NADK2 - BACSU - GREMLIN Contacts

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NADK2 - NAD kinase 2

UniProt:	O34934	Sequences: MTDQRRNVYFFHKQDQETNEQARSLTQLAEEHGFTVVNQHSDANIIASIGGDGTFLQAVRKTNFRDDCLYVGITKKGKAHLYCDFHSDEREKMVDAMTFEQIEVRKYPLIEVTVDQASPFHCLNEVSIRSSIIKTFVMDVLIDDLHFETFRGDGMIISTPTGSTAYNKSVAGAVVDPLLPCMQVSELASLNNNTYRTLGSPFVLSSDRKLTLRVVQDGNEHPIIGLDNEALSTRNVKTIEIKLSNKKIKTVKLKDNSFWEKVKRTFL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	267 (241)
Sequences:	4129 (2854)
Seq/√Len:	183.9

ECOLI - NADK
BACSU - NADK2 NADK1
HALSA - NADK
SULSO - NADK

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
106_K	249_K	3.958	1.00
211_T	238_T	3.622	1.00
209_K	242_K	3.619	1.00
143_D	208_R	3.448	1.00
139_D	213_R	3.174	1.00
167_N	185_S	2.981	1.00
96_A	101_Q	2.930	1.00
138_M	212_L	2.907	1.00
180_P	206_S	2.896	1.00
211_T	240_E	2.835	1.00
213_R	238_T	2.789	1.00
111_E	242_K	2.735	1.00
55_F	250_T	2.596	1.00
116_Q	237_K	2.512	1.00
111_E	119_P	2.511	1.00
32_H	95_D	2.491	1.00
175_V	183_Q	2.400	1.00
106_K	247_K	2.381	1.00
209_K	240_E	2.324	1.00
113_T	240_E	2.228	1.00
141_L	146_H	2.226	1.00
184_V	204_L	2.224	1.00
89_E	92_K	2.211	1.00
144_D	211_T	2.148	1.00
107_Y	161_T	2.081	1.00
141_L	213_R	2.074	1.00
95_D	99_F	1.997	1.00
18_T	22_A	1.933	1.00
141_L	211_T	1.880	1.00
145_L	257_S	1.876	1.00
140_V	184_V	1.839	1.00
112_V	126_V	1.795	1.00
28_L	95_D	1.770	1.00
28_L	91_E	1.766	1.00
46_I	62_T	1.766	1.00
128_I	212_L	1.765	1.00
104_V	249_K	1.738	1.00
60_R	229_E	1.723	1.00
126_V	224_I	1.718	1.00
105_R	252_K	1.706	1.00
109_L	248_I	1.683	1.00
144_D	209_K	1.677	1.00
170_V	185_S	1.670	1.00
121_H	244_S	1.661	1.00
139_D	215_V	1.640	1.00
146_H	149_T	1.621	1.00
142_I	210_L	1.607	1.00
55_F	72_G	1.582	1.00
113_T	242_K	1.577	1.00
24_S	91_E	1.569	1.00
27_Q	31_E	1.557	1.00
164_T	174_V	1.516	1.00
173_A	183_Q	1.506	1.00
49_I	76_K	1.476	1.00
142_I	208_R	1.466	1.00
170_V	188_A	1.464	1.00
26_T	30_E	1.457	1.00
113_T	119_P	1.450	1.00
110_I	182_M	1.440	1.00
157_I	212_L	1.440	1.00
115_D	238_T	1.378	1.00
25_L	94_V	1.378	1.00
28_L	32_H	1.376	1.00
19_N	22_A	1.362	1.00
173_A	203_V	1.359	1.00
84_D	252_K	1.359	1.00
125_E	156_I	1.315	1.00
55_F	83_C	1.298	1.00
59_V	70_Y	1.294	1.00
145_L	260_E	1.294	1.00
140_V	155_M	1.275	1.00
122_C	226_L	1.251	1.00
126_V	241_I	1.240	1.00
74_T	80_H	1.212	1.00
139_D	149_T	1.202	1.00
111_E	244_S	1.196	1.00
176_D	205_S	1.186	1.00
79_A	190_L	1.171	1.00
214_V	222_P	1.151	1.00
153_D	166_Y	1.147	1.00
45_I	97_M	1.142	1.00
25_L	49_I	1.141	1.00
109_L	244_S	1.137	1.00
85_F	93_M	1.135	1.00
258_F	262_V	1.131	1.00
175_V	181_C	1.129	1.00
115_D	240_E	1.114	1.00
176_D	259_W	1.112	1.00
109_L	247_K	1.109	1.00
126_V	226_L	1.098	1.00
64_F	246_K	1.095	1.00
67_D	249_K	1.093	1.00
65_R	68_C	1.087	1.00
158_S	183_Q	1.085	1.00
112_V	226_L	1.083	1.00
111_E	245_N	1.082	1.00
45_I	251_V	1.082	1.00
71_V	97_M	1.076	1.00
23_R	27_Q	1.074	1.00
156_I	170_V	1.066	1.00
234_R	237_K	1.050	1.00
108_P	180_P	1.041	1.00
97_M	102_I	1.038	1.00
25_L	90_R	1.036	1.00
175_V	203_V	1.034	1.00
204_L	210_L	1.030	1.00
37_V	43_A	1.027	1.00
136_F	222_P	1.026	1.00
192_N	196_R	1.012	0.99
260_E	264_R	1.012	0.99
157_I	241_I	1.010	0.99
28_L	94_V	1.006	0.99
168_K	192_N	1.003	0.99
47_A	94_V	1.003	0.99
73_I	85_F	0.996	0.99
221_H	234_R	0.985	0.99
182_M	210_L	0.984	0.99
92_K	96_A	0.982	0.99
180_P	247_K	0.978	0.99
137_V	149_T	0.978	0.99
108_P	243_L	0.977	0.99
127_S	156_I	0.975	0.99
74_T	265_T	0.964	0.99
138_M	152_G	0.962	0.99
155_M	184_V	0.954	0.99
141_L	144_D	0.954	0.99
67_D	246_K	0.952	0.99
41_S	65_R	0.948	0.99
39_Q	43_A	0.946	0.99
157_I	182_M	0.938	0.99
22_A	26_T	0.936	0.99
108_P	206_S	0.934	0.99
101_Q	254_K	0.930	0.99
157_I	184_V	0.926	0.99
103_E	255_D	0.925	0.99
71_V	251_V	0.924	0.99
168_K	190_L	0.921	0.99
81_L	259_W	0.919	0.99
130_S	134_K	0.919	0.99
143_D	209_K	0.919	0.99
176_D	208_R	0.917	0.99
206_S	243_L	0.916	0.99
161_T	177_P	0.909	0.99
107_Y	177_P	0.904	0.99
20_E	24_S	0.900	0.99
71_V	85_F	0.897	0.99
24_S	28_L	0.896	0.99
30_E	35_T	0.896	0.99
183_Q	203_V	0.885	0.99
32_H	98_T	0.876	0.98
205_S	208_R	0.876	0.98
132_I	223_I	0.874	0.98
53_G	77_G	0.869	0.98
59_V	248_I	0.855	0.98
84_D	165_A	0.851	0.98
21_Q	24_S	0.850	0.98
73_I	90_R	0.847	0.98
20_E	23_R	0.847	0.98
243_L	247_K	0.846	0.98
115_D	237_K	0.846	0.98
96_A	253_L	0.837	0.98
108_P	182_M	0.834	0.98
46_I	70_Y	0.833	0.98
168_K	266_F	0.832	0.98
223_I	230_A	0.830	0.98
29_A	34_F	0.824	0.98
176_D	258_F	0.824	0.98
178_L	205_S	0.823	0.98
121_H	246_K	0.819	0.98
180_P	207_D	0.818	0.98
204_L	208_R	0.815	0.98
108_P	160_P	0.815	0.98
168_K	173_A	0.812	0.98
33_G	36_V	0.812	0.98
134_K	229_E	0.812	0.98
115_D	118_S	0.808	0.97
23_R	30_E	0.807	0.97
59_V	123_L	0.806	0.97
108_P	181_C	0.806	0.97
120_F	226_L	0.806	0.97
93_M	253_L	0.797	0.97
125_E	129_R	0.797	0.97
63_N	244_S	0.791	0.97
111_E	121_H	0.791	0.97
256_N	261_K	0.791	0.97
123_L	161_T	0.789	0.97
48_S	58_A	0.787	0.97
131_S	221_H	0.785	0.97
140_V	212_L	0.784	0.97
139_D	146_H	0.784	0.97
55_F	70_Y	0.784	0.97
123_L	248_I	0.783	0.97
116_Q	234_R	0.781	0.97
112_V	239_I	0.778	0.97
157_I	210_L	0.778	0.97
142_I	204_L	0.774	0.97
109_L	123_L	0.774	0.97
34_F	98_T	0.768	0.97
92_K	95_D	0.767	0.97
221_H	232_S	0.761	0.96
137_V	151_R	0.760	0.96
138_M	155_M	0.760	0.96
19_N	23_R	0.758	0.96
257_S	260_E	0.754	0.96
142_I	147_F	0.753	0.96
38_N	41_S	0.750	0.96
105_R	178_L	0.749	0.96
147_F	204_L	0.748	0.96
180_P	243_L	0.748	0.96
223_I	232_S	0.745	0.96
40_H	43_A	0.742	0.96
18_T	21_Q	0.736	0.96
140_V	150_F	0.735	0.96
135_T	151_R	0.734	0.96
67_D	109_L	0.731	0.95
147_F	259_W	0.731	0.95
143_D	207_D	0.717	0.95
185_S	201_P	0.715	0.95
64_F	67_D	0.712	0.95
25_L	28_L	0.711	0.95
46_I	71_V	0.709	0.95
153_D	188_A	0.709	0.95
45_I	71_V	0.705	0.94
49_I	73_I	0.702	0.94
46_I	68_C	0.696	0.94
30_E	33_G	0.693	0.94
25_L	47_A	0.691	0.94
259_W	262_V	0.689	0.94
114_V	233_T	0.685	0.94
30_E	34_F	0.684	0.94
114_V	239_I	0.683	0.93
258_F	261_K	0.681	0.93
78_K	151_R	0.680	0.93
92_K	255_D	0.680	0.93
70_Y	248_I	0.679	0.93
263_K	266_F	0.679	0.93
40_H	65_R	0.676	0.93
47_A	71_V	0.675	0.93
43_A	169_S	0.674	0.93
84_D	261_K	0.673	0.93
170_V	187_L	0.672	0.93
103_E	252_K	0.669	0.93
150_F	174_V	0.669	0.93
154_G	187_L	0.669	0.93
127_S	228_N	0.668	0.93
133_I	225_G	0.667	0.93
32_H	91_E	0.666	0.93
212_L	241_I	0.663	0.92
181_C	203_V	0.663	0.92
177_P	258_F	0.661	0.92
257_S	261_K	0.661	0.92
125_E	229_E	0.661	0.92
40_H	62_T	0.659	0.92
110_I	122_C	0.659	0.92
114_V	237_K	0.658	0.92
21_Q	49_I	0.657	0.92
191_N	196_R	0.655	0.92
178_L	207_D	0.652	0.92
155_M	212_L	0.651	0.92
71_V	93_M	0.651	0.92
30_E	36_V	0.649	0.92
193_N	266_F	0.642	0.91
63_N	109_L	0.642	0.91
23_R	32_H	0.638	0.91
112_V	224_I	0.638	0.91
167_N	183_Q	0.634	0.91
84_D	253_L	0.634	0.91
102_I	251_V	0.633	0.91
57_Q	60_R	0.632	0.91
125_E	169_S	0.631	0.91
29_A	47_A	0.631	0.91
233_T	239_I	0.626	0.90
62_T	68_C	0.623	0.90
42_D	65_R	0.623	0.90
148_E	165_A	0.622	0.90
113_T	118_S	0.622	0.90
89_E	93_M	0.620	0.90
191_N	228_N	0.617	0.90
129_R	223_I	0.614	0.89
20_E	31_E	0.613	0.89
127_S	152_G	0.610	0.89
26_T	36_V	0.610	0.89
106_K	180_P	0.608	0.89
136_F	165_A	0.607	0.89
23_R	26_T	0.607	0.89
22_A	36_V	0.605	0.89
232_S	235_N	0.596	0.88
91_E	95_D	0.593	0.88
86_H	258_F	0.592	0.88
134_K	225_G	0.590	0.87
146_H	263_K	0.588	0.87
69_L	186_E	0.582	0.87
107_Y	258_F	0.581	0.87
84_D	256_N	0.577	0.86
181_C	201_P	0.575	0.86
25_L	34_F	0.575	0.86
80_H	83_C	0.574	0.86
56_L	123_L	0.573	0.86
38_N	42_D	0.570	0.86
51_G	77_G	0.569	0.85
114_V	224_I	0.568	0.85
20_E	245_N	0.567	0.85
207_D	243_L	0.567	0.85
27_Q	30_E	0.564	0.85
202_F	225_G	0.563	0.85
148_E	261_K	0.562	0.85
82_Y	161_T	0.561	0.85
130_S	188_A	0.558	0.84
33_G	37_V	0.558	0.84
86_H	89_E	0.557	0.84
69_L	249_K	0.557	0.84
76_K	175_V	0.556	0.84
87_S	155_M	0.556	0.84
43_A	65_R	0.553	0.84
39_Q	42_D	0.552	0.84
57_Q	229_E	0.551	0.84
32_H	35_T	0.548	0.83
56_L	167_N	0.547	0.83
63_N	246_K	0.546	0.83
60_R	63_N	0.545	0.83
168_K	174_V	0.545	0.83
72_G	80_H	0.545	0.83
174_V	265_T	0.544	0.83
224_I	233_T	0.543	0.83
225_G	230_A	0.542	0.83
48_S	55_F	0.541	0.82
86_H	253_L	0.541	0.82
153_D	185_S	0.538	0.82
97_M	100_E	0.538	0.82
128_I	222_P	0.537	0.82
81_L	196_R	0.537	0.82
127_S	225_G	0.535	0.82
251_V	261_K	0.535	0.82
150_F	186_E	0.533	0.82
115_D	158_S	0.533	0.82
31_E	91_E	0.532	0.81
97_M	253_L	0.526	0.81
110_I	161_T	0.524	0.80
81_L	174_V	0.523	0.80
59_V	191_N	0.523	0.80
169_S	172_G	0.523	0.80
193_N	201_P	0.522	0.80
109_L	121_H	0.521	0.80
125_E	225_G	0.521	0.80
102_I	253_L	0.521	0.80
104_V	251_V	0.520	0.80
32_H	94_V	0.519	0.80
138_M	222_P	0.518	0.80
48_S	167_N	0.517	0.80
183_Q	258_F	0.511	0.79
23_R	115_D	0.509	0.78
179_L	206_S	0.509	0.78
147_F	150_F	0.508	0.78
182_M	208_R	0.508	0.78
21_Q	25_L	0.506	0.78
76_K	125_E	0.504	0.78
79_A	191_N	0.504	0.78
70_Y	174_V	0.503	0.78
28_L	31_E	0.502	0.78
21_Q	87_S	0.501	0.77
131_S	223_I	0.500	0.77
84_D	105_R	0.500	0.77

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3pfnA	4	0.9738	100	0.141	Contact Map
3afoA	4	0.9738	100	0.2	Contact Map
1u0tA	4	0.9551	100	0.313	Contact Map
2an1A	4	0.9363	100	0.32	Contact Map
2i2cA	3	0.9551	100	0.333	Contact Map
1yt5A	4	0.9213	100	0.351	Contact Map
1z0sA	4	0.8914	100	0.361	Contact Map
2qv7A	2	0.9176	100	0.619	Contact Map
3s40A	3	0.8801	100	0.649	Contact Map
4werA	2	0.8689	99.9	0.672	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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