GREMLIN Database
YVRE - Putative sugar lactone lactonase YvrE
UniProt: O34940 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 292 (231)
Sequences: 18880 (15271)
Seq/√Len: 1004.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
124_A128_R3.7711.00
147_G161_D3.0361.00
197_G210_L2.8801.00
239_C253_T2.8341.00
101_D114_T2.7431.00
16_G30_D2.6131.00
28_W38_I2.6031.00
209_A219_I2.4751.00
243_G246_D2.4591.00
103_K149_D2.3911.00
29_V39_F2.3821.00
217_V226_E2.3611.00
251_Y261_E2.3531.00
75_Y84_L2.3041.00
233_P252_I2.2961.00
159_Y169_R2.1981.00
124_A127_Y2.1871.00
208_V218_H2.1791.00
191_S209_A2.1411.00
216_V252_I2.1141.00
167_I209_A2.0871.00
208_V242_F2.0741.00
252_I262_K1.9961.00
112_A150_W1.9931.00
159_Y200_I1.9821.00
141_Q160_I1.9281.00
59_A103_K1.9171.00
160_I170_Y1.9141.00
217_V229_S1.9001.00
159_Y207_W1.8431.00
220_D223_Q1.8331.00
20_D23_N1.8151.00
28_W60_K1.8131.00
149_D199_T1.7721.00
171_S174_P1.7341.00
105_D150_W1.7201.00
61_Y104_C1.7031.00
113_G129_L1.6881.00
161_D195_P1.6791.00
146_N163_P1.6561.00
199_T241_A1.6281.00
78_H81_D1.6261.00
56_T70_M1.5951.00
124_A129_L1.5871.00
40_D43_E1.5511.00
196_D212_G1.5401.00
219_I226_E1.5361.00
20_D60_K1.5271.00
91_K113_G1.5061.00
112_A158_Y1.4951.00
105_D109_R1.4861.00
184_P187_R1.4781.00
151_D200_I1.4681.00
141_Q162_T1.4381.00
208_V250_L1.4211.00
75_Y87_I1.4071.00
36_L69_T1.3961.00
233_P254_T1.3881.00
210_L237_V1.3851.00
201_D242_F1.3841.00
18_L59_A1.3591.00
238_T255_A1.3281.00
68_M76_L1.3281.00
84_L87_I1.3261.00
215_R229_S1.3231.00
18_L58_L1.3221.00
74_F113_G1.3111.00
29_V37_H1.2961.00
112_A148_L1.2931.00
31_I35_E1.2921.00
201_D205_M1.2821.00
51_F69_T1.2781.00
115_T123_Q1.2731.00
208_V240_C1.2691.00
68_M104_C1.2661.00
112_A128_R1.2631.00
161_D198_M1.2581.00
114_T145_S1.2551.00
252_I260_T1.2521.00
226_E229_S1.2491.00
28_W58_L1.2371.00
210_L240_C1.2361.00
31_I34_S1.2181.00
123_Q127_Y1.2021.00
69_T77_Y1.1931.00
103_K148_L1.1931.00
211_F217_V1.1881.00
254_T258_Q1.1851.00
201_D204_G1.1831.00
149_D198_M1.1831.00
77_Y84_L1.1651.00
168_V184_P1.1631.00
20_D25_R1.1531.00
62_S108_G1.1431.00
243_G251_Y1.1251.00
162_T166_E1.1111.00
243_G248_K1.1101.00
159_Y198_M1.1061.00
232_V260_T1.1051.00
232_V262_K1.0951.00
209_A217_V1.0911.00
124_A131_L1.0871.00
146_N196_D1.0871.00
199_T240_C1.0751.00
125_S137_K1.0741.00
28_W67_I1.0701.00
19_W27_Y1.0581.00
51_F77_Y1.0391.00
151_D155_N1.0371.00
190_Q219_I1.0341.00
62_S104_C1.0341.00
221_P224_K1.0311.00
243_G249_T1.0251.00
202_Q247_L1.0231.00
148_L160_I1.0211.00
249_T263_E1.0151.00
206_L218_H1.0151.00
30_D55_V1.0131.00
242_F250_L1.0131.00
243_G247_L1.0121.00
66_L69_T1.0121.00
68_M111_W1.0051.00
147_G197_G1.0031.00
31_I37_H1.0021.00
160_I168_V0.9961.00
206_L227_I0.9911.00
194_L212_G0.9831.00
168_V187_R0.9831.00
191_S211_F0.9771.00
152_R200_I0.9751.00
141_Q145_S0.9721.00
61_Y65_E0.9691.00
144_T163_P0.9671.00
241_A251_Y0.9601.00
202_Q242_F0.9601.00
254_T257_E0.9581.00
59_A102_A0.9581.00
51_F55_V0.9551.00
15_E32_L0.9541.00
100_N146_N0.9361.00
151_D157_M0.9331.00
200_I207_W0.9281.00
102_A113_G0.9131.00
25_R40_D0.9111.00
20_D24_G0.9081.00
150_W158_Y0.9081.00
113_G127_Y0.8981.00
26_L38_I0.8941.00
105_D110_L0.8931.00
65_E68_M0.8891.00
216_V240_C0.8791.00
104_C111_W0.8781.00
59_A104_C0.8781.00
57_A101_D0.8761.00
73_G89_Q0.8731.00
106_P150_W0.8731.00
36_L58_L0.8691.00
37_H46_N0.8651.00
196_D238_T0.8641.00
123_Q128_R0.8581.00
220_D227_I0.8541.00
249_T261_E0.8461.00
41_P44_K0.8461.00
74_F102_A0.8451.00
197_G239_C0.8451.00
233_P237_V0.8441.00
215_R231_S0.8441.00
32_L54_F0.8431.00
101_D148_L0.8421.00
101_D147_G0.8361.00
114_T148_L0.8341.00
127_Y131_L0.8221.00
37_H47_R0.8201.00
128_R131_L0.8171.00
191_S195_P0.8071.00
73_G87_I0.8061.00
207_W221_P0.8041.00
19_W41_P0.7991.00
200_I221_P0.7971.00
152_R204_G0.7971.00
126_L160_I0.7931.00
151_D154_R0.7911.00
79_L82_D0.7871.00
199_T242_F0.7851.00
218_H230_I0.7801.00
211_F215_R0.7801.00
201_D206_L0.7801.00
169_R200_I0.7771.00
240_C252_I0.7751.00
65_E78_H0.7751.00
201_D208_V0.7741.00
145_S160_I0.7731.00
162_T165_Q0.7721.00
182_P185_V0.7691.00
141_Q164_T0.7661.00
78_H85_E0.7651.00
240_C250_L0.7651.00
213_G217_V0.7641.00
150_W172_Y0.7641.00
57_A102_A0.7641.00
135_L138_I0.7621.00
30_D58_L0.7561.00
68_M77_Y0.7501.00
197_G240_C0.7461.00
205_M220_D0.7421.00
30_D34_S0.7361.00
232_V252_I0.7361.00
48_S51_F0.7351.00
148_L158_Y0.7321.00
143_S163_P0.7281.00
140_D170_Y0.7211.00
50_K75_Y0.7211.00
61_Y64_D0.7181.00
195_P209_A0.7171.00
68_M102_A0.7151.00
205_M222_F0.7101.00
17_P29_V0.7061.00
233_P256_T0.7051.00
184_P188_F0.7051.00
33_G37_H0.7021.00
212_G236_Y0.7011.00
147_G198_M0.7001.00
203_N206_L0.6941.00
235_K255_A0.6941.00
104_C150_W0.6941.00
60_K79_L0.6931.00
210_L214_S0.6911.00
18_L60_K0.6891.00
155_N173_D0.6861.00
128_R136_V0.6851.00
141_Q168_V0.6781.00
84_L226_E0.6761.00
164_T168_V0.6751.00
29_V33_G0.6731.00
198_M209_A0.6681.00
185_V188_F0.6671.00
28_W36_L0.6651.00
91_K99_F0.6591.00
14_G17_P0.6581.00
162_T168_V0.6571.00
76_L104_C0.6551.00
61_Y66_L0.6551.00
233_P260_T0.6551.00
99_F115_T0.6531.00
50_K77_Y0.6531.00
220_D225_K0.6531.00
99_F102_A0.6501.00
69_T75_Y0.6451.00
210_L252_I0.6431.00
38_I60_K0.6421.00
25_R42_E0.6391.00
193_G212_G0.6391.00
186_Y189_D0.6371.00
58_L69_T0.6371.00
127_Y137_K0.6351.00
167_I198_M0.6331.00
19_W104_C0.6321.00
74_F88_K0.6301.00
60_K67_I0.6291.00
99_F113_G0.6281.00
237_V252_I0.6271.00
103_K150_W0.6261.00
158_Y172_Y0.6261.00
163_P194_L0.6241.00
110_L114_T0.6241.00
110_L172_Y0.6221.00
20_D28_W0.6211.00
211_F214_S0.6201.00
246_D249_T0.6191.00
78_H83_S0.6191.00
232_V254_T0.6101.00
150_W200_I0.6071.00
53_S70_M0.6061.00
123_Q129_L0.6061.00
191_S213_G0.6051.00
65_E69_T0.6051.00
166_E187_R0.6051.00
54_F70_M0.6021.00
190_Q217_V0.5991.00
27_Y41_P0.5991.00
238_T253_T0.5981.00
174_P183_E0.5931.00
109_R130_N0.5931.00
248_K263_E0.5921.00
106_P154_R0.5911.00
236_Y255_A0.5881.00
256_T260_T0.5831.00
211_F219_I0.5821.00
216_V237_V0.5811.00
103_K112_A0.5801.00
160_I164_T0.5781.00
122_K128_R0.5781.00
40_D44_K0.5771.00
242_F264_R0.5771.00
162_T170_Y0.5771.00
149_D200_I0.5751.00
97_L115_T0.5731.00
141_Q170_Y0.5731.00
188_F191_S0.5721.00
20_D26_L0.5711.00
115_T125_S0.5701.00
181_N184_P0.5681.00
252_I256_T0.5671.00
155_N171_S0.5661.00
35_E47_R0.5661.00
171_S181_N0.5651.00
23_N26_L0.5651.00
90_P113_G0.5641.00
53_S71_K0.5631.00
76_L88_K0.5601.00
71_K75_Y0.5581.00
112_A126_L0.5511.00
171_S183_E0.5491.00
163_P196_D0.5481.00
122_K144_T0.5481.00
169_R183_E0.5481.00
51_F68_M0.5431.00
105_D112_A0.5421.00
140_D168_V0.5411.00
104_C131_L0.5391.00
51_F75_Y0.5381.00
40_D45_I0.5371.00
30_D33_G0.5361.00
174_P182_P0.5311.00
253_T257_E0.5301.00
18_L28_W0.5291.00
145_S162_T0.5281.00
81_D85_E0.5271.00
216_V230_I0.5251.00
253_T259_M0.5241.00
55_V58_L0.5151.00
105_D108_G0.5141.00
57_A69_T0.5141.00
165_Q194_L0.5121.00
91_K115_T0.5121.00
51_F71_K0.5111.00
125_S128_R0.5111.00
135_L139_K0.5101.00
100_N122_K0.5091.00
206_L242_F0.5091.00
56_T100_N0.5091.00
161_D209_A0.5081.00
63_K66_L0.5081.00
66_L85_E0.5011.00
67_I76_L0.5001.00
70_M100_N0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vyhC 1 0.8322 100 0.164 Contact Map
4u1eI 1 0.9178 100 0.185 Contact Map
1gotB 1 0.8322 100 0.194 Contact Map
4wjuA 1 0.8322 100 0.196 Contact Map
3ow8A 3 0.9247 100 0.199 Contact Map
4j73A 1 0.9178 100 0.199 Contact Map
3dm0A 1 0.9281 100 0.203 Contact Map
3sfzA 1 0.9486 100 0.206 Contact Map
3j60g 1 0.8733 100 0.206 Contact Map
4j87A 1 0.9384 100 0.209 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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