GREMLIN Database
YOSS - SPBc2 prophage-derived deoxyuridine 5'-triphosphate nucleotidohydrolase YosS
UniProt: O34919 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 142 (133)
Sequences: 3785 (2201)
Seq/√Len: 190.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
49_E129_G2.6651.00
24_I122_L2.4761.00
103_K106_D2.4681.00
35_K99_D2.4531.00
31_D103_K2.3501.00
56_A111_F2.2861.00
21_G82_S2.0211.00
35_K38_E2.0111.00
68_F100_T2.0051.00
19_E82_S1.9851.00
33_A101_K1.9521.00
66_K90_W1.9051.00
23_W113_I1.8621.00
20_Q81_E1.8621.00
43_P88_D1.8111.00
17_K119_A1.7611.00
70_V100_T1.7391.00
7_Y124_E1.7271.00
11_T104_K1.7141.00
36_K99_D1.6851.00
106_D141_T1.6831.00
59_V78_V1.6691.00
38_E97_L1.6641.00
48_M56_A1.6571.00
33_A99_D1.6511.00
50_L114_M1.6431.00
13_T27_R1.6091.00
41_L66_K1.6061.00
28_A102_I1.6011.00
17_K24_I1.5981.00
50_L56_A1.5771.00
39_F69_G1.5721.00
31_D104_K1.5621.00
49_E84_K1.4951.00
57_H115_K1.4641.00
92_F95_Y1.4311.00
26_L56_A1.4131.00
55_E78_V1.4091.00
57_H78_V1.3801.00
43_P86_D1.3731.00
17_K120_V1.3621.00
56_A114_M1.3511.00
41_L88_D1.3511.00
59_V115_K1.3501.00
16_N27_R1.3411.00
12_Q104_K1.3171.00
89_F109_C1.3151.00
8_L47_A1.2941.00
71_I92_F1.2661.00
54_Y118_P1.2371.00
34_I40_K1.2361.00
114_M120_V1.2311.00
31_D101_K1.2111.00
45_G86_D1.2091.00
90_W136_H1.1921.00
54_Y114_M1.1751.00
26_L111_F1.1471.00
29_A104_K1.1451.00
44_L89_F1.1371.00
12_Q29_A1.1351.00
60_P75_S1.1291.00
58_V111_F1.1171.00
18_M27_R1.1041.00
59_V76_M1.1021.00
50_L54_Y1.0991.00
9_D29_A1.0951.00
55_E59_V1.0941.00
71_I95_Y1.0931.00
60_P71_I1.0871.00
9_D12_Q1.0811.00
61_R107_R1.0571.00
58_V109_C1.0411.00
37_D97_L1.0331.00
55_E115_K1.0331.00
20_Q52_E1.0281.00
7_Y14_R1.0191.00
89_F108_I1.0051.00
48_M87_N0.9950.99
107_R140_G0.9860.99
24_I111_F0.9820.99
22_D81_E0.9740.99
32_V42_V0.9670.99
26_L58_V0.9650.99
22_D55_E0.9290.99
84_K128_L0.9260.99
73_T92_F0.9170.99
68_F106_D0.9170.99
39_F92_F0.9160.99
18_M138_S0.9090.99
71_I75_S0.8970.99
32_V102_I0.8970.99
48_M111_F0.8940.99
73_T90_W0.8850.99
111_F114_M0.8790.99
72_Q91_F0.8710.99
9_D45_G0.8590.98
37_D95_Y0.8570.98
60_P72_Q0.8500.98
68_F141_T0.8470.98
37_D96_A0.8430.98
59_V113_I0.8380.98
60_P76_M0.8270.98
32_V40_K0.8240.98
30_E43_P0.8240.98
69_G96_A0.8210.98
36_K93_P0.8210.98
47_A128_L0.8180.98
42_V91_F0.8180.98
58_V89_F0.8100.98
57_H113_I0.7960.98
29_A43_P0.7940.97
41_L90_W0.7880.97
46_V87_N0.7870.97
34_I93_P0.7780.97
49_E128_L0.7760.97
18_M139_T0.7710.97
125_V128_L0.7670.97
72_Q76_M0.7610.97
66_K88_D0.7570.97
22_D50_L0.7560.97
57_H76_M0.7470.96
28_A42_V0.7410.96
66_K73_T0.7370.96
11_T29_A0.7300.96
50_L81_E0.7260.96
26_L46_V0.7250.96
24_I120_V0.7180.95
65_Y90_W0.7160.95
91_F108_I0.7140.95
79_I90_W0.7070.95
68_F98_R0.7070.95
81_E117_M0.7070.95
39_F95_Y0.7050.95
65_Y73_T0.6830.94
84_K131_G0.6790.94
26_L109_C0.6760.94
52_E81_E0.6730.94
76_M90_W0.6730.94
30_E104_K0.6730.94
19_E139_T0.6720.94
27_R46_V0.6690.93
102_I108_I0.6660.93
12_Q27_R0.6640.93
26_L89_F0.6630.93
55_E113_I0.6620.93
58_V72_Q0.6570.93
7_Y12_Q0.6450.92
60_P74_N0.6420.92
73_T76_M0.6420.92
93_P96_A0.6300.91
22_D117_M0.6280.91
9_D13_T0.6280.91
79_I87_N0.6260.91
14_R124_E0.6130.90
47_A86_D0.6070.90
17_K122_L0.6060.90
13_T104_K0.5960.89
30_E40_K0.5920.88
65_Y76_M0.5880.88
78_V113_I0.5880.88
34_I92_F0.5740.87
10_E13_T0.5740.87
7_Y11_T0.5740.87
28_A31_D0.5730.87
62_S135_G0.5670.86
70_V91_F0.5640.86
60_P64_T0.5590.85
128_L131_G0.5560.85
50_L53_G0.5550.85
22_D114_M0.5530.85
72_Q75_S0.5530.85
75_S95_Y0.5520.85
9_D104_K0.5510.85
45_G88_D0.5510.85
73_T95_Y0.5430.84
36_K97_L0.5410.84
53_G116_K0.5340.83
100_T106_D0.5340.83
120_V124_E0.5300.82
50_L111_F0.5270.82
117_M122_L0.5270.82
8_L12_Q0.5260.82
127_R130_N0.5250.82
75_S92_F0.5240.82
10_E104_K0.5220.81
56_A79_I0.5220.81
47_A124_E0.5210.81
63_S66_K0.5210.81
117_M120_V0.5200.81
73_T87_N0.5190.81
87_N111_F0.5190.81
38_E98_R0.5130.80
66_K136_H0.5130.80
55_E76_M0.5120.80
69_G95_Y0.5090.80
12_Q105_G0.5070.80
115_K118_P0.5040.79
49_E131_G0.5040.79
82_S139_T0.5000.79
30_E45_G0.5000.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3hzaA 3 0.9859 100 0.147 Contact Map
3mdxA 3 0.9085 100 0.147 Contact Map
4gv8A 3 0.8803 100 0.159 Contact Map
3zf6A 3 0.9648 100 0.16 Contact Map
3t64A 3 0.9507 100 0.166 Contact Map
3araA 3 0.8662 100 0.168 Contact Map
4b0hA 3 0.9789 100 0.168 Contact Map
3f4fA 3 0.9366 100 0.17 Contact Map
3tqzA 3 0.9014 100 0.174 Contact Map
1euwA 3 0.8873 100 0.174 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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