GREMLIN Database
NADK2 - NAD kinase 2
UniProt: O34934 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 267 (241)
Sequences: 4129 (2854)
Seq/√Len: 183.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
106_K249_K3.9581.00
211_T238_T3.6221.00
209_K242_K3.6191.00
143_D208_R3.4481.00
139_D213_R3.1741.00
167_N185_S2.9811.00
96_A101_Q2.9301.00
138_M212_L2.9071.00
180_P206_S2.8961.00
211_T240_E2.8351.00
213_R238_T2.7891.00
111_E242_K2.7351.00
55_F250_T2.5961.00
116_Q237_K2.5121.00
111_E119_P2.5111.00
32_H95_D2.4911.00
175_V183_Q2.4001.00
106_K247_K2.3811.00
209_K240_E2.3241.00
113_T240_E2.2281.00
141_L146_H2.2261.00
184_V204_L2.2241.00
89_E92_K2.2111.00
144_D211_T2.1481.00
107_Y161_T2.0811.00
141_L213_R2.0741.00
95_D99_F1.9971.00
18_T22_A1.9331.00
141_L211_T1.8801.00
145_L257_S1.8761.00
140_V184_V1.8391.00
112_V126_V1.7951.00
28_L95_D1.7701.00
28_L91_E1.7661.00
46_I62_T1.7661.00
128_I212_L1.7651.00
104_V249_K1.7381.00
60_R229_E1.7231.00
126_V224_I1.7181.00
105_R252_K1.7061.00
109_L248_I1.6831.00
144_D209_K1.6771.00
170_V185_S1.6701.00
121_H244_S1.6611.00
139_D215_V1.6401.00
146_H149_T1.6211.00
142_I210_L1.6071.00
55_F72_G1.5821.00
113_T242_K1.5771.00
24_S91_E1.5691.00
27_Q31_E1.5571.00
164_T174_V1.5161.00
173_A183_Q1.5061.00
49_I76_K1.4761.00
142_I208_R1.4661.00
170_V188_A1.4641.00
26_T30_E1.4571.00
113_T119_P1.4501.00
110_I182_M1.4401.00
157_I212_L1.4401.00
115_D238_T1.3781.00
25_L94_V1.3781.00
28_L32_H1.3761.00
19_N22_A1.3621.00
173_A203_V1.3591.00
84_D252_K1.3591.00
125_E156_I1.3151.00
55_F83_C1.2981.00
59_V70_Y1.2941.00
145_L260_E1.2941.00
140_V155_M1.2751.00
122_C226_L1.2511.00
126_V241_I1.2401.00
74_T80_H1.2121.00
139_D149_T1.2021.00
111_E244_S1.1961.00
176_D205_S1.1861.00
79_A190_L1.1711.00
214_V222_P1.1511.00
153_D166_Y1.1471.00
45_I97_M1.1421.00
25_L49_I1.1411.00
109_L244_S1.1371.00
85_F93_M1.1351.00
258_F262_V1.1311.00
175_V181_C1.1291.00
115_D240_E1.1141.00
176_D259_W1.1121.00
109_L247_K1.1091.00
126_V226_L1.0981.00
64_F246_K1.0951.00
67_D249_K1.0931.00
65_R68_C1.0871.00
158_S183_Q1.0851.00
112_V226_L1.0831.00
111_E245_N1.0821.00
45_I251_V1.0821.00
71_V97_M1.0761.00
23_R27_Q1.0741.00
156_I170_V1.0661.00
234_R237_K1.0501.00
108_P180_P1.0411.00
97_M102_I1.0381.00
25_L90_R1.0361.00
175_V203_V1.0341.00
204_L210_L1.0301.00
37_V43_A1.0271.00
136_F222_P1.0261.00
192_N196_R1.0120.99
260_E264_R1.0120.99
157_I241_I1.0100.99
28_L94_V1.0060.99
168_K192_N1.0030.99
47_A94_V1.0030.99
73_I85_F0.9960.99
221_H234_R0.9850.99
182_M210_L0.9840.99
92_K96_A0.9820.99
180_P247_K0.9780.99
137_V149_T0.9780.99
108_P243_L0.9770.99
127_S156_I0.9750.99
74_T265_T0.9640.99
138_M152_G0.9620.99
155_M184_V0.9540.99
141_L144_D0.9540.99
67_D246_K0.9520.99
41_S65_R0.9480.99
39_Q43_A0.9460.99
157_I182_M0.9380.99
22_A26_T0.9360.99
108_P206_S0.9340.99
101_Q254_K0.9300.99
157_I184_V0.9260.99
103_E255_D0.9250.99
71_V251_V0.9240.99
168_K190_L0.9210.99
81_L259_W0.9190.99
130_S134_K0.9190.99
143_D209_K0.9190.99
176_D208_R0.9170.99
206_S243_L0.9160.99
161_T177_P0.9090.99
107_Y177_P0.9040.99
20_E24_S0.9000.99
71_V85_F0.8970.99
24_S28_L0.8960.99
30_E35_T0.8960.99
183_Q203_V0.8850.99
32_H98_T0.8760.98
205_S208_R0.8760.98
132_I223_I0.8740.98
53_G77_G0.8690.98
59_V248_I0.8550.98
84_D165_A0.8510.98
21_Q24_S0.8500.98
73_I90_R0.8470.98
20_E23_R0.8470.98
243_L247_K0.8460.98
115_D237_K0.8460.98
96_A253_L0.8370.98
108_P182_M0.8340.98
46_I70_Y0.8330.98
168_K266_F0.8320.98
223_I230_A0.8300.98
29_A34_F0.8240.98
176_D258_F0.8240.98
178_L205_S0.8230.98
121_H246_K0.8190.98
180_P207_D0.8180.98
204_L208_R0.8150.98
108_P160_P0.8150.98
168_K173_A0.8120.98
33_G36_V0.8120.98
134_K229_E0.8120.98
115_D118_S0.8080.97
23_R30_E0.8070.97
59_V123_L0.8060.97
108_P181_C0.8060.97
120_F226_L0.8060.97
93_M253_L0.7970.97
125_E129_R0.7970.97
63_N244_S0.7910.97
111_E121_H0.7910.97
256_N261_K0.7910.97
123_L161_T0.7890.97
48_S58_A0.7870.97
131_S221_H0.7850.97
140_V212_L0.7840.97
139_D146_H0.7840.97
55_F70_Y0.7840.97
123_L248_I0.7830.97
116_Q234_R0.7810.97
112_V239_I0.7780.97
157_I210_L0.7780.97
142_I204_L0.7740.97
109_L123_L0.7740.97
34_F98_T0.7680.97
92_K95_D0.7670.97
221_H232_S0.7610.96
137_V151_R0.7600.96
138_M155_M0.7600.96
19_N23_R0.7580.96
257_S260_E0.7540.96
142_I147_F0.7530.96
38_N41_S0.7500.96
105_R178_L0.7490.96
147_F204_L0.7480.96
180_P243_L0.7480.96
223_I232_S0.7450.96
40_H43_A0.7420.96
18_T21_Q0.7360.96
140_V150_F0.7350.96
135_T151_R0.7340.96
67_D109_L0.7310.95
147_F259_W0.7310.95
143_D207_D0.7170.95
185_S201_P0.7150.95
64_F67_D0.7120.95
25_L28_L0.7110.95
46_I71_V0.7090.95
153_D188_A0.7090.95
45_I71_V0.7050.94
49_I73_I0.7020.94
46_I68_C0.6960.94
30_E33_G0.6930.94
25_L47_A0.6910.94
259_W262_V0.6890.94
114_V233_T0.6850.94
30_E34_F0.6840.94
114_V239_I0.6830.93
258_F261_K0.6810.93
78_K151_R0.6800.93
92_K255_D0.6800.93
70_Y248_I0.6790.93
263_K266_F0.6790.93
40_H65_R0.6760.93
47_A71_V0.6750.93
43_A169_S0.6740.93
84_D261_K0.6730.93
170_V187_L0.6720.93
103_E252_K0.6690.93
150_F174_V0.6690.93
154_G187_L0.6690.93
127_S228_N0.6680.93
133_I225_G0.6670.93
32_H91_E0.6660.93
212_L241_I0.6630.92
181_C203_V0.6630.92
177_P258_F0.6610.92
257_S261_K0.6610.92
125_E229_E0.6610.92
40_H62_T0.6590.92
110_I122_C0.6590.92
114_V237_K0.6580.92
21_Q49_I0.6570.92
191_N196_R0.6550.92
178_L207_D0.6520.92
155_M212_L0.6510.92
71_V93_M0.6510.92
30_E36_V0.6490.92
193_N266_F0.6420.91
63_N109_L0.6420.91
23_R32_H0.6380.91
112_V224_I0.6380.91
167_N183_Q0.6340.91
84_D253_L0.6340.91
102_I251_V0.6330.91
57_Q60_R0.6320.91
125_E169_S0.6310.91
29_A47_A0.6310.91
233_T239_I0.6260.90
62_T68_C0.6230.90
42_D65_R0.6230.90
148_E165_A0.6220.90
113_T118_S0.6220.90
89_E93_M0.6200.90
191_N228_N0.6170.90
129_R223_I0.6140.89
20_E31_E0.6130.89
127_S152_G0.6100.89
26_T36_V0.6100.89
106_K180_P0.6080.89
136_F165_A0.6070.89
23_R26_T0.6070.89
22_A36_V0.6050.89
232_S235_N0.5960.88
91_E95_D0.5930.88
86_H258_F0.5920.88
134_K225_G0.5900.87
146_H263_K0.5880.87
69_L186_E0.5820.87
107_Y258_F0.5810.87
84_D256_N0.5770.86
181_C201_P0.5750.86
25_L34_F0.5750.86
80_H83_C0.5740.86
56_L123_L0.5730.86
38_N42_D0.5700.86
51_G77_G0.5690.85
114_V224_I0.5680.85
20_E245_N0.5670.85
207_D243_L0.5670.85
27_Q30_E0.5640.85
202_F225_G0.5630.85
148_E261_K0.5620.85
82_Y161_T0.5610.85
130_S188_A0.5580.84
33_G37_V0.5580.84
86_H89_E0.5570.84
69_L249_K0.5570.84
76_K175_V0.5560.84
87_S155_M0.5560.84
43_A65_R0.5530.84
39_Q42_D0.5520.84
57_Q229_E0.5510.84
32_H35_T0.5480.83
56_L167_N0.5470.83
63_N246_K0.5460.83
60_R63_N0.5450.83
168_K174_V0.5450.83
72_G80_H0.5450.83
174_V265_T0.5440.83
224_I233_T0.5430.83
225_G230_A0.5420.83
48_S55_F0.5410.82
86_H253_L0.5410.82
153_D185_S0.5380.82
97_M100_E0.5380.82
128_I222_P0.5370.82
81_L196_R0.5370.82
127_S225_G0.5350.82
251_V261_K0.5350.82
150_F186_E0.5330.82
115_D158_S0.5330.82
31_E91_E0.5320.81
97_M253_L0.5260.81
110_I161_T0.5240.80
81_L174_V0.5230.80
59_V191_N0.5230.80
169_S172_G0.5230.80
193_N201_P0.5220.80
109_L121_H0.5210.80
125_E225_G0.5210.80
102_I253_L0.5210.80
104_V251_V0.5200.80
32_H94_V0.5190.80
138_M222_P0.5180.80
48_S167_N0.5170.80
183_Q258_F0.5110.79
23_R115_D0.5090.78
179_L206_S0.5090.78
147_F150_F0.5080.78
182_M208_R0.5080.78
21_Q25_L0.5060.78
76_K125_E0.5040.78
79_A191_N0.5040.78
70_Y174_V0.5030.78
28_L31_E0.5020.78
21_Q87_S0.5010.77
131_S223_I0.5000.77
84_D105_R0.5000.77
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3pfnA 4 0.9738 100 0.141 Contact Map
3afoA 4 0.9738 100 0.2 Contact Map
1u0tA 4 0.9551 100 0.313 Contact Map
2an1A 4 0.9363 100 0.32 Contact Map
2i2cA 3 0.9551 100 0.333 Contact Map
1yt5A 4 0.9213 100 0.351 Contact Map
1z0sA 4 0.8914 100 0.361 Contact Map
2qv7A 2 0.9176 100 0.619 Contact Map
3s40A 3 0.8801 100 0.649 Contact Map
4werA 2 0.8689 99.9 0.672 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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