GREMLIN Database
COAE - Dephospho-CoA kinase
UniProt: O34932 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 197 (189)
Sequences: 5085 (3989)
Seq/√Len: 290.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
53_E83_A3.3331.00
152_E156_V2.7071.00
119_F171_R2.6171.00
129_K174_Q2.3151.00
80_K83_A2.2721.00
25_K190_D2.2371.00
95_E98_N2.1951.00
132_V172_A2.1311.00
144_L155_A1.9811.00
46_A91_A1.9801.00
136_T179_S1.9751.00
88_V92_V1.9671.00
49_Q91_A1.9381.00
95_E99_R1.9221.00
51_I59_L1.8751.00
60_L64_D1.7961.00
142_E146_K1.7781.00
53_E80_K1.7771.00
71_G158_R1.7311.00
18_V185_T1.7251.00
69_K72_A1.7031.00
21_M186_K1.6901.00
141_L156_V1.6901.00
35_I95_E1.6791.00
24_E186_K1.6341.00
7_L19_A1.6241.00
74_V81_R1.6041.00
139_L142_E1.5961.00
134_S165_L1.5861.00
145_M152_E1.5641.00
12_A144_L1.5631.00
21_M190_D1.5561.00
156_V160_R1.5391.00
27_I112_V1.5181.00
124_E171_R1.5011.00
181_T184_E1.4721.00
119_F130_I1.4671.00
20_N23_I1.4671.00
136_T139_L1.4611.00
38_Q99_R1.4351.00
23_I29_V1.4281.00
58_I69_K1.4081.00
73_L80_K1.3921.00
83_A86_A1.3731.00
113_L127_V1.3721.00
4_V100_R1.3651.00
50_I84_L1.3641.00
134_S169_T1.3641.00
22_L112_V1.3531.00
131_I192_I1.3531.00
32_A96_M1.3521.00
18_V189_L1.3361.00
58_I73_L1.3321.00
40_V50_I1.3271.00
137_K156_V1.3251.00
38_Q95_E1.3181.00
141_L152_E1.3111.00
100_R111_V1.3021.00
47_Y65_I1.2901.00
35_I38_Q1.2831.00
60_L66_D1.2781.00
30_I35_I1.2731.00
131_I174_Q1.2691.00
47_Y51_I1.2661.00
145_M155_A1.2501.00
27_I193_M1.2501.00
5_I131_I1.2481.00
77_N80_K1.2371.00
167_E171_R1.2341.00
164_P167_E1.2331.00
167_E170_A1.2321.00
174_Q192_I1.2271.00
110_F193_M1.2191.00
7_L112_V1.2141.00
91_A94_Q1.2051.00
41_E64_D1.1671.00
28_T108_E1.1641.00
65_I70_L1.1521.00
19_A114_D1.1481.00
51_I56_E1.1361.00
3_L129_K1.1311.00
135_V139_L1.1281.00
96_M113_L1.1281.00
74_V84_L1.1271.00
39_A88_V1.1261.00
6_G118_L1.1261.00
163_M167_E1.1251.00
140_Q165_L1.1251.00
188_Q191_E1.1241.00
154_E157_S1.1231.00
133_V178_N1.1141.00
36_A40_V1.1111.00
150_L158_R1.1021.00
25_K186_K1.0901.00
31_D34_I1.0851.00
154_E158_R1.0831.00
66_D69_K1.0831.00
21_M25_K1.0771.00
69_K73_L1.0731.00
76_T157_S1.0691.00
42_K64_D1.0631.00
18_V133_V1.0601.00
78_E81_R1.0551.00
98_N102_E1.0531.00
83_A87_I1.0511.00
6_G127_V1.0491.00
72_A154_E1.0441.00
78_E82_L1.0371.00
99_R102_E1.0351.00
81_R161_S1.0351.00
151_T154_E1.0341.00
34_I38_Q1.0331.00
82_L85_N1.0291.00
21_M24_E1.0281.00
53_E87_I1.0271.00
8_T132_V1.0091.00
17_T182_L1.0081.00
169_T175_V1.0071.00
81_R85_N1.0011.00
135_V140_Q0.9971.00
12_A155_A0.9931.00
20_N24_E0.9901.00
97_L126_L0.9831.00
40_V88_V0.9801.00
16_S20_N0.9781.00
150_L155_A0.9751.00
119_F163_M0.9711.00
94_Q98_N0.9701.00
40_V65_I0.9651.00
50_I58_I0.9581.00
13_S165_L0.9531.00
155_A159_I0.9391.00
100_R113_L0.9321.00
129_K173_D0.9291.00
57_D69_K0.9251.00
38_Q41_E0.9221.00
120_E168_K0.9201.00
180_G184_E0.9181.00
82_L86_A0.9141.00
186_K190_D0.9121.00
10_G165_L0.9081.00
140_Q159_I0.9051.00
48_R52_D0.9041.00
39_A91_A0.8951.00
44_M95_E0.8951.00
137_K160_R0.8881.00
19_A29_V0.8871.00
13_S135_V0.8791.00
163_M168_K0.8781.00
54_F80_K0.8741.00
21_M189_L0.8691.00
28_T99_R0.8601.00
27_I110_F0.8551.00
153_E157_S0.8551.00
13_S140_Q0.8511.00
5_I110_F0.8431.00
132_V168_K0.8411.00
119_F124_E0.8241.00
30_I95_E0.8231.00
165_L168_K0.8111.00
46_A87_I0.8091.00
32_A113_L0.8030.99
35_I99_R0.7990.99
57_D73_L0.7990.99
183_E186_K0.7960.99
184_E187_R0.7940.99
47_Y59_L0.7930.99
144_L148_N0.7890.99
141_L155_A0.7870.99
68_K72_A0.7850.99
30_I96_M0.7840.99
74_V80_K0.7840.99
115_I123_L0.7830.99
75_F158_R0.7800.99
176_I192_I0.7790.99
97_L101_D0.7750.99
44_M47_Y0.7710.99
138_E152_E0.7580.99
49_Q52_D0.7570.99
39_A46_A0.7560.99
139_L179_S0.7550.99
37_K67_R0.7550.99
4_V127_V0.7470.99
164_P168_K0.7470.99
25_K193_M0.7370.99
36_A39_A0.7350.99
48_R51_I0.7240.99
85_N89_H0.7220.99
31_D114_D0.7190.99
36_A92_V0.7150.99
47_Y63_G0.7120.99
5_I129_K0.7110.99
165_L169_T0.7100.99
68_K148_N0.7100.99
45_P91_A0.7020.99
45_P94_Q0.7010.99
187_R191_E0.6970.99
130_I172_A0.6900.98
138_E142_E0.6900.98
58_I70_L0.6890.98
178_N185_T0.6860.98
184_E188_Q0.6850.98
10_G159_I0.6840.98
37_K40_V0.6830.98
30_I99_R0.6770.98
5_I112_V0.6760.98
150_L154_E0.6750.98
17_T20_N0.6730.98
10_G168_K0.6700.98
134_S168_K0.6630.98
22_L189_L0.6590.98
182_L186_K0.6580.98
28_T109_A0.6550.98
49_Q53_E0.6450.98
134_S175_V0.6440.98
190_D194_N0.6390.97
137_K140_Q0.6390.97
43_G47_Y0.6340.97
166_E170_A0.6320.97
23_I34_I0.6300.97
163_M171_R0.6260.97
54_F70_L0.6240.97
85_N121_S0.6240.97
166_E169_T0.6220.97
22_L131_I0.6220.97
28_T107_R0.6200.97
132_V169_T0.6180.97
35_I39_A0.6180.97
148_N154_E0.6180.97
42_K47_Y0.6160.97
4_V113_L0.6120.97
32_A115_I0.6110.97
89_H92_V0.6090.97
141_L159_I0.6050.96
144_L150_L0.6040.96
122_K125_S0.6040.96
36_A116_P0.6030.96
54_F84_L0.6030.96
18_V176_I0.6020.96
28_T106_N0.6000.96
55_G59_L0.6000.96
85_N88_V0.6000.96
115_I127_V0.6000.96
123_L126_L0.5980.96
79_Q82_L0.5960.96
73_L77_N0.5930.96
16_S114_D0.5920.96
177_D188_Q0.5900.96
51_I58_I0.5890.96
124_E127_V0.5850.96
49_Q87_I0.5840.96
41_E44_M0.5820.96
132_V175_V0.5810.96
51_I55_G0.5780.95
120_E163_M0.5670.95
137_K159_I0.5660.95
29_V114_D0.5660.95
80_K84_L0.5610.95
96_M126_L0.5600.95
191_E194_N0.5550.94
25_K189_L0.5520.94
37_K65_I0.5520.94
73_L76_T0.5500.94
58_I65_I0.5470.94
93_R96_M0.5470.94
3_L128_D0.5450.94
181_T185_T0.5450.94
3_L110_F0.5450.94
72_A76_T0.5440.94
22_L27_I0.5400.93
93_R97_L0.5370.93
11_I144_L0.5370.93
21_M185_T0.5340.93
176_I185_T0.5310.93
46_A88_V0.5310.93
10_G140_Q0.5150.92
3_L131_I0.5130.92
61_S66_D0.5100.91
35_I96_M0.5090.91
71_G75_F0.5080.91
17_T21_M0.5070.91
40_V46_A0.5060.91
118_L127_V0.5060.91
134_S166_E0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1dekA 2 0.9137 100 0.39 Contact Map
2if2A 1 0.9797 100 0.418 Contact Map
1uf9A 1 0.9594 100 0.419 Contact Map
2f6rA 1 1 100 0.441 Contact Map
4i1uA 2 0.9848 100 0.444 Contact Map
2grjA 2 0.8985 100 0.446 Contact Map
4ttrA 1 0.9797 100 0.448 Contact Map
1vhtA 1 0.9848 100 0.452 Contact Map
4zo4A 4 0.9746 100 0.458 Contact Map
1jjvA 1 0.9289 100 0.471 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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