GREMLIN Database
YTOI - Uncharacterized protein YtoI
UniProt: O34921 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 439 (432)
Sequences: 343 (231)
Seq/√Len: 11.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
90_A158_E5.5631.00
404_R418_E4.3821.00
152_Q156_E3.7690.99
227_V252_I3.7670.99
229_D267_T3.3240.97
43_E389_F3.3120.97
125_I147_D3.2700.97
59_I296_M3.2210.96
8_I32_V3.0920.95
283_V296_M2.8230.92
53_I56_V2.7920.92
3_T34_E2.7900.92
413_G423_G2.7500.91
8_I26_I2.6920.91
277_V342_Y2.6760.90
237_I363_I2.6680.90
315_V409_G2.6300.89
9_L272_A2.5650.88
212_K215_E2.5350.88
241_K282_E2.5070.87
215_E219_E2.4940.87
200_R219_E2.4820.86
113_T360_F2.4460.86
129_R133_E2.4370.85
150_I161_I2.4030.85
186_K313_P2.3520.83
234_I262_T2.2990.82
224_R282_E2.2930.82
263_V267_T2.2690.81
263_V286_V2.2620.81
185_K396_E2.2200.79
133_E147_D2.2010.79
105_E126_N2.1950.79
327_F342_Y2.1330.76
186_K314_Q2.1280.76
277_V323_V2.1020.75
16_P433_V2.0970.75
240_S387_I2.0740.74
145_N151_V2.0530.74
391_K407_E2.0530.74
253_E258_K2.0500.73
75_A93_H2.0240.72
135_G177_R1.9890.71
109_M127_A1.9210.68
43_E404_R1.9200.68
346_P394_Q1.9140.68
310_Q416_E1.8750.66
85_V155_D1.8610.66
64_K146_T1.8360.65
117_N284_L1.8270.64
208_D212_K1.8230.64
128_H155_D1.8130.64
51_S61_I1.8090.63
157_L284_L1.8050.63
375_K405_I1.7940.63
361_T385_I1.7560.61
214_Y248_R1.7460.61
286_V297_I1.7220.59
252_I258_K1.7130.59
277_V298_S1.6910.58
201_T238_L1.6810.58
204_L368_A1.6800.57
49_F369_N1.6780.57
237_I283_V1.6720.57
54_E434_Q1.6690.57
382_I431_L1.6590.56
368_A431_L1.6540.56
221_G258_K1.6440.56
217_N406_L1.6380.55
127_A136_A1.6170.54
380_L437_E1.6160.54
158_E298_S1.6140.54
9_L116_G1.6090.54
113_T136_A1.6070.54
185_K416_E1.6040.54
250_A383_E1.5860.53
238_L252_I1.5820.53
268_S310_Q1.5790.53
284_L413_G1.5780.53
212_K225_F1.5730.52
278_W304_K1.5700.52
13_D49_F1.5690.52
146_T407_E1.5660.52
303_L384_S1.5660.52
63_Q368_A1.5480.51
191_V409_G1.5290.50
195_L413_G1.5250.50
266_K396_E1.5240.50
288_D292_K1.5160.50
87_G138_V1.5150.50
220_T257_T1.5110.49
286_V295_G1.5030.49
56_V391_K1.4960.49
412_F430_M1.4950.49
238_L255_V1.4820.48
228_V425_I1.4800.48
43_E363_I1.4790.48
174_M390_L1.4740.48
366_Q383_E1.4720.47
131_A194_I1.4580.47
341_E400_E1.4500.46
116_G173_A1.4470.46
106_L314_Q1.4370.46
364_L417_V1.4340.46
156_E238_L1.4190.45
412_F419_V1.4150.45
182_Q342_Y1.4050.44
3_T7_Q1.3930.44
43_E46_N1.3700.43
278_W313_P1.3570.42
31_K156_E1.3530.42
15_L50_V1.3330.41
29_E419_V1.3180.40
230_D235_H1.3150.40
371_F425_I1.3130.40
274_Q433_V1.3100.40
340_Y361_T1.3000.39
335_E408_A1.2970.39
28_K434_Q1.2950.39
363_I425_I1.2940.39
238_L243_I1.2930.39
164_T342_Y1.2900.39
180_Y349_T1.2850.39
432_M437_E1.2820.38
56_V187_E1.2810.38
274_Q318_K1.2810.38
90_A218_F1.2800.38
397_S406_L1.2690.38
163_S229_D1.2690.38
379_E384_S1.2680.38
8_I69_I1.2680.38
148_D152_Q1.2590.37
402_K419_V1.2590.37
84_Q303_L1.2580.37
150_I411_K1.2490.37
383_E434_Q1.2430.37
85_V92_L1.2420.37
20_K352_L1.2420.37
322_I433_V1.2390.37
20_K187_E1.2380.37
358_G411_K1.2270.36
417_V432_M1.2210.36
366_Q430_M1.2180.36
180_Y362_T1.2170.36
77_V82_D1.2140.35
195_L419_V1.2070.35
165_S436_M1.2020.35
127_A238_L1.1980.35
194_I297_I1.1960.35
268_S352_L1.1930.35
127_A320_D1.1910.34
151_V240_S1.1900.34
405_I416_E1.1860.34
85_V218_F1.1840.34
105_E273_A1.1840.34
98_K192_E1.1730.34
206_P235_H1.1710.34
229_D292_K1.1710.34
97_N117_N1.1510.33
218_F375_K1.1490.33
59_I147_D1.1470.33
89_R93_H1.1430.32
390_L396_E1.1430.32
32_V39_R1.1430.32
239_T282_E1.1370.32
43_E269_V1.1370.32
340_Y370_R1.1360.32
203_Y232_M1.1360.32
198_A229_D1.1360.32
239_T283_V1.1330.32
76_E307_Q1.1330.32
166_Y222_H1.1300.32
177_R181_D1.1270.32
78_V284_L1.1240.32
217_N416_E1.1190.31
213_W282_E1.1190.31
85_V137_A1.1130.31
281_I317_E1.1060.31
237_I319_L1.1060.31
291_Q296_M1.1040.31
229_D379_E1.1030.31
8_I409_G1.1020.31
222_H301_D1.0930.30
3_T28_K1.0930.30
64_K403_P1.0890.30
400_E420_H1.0880.30
182_Q327_F1.0870.30
81_I162_L1.0850.30
186_K278_W1.0800.30
107_D261_V1.0790.30
394_Q425_I1.0780.30
128_H262_T1.0760.30
272_A327_F1.0690.29
278_W307_Q1.0670.29
229_D262_T1.0670.29
5_H39_R1.0630.29
298_S301_D1.0630.29
177_R347_Q1.0610.29
229_D284_L1.0580.29
91_G160_P1.0540.29
181_D434_Q1.0500.29
228_V232_M1.0480.28
106_L277_V1.0480.28
119_L131_A1.0370.28
235_H286_V1.0350.28
213_W389_F1.0310.28
59_I192_E1.0260.28
30_M437_E1.0260.28
117_N413_G1.0250.28
152_Q363_I1.0220.27
192_E266_K1.0210.27
49_F111_R1.0180.27
195_L327_F1.0150.27
388_F392_P1.0070.27
272_A412_F1.0000.27
321_D350_N0.9960.26
364_L430_M0.9960.26
162_L390_L0.9940.26
83_G96_L0.9900.26
317_E392_P0.9850.26
210_L328_K0.9800.26
16_P419_V0.9780.26
63_Q308_M0.9720.26
48_G224_R0.9710.26
119_L128_H0.9700.26
81_I272_A0.9680.25
113_T125_I0.9680.25
360_F432_M0.9670.25
357_Y427_S0.9650.25
251_S297_I0.9620.25
9_L73_T0.9620.25
238_L343_E0.9610.25
11_Y305_A0.9600.25
361_T372_L0.9600.25
157_L423_G0.9590.25
148_D330_E0.9590.25
26_I76_E0.9590.25
173_A268_S0.9590.25
370_R407_E0.9530.25
174_M436_M0.9510.25
129_R149_S0.9490.25
390_L437_E0.9470.25
409_G432_M0.9450.25
222_H226_P0.9440.25
54_E173_A0.9440.25
171_V238_L0.9430.25
307_Q318_K0.9420.24
215_E400_E0.9420.24
195_L246_H0.9420.24
364_L409_G0.9410.24
98_K173_A0.9400.24
71_K284_L0.9390.24
11_Y155_D0.9360.24
342_Y395_M0.9320.24
164_T171_V0.9310.24
406_L437_E0.9310.24
56_V150_I0.9290.24
7_Q28_K0.9280.24
141_T171_V0.9270.24
150_I264_I0.9260.24
44_A85_V0.9260.24
62_E85_V0.9240.24
330_E415_M0.9240.24
21_I391_K0.9190.24
281_I392_P0.9140.24
360_F424_H0.9140.24
12_I27_A0.9110.23
98_K314_Q0.9100.23
134_A431_L0.9090.23
34_E272_A0.9090.23
74_Y375_K0.9080.23
190_L296_M0.9080.23
158_E238_L0.9010.23
90_A405_I0.8990.23
150_I305_A0.8960.23
41_I99_F0.8960.23
82_D227_V0.8950.23
280_G316_G0.8900.23
182_Q357_Y0.8880.23
55_R160_P0.8870.23
139_L318_K0.8860.23
349_T376_K0.8830.22
138_V293_L0.8800.22
70_E80_V0.8750.22
79_N391_K0.8730.22
364_L368_A0.8730.22
282_E301_D0.8730.22
94_K158_E0.8730.22
35_G50_V0.8710.22
82_D307_Q0.8690.22
59_I311_K0.8690.22
305_A431_L0.8680.22
4_K50_V0.8660.22
41_I295_G0.8620.22
210_L298_S0.8580.22
323_V330_E0.8570.22
263_V363_I0.8540.21
161_I262_T0.8510.21
229_D431_L0.8510.21
166_Y350_N0.8500.21
233_K436_M0.8440.21
151_V387_I0.8440.21
107_D147_D0.8430.21
235_H435_L0.8420.21
341_E398_V0.8390.21
258_K354_T0.8390.21
22_S38_Y0.8370.21
20_K56_V0.8370.21
298_S307_Q0.8370.21
71_K430_M0.8340.21
170_T358_G0.8330.21
21_I96_L0.8300.21
304_K307_Q0.8260.21
37_A76_E0.8260.21
211_E248_R0.8260.21
317_E388_F0.8260.21
17_V343_E0.8220.20
202_V225_F0.8200.20
165_S366_Q0.8190.20
363_I387_I0.8140.20
405_I415_M0.8130.20
148_D425_I0.8100.20
75_A137_A0.8060.20
127_A253_E0.8030.20
5_H32_V0.8010.20
108_A189_V0.7970.20
347_Q434_Q0.7960.20
49_F80_V0.7920.20
137_A380_L0.7900.19
268_S394_Q0.7890.19
33_S52_T0.7870.19
10_T161_I0.7850.19
173_A273_A0.7830.19
166_Y349_T0.7830.19
188_I280_G0.7820.19
314_Q317_E0.7810.19
28_K217_N0.7810.19
228_V364_L0.7790.19
164_T344_V0.7790.19
36_T42_K0.7780.19
82_D166_Y0.7770.19
188_I302_V0.7760.19
328_K331_G0.7700.19
223_G364_L0.7700.19
396_E431_L0.7690.19
199_D237_I0.7670.19
181_D345_T0.7640.19
362_T379_E0.7590.19
201_T405_I0.7590.19
3_T6_E0.7560.18
187_E391_K0.7560.18
211_E249_N0.7550.18
319_L430_M0.7550.18
113_T294_I0.7550.18
261_V373_R0.7540.18
385_I436_M0.7540.18
342_Y360_F0.7530.18
8_I372_L0.7500.18
30_M50_V0.7500.18
59_I134_A0.7490.18
49_F335_E0.7480.18
56_V241_K0.7470.18
23_V38_Y0.7470.18
184_I318_K0.7460.18
129_R150_I0.7440.18
182_Q347_Q0.7420.18
70_E78_V0.7380.18
145_N155_D0.7350.18
69_I78_V0.7340.18
388_F393_V0.7340.18
342_Y357_Y0.7330.18
181_D347_Q0.7330.18
49_F395_M0.7310.18
339_V425_I0.7300.18
98_K387_I0.7290.18
192_E396_E0.7280.18
97_N113_T0.7280.18
44_A92_L0.7280.18
166_Y307_Q0.7270.18
186_K312_Q0.7260.18
216_K258_K0.7250.18
153_L239_T0.7240.18
271_S355_I0.7210.17
5_H42_K0.7200.17
145_N148_D0.7190.17
19_E342_Y0.7180.17
205_S230_D0.7180.17
64_K67_E0.7170.17
130_Q209_K0.7120.17
190_L388_F0.7120.17
164_T238_L0.7110.17
89_R155_D0.7090.17
205_S225_F0.7090.17
367_A431_L0.7070.17
268_S358_G0.7070.17
376_K390_L0.7050.17
324_S364_L0.7050.17
42_K45_E0.7050.17
133_E228_V0.7040.17
233_K291_Q0.7030.17
195_L284_L0.7020.17
364_L385_I0.7010.17
222_H319_L0.7010.17
165_S307_Q0.7010.17
171_V403_P0.7000.17
10_T17_V0.7000.17
28_K240_S0.6990.17
355_I405_I0.6980.17
165_S304_K0.6970.17
291_Q342_Y0.6910.17
221_G244_A0.6910.17
246_H368_A0.6910.17
305_A368_A0.6910.17
210_L240_S0.6900.17
71_K413_G0.6890.17
81_I433_V0.6880.17
398_V431_L0.6880.17
380_L436_M0.6860.17
114_A117_N0.6850.16
288_D437_E0.6830.16
244_A337_Q0.6820.16
49_F223_G0.6820.16
140_V161_I0.6790.16
215_E248_R0.6770.16
233_K254_K0.6770.16
74_Y306_L0.6750.16
371_F437_E0.6710.16
43_E117_N0.6700.16
190_L386_T0.6700.16
108_A253_E0.6690.16
199_D290_H0.6690.16
137_A187_E0.6680.16
306_L398_V0.6680.16
148_D179_I0.6670.16
27_A183_L0.6660.16
246_H327_F0.6660.16
63_Q327_F0.6660.16
23_V57_G0.6650.16
277_V282_E0.6650.16
320_D328_K0.6640.16
219_E400_E0.6640.16
98_K323_V0.6610.16
113_T129_R0.6610.16
91_G410_R0.6590.16
179_I349_T0.6590.16
350_N434_Q0.6590.16
163_S304_K0.6590.16
193_D313_P0.6570.16
406_L423_G0.6570.16
77_V234_I0.6560.16
357_Y360_F0.6560.16
349_T391_K0.6550.16
97_N309_I0.6550.16
16_P19_E0.6540.16
351_Q362_T0.6540.16
228_V311_K0.6520.16
66_K427_S0.6520.16
53_I66_K0.6520.16
133_E387_I0.6510.16
54_E352_L0.6500.16
59_I357_Y0.6490.16
160_P172_A0.6470.16
138_V160_P0.6460.15
192_E393_V0.6450.15
385_I429_A0.6440.15
4_K15_L0.6430.15
61_I80_V0.6420.15
59_I131_A0.6400.15
203_Y294_I0.6400.15
296_M432_M0.6380.15
3_T300_Q0.6380.15
359_V385_I0.6370.15
69_I99_F0.6370.15
365_T399_I0.6370.15
253_E385_I0.6370.15
298_S319_L0.6350.15
87_G96_L0.6340.15
77_V86_L0.6330.15
70_E419_V0.6310.15
105_E225_F0.6300.15
12_I83_G0.6300.15
365_T370_R0.6290.15
274_Q304_K0.6290.15
106_L180_Y0.6290.15
205_S331_G0.6280.15
156_E311_K0.6280.15
209_K404_R0.6260.15
323_V435_L0.6250.15
239_T257_T0.6240.15
402_K420_H0.6230.15
232_M244_A0.6220.15
55_R91_G0.6210.15
111_R384_S0.6210.15
106_L147_D0.6210.15
189_V420_H0.6210.15
243_I396_E0.6200.15
46_N416_E0.6190.15
48_G359_V0.6190.15
113_T196_T0.6190.15
294_I360_F0.6180.15
11_Y168_T0.6180.15
189_V364_L0.6170.15
327_F392_P0.6170.15
262_T281_I0.6170.15
129_R296_M0.6150.15
105_E373_R0.6150.15
235_H395_M0.6140.15
265_G363_I0.6140.15
14_S302_V0.6130.15
195_L416_E0.6130.15
100_V136_A0.6120.15
165_S349_T0.6120.15
340_Y403_P0.6120.15
180_Y316_G0.6110.15
22_S58_T0.6110.15
328_K399_I0.6110.15
203_Y234_I0.6110.15
43_E252_I0.6100.15
284_L292_K0.6100.15
230_D252_I0.6090.15
14_S337_Q0.6080.15
41_I166_Y0.6080.15
179_I278_W0.6050.14
190_L356_S0.6050.14
21_I409_G0.6040.14
223_G282_E0.6040.14
377_R435_L0.6040.14
368_A371_F0.6020.14
28_K54_E0.6010.14
398_V420_H0.6010.14
123_N193_D0.6000.14
79_N298_S0.5980.14
386_T401_V0.5980.14
273_A381_V0.5980.14
294_I311_K0.5980.14
225_F324_S0.5970.14
416_E420_H0.5940.14
195_L265_G0.5940.14
196_T360_F0.5920.14
268_S411_K0.5920.14
28_K406_L0.5910.14
3_T44_A0.5910.14
269_V355_I0.5900.14
182_Q406_L0.5890.14
78_V93_H0.5880.14
164_T182_Q0.5870.14
371_F413_G0.5870.14
308_M342_Y0.5870.14
32_V118_L0.5860.14
215_E343_E0.5860.14
234_I370_R0.5850.14
212_K306_L0.5840.14
327_F433_V0.5830.14
108_A352_L0.5820.14
6_E10_T0.5820.14
97_N116_G0.5820.14
34_E37_A0.5810.14
320_D356_S0.5810.14
252_I339_V0.5800.14
261_V281_I0.5800.14
364_L431_L0.5800.14
81_I179_I0.5800.14
158_E385_I0.5790.14
282_E302_V0.5760.14
65_K383_E0.5750.14
157_L413_G0.5740.14
162_L389_F0.5740.14
362_T368_A0.5730.14
264_I272_A0.5730.14
69_I166_Y0.5720.14
157_L252_I0.5670.14
367_A408_A0.5670.14
105_E128_H0.5650.14
377_R436_M0.5640.14
287_T408_A0.5640.14
331_G405_I0.5640.14
100_V128_H0.5630.13
3_T177_R0.5630.13
69_I231_Q0.5630.13
136_A181_D0.5610.13
174_M368_A0.5590.13
13_D111_R0.5590.13
340_Y354_T0.5580.13
21_I414_K0.5580.13
164_T168_T0.5570.13
272_A387_I0.5570.13
218_F365_T0.5570.13
47_K419_V0.5540.13
148_D151_V0.5540.13
282_E417_V0.5530.13
424_H431_L0.5530.13
192_E275_M0.5530.13
206_P415_M0.5520.13
41_I56_V0.5510.13
210_L401_V0.5510.13
131_A309_I0.5490.13
379_E392_P0.5490.13
125_I400_E0.5490.13
349_T366_Q0.5490.13
272_A297_I0.5460.13
166_Y186_K0.5460.13
187_E359_V0.5430.13
34_E78_V0.5420.13
284_L362_T0.5420.13
331_G415_M0.5420.13
372_L393_V0.5420.13
303_L388_F0.5410.13
351_Q387_I0.5410.13
406_L414_K0.5410.13
397_S435_L0.5380.13
137_A315_V0.5360.13
384_S432_M0.5360.13
177_R432_M0.5350.13
120_I142_G0.5350.13
179_I304_K0.5340.13
119_L155_D0.5310.13
189_V427_S0.5300.13
209_K294_I0.5290.13
349_T434_Q0.5270.13
74_Y98_K0.5260.13
56_V304_K0.5260.13
41_I58_T0.5250.13
47_K113_T0.5240.13
373_R395_M0.5230.13
30_M221_G0.5230.13
344_V431_L0.5220.13
117_N195_L0.5200.13
392_P433_V0.5190.13
166_Y301_D0.5180.13
396_E426_V0.5180.13
201_T293_L0.5160.12
55_R188_I0.5160.12
216_K384_S0.5130.12
126_N363_I0.5120.12
115_A361_T0.5110.12
221_G271_S0.5110.12
227_V363_I0.5100.12
83_G123_N0.5080.12
210_L360_F0.5050.12
27_A37_A0.5030.12
43_E202_V0.5020.12
204_L209_K0.5020.12
386_T392_P0.5020.12
157_L245_G0.5020.12
36_T40_A0.5010.12
261_V425_I0.5010.12
65_K161_I0.5000.12
23_V58_T0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l2bA 2 0.5171 99.9 0.859 Contact Map
3k6eA 2 0.328 99.9 0.872 Contact Map
1vrdA 3 0.3804 99.9 0.873 Contact Map
1jcnA 6 0.5786 99.9 0.874 Contact Map
3usbA 4 0.7107 99.9 0.876 Contact Map
3sl7A 2 0.2893 99.9 0.876 Contact Map
3orgA 2 0.5968 99.9 0.877 Contact Map
3fhmA 2 0.2916 99.9 0.878 Contact Map
2j9lA 3 0.3052 99.9 0.879 Contact Map
1yavA 2 0.287 99.9 0.879 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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