GREMLIN Database
YTPI - Uncharacterized membrane protein YtpI
UniProt: O34922 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 100 (96)
Sequences: 120 (94)
Seq/√Len: 9.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
50_G69_F3.5290.97
61_L65_I3.3550.96
44_S48_F2.8820.90
84_F89_P2.8500.90
18_Y34_C2.7310.87
63_L67_G2.2660.75
9_G17_Y2.2600.75
4_L10_L2.1380.71
83_A87_Y2.0820.69
53_Q57_F2.0390.67
65_I68_I2.0110.66
36_A83_A1.9150.62
4_L48_F1.8130.57
18_Y59_S1.7900.56
8_I52_N1.6770.51
47_L65_I1.6350.49
62_T66_G1.5700.47
20_V23_V1.5600.46
39_S76_S1.5480.46
77_A86_H1.5260.45
3_V71_V1.4890.43
4_L11_S1.4840.43
56_L72_I1.4500.41
15_Y23_V1.4500.41
36_A46_V1.3370.36
8_I38_S1.3340.36
12_A64_V1.3280.36
11_S17_Y1.3280.36
29_L87_Y1.2650.33
17_Y91_H1.2000.31
19_K39_S1.2000.31
12_A72_I1.1930.31
37_K84_F1.1850.30
59_S75_G1.1530.29
77_A81_Y1.1350.28
63_L66_G1.1300.28
44_S96_E1.1140.28
20_V67_G1.0960.27
54_M69_F1.0580.26
48_F61_L1.0540.26
82_K90_L1.0500.25
46_V78_W1.0460.25
49_Y55_I1.0410.25
47_L61_L1.0370.25
2_L55_I1.0250.25
53_Q56_L1.0110.24
75_G79_A1.0090.24
38_S76_S1.0040.24
93_K96_E0.9930.24
72_I76_S0.9910.24
33_I95_A0.9910.24
10_L68_I0.9770.23
4_L88_N0.9760.23
69_F85_R0.9700.23
56_L62_T0.9700.23
16_V20_V0.9570.22
10_L26_K0.9480.22
2_L13_C0.9440.22
50_G85_R0.9370.22
23_V91_H0.9270.22
3_V26_K0.9110.21
37_K45_L0.8920.20
16_V85_R0.8820.20
25_A31_K0.8780.20
22_G38_S0.8680.20
51_L72_I0.8660.20
87_Y90_L0.8640.20
16_V29_L0.8600.20
18_Y44_S0.8500.19
37_K40_M0.8490.19
7_L47_L0.8420.19
2_L86_H0.8380.19
30_A89_P0.8280.19
17_Y29_L0.8260.19
9_G78_W0.8180.18
29_L61_L0.8150.18
57_F62_T0.8120.18
20_V85_R0.8120.18
74_A85_R0.8070.18
44_S47_L0.7950.18
57_F72_I0.7850.18
21_K31_K0.7720.17
7_L71_V0.7650.17
72_I75_G0.7550.17
54_M67_G0.7510.17
24_R42_L0.7420.16
20_V59_S0.7230.16
38_S46_V0.7110.16
38_S55_I0.7070.16
68_I88_N0.7050.16
26_K67_G0.7020.15
12_A16_V0.7000.15
33_I91_H0.6970.15
11_S83_A0.6890.15
7_L24_R0.6860.15
29_L76_S0.6860.15
9_G96_E0.6820.15
20_V90_L0.6750.15
29_L90_L0.6730.15
47_L77_A0.6720.15
40_M70_I0.6630.15
14_F92_A0.6530.14
32_E82_K0.6480.14
67_G74_A0.6460.14
29_L86_H0.6350.14
91_H95_A0.6300.14
39_S79_A0.6300.14
17_Y84_F0.6290.14
66_G82_K0.6250.14
35_S63_L0.6170.14
54_M59_S0.6160.14
33_I84_F0.6150.14
12_A51_L0.6110.13
25_A66_G0.6080.13
24_R50_G0.6080.13
5_V52_N0.5920.13
7_L48_F0.5810.13
15_Y53_Q0.5710.13
76_S80_G0.5620.12
3_V87_Y0.5570.12
16_V38_S0.5470.12
12_A33_I0.5450.12
29_L33_I0.5410.12
84_F88_N0.5400.12
4_L67_G0.5370.12
61_L64_V0.5340.12
13_C20_V0.5300.12
35_S76_S0.5300.12
54_M70_I0.5300.12
44_S77_A0.5290.12
25_A71_V0.5280.12
36_A87_Y0.5250.12
39_S57_F0.5230.12
35_S94_E0.5220.12
2_L49_Y0.5190.12
86_H92_A0.5160.12
45_L72_I0.5110.11
33_I94_E0.5110.11
33_I85_R0.5080.11
80_G91_H0.5060.11
65_I82_K0.5050.11
23_V93_K0.5050.11
7_L65_I0.5030.11
38_S80_G0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l1lA 2 0.85 46.2 0.916 Contact Map
2xq2A 2 0.79 18.1 0.931 Contact Map
4k5yA 1 0.85 14.1 0.935 Contact Map
4kjrA 3 0.76 13.6 0.935 Contact Map
4o6yA 2 0.81 12.7 0.936 Contact Map
4djkA 2 0.8 11.9 0.937 Contact Map
3giaA 1 0.86 9.9 0.939 Contact Map
4kppA 1 0.9 9.2 0.94 Contact Map
2r9rB 3 0.81 9 0.94 Contact Map
3b9wA 3 0.98 8.9 0.94 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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