GREMLIN Database
DEOD - Purine nucleoside phosphorylase DeoD-type
UniProt: O34925 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 233 (215)
Sequences: 6883 (4952)
Seq/√Len: 337.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
35_N51_T3.1891.00
91_C201_V3.1301.00
188_A195_A2.8871.00
14_D83_Q2.7951.00
77_I193_R2.7391.00
154_F174_V2.7091.00
130_D194_K2.5861.00
181_T197_S2.5451.00
107_M150_V2.4841.00
108_T152_S2.4841.00
138_Y150_V2.4831.00
51_T56_K2.3851.00
15_T84_N2.2981.00
167_E171_K2.2731.00
66_V157_D2.2351.00
84_N194_K2.0491.00
108_T128_C2.0401.00
26_K30_E1.9951.00
106_A153_V1.9931.00
104_I176_G1.9881.00
95_R175_L1.9731.00
168_K172_Y1.9351.00
124_D127_P1.9231.00
41_E46_Y1.8871.00
99_K102_D1.8701.00
16_V76_L1.8521.00
91_C176_G1.7991.00
74_N191_H1.7591.00
75_E78_Q1.7271.00
178_E181_T1.7191.00
17_L28_I1.6841.00
138_Y142_K1.6591.00
151_G175_L1.6481.00
66_V183_A1.6451.00
22_P61_G1.6431.00
212_T215_E1.6291.00
74_N78_Q1.6191.00
98_V149_T1.5971.00
135_K139_D1.5541.00
104_I175_L1.5511.00
37_E49_T1.5321.00
19_P25_A1.5121.00
221_H225_E1.4991.00
153_V176_G1.4961.00
29_A48_F1.4961.00
27_F221_H1.4911.00
14_D56_K1.4861.00
133_L196_L1.4631.00
83_Q193_R1.4511.00
134_L150_V1.4491.00
78_Q191_H1.4461.00
105_L148_V1.4391.00
165_Q168_K1.4351.00
73_V187_L1.4111.00
105_L134_L1.4041.00
129_A134_L1.3981.00
60_Q72_Y1.3941.00
213_A216_R1.3931.00
49_T58_S1.3831.00
134_L137_A1.3711.00
73_V85_L1.3701.00
111_T186_T1.3691.00
167_E170_A1.3541.00
66_V155_T1.3541.00
114_Q117_R1.3271.00
176_G201_V1.3081.00
134_L196_L1.3061.00
131_F135_K1.3051.00
15_T55_K1.3011.00
218_T222_D1.2791.00
69_I184_L1.2711.00
18_L62_T1.2701.00
102_D149_T1.2481.00
25_A59_V1.2321.00
18_L85_L1.2311.00
141_A148_V1.2301.00
119_A123_V1.2281.00
37_E56_K1.2231.00
162_D165_Q1.2211.00
137_A196_L1.2211.00
20_G87_R1.2101.00
97_D149_T1.2021.00
134_L138_Y1.1931.00
118_V123_V1.1911.00
39_Y46_Y1.1901.00
204_H207_T1.1891.00
153_V199_L1.1871.00
38_C41_E1.1711.00
77_I85_L1.1621.00
34_E51_T1.1611.00
108_T126_A1.1551.00
93_A98_V1.1501.00
45_M61_G1.1451.00
40_N80_Y1.1381.00
67_P157_D1.1321.00
93_A201_V1.1261.00
33_L36_V1.1251.00
25_A48_F1.1221.00
85_L188_A1.1191.00
120_F123_V1.1121.00
149_T175_L1.1011.00
33_L50_G1.0971.00
87_R184_L1.0891.00
28_I59_V1.0631.00
109_S181_T1.0581.00
52_Y228_L1.0561.00
135_K138_Y1.0551.00
132_E194_K1.0531.00
136_N140_A1.0521.00
185_Y195_A1.0391.00
109_S185_Y1.0331.00
119_A122_S1.0301.00
94_I177_V1.0271.00
144_K229_H1.0261.00
51_T54_G1.0231.00
131_F134_L1.0151.00
47_G58_S1.0151.00
20_G24_R1.0131.00
70_S187_L1.0121.00
16_V82_V1.0111.00
93_A204_H1.0021.00
49_T56_K1.0011.00
77_I82_V0.9861.00
47_G60_Q0.9751.00
22_P26_K0.9661.00
211_T214_E0.9651.00
225_E229_H0.9541.00
168_K171_K0.9501.00
112_D115_M0.9501.00
77_I191_H0.9481.00
111_T182_T0.9421.00
138_Y148_V0.9391.00
99_K209_E0.9261.00
104_I201_V0.9261.00
53_K229_H0.9101.00
220_F224_I0.9041.00
139_D142_K0.9021.00
136_N139_D0.8981.00
109_S197_S0.8941.00
217_Q221_H0.8851.00
221_H224_I0.8841.00
92_G205_V0.8841.00
99_K207_T0.8711.00
144_K225_E0.8661.00
222_D225_E0.8621.00
40_N49_T0.8621.00
91_C199_L0.8611.00
211_T215_E0.8601.00
94_I170_A0.8601.00
71_I187_L0.8571.00
107_M152_S0.8531.00
76_L82_V0.8531.00
132_E136_N0.8501.00
27_F30_E0.8491.00
94_I174_V0.8431.00
27_F224_I0.8421.00
110_S154_F0.8361.00
137_A140_A0.8351.00
155_T181_T0.8351.00
159_F179_M0.8281.00
105_L138_Y0.8281.00
118_V122_S0.8271.00
122_S172_Y0.8211.00
25_A61_G0.8141.00
39_Y60_Q0.8081.00
90_S203_D0.8081.00
118_V121_G0.7961.00
183_A187_L0.7961.00
131_F138_Y0.7911.00
45_M72_Y0.7891.00
99_K204_H0.7881.00
71_I74_N0.7861.00
33_L59_V0.7851.00
106_A185_Y0.7791.00
69_I183_A0.7771.00
140_A144_K0.7761.00
133_L137_A0.7721.00
32_Y228_L0.7721.00
73_V184_L0.7701.00
219_T223_M0.7651.00
105_L196_L0.7651.00
128_C131_F0.7601.00
143_D229_H0.7591.00
113_S117_R0.7571.00
115_M118_V0.7561.00
114_Q120_F0.7561.00
19_P88_V0.7501.00
130_D134_L0.7471.00
105_L150_V0.7450.99
115_M120_F0.7410.99
106_A199_L0.7400.99
112_D116_N0.7390.99
106_A176_G0.7370.99
47_G80_Y0.7360.99
177_V205_V0.7330.99
58_S80_Y0.7320.99
71_I75_E0.7300.99
95_R98_V0.7300.99
22_P29_A0.7270.99
60_Q76_L0.7260.99
218_T221_H0.7240.99
223_M227_A0.7240.99
43_R75_E0.7220.99
96_K170_A0.7140.99
140_A143_D0.7130.99
98_V104_I0.7120.99
105_L223_M0.7100.99
94_I205_V0.7000.99
126_A152_S0.7000.99
43_R79_S0.6990.99
154_F169_L0.6980.99
169_L172_Y0.6960.99
42_V79_S0.6960.99
163_D167_E0.6900.99
103_V200_T0.6900.99
16_V58_S0.6890.99
36_V48_F0.6880.99
112_D156_A0.6850.99
92_G177_V0.6820.99
101_R219_T0.6790.99
90_S202_S0.6780.99
52_Y57_I0.6770.99
26_K29_A0.6770.99
185_Y197_S0.6700.99
160_Y177_V0.6700.99
69_I73_V0.6620.99
14_D55_K0.6600.99
146_V225_E0.6580.99
131_F140_A0.6540.99
91_C104_I0.6500.99
42_V78_Q0.6480.99
84_N133_L0.6460.99
217_Q220_F0.6440.99
66_V113_S0.6410.98
130_D133_L0.6390.98
141_A226_V0.6350.98
128_C132_E0.6330.98
200_T216_R0.6320.98
21_D24_R0.6290.98
158_Q165_Q0.6280.98
133_L136_N0.6270.98
115_M119_A0.6260.98
212_T216_R0.6220.98
68_S71_I0.6190.98
202_S211_T0.6160.98
139_D143_D0.6150.98
95_R149_T0.6120.98
164_S167_E0.6110.98
70_S183_A0.6110.98
18_L184_L0.6110.98
70_S74_N0.6070.98
101_R211_T0.6070.98
29_A59_V0.6040.98
128_C189_A0.6010.98
134_L140_A0.6000.98
103_V226_V0.5990.98
125_F128_C0.5950.98
29_A36_V0.5940.98
135_K142_K0.5920.97
162_D190_K0.5910.97
46_Y61_G0.5880.97
152_S174_V0.5870.97
45_M60_Q0.5860.97
23_L26_K0.5810.97
132_E135_K0.5790.97
102_D147_P0.5790.97
38_C46_Y0.5780.97
40_N79_S0.5780.97
44_G71_I0.5770.97
23_L41_E0.5770.97
178_E197_S0.5750.97
223_M226_V0.5720.97
156_A160_Y0.5720.97
116_N122_S0.5720.97
112_D117_R0.5700.97
103_V146_V0.5610.97
34_E50_G0.5590.96
47_G75_E0.5540.96
85_L193_R0.5530.96
53_K228_L0.5530.96
50_G57_I0.5520.96
111_T114_Q0.5490.96
110_S126_A0.5460.96
19_P28_I0.5460.96
25_A29_A0.5460.96
106_A129_A0.5440.96
85_L184_L0.5440.96
181_T199_L0.5430.96
129_A185_Y0.5430.96
36_V39_Y0.5420.96
211_T216_R0.5420.96
110_S152_S0.5400.96
177_V203_D0.5400.96
166_I204_H0.5400.96
28_I88_V0.5390.96
66_V182_T0.5370.96
169_L174_V0.5360.95
127_P186_T0.5350.95
224_I227_A0.5340.95
115_M187_L0.5320.95
166_I169_L0.5310.95
32_Y221_H0.5300.95
99_K147_P0.5280.95
32_Y225_E0.5280.95
24_R199_L0.5260.95
44_G75_E0.5200.95
220_F223_M0.5160.94
98_V201_V0.5160.94
214_E217_Q0.5140.94
135_K150_V0.5140.94
64_M179_M0.5120.94
18_L73_V0.5120.94
19_P61_G0.5090.94
202_S220_F0.5070.94
107_M131_F0.5070.94
87_R90_S0.5060.94
129_A133_L0.5040.94
21_D64_M0.5030.94
140_A229_H0.5020.94
179_M203_D0.5020.94
131_F150_V0.5010.94
14_D49_T0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1je0A 3 0.9614 100 0.184 Contact Map
2b94A 4 0.9485 100 0.2 Contact Map
3bjeA 2 0.9914 100 0.2 Contact Map
3phcA 5 0.9871 100 0.204 Contact Map
3uawA 5 0.9914 100 0.204 Contact Map
4mchA 3 0.97 100 0.207 Contact Map
1z34A 3 0.9742 100 0.212 Contact Map
4rj2A 3 0.9957 100 0.213 Contact Map
4tymA 5 0.9914 100 0.213 Contact Map
4m7wA 5 0.9957 100 0.214 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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