GREMLIN Database
YTOP - Putative aminopeptidase YtoP
UniProt: O34924 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 357 (336)
Sequences: 2601 (1692)
Seq/√Len: 92.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
145_K149_I4.6891.00
15_L28_F3.5061.00
173_K327_H3.1991.00
85_F138_I2.8801.00
333_A336_E2.7661.00
18_A88_L2.7011.00
13_T176_S2.6741.00
10_Q14_Q2.6501.00
271_M310_A2.6021.00
251_Q254_K2.5931.00
142_A148_A2.5881.00
190_E193_K2.5411.00
104_Q160_V2.4961.00
64_A209_T2.4281.00
78_T84_R2.4091.00
282_H340_K2.4071.00
61_I342_V2.3491.00
30_K34_A2.2841.00
83_L103_I2.2581.00
60_R205_Y2.2451.00
285_P333_A2.1901.00
30_K42_Q2.1731.00
51_V203_T2.1061.00
112_G138_I2.0931.00
19_P88_L2.0831.00
277_D281_T2.0811.00
69_E177_K2.0731.00
340_K343_T2.0641.00
146_E149_I2.0341.00
275_V310_A2.0181.00
194_E339_I2.0181.00
83_L159_I1.9991.00
198_K343_T1.9601.00
332_A336_E1.9591.00
275_V341_L1.9531.00
172_K329_D1.9461.00
227_K304_N1.9391.00
146_E150_K1.9351.00
192_L206_A1.9241.00
256_F333_A1.9191.00
29_M185_C1.9181.00
21_N158_Q1.9081.00
31_Q34_A1.8931.00
74_V159_I1.8911.00
11_T28_F1.8821.00
11_T32_E1.8821.00
140_I153_I1.8581.00
51_V205_Y1.8401.00
79_D145_K1.8001.00
140_I148_A1.7531.00
53_R203_T1.7471.00
17_G25_V1.7251.00
260_I288_Y1.7181.00
326_I331_Y1.7071.00
11_T31_Q1.7041.00
103_I138_I1.6951.00
65_G188_S1.6931.00
224_H304_N1.6781.00
60_R203_T1.6771.00
101_V138_I1.6721.00
78_T82_L1.6571.00
183_Y331_Y1.6471.00
142_A151_I1.6401.00
117_I126_Q1.6301.00
258_L286_Y1.6011.00
26_R67_M1.5881.00
39_D51_V1.5691.00
105_T108_G1.5451.00
30_K48_V1.5331.00
154_R157_Q1.5201.00
62_M300_V1.4841.00
54_G203_T1.4711.00
154_R280_E1.4691.00
64_A296_D1.4671.00
111_P166_T1.4671.00
37_A50_G1.4631.00
194_E336_E1.4621.00
17_G182_R1.4581.00
220_Q299_K1.4410.99
7_A10_Q1.4390.99
278_M282_H1.4260.99
32_E193_K1.4240.99
62_M222_A1.4230.99
40_I48_V1.4100.99
32_E35_K1.4050.99
85_F136_M1.4050.99
47_S221_T1.4040.99
73_M86_Q1.4040.99
6_K167_T1.3950.99
91_W161_P1.3940.99
193_K197_G1.3740.99
33_L189_I1.3730.99
185_C208_A1.3620.99
85_F159_I1.3580.99
63_V342_V1.3560.99
167_T328_I1.3380.99
144_D147_D1.3380.99
10_Q165_F1.3340.99
212_E320_H1.3340.99
174_I179_W1.3150.99
74_V83_L1.3060.99
62_M207_G1.3060.99
77_I148_A1.3040.99
191_L338_L1.2860.99
7_A11_T1.2850.99
29_M189_I1.2790.99
172_K327_H1.2760.99
274_F341_L1.2720.99
316_S319_I1.2700.99
62_M228_P1.2680.99
187_L334_A1.2630.99
72_F96_L1.2570.99
276_L286_Y1.2510.99
18_A71_G1.2500.99
231_F300_V1.2490.99
29_M208_A1.2480.99
233_A297_A1.2440.98
8_L28_F1.2430.98
335_K339_I1.2360.98
232_F275_V1.2350.98
149_I154_R1.2310.98
191_L339_I1.2240.98
253_G327_H1.2210.98
101_V114_I1.2180.98
27_A31_Q1.2060.98
143_D147_D1.2010.98
213_E320_H1.1980.98
19_P71_G1.1920.98
16_P102_E1.1770.98
41_V225_M1.1750.98
13_T165_F1.1730.98
237_S257_L1.1560.98
183_Y326_I1.1500.97
297_A309_S1.1420.97
103_I159_I1.1360.97
76_S84_R1.1340.97
26_R42_Q1.1340.97
62_M226_I1.1200.97
191_L335_K1.1170.97
8_L32_E1.1130.97
256_F334_A1.1090.97
87_T93_S1.1080.97
83_L140_I1.1050.97
205_Y226_I1.1040.97
16_P104_Q1.0980.97
67_M185_C1.0950.97
274_F278_M1.0940.97
100_R166_T1.0890.96
236_A319_I1.0870.96
88_L158_Q1.0800.96
33_L50_G1.0780.96
100_R162_V1.0760.96
60_R229_D1.0670.96
8_L189_I1.0650.96
258_L272_R1.0610.96
207_G222_A1.0550.96
188_S234_L1.0540.96
103_I157_Q1.0540.96
276_L288_Y1.0530.96
85_F114_I1.0480.96
106_D273_E1.0480.96
15_L24_Q1.0440.95
190_E194_E1.0440.95
36_Y193_K1.0390.95
39_D53_R1.0390.95
272_R276_L1.0340.95
49_F207_G1.0310.95
148_A153_I1.0300.95
106_D157_Q1.0260.95
186_G331_Y1.0250.95
312_I334_A1.0220.95
168_M175_L1.0200.95
237_S289_F1.0080.95
28_F32_E1.0080.95
124_D127_R1.0070.95
102_E162_V1.0060.94
27_A30_K1.0010.94
186_G335_K0.9990.94
237_S313_G0.9930.94
233_A300_V0.9930.94
256_F312_I0.9910.94
147_D150_K0.9910.94
180_D320_H0.9880.94
57_D203_T0.9810.94
54_G58_A0.9800.94
268_H308_P0.9760.94
29_M67_M0.9760.94
339_I343_T0.9750.94
280_E286_Y0.9740.93
125_A128_N0.9730.93
33_L192_L0.9700.93
223_S300_V0.9680.93
284_I337_M0.9590.93
270_G308_P0.9560.93
128_N132_D0.9560.93
329_D332_A0.9530.93
256_F337_M0.9500.93
227_K305_S0.9430.92
111_P162_V0.9380.92
265_T311_V0.9370.92
175_L325_I0.9360.92
56_E59_P0.9350.92
273_E277_D0.9280.92
101_V112_G0.9260.92
23_H270_G0.9230.92
6_K165_F0.9160.91
38_D50_G0.9160.91
254_K285_P0.9150.91
59_P229_D0.9120.91
33_L208_A0.9110.91
26_R48_V0.9050.91
21_N104_Q0.9030.91
195_L200_L0.8980.90
190_E331_Y0.8980.90
50_G208_A0.8960.90
125_A129_R0.8960.90
96_L114_I0.8950.90
188_S206_A0.8900.90
179_W326_I0.8900.90
236_A316_S0.8870.90
187_L335_K0.8840.90
43_D47_S0.8840.90
24_Q104_Q0.8820.90
180_D212_E0.8810.90
61_I202_N0.8780.89
24_Q109_P0.8760.89
83_L148_A0.8760.89
255_G330_D0.8750.89
58_A203_T0.8740.89
241_D317_R0.8710.89
53_R57_D0.8690.89
234_L338_L0.8670.89
181_N184_G0.8660.89
115_S318_Y0.8640.89
264_T298_G0.8570.88
18_A158_Q0.8570.88
46_G210_V0.8530.88
232_F338_L0.8520.88
67_M208_A0.8510.88
298_G301_H0.8500.88
23_H27_A0.8450.87
93_S96_L0.8430.87
258_L310_A0.8420.87
190_E335_K0.8420.87
259_R289_F0.8420.87
69_E178_A0.8420.87
40_I50_G0.8390.87
216_L299_K0.8380.87
235_D289_F0.8380.87
30_K40_I0.8320.87
14_Q165_F0.8300.87
59_P202_N0.8300.87
97_L136_M0.8280.86
54_G200_L0.8270.86
174_I328_I0.8130.85
194_E335_K0.8120.85
51_V60_R0.8110.85
72_F159_I0.8030.85
9_F186_G0.8030.85
132_D135_N0.8020.85
276_L280_E0.8020.85
90_G320_H0.8020.85
123_T126_Q0.8010.85
211_Q216_L0.8010.85
86_Q261_L0.7960.84
238_P319_I0.7960.84
103_I140_I0.7950.84
110_V140_I0.7950.84
250_G257_L0.7920.84
255_G287_Q0.7900.84
41_V51_V0.7900.84
216_L298_G0.7890.84
9_F179_W0.7880.84
275_V312_I0.7850.83
303_S307_V0.7840.83
90_G212_E0.7840.83
102_E109_P0.7790.83
180_D213_E0.7780.83
61_I204_L0.7780.83
237_S250_G0.7780.83
187_L191_L0.7750.83
168_M325_I0.7730.82
181_N236_A0.7720.82
336_E340_K0.7720.82
314_I334_A0.7640.82
289_F313_G0.7610.81
52_R192_L0.7610.81
65_G181_N0.7560.81
10_Q167_T0.7500.80
6_K176_S0.7500.80
15_L25_V0.7500.80
293_G319_I0.7490.80
33_L37_A0.7470.80
25_V67_M0.7430.80
110_V153_I0.7410.80
240_N248_E0.7410.80
233_A309_S0.7400.80
75_T86_Q0.7390.79
300_V307_V0.7370.79
102_E111_P0.7360.79
232_F310_A0.7340.79
29_M48_V0.7340.79
61_I230_L0.7320.79
187_L331_Y0.7290.79
186_G190_E0.7260.78
240_N249_F0.7260.78
15_L32_E0.7250.78
187_L234_L0.7240.78
224_H305_S0.7230.78
267_M311_V0.7210.78
263_R294_G0.7190.78
252_L315_C0.7150.77
37_A40_I0.7150.77
115_S137_M0.7130.77
66_H212_E0.7110.77
83_L110_V0.7080.77
331_Y335_K0.7070.76
329_D333_A0.7070.76
112_G140_I0.7050.76
204_L342_V0.7030.76
92_W95_V0.7030.76
294_G298_G0.6970.75
82_L243_S0.6950.75
90_G294_G0.6940.75
9_F174_I0.6930.75
231_F307_V0.6900.75
165_F176_S0.6850.74
6_K10_Q0.6850.74
76_S242_M0.6830.74
38_D52_R0.6820.74
42_Q48_V0.6810.74
316_S326_I0.6810.74
140_I151_I0.6800.74
278_M340_K0.6780.73
191_L342_V0.6750.73
154_R276_L0.6750.73
225_M305_S0.6720.73
319_I324_T0.6680.72
194_E198_K0.6680.72
105_T110_V0.6650.72
211_Q214_V0.6610.71
149_I280_E0.6600.71
105_T152_G0.6570.71
267_M272_R0.6560.71
219_A223_S0.6540.71
165_F174_I0.6530.71
215_G294_G0.6510.70
69_E115_S0.6500.70
72_F85_F0.6500.70
44_R308_P0.6480.70
79_D125_A0.6460.70
90_G213_E0.6420.69
28_F31_Q0.6410.69
195_L204_L0.6410.69
33_L40_I0.6380.69
167_T172_K0.6370.69
269_R308_P0.6350.68
277_D280_E0.6340.68
13_T177_K0.6340.68
280_E283_D0.6330.68
64_A233_A0.6330.68
223_S303_S0.6310.68
279_A337_M0.6290.68
200_L204_L0.6290.68
230_L341_L0.6280.68
49_F205_Y0.6280.68
269_R273_E0.6270.67
105_T157_Q0.6250.67
21_N24_Q0.6250.67
24_Q31_Q0.6240.67
236_A289_F0.6240.67
282_H336_E0.6230.67
252_L255_G0.6190.66
36_Y196_H0.6190.66
181_N235_D0.6180.66
38_D192_L0.6180.66
188_S191_L0.6180.66
82_L137_M0.6180.66
233_A236_A0.6170.66
47_S207_G0.6150.66
262_D293_G0.6140.66
12_L25_V0.6120.66
23_H26_R0.6110.65
110_V142_A0.6110.65
103_I153_I0.6110.65
274_F277_D0.6100.65
56_E203_T0.6090.65
176_S325_I0.6080.65
287_Q330_D0.6080.65
123_T127_R0.6050.65
233_A338_L0.6040.65
294_G320_H0.6030.64
44_R229_D0.6030.64
100_R322_N0.6000.64
16_P24_Q0.5990.64
207_G231_F0.5980.64
245_D248_E0.5960.64
295_T320_H0.5950.63
250_G289_F0.5930.63
278_M341_L0.5920.63
73_M88_L0.5920.63
70_V324_T0.5920.63
18_A160_V0.5920.63
78_T137_M0.5900.63
38_D196_H0.5880.63
259_R313_G0.5880.63
257_L313_G0.5870.62
215_G262_D0.5870.62
77_I276_L0.5860.62
278_M284_I0.5860.62
98_A322_N0.5850.62
183_Y335_K0.5840.62
194_E197_G0.5840.62
230_L271_M0.5830.62
311_V319_I0.5830.62
195_L342_V0.5820.62
256_F336_E0.5800.61
76_S79_D0.5780.61
245_D249_F0.5780.61
216_L294_G0.5780.61
211_Q217_R0.5760.61
233_A237_S0.5750.61
34_A40_I0.5740.61
181_N212_E0.5740.61
106_D277_D0.5730.61
63_V338_L0.5710.60
41_V205_Y0.5700.60
143_D329_D0.5700.60
93_S131_M0.5680.60
147_D170_N0.5670.60
124_D128_N0.5670.60
14_Q164_P0.5670.60
259_R311_V0.5650.59
266_V298_G0.5640.59
104_Q159_I0.5640.59
267_M293_G0.5630.59
173_K325_I0.5620.59
9_F13_T0.5620.59
54_G57_D0.5610.59
100_R323_A0.5600.59
293_G311_V0.5590.59
6_K328_I0.5570.58
179_W331_Y0.5570.58
37_A192_L0.5550.58
66_H213_E0.5540.58
48_V73_M0.5530.58
29_M50_G0.5520.58
255_G317_R0.5510.58
327_H331_Y0.5510.58
218_G221_T0.5500.57
62_M231_F0.5500.57
221_T306_G0.5480.57
63_V188_S0.5460.57
21_N88_L0.5440.57
238_P289_F0.5430.56
124_D130_P0.5430.56
72_F91_W0.5420.56
49_F222_A0.5420.56
176_S179_W0.5410.56
258_L276_L0.5400.56
8_L190_E0.5400.56
260_I272_R0.5400.56
38_D51_V0.5390.56
72_F161_P0.5380.56
273_E276_L0.5380.56
93_S133_I0.5360.56
16_P160_V0.5350.55
175_L323_A0.5350.55
48_V189_I0.5330.55
32_E189_I0.5320.55
212_E295_T0.5320.55
141_G255_G0.5300.55
262_D298_G0.5300.55
26_R46_G0.5300.55
20_G158_Q0.5290.55
183_Y314_I0.5290.55
61_I232_F0.5290.55
328_I332_A0.5280.54
87_T133_I0.5260.54
235_D295_T0.5240.54
91_W119_P0.5240.54
66_H320_H0.5240.54
317_R330_D0.5230.54
38_D53_R0.5220.54
25_V178_A0.5200.53
144_D148_A0.5170.53
63_V191_L0.5160.53
174_I326_I0.5150.53
84_R279_A0.5150.53
64_A271_M0.5130.52
115_S120_H0.5130.52
33_L36_Y0.5120.52
241_D252_L0.5110.52
17_G177_K0.5100.52
301_H309_S0.5090.52
141_G254_K0.5080.52
142_A147_D0.5070.52
91_W122_L0.5060.51
71_G88_L0.5050.51
295_T311_V0.5050.51
91_W322_N0.5010.51
10_Q52_R0.5010.51
11_T14_Q0.5010.51
7_A146_E0.5000.51
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4wwvA 4 0.9804 100 0.394 Contact Map
1y0yA 5 0.9244 100 0.414 Contact Map
2wyrA 4 0.9132 100 0.42 Contact Map
2wznA 4 0.9356 100 0.421 Contact Map
3wt4A 4 0.9384 100 0.422 Contact Map
3vatA 4 0.9888 100 0.428 Contact Map
2fvgA 1 0.8627 100 0.428 Contact Map
2gljA 6 0.944 100 0.439 Contact Map
2glfA 4 0.9412 100 0.444 Contact Map
1y7eA 4 0.8487 100 0.455 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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