GREMLIN Database
CYPX - Pulcherriminic acid synthase
UniProt: O34926 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 405 (370)
Sequences: 44545 (33213)
Seq/√Len: 1726.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
320_Q323_V3.9151.00
320_Q325_N3.4111.00
268_R330_D3.3891.00
258_D327_H3.2281.00
292_V297_E3.1251.00
113_E369_I3.0911.00
245_M273_T3.0861.00
299_K302_T3.0141.00
245_M367_A2.9931.00
241_T363_I2.8791.00
267_P364_E2.7741.00
197_R220_D2.7511.00
290_D300_K2.7061.00
45_R48_D2.6951.00
248_H277_K2.5911.00
256_M260_L2.5651.00
290_D297_E2.5571.00
196_R203_D2.3901.00
58_I289_Q2.3691.00
255_Q265_L2.3651.00
313_R322_D2.3611.00
259_V269_A2.3291.00
287_L298_I2.3201.00
59_F291_T2.3181.00
120_L374_M2.2851.00
41_Y302_T2.1811.00
48_D294_G2.1721.00
190_M224_L2.1571.00
194_K220_D2.1411.00
109_K369_I2.1161.00
107_L142_D2.1111.00
252_N255_Q2.0781.00
190_M220_D2.0761.00
195_E199_N2.0651.00
258_D265_L2.0601.00
120_L373_K2.0461.00
135_F366_V2.0421.00
248_H276_Y2.0391.00
24_S27_R1.9951.00
260_L375_R1.9561.00
352_N356_A1.9451.00
292_V295_G1.8861.00
190_M194_K1.8441.00
49_V311_A1.8361.00
247_Y251_N1.8351.00
270_I363_I1.8101.00
32_V43_I1.7941.00
43_I52_I1.7821.00
255_Q258_D1.7761.00
271_A360_K1.7601.00
22_Y25_Q1.7511.00
273_T324_F1.7411.00
256_M375_R1.7291.00
50_R54_Q1.7271.00
156_E160_G1.6951.00
242_L366_V1.6761.00
180_W184_Q1.6541.00
88_K226_L1.6501.00
57_D289_Q1.6411.00
111_N142_D1.6321.00
290_D299_K1.6321.00
111_N114_N1.6251.00
257_N375_R1.6231.00
132_G246_I1.5971.00
219_S222_D1.5891.00
191_P195_E1.5791.00
256_M371_L1.5771.00
31_P45_R1.5761.00
194_K198_V1.5751.00
245_M249_L1.5741.00
274_L345_A1.5651.00
47_H294_G1.5481.00
110_Q142_D1.5461.00
309_G313_R1.5431.00
132_G242_L1.5411.00
248_H252_N1.5381.00
245_M269_A1.5361.00
107_L110_Q1.5331.00
257_N260_L1.5101.00
369_I372_D1.4911.00
315_P322_D1.4591.00
153_K157_W1.4511.00
34_Y39_D1.4501.00
109_K113_E1.4401.00
22_Y26_L1.4231.00
203_D206_S1.4191.00
370_V377_I1.4111.00
259_V371_L1.4061.00
118_P122_R1.4041.00
268_R327_H1.4031.00
43_I48_D1.4021.00
206_S210_T1.3951.00
276_Y313_R1.3921.00
200_P210_T1.3731.00
100_A103_H1.3701.00
122_R130_D1.3651.00
49_V306_C1.3651.00
117_A373_K1.3631.00
194_K197_R1.3581.00
246_I370_V1.3461.00
265_L327_H1.3391.00
24_S322_D1.3351.00
259_V266_V1.3271.00
105_S364_E1.3261.00
312_N345_A1.3131.00
111_N138_C1.3111.00
187_Q191_P1.3051.00
124_K380_E1.3021.00
51_Y55_H1.2981.00
241_T279_P1.2981.00
83_K86_S1.2861.00
315_P321_P1.2831.00
266_V371_L1.2741.00
255_Q269_A1.2741.00
82_G86_S1.2551.00
192_V195_E1.2521.00
31_P316_E1.2511.00
157_W184_Q1.2431.00
267_P271_A1.2411.00
183_E187_Q1.2411.00
55_H58_I1.2401.00
250_L256_M1.2361.00
60_T288_S1.2311.00
260_L371_L1.2231.00
266_V368_N1.2141.00
289_Q300_K1.2131.00
25_Q29_E1.2121.00
113_E117_A1.2091.00
317_A342_R1.2071.00
286_Q301_D1.2001.00
83_K87_A1.1991.00
25_Q28_E1.1901.00
160_G177_H1.1771.00
269_A273_T1.1741.00
140_T234_A1.1721.00
269_A324_F1.1681.00
112_A135_F1.1611.00
319_E325_N1.1601.00
255_Q326_I1.1561.00
176_A180_W1.1561.00
116_L369_I1.1531.00
80_M84_E1.1511.00
116_L374_M1.1491.00
45_R316_E1.1471.00
102_D105_S1.1451.00
126_D129_N1.1431.00
40_S305_F1.1401.00
153_K184_Q1.1321.00
195_E198_V1.1321.00
271_A343_H1.1281.00
186_S224_L1.1221.00
356_A360_K1.1221.00
51_Y294_G1.1211.00
108_I139_V1.1141.00
248_H273_T1.1141.00
186_S190_M1.1071.00
41_Y298_I1.1041.00
109_K365_I1.1031.00
44_S307_M1.1021.00
105_S365_I1.1001.00
263_R372_D1.1001.00
105_S109_K1.0881.00
255_Q327_H1.0881.00
112_A369_I1.0861.00
87_A222_D1.0831.00
33_H42_F1.0781.00
112_A116_L1.0781.00
114_N138_C1.0761.00
75_P84_E1.0761.00
153_K156_E1.0741.00
114_N118_P1.0691.00
110_Q114_N1.0651.00
108_I361_N1.0621.00
115_L135_F1.0571.00
221_K225_A1.0561.00
76_V80_M1.0551.00
112_A365_I1.0541.00
142_D147_D1.0531.00
249_L259_V1.0491.00
196_R206_S1.0421.00
184_Q187_Q1.0421.00
287_L302_T1.0371.00
114_N117_A1.0371.00
160_G181_C1.0351.00
220_D224_L1.0341.00
312_N343_H1.0321.00
177_H181_C1.0291.00
48_D51_Y1.0251.00
27_R315_P1.0141.00
117_A120_L1.0091.00
109_K368_N1.0021.00
252_N323_V1.0011.00
259_V265_L0.9991.00
248_H251_N0.9991.00
137_V235_T0.9981.00
47_H51_Y0.9951.00
46_Y317_A0.9931.00
182_S186_S0.9901.00
249_L255_Q0.9891.00
58_I291_T0.9861.00
30_D33_H0.9841.00
101_L361_N0.9841.00
244_L277_K0.9811.00
197_R200_P0.9771.00
286_Q303_I0.9771.00
97_I100_A0.9731.00
381_E384_C0.9711.00
291_T297_E0.9701.00
265_L268_R0.9701.00
263_R368_N0.9701.00
84_E87_A0.9661.00
287_L290_D0.9651.00
98_G102_D0.9601.00
47_H316_E0.9581.00
207_I210_T0.9581.00
107_L111_N0.9551.00
269_A326_I0.9501.00
156_E159_S0.9481.00
146_L195_E0.9431.00
113_E373_K0.9431.00
377_I384_C0.9411.00
253_P257_N0.9401.00
369_I373_K0.9381.00
166_T172_P0.9331.00
43_I49_V0.9291.00
315_P319_E0.9291.00
167_S172_P0.9271.00
368_N372_D0.9271.00
173_E177_H0.9201.00
380_E383_F0.9201.00
250_L379_L0.9171.00
249_L256_M0.9071.00
86_S90_R0.9071.00
265_L326_I0.9061.00
196_R200_P0.9021.00
379_L382_D0.8921.00
359_A363_I0.8921.00
267_P360_K0.8911.00
202_S206_S0.8881.00
192_V196_R0.8881.00
116_L373_K0.8861.00
283_I308_I0.8841.00
272_E275_R0.8831.00
118_P134_T0.8801.00
163_D166_T0.8791.00
242_L363_I0.8791.00
264_S268_R0.8761.00
196_R199_N0.8741.00
197_R212_E0.8721.00
254_E258_D0.8661.00
339_G342_R0.8621.00
67_R70_P0.8621.00
47_H50_R0.8611.00
111_N147_D0.8611.00
21_A24_S0.8571.00
262_D265_L0.8551.00
218_L222_D0.8551.00
175_R179_L0.8551.00
250_L377_I0.8491.00
179_L183_E0.8491.00
212_E217_A0.8471.00
375_R378_R0.8451.00
61_T288_S0.8441.00
92_V354_V0.8431.00
56_P291_T0.8401.00
96_F354_V0.8401.00
52_I306_C0.8391.00
105_S361_N0.8391.00
184_Q188_Y0.8331.00
84_E88_K0.8321.00
51_Y291_T0.8271.00
377_I382_D0.8261.00
60_T81_H0.8251.00
84_E222_D0.8251.00
118_P121_E0.8251.00
127_L246_I0.8241.00
66_E69_E0.8241.00
205_I227_I0.8231.00
106_P110_Q0.8221.00
99_D103_H0.8221.00
360_K364_E0.8221.00
191_P194_K0.8201.00
385_Y395_P0.8201.00
287_L299_K0.8121.00
49_V344_L0.8101.00
26_L33_H0.8091.00
45_R294_G0.8061.00
183_E186_S0.8061.00
236_E240_K0.8051.00
54_Q348_S0.8041.00
181_C184_Q0.8001.00
155_S159_S0.7991.00
186_S228_L0.7981.00
173_E176_A0.7981.00
42_F307_M0.7961.00
38_I303_I0.7941.00
241_T273_T0.7941.00
39_D302_T0.7911.00
117_A121_E0.7911.00
141_M148_K0.7901.00
130_D134_T0.7891.00
32_V48_D0.7861.00
246_I371_L0.7851.00
135_F139_V0.7821.00
268_R329_E0.7761.00
108_I358_F0.7761.00
76_V229_N0.7751.00
298_I304_V0.7751.00
266_V364_E0.7631.00
253_P256_M0.7611.00
364_E368_N0.7611.00
46_Y50_R0.7601.00
30_D296_M0.7601.00
169_S172_P0.7571.00
254_E257_N0.7561.00
139_V362_E0.7551.00
70_P73_R0.7551.00
134_T138_C0.7531.00
189_L227_I0.7521.00
167_S170_Q0.7501.00
126_D130_D0.7491.00
187_Q190_M0.7481.00
168_I172_P0.7481.00
24_S310_A0.7461.00
131_F366_V0.7451.00
40_S303_I0.7441.00
365_I369_I0.7401.00
103_H202_S0.7401.00
177_H180_W0.7401.00
238_A362_E0.7381.00
132_G243_A0.7381.00
387_E395_P0.7381.00
201_G206_S0.7371.00
110_Q147_D0.7371.00
330_D341_A0.7351.00
92_V230_V0.7341.00
85_H89_R0.7271.00
297_E300_K0.7271.00
166_T169_S0.7261.00
31_P314_D0.7241.00
186_S221_K0.7221.00
136_A238_A0.7211.00
52_I293_V0.7211.00
174_A178_S0.7181.00
52_I59_F0.7161.00
59_F62_K0.7151.00
95_S207_I0.7151.00
322_D325_N0.7111.00
99_D102_D0.7091.00
80_M88_K0.7091.00
255_Q325_N0.7071.00
160_G184_Q0.7071.00
249_L269_A0.7041.00
53_L306_C0.7031.00
249_L371_L0.7031.00
245_M270_I0.7011.00
293_V298_I0.7001.00
114_N147_D0.6971.00
388_S391_Y0.6961.00
157_W160_G0.6931.00
241_T274_L0.6921.00
358_F362_E0.6921.00
106_P109_K0.6901.00
36_E39_D0.6881.00
119_Y125_S0.6871.00
390_L394_G0.6831.00
32_V296_M0.6831.00
197_R213_Y0.6821.00
51_Y56_P0.6821.00
193_I197_R0.6791.00
245_M324_F0.6771.00
390_L395_P0.6771.00
212_E220_D0.6761.00
31_P294_G0.6761.00
294_G297_E0.6741.00
314_D317_A0.6741.00
89_R93_V0.6731.00
175_R178_S0.6721.00
287_L301_D0.6711.00
278_P312_N0.6681.00
268_R326_I0.6671.00
288_S300_K0.6671.00
266_V367_A0.6651.00
92_V226_L0.6651.00
265_L269_A0.6621.00
379_L383_F0.6621.00
307_M310_A0.6611.00
308_I344_L0.6611.00
391_Y394_G0.6611.00
247_Y379_L0.6601.00
158_H162_A0.6601.00
234_A237_P0.6601.00
98_G357_A0.6581.00
253_P375_R0.6561.00
276_Y322_D0.6551.00
50_R341_A0.6531.00
112_A366_V0.6521.00
87_A216_M0.6511.00
190_M221_K0.6491.00
202_S207_I0.6491.00
156_E184_Q0.6471.00
274_L343_H0.6451.00
348_S352_N0.6441.00
257_N261_A0.6421.00
233_A237_P0.6411.00
284_P305_F0.6391.00
119_Y131_F0.6381.00
320_Q328_R0.6381.00
164_F167_S0.6371.00
167_S171_S0.6331.00
388_S394_G0.6291.00
380_E384_C0.6291.00
325_N328_R0.6291.00
112_A115_L0.6271.00
270_I364_E0.6271.00
378_R381_E0.6251.00
46_Y314_D0.6241.00
270_I360_K0.6241.00
335_S338_S0.6241.00
64_L67_R0.6221.00
176_A179_L0.6221.00
145_G203_D0.6211.00
188_Y191_P0.6211.00
59_F287_L0.6201.00
140_T143_M0.6201.00
118_P130_D0.6171.00
188_Y192_V0.6161.00
152_E156_E0.6161.00
261_A264_S0.6141.00
246_I367_A0.6141.00
179_L182_S0.6091.00
77_L229_N0.6071.00
287_L304_V0.6071.00
178_S181_C0.6031.00
100_A104_L0.6021.00
59_F304_V0.6021.00
24_S28_E0.5991.00
51_Y293_V0.5981.00
53_L308_I0.5981.00
35_E40_S0.5971.00
100_A207_I0.5941.00
118_P138_C0.5931.00
244_L386_A0.5931.00
82_G350_I0.5921.00
248_H324_F0.5921.00
136_A362_E0.5881.00
58_I288_S0.5881.00
146_L192_V0.5871.00
77_L80_M0.5871.00
266_V269_A0.5861.00
28_E316_E0.5831.00
154_I158_H0.5821.00
211_S214_E0.5811.00
287_L300_K0.5801.00
186_S225_A0.5791.00
138_C151_H0.5781.00
61_T81_H0.5781.00
346_F360_K0.5771.00
153_K191_P0.5771.00
389_G393_R0.5771.00
241_T270_I0.5761.00
20_Y309_G0.5741.00
200_P206_S0.5741.00
50_R348_S0.5731.00
291_T294_G0.5731.00
115_L119_Y0.5711.00
249_L252_N0.5691.00
319_E323_V0.5671.00
178_S182_S0.5651.00
51_Y292_V0.5631.00
136_A239_D0.5631.00
251_N379_L0.5631.00
63_S66_E0.5621.00
258_D262_D0.5601.00
101_L358_F0.5601.00
21_A25_Q0.5591.00
41_Y296_M0.5561.00
266_V270_I0.5551.00
212_E215_G0.5551.00
23_F26_L0.5551.00
163_D169_S0.5541.00
318_F321_P0.5531.00
110_Q113_E0.5521.00
287_L291_T0.5521.00
389_G394_G0.5521.00
108_I362_E0.5501.00
203_D207_I0.5491.00
253_P378_R0.5481.00
44_S314_D0.5481.00
365_I368_N0.5471.00
208_L223_I0.5461.00
154_I157_W0.5461.00
75_P80_M0.5461.00
60_T63_S0.5451.00
48_D293_V0.5431.00
88_K222_D0.5421.00
202_S210_T0.5421.00
327_H330_D0.5421.00
68_A71_V0.5421.00
391_Y395_P0.5391.00
150_D153_K0.5381.00
76_V79_Q0.5371.00
204_L208_L0.5351.00
258_D326_I0.5351.00
268_R325_N0.5341.00
168_I171_S0.5341.00
47_H317_A0.5331.00
96_F230_V0.5331.00
197_R209_C0.5321.00
158_H161_V0.5321.00
133_K239_D0.5311.00
49_V53_L0.5311.00
245_M363_I0.5311.00
180_W183_E0.5311.00
278_P281_Q0.5311.00
226_L229_N0.5301.00
377_I380_E0.5301.00
77_L226_L0.5301.00
42_F305_F0.5291.00
193_I209_C0.5281.00
158_H235_T0.5241.00
347_G352_N0.5241.00
104_L108_I0.5241.00
133_K159_S0.5221.00
108_I365_I0.5201.00
45_R49_V0.5201.00
313_R321_P0.5191.00
390_L393_R0.5181.00
137_V231_L0.5181.00
132_G363_I0.5161.00
67_R73_R0.5161.00
142_D151_H0.5151.00
33_H44_S0.5141.00
222_D226_L0.5131.00
31_P44_S0.5121.00
200_P213_Y0.5121.00
213_Y216_M0.5111.00
318_F341_A0.5111.00
263_R266_V0.5101.00
20_Y24_S0.5091.00
284_P303_I0.5081.00
127_L132_G0.5081.00
377_I383_F0.5071.00
27_R44_S0.5071.00
61_T80_M0.5051.00
159_S162_A0.5041.00
157_W161_V0.5031.00
240_K394_G0.5021.00
264_S267_P0.5021.00
133_K155_S0.5021.00
69_E73_R0.5011.00
75_P221_K0.5011.00
341_A348_S0.5011.00
254_E323_V0.5001.00
63_S286_Q0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3nc3A 1 0.9481 100 0.174 Contact Map
2z3tA 1 0.9333 100 0.199 Contact Map
2xkrA 1 0.9531 100 0.199 Contact Map
4tpnA 1 0.9259 100 0.206 Contact Map
2uuqA 2 0.9358 100 0.209 Contact Map
2jjnA 1 0.9531 100 0.21 Contact Map
3bujA 1 0.9506 100 0.213 Contact Map
4e2pA 1 0.8963 100 0.217 Contact Map
4ggvA 1 0.9531 100 0.218 Contact Map
3ejbB 1 0.9358 100 0.221 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0115 seconds.