GREMLIN Database
YCZE - Uncharacterized membrane protein YczE
UniProt: O34927 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 215 (190)
Sequences: 1928 (1514)
Seq/√Len: 109.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
51_T91_D4.6211.00
57_I87_G4.4601.00
118_G185_I3.6661.00
103_Y173_F2.6581.00
39_A164_A2.5491.00
119_Y189_S2.5371.00
51_T54_Q2.5351.00
24_S93_F2.5071.00
26_T113_G2.4781.00
50_L58_I2.4751.00
20_A89_F2.4651.00
44_L55_W2.4171.00
21_F93_F2.3181.00
103_Y172_G2.2521.00
18_I120_G2.1691.00
27_I52_V2.1441.00
25_L112_L2.1091.00
148_N151_W2.1061.00
103_Y107_I2.0051.00
88_V92_F1.9081.00
22_G116_L1.9071.00
60_G83_M1.8511.00
158_L179_A1.8331.00
188_F192_Q1.8071.00
15_G120_G1.7781.00
31_A106_S1.7541.00
150_Q187_R1.7061.00
131_A139_M1.6611.00
147_W151_W1.6501.00
22_G117_I1.6431.00
114_V177_L1.6381.00
17_I93_F1.6301.00
52_V90_I1.6221.00
24_S94_N1.5901.00
43_S168_G1.5831.00
13_F81_L1.5781.00
17_I89_F1.5771.00
42_Y170_P1.5631.00
162_F166_G1.5431.00
50_L55_W1.5341.00
117_I178_T1.5011.00
82_N130_G1.4791.00
15_G127_A1.4771.00
7_L11_F1.4491.00
38_D41_H1.4361.00
119_Y123_V1.3971.00
185_I189_S1.3961.00
177_L181_L1.3851.00
142_T145_T1.3681.00
110_F174_G1.3461.00
23_V38_D1.3421.00
104_T108_I1.3261.00
37_W160_I1.3150.99
63_I137_L1.3140.99
66_F137_L1.3100.99
37_W157_E1.3090.99
54_Q58_I1.3050.99
28_E94_N1.2690.99
122_G189_S1.2450.99
100_L106_S1.2440.99
23_V90_I1.2370.99
153_R157_E1.2340.99
54_Q88_V1.2240.99
78_G130_G1.2020.99
110_F114_V1.1980.99
27_I42_Y1.1940.99
152_V156_M1.1940.99
20_A24_S1.1880.99
14_A18_I1.1720.99
115_V185_I1.1690.99
41_H59_I1.1670.99
84_V88_V1.1600.99
158_L162_F1.1580.99
14_A123_V1.1540.99
28_E97_L1.1470.99
22_G120_G1.1340.98
43_S164_A1.1230.98
20_A93_F1.1100.98
19_L120_G1.1100.98
60_G157_E1.1060.98
165_W171_I1.1020.98
108_I112_L1.1010.98
37_W134_R1.0850.98
35_S40_F1.0800.98
92_F95_F1.0720.98
154_N158_L1.0660.98
20_A86_I1.0520.97
155_G159_T1.0470.97
72_R144_K1.0450.97
19_L121_V1.0240.97
182_T186_L1.0240.97
91_D95_F1.0190.97
36_P179_A1.0140.97
60_G133_P0.9980.96
67_T79_A0.9920.96
53_G91_D0.9860.96
78_G81_L0.9780.96
57_I88_V0.9750.96
192_Q195_Q0.9690.96
76_K82_N0.9610.96
12_Y76_K0.9590.96
29_G113_G0.9560.96
162_F165_W0.9540.95
89_F92_F0.9470.95
54_Q91_D0.9440.95
73_A143_E0.9430.95
50_L54_Q0.9400.95
152_V155_G0.9310.95
161_L171_I0.9290.95
118_G122_G0.9290.95
130_G164_A0.9280.95
39_A43_S0.9250.95
121_V186_L0.9160.94
141_I145_T0.9060.94
177_L180_I0.8980.94
82_N132_G0.8900.93
83_M133_P0.8870.93
29_G32_L0.8830.93
122_G190_L0.8820.93
122_G126_S0.8810.93
40_F163_A0.8780.93
126_S193_S0.8710.93
41_H56_S0.8690.93
26_T178_T0.8670.93
11_F126_S0.8590.92
11_F123_V0.8580.92
141_I152_V0.8570.92
111_S115_V0.8570.92
31_A116_L0.8530.92
163_A166_G0.8510.92
42_Y46_Q0.8440.92
12_Y127_A0.8420.91
125_V131_A0.8370.91
131_A136_S0.8200.90
101_S105_G0.8190.90
102_T105_G0.8140.90
18_I123_V0.8100.90
134_R157_E0.8060.90
63_I160_I0.8060.90
43_S172_G0.8020.89
122_G193_S0.7990.89
57_I83_M0.7970.89
58_I62_L0.7970.89
36_P182_T0.7930.89
78_G82_N0.7900.89
138_M157_E0.7850.88
59_I63_I0.7840.88
6_V10_T0.7830.88
25_L109_V0.7830.88
14_A77_I0.7790.88
123_V193_S0.7740.88
80_L115_V0.7730.88
67_T136_S0.7690.87
19_L178_T0.7690.87
68_S75_P0.7680.87
32_L106_S0.7650.87
108_I188_F0.7650.87
25_L93_F0.7620.87
29_G110_F0.7620.87
7_L80_L0.7610.87
179_A183_G0.7570.86
56_S90_I0.7570.86
159_T163_A0.7540.86
157_E160_I0.7530.86
64_V83_M0.7460.86
80_L84_V0.7460.86
19_L117_I0.7450.86
10_T13_F0.7440.85
70_F140_L0.7420.85
100_L109_V0.7420.85
13_F77_I0.7400.85
128_G194_I0.7400.85
145_T152_V0.7390.85
44_L58_I0.7390.85
114_V185_I0.7360.85
125_V186_L0.7210.84
34_I161_L0.7180.83
158_L161_L0.7180.83
138_M149_V0.7170.83
44_L49_G0.7150.83
29_G83_M0.7120.83
74_W143_E0.7120.83
23_V86_I0.7000.82
37_W138_M0.6990.82
60_G132_G0.6970.82
22_G113_G0.6970.82
56_S182_T0.6960.81
37_W41_H0.6940.81
68_S76_K0.6910.81
105_G108_I0.6910.81
66_F108_I0.6870.81
119_Y193_S0.6850.80
40_F59_I0.6780.80
57_I84_V0.6760.80
82_N134_R0.6760.80
76_K130_G0.6750.79
37_W135_D0.6720.79
103_Y106_S0.6700.79
6_V163_A0.6680.79
76_K136_S0.6670.79
178_T182_T0.6650.78
89_F93_F0.6600.78
79_A134_R0.6590.78
185_I188_F0.6570.78
62_L66_F0.6560.78
29_G182_T0.6520.77
148_N187_R0.6500.77
79_A130_G0.6480.77
16_L36_P0.6440.76
104_T107_I0.6410.76
51_T55_W0.6410.76
55_W58_I0.6310.75
109_V112_L0.6270.74
35_S38_D0.6260.74
147_W152_V0.6210.74
10_T112_L0.6190.73
21_F25_L0.6160.73
155_G158_L0.6150.73
151_W154_N0.6140.73
34_I42_Y0.6100.72
43_S130_G0.6090.72
105_G141_I0.6080.72
81_L85_L0.6050.72
34_I110_F0.6050.72
6_V13_F0.5970.71
145_T155_G0.5960.71
49_G111_S0.5950.70
114_V124_Y0.5940.70
17_I96_I0.5920.70
26_T60_G0.5910.70
166_G170_P0.5890.70
118_G189_S0.5890.70
76_K79_A0.5880.69
95_F176_I0.5880.69
65_G69_L0.5880.69
64_V70_F0.5870.69
133_P136_S0.5820.69
138_M156_M0.5810.69
138_M186_L0.5780.68
12_Y78_G0.5770.68
41_H134_R0.5770.68
124_Y138_M0.5750.68
54_Q57_I0.5690.67
137_L141_I0.5690.67
37_W133_P0.5680.67
117_I121_V0.5660.67
61_A111_S0.5660.67
60_G138_M0.5640.66
124_Y132_G0.5630.66
45_F52_V0.5630.66
43_S167_M0.5550.65
60_G90_I0.5530.65
138_M153_R0.5530.65
23_V117_I0.5500.64
186_L189_S0.5480.64
90_I94_N0.5480.64
118_G187_R0.5450.64
147_W155_G0.5440.64
105_G112_L0.5430.63
23_V87_G0.5400.63
40_F160_I0.5380.63
49_G169_G0.5370.63
86_I157_E0.5360.62
39_A171_I0.5350.62
114_V181_L0.5340.62
9_W129_L0.5290.61
107_I162_F0.5270.61
100_L105_G0.5260.61
61_A83_M0.5250.61
142_T149_V0.5210.60
35_S161_L0.5200.60
18_I116_L0.5140.59
141_I155_G0.5140.59
92_F96_I0.5120.59
188_F191_P0.5120.59
37_W60_G0.5100.59
113_G122_G0.5070.58
28_E99_A0.5070.58
49_G146_G0.5040.58
90_I124_Y0.5030.58
39_A168_G0.5030.58
13_F85_L0.5030.58
60_G82_N0.5020.57
181_L184_L0.5010.57
101_S108_I0.5000.57
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2cfqA 1 0.907 73 0.921 Contact Map
4dx5A 3 0.8233 37.9 0.937 Contact Map
4ldsA 2 0.8233 36.6 0.937 Contact Map
4tphA 2 0.7721 25.7 0.942 Contact Map
4mt1A 3 0.7907 23.7 0.943 Contact Map
1j4nA 4 0.7302 22.3 0.944 Contact Map
4gc0A 1 0.907 19.3 0.945 Contact Map
4j05A 3 0.7581 17.9 0.946 Contact Map
3o7qA 1 0.8605 16.5 0.947 Contact Map
4pypA 1 0.8233 13.7 0.949 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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