GREMLIN Database
YOBV - Uncharacterized HTH-type transcriptional regulator YobV
UniProt: O34920 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 313 (301)
Sequences: 6843 (5214)
Seq/√Len: 300.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
142_I152_I4.3681.00
238_L289_E3.5581.00
236_V292_Q3.4961.00
236_V266_Q3.4791.00
154_F168_T3.4311.00
304_I307_M3.1321.00
151_T169_E3.0721.00
168_T182_L3.0321.00
289_E297_R2.9921.00
169_E187_L2.9551.00
153_S204_A2.9011.00
154_F200_M2.8881.00
234_E268_V2.7981.00
238_L264_I2.7371.00
153_S167_E2.7201.00
153_S165_L2.5681.00
294_L298_D2.5391.00
155_T202_D2.5191.00
151_T167_E2.5171.00
150_L205_I2.4791.00
155_T165_L2.4411.00
238_L291_L2.4241.00
236_V268_V2.4031.00
240_Q287_D2.3991.00
144_A148_R2.3171.00
151_T187_L2.3121.00
5_R38_D2.3121.00
234_E270_S2.2401.00
238_L266_Q2.2181.00
290_V300_V2.1981.00
151_T208_Q2.1871.00
30_V35_I2.1741.00
237_I288_I2.0511.00
266_Q291_L2.0471.00
168_T184_A2.0371.00
22_A26_E2.0031.00
260_E266_Q1.9601.00
286_K303_T1.8851.00
278_I299_K1.8661.00
301_K305_H1.8631.00
305_H308_Q1.8591.00
298_D302_E1.8411.00
153_S206_L1.7701.00
20_Q23_E1.7511.00
238_L260_E1.7501.00
166_R195_F1.7341.00
141_K203_L1.7301.00
76_E102_K1.7271.00
274_D295_H1.7211.00
260_E264_I1.6911.00
236_V291_L1.6671.00
302_E306_H1.6571.00
166_R186_C1.6561.00
286_K306_H1.6471.00
304_I308_Q1.6211.00
282_L303_T1.6191.00
142_I197_L1.6161.00
150_L207_H1.6131.00
12_L19_V1.6071.00
149_L212_R1.6071.00
155_T163_T1.5961.00
157_T201_K1.5721.00
240_Q264_I1.5621.00
258_C266_Q1.5541.00
21_A36_Y1.5451.00
278_I303_T1.5281.00
216_Q219_T1.5271.00
233_T295_H1.5271.00
242_S287_D1.5151.00
155_T201_K1.5001.00
274_D299_K1.4781.00
281_L300_V1.4741.00
299_K302_E1.4711.00
167_E187_L1.4691.00
32_V36_Y1.4661.00
22_A32_V1.4561.00
234_E292_Q1.4511.00
297_R301_K1.4421.00
281_L288_I1.4381.00
50_V62_M1.4371.00
157_T163_T1.4361.00
40_E43_N1.4291.00
21_A32_V1.4241.00
305_H309_K1.4241.00
239_V247_I1.4101.00
24_L35_I1.4051.00
237_I267_A1.4041.00
261_E264_I1.4011.00
18_Q60_G1.4001.00
186_C189_R1.3661.00
237_I281_L1.3551.00
150_L209_T1.3511.00
149_L210_F1.3461.00
141_K205_I1.3321.00
167_E208_Q1.3281.00
184_A195_F1.3251.00
186_C193_R1.3251.00
154_F195_F1.3221.00
185_Y190_N1.2991.00
294_L297_R1.2981.00
215_I220_L1.2931.00
154_F203_L1.2881.00
275_Q299_K1.2841.00
200_M203_L1.2831.00
173_L197_L1.2821.00
239_V284_F1.2511.00
299_K303_T1.2431.00
158_S164_L1.2251.00
154_F184_A1.2241.00
258_C268_V1.2201.00
179_H196_K1.2071.00
40_E44_R1.2061.00
167_E206_L1.1991.00
302_E305_H1.1991.00
171_Y210_F1.1951.00
278_I300_V1.1941.00
142_I200_M1.1941.00
50_V60_G1.1921.00
39_I59_I1.1751.00
23_E26_E1.1621.00
301_K308_Q1.1581.00
169_E210_F1.1481.00
18_Q58_G1.1421.00
256_L268_V1.1411.00
150_L206_L1.1391.00
144_A205_I1.1391.00
151_T206_L1.1321.00
171_Y192_F1.1131.00
152_I168_T1.1021.00
21_A59_I1.1001.00
186_C195_F1.0951.00
12_L27_L1.0951.00
167_E188_V1.0921.00
25_A35_I1.0821.00
141_K144_A1.0781.00
152_I203_L1.0771.00
235_L271_L1.0721.00
163_T201_K1.0621.00
158_S162_E1.0561.00
239_V288_I1.0341.00
243_A287_D1.0321.00
34_T37_R1.0261.00
189_R193_R1.0201.00
306_H309_K1.0191.00
138_L203_L0.9991.00
241_P263_E0.9961.00
172_T183_Y0.9871.00
246_R250_W0.9801.00
23_E27_L0.9741.00
303_T306_H0.9711.00
138_L141_K0.9681.00
282_L307_M0.9661.00
174_V183_Y0.9641.00
142_I203_L0.9571.00
280_F283_Q0.9561.00
145_A205_I0.9551.00
235_L296_I0.9541.00
278_I296_I0.9511.00
9_M35_I0.9501.00
282_L300_V0.9491.00
172_T217_L0.9481.00
170_P182_L0.9421.00
210_F213_K0.9401.00
298_D301_K0.9361.00
171_Y184_A0.9341.00
31_S34_T0.9321.00
25_A32_V0.9211.00
166_R193_R0.9151.00
125_D176_K0.9141.00
157_T161_G0.9091.00
51_T59_I0.9051.00
274_D296_I0.9051.00
185_Y189_R0.8961.00
194_F220_L0.8951.00
183_Y220_L0.8931.00
12_L28_F0.8851.00
166_R189_R0.8801.00
169_E185_Y0.8791.00
103_I107_I0.8711.00
39_I43_N0.8701.00
48_P65_Y0.8691.00
274_D278_I0.8671.00
19_V24_L0.8651.00
73_K76_E0.8621.00
10_V42_I0.8611.00
169_E213_K0.8591.00
232_L272_P0.8551.00
233_T273_E0.8531.00
25_A30_V0.8511.00
123_F172_T0.8461.00
240_Q243_A0.8401.00
30_V38_D0.8381.00
219_T224_K0.8361.00
51_T54_G0.8311.00
58_G61_I0.8291.00
240_Q289_E0.8281.00
158_S161_G0.8241.00
25_A31_S0.8211.00
33_R36_Y0.8191.00
47_I65_Y0.8171.00
279_G303_T0.8161.00
108_P111_S0.8151.00
8_A11_V0.8091.00
202_D205_I0.8041.00
192_F220_L0.8031.00
245_Q249_E0.8031.00
183_Y217_L0.8001.00
109_E113_Q0.7991.00
251_F255_V0.7981.00
154_F202_D0.7941.00
137_T141_K0.7890.99
192_F213_K0.7880.99
21_A35_I0.7850.99
47_I61_I0.7850.99
260_E263_E0.7810.99
282_L304_I0.7780.99
85_Q88_S0.7760.99
181_Y196_K0.7740.99
252_G255_V0.7720.99
279_G283_Q0.7720.99
232_L270_S0.7700.99
12_L24_L0.7660.99
251_F267_A0.7650.99
28_F35_I0.7650.99
10_V47_I0.7580.99
35_I38_D0.7530.99
139_R143_S0.7520.99
146_I173_L0.7480.99
160_S163_T0.7480.99
21_A25_A0.7480.99
181_Y199_R0.7450.99
171_Y215_I0.7400.99
16_K19_V0.7360.99
225_S229_K0.7330.99
233_T274_D0.7320.99
80_I84_L0.7280.99
30_V34_T0.7230.99
7_L11_V0.7220.99
87_V91_Y0.7180.99
99_A102_K0.7180.99
120_E124_I0.7170.99
164_L188_V0.7150.99
125_D129_W0.7140.99
4_E8_A0.7130.99
21_A58_G0.7120.99
145_A152_I0.7110.99
286_K307_M0.7100.99
108_P112_T0.7070.99
185_Y213_K0.7060.99
41_T45_A0.7040.99
84_L89_S0.7040.99
251_F254_D0.7020.99
292_Q295_H0.7000.99
146_I170_P0.6970.99
100_Y103_I0.6970.99
243_A246_R0.6970.99
199_R249_E0.6950.99
276_W280_F0.6950.99
183_Y215_I0.6940.99
223_D227_Y0.6930.99
257_H265_C0.6930.99
244_R248_G0.6880.99
168_T200_M0.6860.99
96_H99_A0.6850.99
246_R279_G0.6830.99
140_E144_A0.6800.98
183_Y194_F0.6800.98
155_T204_A0.6790.98
171_Y213_K0.6780.98
225_S228_Q0.6750.98
156_Y199_R0.6750.98
139_R180_W0.6750.98
264_I289_E0.6730.98
8_A28_F0.6720.98
239_V265_C0.6710.98
148_R205_I0.6700.98
97_S101_Q0.6680.98
13_L61_I0.6670.98
77_L107_I0.6660.98
146_I182_L0.6620.98
250_W283_Q0.6610.98
154_F201_K0.6590.98
6_L10_V0.6590.98
6_L42_I0.6590.98
25_A29_E0.6590.98
284_F288_I0.6590.98
300_V304_I0.6560.98
88_S97_S0.6530.98
4_E41_T0.6500.98
84_L99_A0.6490.98
54_G57_G0.6480.98
35_I39_I0.6450.98
240_Q263_E0.6440.98
244_R265_C0.6420.98
81_A100_Y0.6400.98
123_F218_D0.6400.98
96_H100_Y0.6400.98
38_D42_I0.6380.98
275_Q279_G0.6370.98
259_C266_Q0.6350.98
18_Q52_S0.6340.98
285_G303_T0.6330.98
72_L76_E0.6300.98
8_A27_L0.6300.98
51_T58_G0.6300.98
280_F284_F0.6300.98
19_V27_L0.6270.97
142_I145_A0.6270.97
247_I251_F0.6240.97
9_M13_L0.6220.97
239_V243_A0.6190.97
33_R58_G0.6180.97
51_T57_G0.6180.97
143_S173_L0.6170.97
293_P296_I0.6120.97
159_A163_T0.6110.97
228_Q276_W0.6110.97
237_I269_I0.6110.97
172_T215_I0.6110.97
8_A12_L0.6100.97
16_K27_L0.6100.97
285_G307_M0.6080.97
157_T160_S0.6080.97
84_L87_V0.6050.97
33_R37_R0.6040.97
151_T211_I0.6040.97
43_N49_I0.6030.97
235_L277_L0.6030.97
235_L281_L0.6030.97
121_K149_L0.6020.97
43_N50_V0.6020.97
210_F215_I0.6000.97
219_T223_D0.5970.97
43_N47_I0.5970.97
174_V179_H0.5960.97
38_D41_T0.5940.96
165_L204_A0.5940.96
179_H198_N0.5930.96
9_M12_L0.5920.96
239_V267_A0.5920.96
188_V193_R0.5920.96
101_Q104_K0.5910.96
43_N51_T0.5870.96
10_V14_I0.5860.96
109_E112_T0.5850.96
171_Y220_L0.5840.96
292_Q297_R0.5810.96
275_Q303_T0.5790.96
297_R308_Q0.5770.96
47_I59_I0.5760.96
54_G64_T0.5720.96
57_G61_I0.5710.96
49_I54_G0.5650.95
52_S56_G0.5650.95
187_L208_Q0.5640.95
164_L195_F0.5630.95
69_R72_L0.5590.95
235_L290_V0.5590.95
67_L70_E0.5590.95
170_P210_F0.5590.95
10_V61_I0.5580.95
88_S91_Y0.5580.95
16_K23_E0.5580.95
139_R173_L0.5570.95
29_E53_Q0.5570.95
182_L200_M0.5560.95
74_E111_S0.5550.95
19_V23_E0.5540.95
120_E123_F0.5540.95
170_P184_A0.5530.95
258_C263_E0.5530.95
235_L269_I0.5520.95
74_E110_Q0.5510.95
278_I281_L0.5510.95
22_A25_A0.5500.95
152_I184_A0.5500.95
83_A87_V0.5500.95
276_W279_G0.5500.95
14_I42_I0.5490.95
33_R38_D0.5460.94
281_L284_F0.5460.94
149_L213_K0.5460.94
222_W226_W0.5460.94
220_L224_K0.5460.94
45_A48_P0.5450.94
95_S98_T0.5450.94
142_I182_L0.5450.94
12_L16_K0.5440.94
271_L280_F0.5440.94
41_T44_R0.5430.94
196_K249_E0.5410.94
9_M19_V0.5400.94
37_R40_E0.5370.94
214_D218_D0.5370.94
75_E95_S0.5370.94
9_M24_L0.5370.94
21_A51_T0.5370.94
290_V297_R0.5360.94
48_P62_M0.5350.94
269_I277_L0.5340.94
259_C262_D0.5340.94
302_E309_K0.5340.94
9_M38_D0.5330.94
84_L91_Y0.5330.94
100_Y104_K0.5330.94
138_L200_M0.5320.94
189_R195_F0.5320.94
292_Q298_D0.5310.94
26_E29_E0.5310.94
121_K146_I0.5310.94
75_E78_F0.5310.94
253_Y256_L0.5280.93
168_T195_F0.5280.93
161_G164_L0.5270.93
52_S60_G0.5270.93
95_S99_A0.5250.93
43_N62_M0.5250.93
217_L220_L0.5250.93
72_L102_K0.5240.93
300_V303_T0.5230.93
78_F82_S0.5220.93
235_L270_S0.5220.93
149_L211_I0.5200.93
255_V267_A0.5200.93
258_C264_I0.5200.93
107_I112_T0.5180.93
196_K199_R0.5180.93
273_E295_H0.5170.93
247_I280_F0.5170.93
273_E276_W0.5160.93
137_T275_Q0.5150.92
273_E299_K0.5150.92
84_L90_M0.5140.92
238_L261_E0.5120.92
85_Q89_S0.5120.92
164_L209_T0.5120.92
269_I276_W0.5100.92
159_A199_R0.5090.92
183_Y222_W0.5090.92
271_L274_D0.5080.92
257_H267_A0.5070.92
54_G58_G0.5060.92
6_L41_T0.5060.92
274_D277_L0.5060.92
250_W284_F0.5050.92
79_A99_A0.5050.92
290_V296_I0.5050.92
165_L202_D0.5040.92
258_C261_E0.5030.92
224_K227_Y0.5020.92
251_F277_L0.5010.91
139_R197_L0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1j5yA 4 0.4601 98.2 0.853 Contact Map
1oyiA 1 0.1917 97.9 0.865 Contact Map
2vxzA 1 0.4569 97.8 0.868 Contact Map
2heoA 1 0.1853 97.7 0.869 Contact Map
4a0zA 2 0.5591 97.7 0.871 Contact Map
2l0kA 1 0.2843 97.6 0.874 Contact Map
2p5kA 1 0.1789 97.4 0.876 Contact Map
1biaA 1 0.7061 97.4 0.878 Contact Map
4hf0A 3 0.3546 97.3 0.879 Contact Map
2y75A 5 0.3802 97.3 0.88 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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