GREMLIN Database
TCYM - L-cystine transport system permease protein TcyM
UniProt: O34931 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 235 (206)
Sequences: 15534 (9090)
Seq/√Len: 633.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
32_F109_S3.3541.00
163_T220_N3.2371.00
135_A145_T3.0411.00
104_V176_A2.9611.00
197_A200_E2.9041.00
188_A205_A2.8191.00
20_P24_M2.7691.00
43_V55_S2.6071.00
141_T144_Q2.5961.00
40_N117_T2.4991.00
131_Q153_Q2.4351.00
65_T70_H2.1921.00
132_V145_T2.1141.00
136_Y145_T2.0771.00
40_N113_G2.0731.00
44_R56_R2.0641.00
218_S222_V2.0571.00
132_V136_Y1.9571.00
123_G158_S1.9251.00
50_G54_C1.9221.00
21_L24_M1.9151.00
99_P102_M1.8971.00
50_G53_A1.8751.00
143_S147_R1.8691.00
192_A198_F1.8351.00
25_M176_A1.7841.00
59_V117_T1.7631.00
49_K53_A1.7501.00
45_I125_L1.7401.00
24_M101_S1.7251.00
126_A157_V1.7241.00
28_L105_I1.7091.00
214_L218_S1.7071.00
19_I212_L1.6961.00
74_I107_A1.6581.00
40_N55_S1.6581.00
218_S221_G1.6551.00
36_V113_G1.6501.00
188_A201_A1.6371.00
141_T145_T1.6251.00
17_K20_P1.6131.00
41_I120_I1.6131.00
26_A170_L1.5851.00
210_W214_L1.5711.00
16_V20_P1.5491.00
21_L181_V1.5361.00
118_E121_R1.5181.00
222_V225_R1.5111.00
142_Y146_F1.5021.00
33_G112_A1.4731.00
116_L162_F1.4641.00
38_L120_I1.4471.00
144_Q148_R1.4131.00
48_I53_A1.3931.00
186_G190_I1.3641.00
14_E17_K1.3591.00
144_Q147_R1.3571.00
62_F110_L1.3251.00
49_K52_V1.3211.00
187_T190_I1.2811.00
219_A222_V1.2771.00
70_H111_T1.2701.00
140_L144_Q1.2681.00
26_A173_T1.2621.00
132_V150_I1.2581.00
44_R118_E1.2571.00
101_S105_I1.2341.00
39_G43_V1.2341.00
28_L109_S1.2341.00
136_Y142_Y1.2191.00
45_I124_I1.2191.00
53_A57_F1.2191.00
30_I166_G1.1961.00
71_I107_A1.1921.00
54_C57_F1.1841.00
12_M16_V1.1801.00
14_E187_T1.1791.00
121_R125_L1.1731.00
124_I150_I1.1611.00
24_M28_L1.1581.00
186_G189_T1.1561.00
192_A202_F1.1521.00
100_V180_A1.1501.00
182_P186_G1.1491.00
65_T111_T1.1461.00
32_F105_I1.1391.00
170_L212_L1.1241.00
120_I158_S1.1201.00
43_V46_F1.1171.00
19_I208_I1.1121.00
37_A116_L1.1061.00
135_A149_V1.1041.00
43_V51_L1.0981.00
176_A183_E1.0911.00
57_F60_S1.0861.00
48_I51_L1.0791.00
34_F162_F1.0731.00
52_V56_R1.0611.00
105_I109_S1.0581.00
74_I103_F1.0461.00
55_S117_T1.0451.00
60_S214_L1.0341.00
58_Y113_G1.0291.00
119_I165_L1.0241.00
189_T192_A1.0231.00
191_V201_A1.0161.00
13_K17_K1.0131.00
62_F114_A1.0121.00
54_C58_Y1.0021.00
47_R52_V1.0001.00
221_G225_R0.9931.00
71_I175_I0.9851.00
170_L216_L0.9841.00
26_A166_G0.9841.00
60_S210_W0.9781.00
200_E203_I0.9741.00
116_L165_L0.9681.00
17_K21_L0.9651.00
146_F151_L0.9621.00
70_H74_I0.9611.00
142_Y145_T0.9531.00
98_I102_M0.9491.00
222_V226_K0.9471.00
127_M154_A0.9361.00
140_L148_R0.9331.00
168_G172_T0.9311.00
174_S209_Y0.9301.00
22_T170_L0.9231.00
67_A111_T0.9161.00
132_V142_Y0.9131.00
29_P109_S0.9131.00
75_Y103_F0.9131.00
71_I176_A0.9011.00
58_Y62_F0.8991.00
102_M105_I0.8971.00
221_G224_E0.8861.00
178_I182_P0.8851.00
31_V35_L0.8831.00
41_I45_I0.8821.00
73_L77_G0.8741.00
146_F150_I0.8701.00
215_I219_A0.8691.00
44_R59_V0.8691.00
36_V109_S0.8631.00
67_A172_T0.8581.00
190_I194_D0.8531.00
195_N198_F0.8521.00
219_A223_L0.8511.00
75_Y179_V0.8511.00
102_M106_M0.8501.00
22_T209_Y0.8461.00
112_A165_L0.8421.00
53_A56_R0.8381.00
104_V179_V0.8311.00
127_M157_V0.8291.00
48_I52_V0.8271.00
46_F55_S0.8261.00
100_V181_V0.8251.00
116_L120_I0.8241.00
130_G134_A0.8241.00
56_R60_S0.8211.00
101_S181_V0.8171.00
211_V215_I0.8121.00
44_R52_V0.8081.00
170_L213_T0.8031.00
48_I54_C0.8001.00
157_V161_N0.7921.00
182_P187_T0.7851.00
185_T202_F0.7831.00
185_T209_Y0.7771.00
58_Y114_A0.7741.00
108_L173_T0.7731.00
35_L39_G0.7681.00
119_I161_N0.7671.00
176_A181_V0.7661.00
72_M76_L0.7651.00
129_T133_E0.7611.00
25_M173_T0.7601.00
184_I208_I0.7591.00
112_A172_T0.7581.00
19_I184_I0.7571.00
30_I169_F0.7481.00
27_V31_V0.7421.00
28_L32_F0.7421.00
21_L183_E0.7411.00
70_H107_A0.7411.00
25_M181_V0.7341.00
78_I83_D0.7341.00
22_T26_A0.7331.00
41_I124_I0.7271.00
51_L54_C0.7271.00
129_T132_V0.7271.00
23_L27_V0.7231.00
75_Y100_V0.7221.00
28_L101_S0.7151.00
25_M104_V0.7131.00
124_I154_A0.7121.00
177_A186_G0.7041.00
29_P169_F0.7021.00
124_I146_F0.7021.00
36_V40_N0.6981.00
44_R117_T0.6981.00
188_A192_A0.6971.00
68_I178_I0.6941.00
35_L109_S0.6901.00
108_L169_F0.6881.00
100_V179_V0.6861.00
207_I211_V0.6831.00
192_A201_A0.6811.00
11_A191_V0.6801.00
38_L151_L0.6741.00
185_T205_A0.6711.00
203_I207_I0.6711.00
46_F142_Y0.6661.00
42_I146_F0.6661.00
127_M150_I0.6641.00
201_A205_A0.6631.00
40_N43_V0.6581.00
174_S185_T0.6581.00
112_A116_L0.6541.00
43_V48_I0.6541.00
33_G116_L0.6521.00
62_F70_H0.6491.00
73_L203_I0.6471.00
174_S177_A0.6431.00
167_I216_L0.6431.00
43_V54_C0.6401.00
17_K187_T0.6381.00
204_G208_I0.6281.00
133_E148_R0.6241.00
47_R50_G0.6231.00
108_L176_A0.6161.00
68_I72_M0.6161.00
194_D197_A0.6101.00
177_A180_A0.6081.00
38_L155_L0.6051.00
205_A208_I0.6041.00
112_A169_F0.6031.00
40_N58_Y0.6011.00
21_L101_S0.6001.00
140_L145_T0.6001.00
216_L220_N0.6001.00
34_F120_I0.5961.00
141_T148_R0.5951.00
199_L203_I0.5911.00
150_I153_Q0.5911.00
32_F35_L0.5911.00
217_E221_G0.5891.00
61_F65_T0.5891.00
215_I222_V0.5881.00
57_F61_F0.5881.00
23_L212_L0.5811.00
78_I82_A0.5711.00
156_K227_A0.5701.00
165_L168_G0.5701.00
13_K16_V0.5701.00
71_I179_V0.5681.00
15_M188_A0.5681.00
223_L227_A0.5651.00
215_I218_S0.5611.00
210_W213_T0.5551.00
191_V195_N0.5531.00
17_K24_M0.5521.00
40_N44_R0.5511.00
14_E191_V0.5491.00
16_V208_I0.5481.00
11_A14_E0.5461.00
74_I77_G0.5451.00
25_M29_P0.5451.00
15_M208_I0.5451.00
56_R59_V0.5451.00
130_G133_E0.5441.00
55_S59_V0.5421.00
42_I46_F0.5350.99
82_A98_I0.5340.99
111_T172_T0.5330.99
167_I213_T0.5330.99
111_T165_L0.5330.99
35_L38_L0.5330.99
122_S161_N0.5320.99
184_I209_Y0.5300.99
20_P23_L0.5290.99
46_F49_K0.5280.99
18_T187_T0.5270.99
161_N164_N0.5240.99
34_F166_G0.5240.99
159_I227_A0.5230.99
25_M101_S0.5190.99
109_S113_G0.5180.99
145_T150_I0.5160.99
51_L55_S0.5160.99
46_F52_V0.5150.99
77_G81_V0.5150.99
132_V135_A0.5150.99
37_A120_I0.5150.99
15_M191_V0.5140.99
180_A186_G0.5130.99
202_F205_A0.5130.99
135_A138_I0.5120.99
63_R118_E0.5120.99
67_A108_L0.5110.99
100_V103_F0.5100.99
120_I124_I0.5100.99
71_I104_V0.5090.99
47_R51_L0.5080.99
29_P108_L0.5070.99
119_I158_S0.5060.99
16_V19_I0.5020.99
12_M15_M0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ymuD 2 0.9149 100 0.565 Contact Map
3tuiA 2 0.8894 99.9 0.651 Contact Map
2onkC 2 0.9362 99.9 0.662 Contact Map
3rlfF 1 0.9234 99.9 0.67 Contact Map
3d31C 2 0.9191 99.9 0.67 Contact Map
4tquM 1 0.9702 99.9 0.683 Contact Map
3rlfG 1 0.9574 99.8 0.696 Contact Map
4tquN 1 0.8979 99.7 0.732 Contact Map
4uisB 1 0.1787 16 0.958 Contact Map
5a63B 1 0.2638 13.9 0.959 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0086 seconds.