COAE - BACSU - GREMLIN Contacts

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COAE - Dephospho-CoA kinase

UniProt:	O34932	Sequences: MTLVIGLTGGIASGKSTVANMLIEKGITVIDADIIAKQAVEKGMPAYRQIIDEFGEDILLSNGDIDRKKLGALVFTNEQKRLALNAIVHPAVRQEMLNRRDEAVANREAFVVLDIPLLFESKLESLVDKIIVVSVTKELQLERLMKRNQLTEEEAVSRIRSQMPLEEKTARADQVIDNSGTLEETKRQLDEIMNSWA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	197 (189)
Sequences:	5085 (3989)
Seq/√Len:	290.2

ECOLI - COAE
BACSU - COAE

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
53_E	83_A	3.333	1.00
152_E	156_V	2.707	1.00
119_F	171_R	2.617	1.00
129_K	174_Q	2.315	1.00
80_K	83_A	2.272	1.00
25_K	190_D	2.237	1.00
95_E	98_N	2.195	1.00
132_V	172_A	2.131	1.00
144_L	155_A	1.981	1.00
46_A	91_A	1.980	1.00
136_T	179_S	1.975	1.00
88_V	92_V	1.967	1.00
49_Q	91_A	1.938	1.00
95_E	99_R	1.922	1.00
51_I	59_L	1.875	1.00
60_L	64_D	1.796	1.00
142_E	146_K	1.778	1.00
53_E	80_K	1.777	1.00
71_G	158_R	1.731	1.00
18_V	185_T	1.725	1.00
69_K	72_A	1.703	1.00
21_M	186_K	1.690	1.00
141_L	156_V	1.690	1.00
35_I	95_E	1.679	1.00
24_E	186_K	1.634	1.00
7_L	19_A	1.624	1.00
74_V	81_R	1.604	1.00
139_L	142_E	1.596	1.00
134_S	165_L	1.586	1.00
145_M	152_E	1.564	1.00
12_A	144_L	1.563	1.00
21_M	190_D	1.556	1.00
156_V	160_R	1.539	1.00
27_I	112_V	1.518	1.00
124_E	171_R	1.501	1.00
181_T	184_E	1.472	1.00
119_F	130_I	1.467	1.00
20_N	23_I	1.467	1.00
136_T	139_L	1.461	1.00
38_Q	99_R	1.435	1.00
23_I	29_V	1.428	1.00
58_I	69_K	1.408	1.00
73_L	80_K	1.392	1.00
83_A	86_A	1.373	1.00
113_L	127_V	1.372	1.00
4_V	100_R	1.365	1.00
50_I	84_L	1.364	1.00
134_S	169_T	1.364	1.00
22_L	112_V	1.353	1.00
131_I	192_I	1.353	1.00
32_A	96_M	1.352	1.00
18_V	189_L	1.336	1.00
58_I	73_L	1.332	1.00
40_V	50_I	1.327	1.00
137_K	156_V	1.325	1.00
38_Q	95_E	1.318	1.00
141_L	152_E	1.311	1.00
100_R	111_V	1.302	1.00
47_Y	65_I	1.290	1.00
35_I	38_Q	1.283	1.00
60_L	66_D	1.278	1.00
30_I	35_I	1.273	1.00
131_I	174_Q	1.269	1.00
47_Y	51_I	1.266	1.00
145_M	155_A	1.250	1.00
27_I	193_M	1.250	1.00
5_I	131_I	1.248	1.00
77_N	80_K	1.237	1.00
167_E	171_R	1.234	1.00
164_P	167_E	1.233	1.00
167_E	170_A	1.232	1.00
174_Q	192_I	1.227	1.00
110_F	193_M	1.219	1.00
7_L	112_V	1.214	1.00
91_A	94_Q	1.205	1.00
41_E	64_D	1.167	1.00
28_T	108_E	1.164	1.00
65_I	70_L	1.152	1.00
19_A	114_D	1.148	1.00
51_I	56_E	1.136	1.00
3_L	129_K	1.131	1.00
135_V	139_L	1.128	1.00
96_M	113_L	1.128	1.00
74_V	84_L	1.127	1.00
39_A	88_V	1.126	1.00
6_G	118_L	1.126	1.00
163_M	167_E	1.125	1.00
140_Q	165_L	1.125	1.00
188_Q	191_E	1.124	1.00
154_E	157_S	1.123	1.00
133_V	178_N	1.114	1.00
36_A	40_V	1.111	1.00
150_L	158_R	1.102	1.00
25_K	186_K	1.090	1.00
31_D	34_I	1.085	1.00
154_E	158_R	1.083	1.00
66_D	69_K	1.083	1.00
21_M	25_K	1.077	1.00
69_K	73_L	1.073	1.00
76_T	157_S	1.069	1.00
42_K	64_D	1.063	1.00
18_V	133_V	1.060	1.00
78_E	81_R	1.055	1.00
98_N	102_E	1.053	1.00
83_A	87_I	1.051	1.00
6_G	127_V	1.049	1.00
72_A	154_E	1.044	1.00
78_E	82_L	1.037	1.00
99_R	102_E	1.035	1.00
81_R	161_S	1.035	1.00
151_T	154_E	1.034	1.00
34_I	38_Q	1.033	1.00
82_L	85_N	1.029	1.00
21_M	24_E	1.028	1.00
53_E	87_I	1.027	1.00
8_T	132_V	1.009	1.00
17_T	182_L	1.008	1.00
169_T	175_V	1.007	1.00
81_R	85_N	1.001	1.00
135_V	140_Q	0.997	1.00
12_A	155_A	0.993	1.00
20_N	24_E	0.990	1.00
97_L	126_L	0.983	1.00
40_V	88_V	0.980	1.00
16_S	20_N	0.978	1.00
150_L	155_A	0.975	1.00
119_F	163_M	0.971	1.00
94_Q	98_N	0.970	1.00
40_V	65_I	0.965	1.00
50_I	58_I	0.958	1.00
13_S	165_L	0.953	1.00
155_A	159_I	0.939	1.00
100_R	113_L	0.932	1.00
129_K	173_D	0.929	1.00
57_D	69_K	0.925	1.00
38_Q	41_E	0.922	1.00
120_E	168_K	0.920	1.00
180_G	184_E	0.918	1.00
82_L	86_A	0.914	1.00
186_K	190_D	0.912	1.00
10_G	165_L	0.908	1.00
140_Q	159_I	0.905	1.00
48_R	52_D	0.904	1.00
39_A	91_A	0.895	1.00
44_M	95_E	0.895	1.00
137_K	160_R	0.888	1.00
19_A	29_V	0.887	1.00
13_S	135_V	0.879	1.00
163_M	168_K	0.878	1.00
54_F	80_K	0.874	1.00
21_M	189_L	0.869	1.00
28_T	99_R	0.860	1.00
27_I	110_F	0.855	1.00
153_E	157_S	0.855	1.00
13_S	140_Q	0.851	1.00
5_I	110_F	0.843	1.00
132_V	168_K	0.841	1.00
119_F	124_E	0.824	1.00
30_I	95_E	0.823	1.00
165_L	168_K	0.811	1.00
46_A	87_I	0.809	1.00
32_A	113_L	0.803	0.99
35_I	99_R	0.799	0.99
57_D	73_L	0.799	0.99
183_E	186_K	0.796	0.99
184_E	187_R	0.794	0.99
47_Y	59_L	0.793	0.99
144_L	148_N	0.789	0.99
141_L	155_A	0.787	0.99
68_K	72_A	0.785	0.99
30_I	96_M	0.784	0.99
74_V	80_K	0.784	0.99
115_I	123_L	0.783	0.99
75_F	158_R	0.780	0.99
176_I	192_I	0.779	0.99
97_L	101_D	0.775	0.99
44_M	47_Y	0.771	0.99
138_E	152_E	0.758	0.99
49_Q	52_D	0.757	0.99
39_A	46_A	0.756	0.99
139_L	179_S	0.755	0.99
37_K	67_R	0.755	0.99
4_V	127_V	0.747	0.99
164_P	168_K	0.747	0.99
25_K	193_M	0.737	0.99
36_A	39_A	0.735	0.99
48_R	51_I	0.724	0.99
85_N	89_H	0.722	0.99
31_D	114_D	0.719	0.99
36_A	92_V	0.715	0.99
47_Y	63_G	0.712	0.99
5_I	129_K	0.711	0.99
165_L	169_T	0.710	0.99
68_K	148_N	0.710	0.99
45_P	91_A	0.702	0.99
45_P	94_Q	0.701	0.99
187_R	191_E	0.697	0.99
130_I	172_A	0.690	0.98
138_E	142_E	0.690	0.98
58_I	70_L	0.689	0.98
178_N	185_T	0.686	0.98
184_E	188_Q	0.685	0.98
10_G	159_I	0.684	0.98
37_K	40_V	0.683	0.98
30_I	99_R	0.677	0.98
5_I	112_V	0.676	0.98
150_L	154_E	0.675	0.98
17_T	20_N	0.673	0.98
10_G	168_K	0.670	0.98
134_S	168_K	0.663	0.98
22_L	189_L	0.659	0.98
182_L	186_K	0.658	0.98
28_T	109_A	0.655	0.98
49_Q	53_E	0.645	0.98
134_S	175_V	0.644	0.98
190_D	194_N	0.639	0.97
137_K	140_Q	0.639	0.97
43_G	47_Y	0.634	0.97
166_E	170_A	0.632	0.97
23_I	34_I	0.630	0.97
163_M	171_R	0.626	0.97
54_F	70_L	0.624	0.97
85_N	121_S	0.624	0.97
166_E	169_T	0.622	0.97
22_L	131_I	0.622	0.97
28_T	107_R	0.620	0.97
132_V	169_T	0.618	0.97
35_I	39_A	0.618	0.97
148_N	154_E	0.618	0.97
42_K	47_Y	0.616	0.97
4_V	113_L	0.612	0.97
32_A	115_I	0.611	0.97
89_H	92_V	0.609	0.97
141_L	159_I	0.605	0.96
144_L	150_L	0.604	0.96
122_K	125_S	0.604	0.96
36_A	116_P	0.603	0.96
54_F	84_L	0.603	0.96
18_V	176_I	0.602	0.96
28_T	106_N	0.600	0.96
55_G	59_L	0.600	0.96
85_N	88_V	0.600	0.96
115_I	127_V	0.600	0.96
123_L	126_L	0.598	0.96
79_Q	82_L	0.596	0.96
73_L	77_N	0.593	0.96
16_S	114_D	0.592	0.96
177_D	188_Q	0.590	0.96
51_I	58_I	0.589	0.96
124_E	127_V	0.585	0.96
49_Q	87_I	0.584	0.96
41_E	44_M	0.582	0.96
132_V	175_V	0.581	0.96
51_I	55_G	0.578	0.95
120_E	163_M	0.567	0.95
137_K	159_I	0.566	0.95
29_V	114_D	0.566	0.95
80_K	84_L	0.561	0.95
96_M	126_L	0.560	0.95
191_E	194_N	0.555	0.94
25_K	189_L	0.552	0.94
37_K	65_I	0.552	0.94
73_L	76_T	0.550	0.94
58_I	65_I	0.547	0.94
93_R	96_M	0.547	0.94
3_L	128_D	0.545	0.94
181_T	185_T	0.545	0.94
3_L	110_F	0.545	0.94
72_A	76_T	0.544	0.94
22_L	27_I	0.540	0.93
93_R	97_L	0.537	0.93
11_I	144_L	0.537	0.93
21_M	185_T	0.534	0.93
176_I	185_T	0.531	0.93
46_A	88_V	0.531	0.93
10_G	140_Q	0.515	0.92
3_L	131_I	0.513	0.92
61_S	66_D	0.510	0.91
35_I	96_M	0.509	0.91
71_G	75_F	0.508	0.91
17_T	21_M	0.507	0.91
40_V	46_A	0.506	0.91
118_L	127_V	0.506	0.91
134_S	166_E	0.500	0.91

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1dekA	2	0.9137	100	0.39	Contact Map
2if2A	1	0.9797	100	0.418	Contact Map
1uf9A	1	0.9594	100	0.419	Contact Map
2f6rA	1	1	100	0.441	Contact Map
4i1uA	2	0.9848	100	0.444	Contact Map
2grjA	2	0.8985	100	0.446	Contact Map
4ttrA	1	0.9797	100	0.448	Contact Map
1vhtA	1	0.9848	100	0.452	Contact Map
4zo4A	4	0.9746	100	0.458	Contact Map
1jjvA	1	0.9289	100	0.471	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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