GREMLIN Database
RAPK - Response regulator aspartate phosphatase K
UniProt: O34930 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 371 (313)
Sequences: 1531 (1382)
Seq/√Len: 78.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
269_E272_K4.9801.00
222_S238_L4.5921.00
190_R193_E4.5831.00
230_K233_K4.3681.00
182_A198_Y4.3291.00
137_Y156_Y4.3151.00
141_S157_I4.1361.00
346_A349_E3.6931.00
149_Q152_V3.3181.00
101_A117_Y3.1151.00
264_L269_E3.0641.00
109_N112_R2.9921.00
195_E221_L2.8711.00
97_Y116_L2.6941.00
178_T197_Y2.5391.00
218_F237_S2.4541.00
261_I277_Y2.4031.00
181_A185_Y2.3951.00
186_A198_Y2.3851.00
260_M264_L2.3781.00
235_I263_E2.3731.00
314_C317_N2.3691.00
218_F240_K2.3241.00
342_E355_N2.2991.00
264_L272_K2.2181.00
235_I267_I2.2121.00
225_Y233_K2.1961.00
154_Q181_A2.1821.00
100_E104_E2.1281.00
260_M276_F2.1181.00
238_L259_M2.0551.00
338_A354_F2.0311.00
104_E112_R2.0311.00
144_Y152_V2.0251.00
97_Y119_L1.9981.00
341_F346_A1.9961.00
137_Y159_N1.9531.00
157_I180_I1.9441.00
195_E228_W1.9381.00
334_S353_F1.8951.00
257_L276_F1.8711.00
349_E352_S1.8511.00
215_A241_A1.8401.00
337_A341_F1.8281.00
333_L337_A1.7911.00
232_D267_I1.7851.00
334_S356_A1.7691.00
231_P263_E1.7651.00
198_Y220_N1.7071.00
222_S234_C1.7031.00
272_K275_N1.7001.00
235_I239_E1.6801.00
239_E260_M1.6441.00
140_V144_Y1.6361.00
223_I238_L1.6211.00
195_E225_Y1.6051.00
235_I264_L1.5821.00
104_E109_N1.5791.00
134_A160_A1.5720.99
101_A120_A1.5720.99
219_H259_M1.5710.99
46_Q49_L1.5690.99
59_H63_L1.5120.99
322_K356_A1.4990.99
79_E83_N1.4740.99
182_A201_A1.4660.99
56_E60_K1.4530.99
185_Y193_E1.4470.99
239_E272_K1.4410.99
178_T200_E1.4390.99
158_K181_A1.4110.99
195_E199_L1.3990.99
179_M220_N1.3970.99
206_K214_K1.3960.99
233_K236_E1.3960.99
154_Q184_N1.3830.99
71_L74_H1.3660.99
242_I260_M1.3570.98
310_N314_C1.3430.98
101_A116_L1.3370.98
242_I257_L1.3330.98
182_A197_Y1.3300.98
114_I144_Y1.3250.98
138_S180_I1.3140.98
94_Y120_A1.3120.98
265_F277_Y1.3040.98
225_Y230_K1.3020.98
101_A105_A1.2940.98
93_E97_Y1.2820.98
38_L42_M1.2730.98
182_A224_V1.2690.98
296_I299_L1.2690.98
105_A117_Y1.2550.97
341_F349_E1.2510.97
157_I177_S1.2500.97
141_S160_A1.2470.97
195_E224_V1.2440.97
202_I214_K1.2270.97
310_N317_N1.2260.97
254_I261_I1.2260.97
37_K40_D1.2240.97
261_I280_A1.2200.97
102_M117_Y1.2170.97
222_S237_S1.2160.97
310_N313_N1.2150.97
138_S177_S1.2110.97
112_R115_N1.2110.97
263_E267_I1.2010.97
36_K39_F1.1920.97
179_M217_L1.1550.96
37_K43_E1.1520.96
175_A205_A1.1500.96
223_I259_M1.1400.96
159_N162_S1.1230.95
161_I178_T1.1220.95
178_T204_I1.1210.95
49_L52_Y1.1180.95
154_Q188_M1.1080.95
52_Y59_H1.1080.95
47_E50_A1.1060.95
221_L260_M1.0970.95
183_A220_N1.0960.94
351_T355_N1.0900.94
199_L237_S1.0760.94
117_Y139_K1.0700.94
183_A198_Y1.0560.93
350_A358_I1.0550.93
177_S180_I1.0460.93
186_A224_V1.0450.93
119_L122_K1.0430.93
98_L139_K1.0340.93
342_E354_F1.0260.92
218_F241_A1.0220.92
318_I321_L1.0200.92
242_I256_S1.0180.92
221_L225_Y1.0160.92
199_L221_L1.0120.92
194_A224_V1.0120.92
154_Q185_Y1.0120.92
77_F81_N1.0040.91
235_I260_M1.0010.91
166_R169_D0.9990.91
314_C319_E0.9980.91
165_K169_D0.9980.91
264_L276_F0.9950.91
51_Y54_L0.9940.91
138_S198_Y0.9910.91
205_A214_K0.9900.91
45_D51_Y0.9790.90
259_M262_K0.9780.90
114_I118_G0.9770.90
143_L147_V0.9730.90
53_S56_E0.9700.90
55_L60_K0.9670.90
98_L143_L0.9650.90
327_L330_V0.9640.90
300_Y305_G0.9600.90
316_S319_E0.9580.89
184_N188_M0.9580.89
315_I319_E0.9480.89
153_A184_N0.9470.89
139_K142_Y0.9470.89
275_N279_K0.9430.89
114_I149_Q0.9390.88
136_F139_K0.9360.88
47_E53_S0.9230.88
318_I329_S0.9180.87
349_E353_F0.9180.87
137_Y160_A0.9140.87
300_Y303_Y0.9050.87
214_K218_F0.8970.86
49_L53_S0.8890.86
36_K41_E0.8750.85
37_K41_E0.8750.85
257_L279_K0.8730.85
124_L160_A0.8700.84
280_A296_I0.8680.84
145_T184_N0.8670.84
104_E116_L0.8630.84
339_K354_F0.8630.84
36_K42_M0.8630.84
140_V156_Y0.8630.84
36_K43_E0.8600.84
175_A201_A0.8580.83
193_E196_Q0.8550.83
117_Y143_L0.8540.83
179_M183_A0.8500.83
348_E352_S0.8480.83
185_Y190_R0.8480.83
40_D43_E0.8440.82
104_E141_S0.8430.82
303_Y307_L0.8420.82
85_I88_T0.8410.82
236_E240_K0.8380.82
296_I303_Y0.8370.82
284_L288_E0.8360.82
114_I143_L0.8360.82
186_A189_K0.8330.82
226_S231_P0.8320.82
89_N119_L0.8320.82
36_K40_D0.8300.81
338_A357_K0.8290.81
106_Y110_Y0.8250.81
52_Y58_R0.8240.81
108_K112_R0.8210.81
105_A143_L0.8170.80
36_K61_M0.8150.80
70_P73_K0.8150.80
57_E60_K0.8140.80
47_E51_Y0.8140.80
48_V52_Y0.8100.80
40_D45_D0.8090.80
74_H81_N0.8080.80
51_Y62_L0.8070.80
222_S259_M0.8070.80
336_I339_K0.8070.80
300_Y304_C0.8060.79
133_A137_Y0.8050.79
287_M290_K0.8050.79
195_E198_Y0.7970.79
201_A217_L0.7970.79
179_M219_H0.7960.79
240_K244_N0.7900.78
45_D52_Y0.7890.78
120_A139_K0.7870.78
241_A245_E0.7860.78
144_Y156_Y0.7830.77
97_Y120_A0.7800.77
320_F323_Q0.7800.77
221_L237_S0.7790.77
114_I147_V0.7770.77
61_M65_S0.7770.77
173_K176_T0.7730.77
258_F277_Y0.7730.77
99_F102_M0.7700.76
270_K274_I0.7700.76
295_K298_I0.7680.76
96_F103_Y0.7640.76
38_L43_E0.7620.76
51_Y57_E0.7610.75
245_E256_S0.7600.75
340_R344_I0.7590.75
45_D56_E0.7570.75
241_A244_N0.7560.75
174_L177_S0.7550.75
41_E50_A0.7550.75
137_Y144_Y0.7550.75
213_L280_A0.7500.74
144_Y280_A0.7420.74
35_I38_L0.7410.74
74_H80_D0.7380.73
297_S302_L0.7380.73
121_E136_F0.7360.73
231_P238_L0.7360.73
118_G140_V0.7350.73
112_R126_E0.7350.73
279_K283_R0.7350.73
100_E116_L0.7290.72
344_I352_S0.7280.72
150_S184_N0.7280.72
59_H65_S0.7270.72
42_M46_Q0.7220.72
285_I288_E0.7210.71
43_E48_V0.7210.71
331_D338_A0.7190.71
286_L332_E0.7150.71
325_N345_G0.7150.71
295_K300_Y0.7150.71
131_I167_H0.7140.71
161_I174_L0.7130.71
72_Q76_Y0.7120.71
77_F85_I0.7110.70
226_S255_N0.7110.70
118_G156_Y0.7100.70
328_E336_I0.7090.70
271_M274_I0.7080.70
301_N349_E0.7080.70
185_Y197_Y0.7070.70
108_K148_K0.7060.70
94_Y124_L0.7030.70
41_E45_D0.7000.69
342_E353_F0.6990.69
299_L303_Y0.6970.69
210_D214_K0.6960.69
117_Y121_E0.6940.69
240_K289_N0.6930.68
242_I253_Y0.6900.68
49_L56_E0.6890.68
144_Y149_Q0.6890.68
37_K48_V0.6860.68
229_N268_D0.6860.68
300_Y306_E0.6840.67
54_L58_R0.6820.67
42_M52_Y0.6810.67
158_K193_E0.6800.67
210_D238_L0.6790.67
186_A191_F0.6770.67
36_K140_V0.6760.67
134_A163_I0.6760.67
197_Y201_A0.6710.66
310_N321_L0.6700.66
295_K329_S0.6690.66
245_E253_Y0.6690.66
37_K42_M0.6680.66
41_E48_V0.6660.65
288_E291_V0.6620.65
315_I352_S0.6580.64
331_D357_K0.6580.64
38_L50_A0.6560.64
125_A133_A0.6560.64
48_V58_R0.6560.64
280_A284_L0.6560.64
211_E214_K0.6550.64
57_E62_L0.6540.64
102_M138_S0.6520.64
50_A57_E0.6510.64
98_L102_M0.6510.64
35_I42_M0.6500.64
211_E244_N0.6500.64
222_S241_A0.6500.64
45_D49_L0.6500.64
76_Y79_E0.6490.63
95_N99_F0.6480.63
348_E355_N0.6460.63
205_A217_L0.6450.63
243_G288_E0.6440.63
181_A254_I0.6420.63
174_L178_T0.6410.62
346_A356_A0.6400.62
196_Q235_I0.6390.62
355_N358_I0.6380.62
325_N358_I0.6350.62
223_I226_S0.6330.61
161_I165_K0.6320.61
84_F87_K0.6310.61
338_A358_I0.6310.61
201_A241_A0.6310.61
181_A221_L0.6290.61
233_K237_S0.6290.61
45_D48_V0.6290.61
101_A139_K0.6270.61
101_A277_Y0.6260.61
217_L354_F0.6250.60
151_I155_H0.6230.60
50_A163_I0.6220.60
59_H62_L0.6210.60
39_F57_E0.6190.60
319_E323_Q0.6170.59
183_A186_A0.6170.59
219_H262_K0.6160.59
347_F351_T0.6160.59
141_S222_S0.6160.59
62_L66_S0.6160.59
319_E322_K0.6140.59
352_S355_N0.6140.59
192_E303_Y0.6140.59
133_A264_L0.6120.59
46_Q277_Y0.6100.59
110_Y153_A0.6090.59
315_I318_I0.6080.58
58_R65_S0.6070.58
138_S179_M0.6060.58
39_F43_E0.6050.58
229_N266_K0.6040.58
80_D85_I0.6010.58
42_M53_S0.5960.57
311_F314_C0.5960.57
332_E345_G0.5960.57
144_Y159_N0.5950.57
179_M201_A0.5950.57
313_N316_S0.5940.57
43_E59_H0.5940.57
74_H77_F0.5920.56
65_S78_T0.5900.56
273_A280_A0.5900.56
299_L306_E0.5860.56
120_A124_L0.5840.55
51_Y59_H0.5840.55
306_E311_F0.5830.55
294_A301_N0.5830.55
254_I258_F0.5820.55
75_T79_E0.5800.55
135_E139_K0.5790.55
54_L59_H0.5760.54
50_A67_R0.5760.54
285_I315_I0.5740.54
60_K64_H0.5740.54
48_V56_E0.5720.54
226_S238_L0.5710.54
153_A164_Y0.5700.54
71_L78_T0.5700.54
185_Y235_I0.5690.53
278_N320_F0.5660.53
72_Q82_Q0.5660.53
330_V358_I0.5660.53
37_K60_K0.5640.53
95_N141_S0.5620.53
348_E358_I0.5600.52
317_N324_Q0.5590.52
330_V334_S0.5580.52
217_L221_L0.5570.52
162_S232_D0.5560.52
119_L274_I0.5540.52
124_L133_A0.5540.52
326_E329_S0.5540.52
46_Q54_L0.5530.51
144_Y264_L0.5530.51
348_E354_F0.5530.51
316_S320_F0.5530.51
106_Y189_K0.5530.51
152_V155_H0.5530.51
239_E245_E0.5490.51
340_R343_S0.5480.51
98_L136_F0.5480.51
138_S220_N0.5480.51
38_L49_L0.5410.50
107_N341_F0.5410.50
39_F52_Y0.5410.50
134_A164_Y0.5400.50
138_S145_T0.5400.50
206_K221_L0.5390.50
257_L280_A0.5380.49
83_N232_D0.5380.49
35_I39_F0.5380.49
157_I190_R0.5380.49
181_A188_M0.5360.49
52_Y56_E0.5340.49
41_E49_L0.5340.49
57_E61_M0.5330.49
311_F315_I0.5320.49
162_S272_K0.5320.49
324_Q335_Y0.5300.48
57_E63_L0.5300.48
340_R347_F0.5290.48
240_K243_G0.5290.48
46_Q64_H0.5280.48
103_Y107_N0.5270.48
102_M106_Y0.5250.48
181_A197_Y0.5250.48
102_M105_A0.5230.48
186_A239_E0.5220.47
302_L307_L0.5210.47
63_L67_R0.5200.47
88_T119_L0.5170.47
43_E46_Q0.5170.47
43_E62_L0.5170.47
56_E199_L0.5160.47
157_I161_I0.5150.47
320_F354_F0.5140.46
132_E164_Y0.5130.46
202_I218_F0.5130.46
47_E58_R0.5130.46
345_G348_E0.5130.46
273_A330_V0.5120.46
231_P234_C0.5080.46
217_L224_V0.5080.46
317_N320_F0.5070.46
54_L60_K0.5070.46
50_A56_E0.5070.46
51_Y61_M0.5070.46
164_Y167_H0.5070.46
67_R75_T0.5060.45
261_I300_Y0.5050.45
295_K302_L0.5050.45
165_K286_L0.5030.45
79_E316_S0.5030.45
261_I276_F0.5020.45
42_M51_Y0.5010.45
55_L61_M0.5000.45
46_Q67_R0.5000.45
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4i1aA 2 0.9623 100 0.225 Contact Map
3q15A 2 0.9784 100 0.225 Contact Map
3ulqA 1 0.9838 100 0.231 Contact Map
4gyoA 2 0.9704 100 0.236 Contact Map
4gpkA 3 0.9326 100 0.301 Contact Map
4l9pA 1 0.7547 100 0.39 Contact Map
3q7aA 1 0.7493 100 0.393 Contact Map
3dssA 1 0.7116 100 0.396 Contact Map
1w3bA 2 0.8194 100 0.397 Contact Map
4ui9C 2 0.9137 100 0.403 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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