_T455_A0.6200.93
211_S219_P0.6200.93
116_D436_H0.6200.93
281_L285_F0.6200.93
124_A173_P0.6190.93
66_G159_H0.6190.93
261_R266_S0.6190.93
91_P438_K0.6180.92
219_P229_P0.6150.92
13_D129_K0.6130.92
245_T248_K0.6130.92
186_I350_Y0.6130.92
70_H160_Y0.6110.92
123_A454_Y0.6090.92
255_N260_L0.6090.92
82_V144_M0.6090.92
84_C146_I0.6090.92
50_L84_C0.6080.92
50_L125_F0.6080.92
383_S420_A0.6080.92
116_D127_A0.6070.92
252_A264_G0.6050.92
25_N91_P0.6040.92
118_K125_F0.6040.92
449_R452_A0.6020.91
13_D17_D0.6020.91
175_A423_A0.6000.91
134_M137_P0.6000.91
116_D151_E0.5980.91
109_I444_I0.5970.91
116_D124_A0.5960.91
171_F457_A0.5950.91
140_K458_I0.5950.91
286_L289_T0.5920.91
85_H150_E0.5920.91
285_F291_L0.5920.91
310_T313_K0.5920.91
424_F457_A0.5900.91
119_G123_A0.5890.91
28_M149_D0.5890.91
188_D215_L0.5880.91
234_I242_L0.5870.90
81_G145_I0.5860.90
282_L291_L0.5860.90
131_V139_S0.5850.90
251_A260_L0.5850.90
55_E61_T0.5840.90
115_I121_T0.5830.90
177_F450_S0.5810.90
253_I264_G0.5800.90
174_D212_G0.5800.90
97_S101_S0.5790.90
415_A423_A0.5790.90
188_D374_F0.5780.90
20_E52_E0.5770.90
395_V398_G0.5760.90
73_W139_S0.5760.90
264_G267_C0.5750.90
261_R268_H0.5740.89
160_Y164_E0.5740.89
262_M268_H0.5700.89
261_R267_C0.5690.89
327_L332_G0.5680.89
122_M130_I0.5660.89
251_A255_N0.5660.89
127_A131_V0.5650.89
178_P407_I0.5650.89
244_T353_T0.5640.89
181_N408_S0.5640.89
205_V211_S0.5640.89
64_L68_A0.5640.89
54_G144_M0.5630.89
179_I453_L0.5610.88
326_E355_E0.5590.88
211_S221_A0.5590.88
403_K406_L0.5580.88
219_P222_A0.5580.88
78_D387_P0.5570.88
253_I259_I0.5560.88
238_F242_L0.5550.88
256_G261_R0.5550.88
257_Q262_M0.5550.88
121_T146_I0.5540.88
246_D250_E0.5540.88
208_S223_E0.5500.87
207_V225_V0.5450.87
251_A261_R0.5440.87
368_E375_K0.5430.87
20_E56_K0.5430.87
43_V148_T0.5420.87
259_I266_S0.5420.87
263_Y268_H0.5400.86
367_S371_L0.5390.86
17_D122_M0.5390.86
242_L245_T0.5380.86
206_L219_P0.5370.86
117_D122_M0.5360.86
209_F409_I0.5360.86
189_A360_R0.5340.86
445_D448_L0.5340.86
246_D249_G0.5320.86
426_P430_G0.5310.86
332_G347_N0.5290.85
115_I429_P0.5280.85
309_D314_K0.5280.85
270_M273_N0.5250.85
384_A387_P0.5240.85
247_Q251_A0.5240.85
261_R269_A0.5230.85
260_L268_H0.5220.85
256_G260_L0.5190.84
430_G441_Y0.5190.84
71_I146_I0.5190.84
56_K129_K0.5180.84
80_I140_K0.5170.84
325_G328_T0.5170.84
357_K376_D0.5160.84
120_P125_F0.5160.84
281_L287_Q0.5130.84
119_G130_I0.5120.83
240_D244_T0.5120.83
216_N316_D0.5120.83
15_I109_I0.5110.83
207_V227_E0.5110.83
114_A442_I0.5110.83
313_K317_I0.5100.83
257_Q265_L0.5100.83
327_L330_N0.5100.83
259_I264_G0.5090.83
83_L147_G0.5090.83
130_I133_D0.5070.83
120_P123_A0.5070.83
78_D140_K0.5060.83
21_F122_M0.5060.83
179_I406_L0.5050.83
153_D183_E0.5040.82
197_P340_Q0.5040.82
85_H151_E0.5030.82
17_D132_K0.5000.82
221_A225_V0.5000.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1lfwA 1 0.9957 100 0.329 Contact Map
3khxA 1 0.9136 100 0.329 Contact Map
2zogA 2 0.9071 100 0.41 Contact Map
3dljA 2 0.9114 100 0.412 Contact Map
4g1pA 2 0.9114 100 0.415 Contact Map
3pfeA 2 0.905 100 0.421 Contact Map
4mmoA 2 0.8747 100 0.422 Contact Map
2pokA 2 0.905 100 0.427 Contact Map
3pfoA 2 0.797 100 0.431 Contact Map
2qyvA 2 0.8942 100 0.433 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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