GREMLIN Database
YOAJ - Expansin-YoaJ
UniProt: O34918 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 232 (210)
Sequences: 1633 (926)
Seq/√Len: 63.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
97_Y100_G5.2181.00
81_E128_R4.7171.00
166_E197_R4.5381.00
155_V165_M4.1471.00
79_Y132_A3.5781.00
138_F206_V3.2401.00
90_T130_V2.7011.00
46_A96_L2.4981.00
199_T205_V2.4551.00
34_Y122_K2.3231.00
153_I196_V2.2921.00
138_F208_D2.2701.00
78_S161_P2.2541.00
47_F76_A2.1011.00
74_A178_K2.0911.00
83_E126_K2.0821.00
59_T93_V2.0511.00
81_E90_T2.0431.00
116_G123_I2.0111.00
59_T91_V1.9111.00
98_P106_D1.9041.00
82_V105_L1.8921.00
63_P96_L1.8481.00
81_E88_K1.8271.00
60_A106_D1.8191.00
115_I123_I1.7501.00
226_G229_Q1.7360.99
140_Y208_D1.7310.99
63_P99_E1.6900.99
109_P118_M1.6610.99
152_A185_V1.6490.99
75_L78_S1.6440.99
106_D121_G1.5850.99
14_L19_F1.5590.99
60_A98_P1.5230.99
38_T106_D1.5180.99
80_L91_V1.5090.99
80_L127_W1.5030.98
36_T106_D1.4830.98
76_A79_Y1.4670.98
46_A66_L1.4640.98
173_W197_R1.4340.98
80_L105_L1.4330.98
162_V198_M1.4310.98
165_M184_F1.4180.98
143_K150_W1.3990.98
197_R207_K1.3860.97
96_L99_E1.3710.97
112_F120_D1.3590.97
203_G229_Q1.3570.97
152_A183_H1.3550.97
43_S52_I1.3510.97
217_G229_Q1.3360.97
51_P54_S1.3250.97
170_D193_S1.3010.96
173_W195_K1.2820.96
177_E185_V1.2730.96
15_T20_S1.2720.96
58_I95_D1.2720.96
37_Y118_M1.2590.95
83_E88_K1.2560.95
58_I108_S1.2440.95
15_T18_C1.2400.95
87_G115_I1.2310.95
129_V161_P1.2280.95
36_T39_G1.2270.95
38_T60_A1.2230.95
72_K96_L1.2100.94
161_P201_I1.2090.94
76_A97_Y1.2050.94
103_G127_W1.1950.94
76_A132_A1.1940.94
162_V165_M1.1940.94
213_L216_S1.1700.93
13_L16_I1.1670.93
19_F22_Q1.1640.93
166_E199_T1.1630.93
179_M185_V1.1620.93
47_F79_Y1.1570.93
19_F23_A1.1570.93
12_V17_F1.1560.93
16_I19_F1.1560.93
112_F116_G1.1460.93
112_F117_N1.1450.93
57_E114_K1.1320.92
142_I153_I1.1260.92
38_T121_G1.1130.91
12_V15_T1.1110.91
35_A104_A1.1010.91
35_A125_I1.1000.91
39_G42_Y1.0950.91
62_N65_D1.0890.90
25_A28_D1.0880.90
182_N226_G1.0810.90
21_P25_A1.0710.90
107_L112_F1.0700.90
84_G87_G1.0570.89
48_L181_Y1.0530.89
65_D105_L1.0510.89
49_L63_P1.0500.89
88_K126_K1.0220.87
80_L129_V1.0200.87
64_A99_E1.0140.87
165_M197_R1.0040.87
13_L21_P1.0030.86
89_T115_I0.9990.86
40_S58_I0.9970.86
152_A179_M0.9900.86
20_S23_A0.9800.85
31_H103_G0.9760.85
61_I93_V0.9720.85
22_Q26_A0.9710.85
197_R205_V0.9700.85
113_R118_M0.9690.85
89_T107_L0.9670.84
141_R156_R0.9670.84
26_A229_Q0.9610.84
47_F97_Y0.9520.83
17_F22_Q0.9440.83
147_S151_A0.9430.83
208_D226_G0.9390.83
12_V16_I0.9300.82
23_A26_A0.9240.82
85_P126_K0.9190.81
39_G109_P0.9160.81
39_G44_G0.9150.81
80_L93_V0.9130.81
166_E175_N0.9100.81
64_A125_I0.9090.81
47_F132_A0.9070.80
79_Y200_D0.9030.80
14_L20_S0.8990.80
143_K183_H0.8990.80
165_M176_M0.8960.80
57_E111_A0.8950.79
84_G94_T0.8860.79
76_A100_G0.8790.78
166_E173_W0.8790.78
14_L17_F0.8750.78
14_L18_C0.8730.78
14_L21_P0.8690.77
37_Y121_G0.8690.77
18_C22_Q0.8690.77
35_A94_T0.8670.77
66_L195_K0.8670.77
161_P182_N0.8600.77
109_P113_R0.8580.77
154_Q184_F0.8540.76
167_Y174_I0.8540.76
200_D204_K0.8480.76
31_H127_W0.8460.76
91_V115_I0.8440.75
160_Y200_D0.8430.75
92_Y157_N0.8420.75
32_E126_K0.8360.75
89_T114_K0.8260.74
16_I20_S0.8160.73
174_I207_K0.8140.73
36_T60_A0.8130.73
23_A27_Y0.8100.72
176_M196_V0.8020.72
32_E165_M0.7990.71
86_K107_L0.7900.70
78_S204_K0.7880.70
176_M184_F0.7860.70
66_L184_F0.7850.70
35_A38_T0.7820.70
41_G50_D0.7750.69
41_G44_G0.7700.68
30_L128_R0.7680.68
158_H161_P0.7650.68
56_M110_N0.7650.68
78_S129_V0.7590.67
38_T104_A0.7570.67
48_L129_V0.7560.67
18_C21_P0.7550.67
177_E186_S0.7530.67
148_R190_G0.7490.66
213_L224_V0.7470.66
84_G129_V0.7450.66
33_G103_G0.7420.66
24_S28_D0.7420.66
204_K207_K0.7410.65
34_Y104_A0.7240.64
17_F21_P0.7240.64
63_P214_P0.7180.63
21_P24_S0.7150.63
166_E207_K0.7110.62
104_A122_K0.7080.62
36_T104_A0.7050.62
147_S229_Q0.7040.61
131_K174_I0.7040.61
94_T181_Y0.6930.60
143_K167_Y0.6890.60
82_V127_W0.6890.60
135_T163_M0.6880.60
87_G226_G0.6880.60
132_A200_D0.6860.60
134_I157_N0.6850.59
35_A116_G0.6850.59
87_G90_T0.6850.59
78_S107_L0.6840.59
47_F100_G0.6830.59
126_K212_K0.6810.59
177_E187_T0.6770.58
167_Y194_L0.6760.58
19_F25_A0.6730.58
66_L82_V0.6730.58
79_Y202_R0.6720.58
107_L111_A0.6710.58
168_E172_K0.6710.58
163_M208_D0.6670.57
210_I214_P0.6670.57
61_I75_L0.6620.57
176_M195_K0.6620.57
12_V18_C0.6600.57
36_T98_P0.6540.56
84_G181_Y0.6530.56
133_P155_V0.6520.56
112_F115_I0.6500.55
79_Y160_Y0.6500.55
137_N198_M0.6480.55
40_S108_S0.6460.55
154_Q165_M0.6440.55
65_D78_S0.6390.54
160_Y202_R0.6390.54
171_G190_G0.6360.54
73_A216_S0.6340.54
58_I61_I0.6320.53
104_A160_Y0.6320.53
82_V107_L0.6290.53
22_Q27_Y0.6280.53
92_Y134_I0.6270.53
105_L127_W0.6260.53
132_A160_Y0.6250.53
178_K182_N0.6250.53
24_S27_Y0.6240.52
168_E195_K0.6200.52
16_I23_A0.6200.52
165_M227_H0.6200.52
116_G120_D0.6200.52
188_N207_K0.6190.52
136_G157_N0.6150.51
41_G60_A0.6140.51
35_A61_I0.6140.51
12_V19_F0.6120.51
27_Y87_G0.6120.51
60_A97_Y0.6100.51
12_V25_A0.6100.51
90_T215_E0.6080.51
13_L19_F0.6080.51
35_A107_L0.6080.51
83_E205_V0.6010.50
67_N74_A0.6010.50
134_I137_N0.6000.50
40_S44_G0.5970.49
20_S24_S0.5940.49
22_Q25_A0.5940.49
107_L226_G0.5940.49
119_K197_R0.5900.48
28_D31_H0.5860.48
163_M212_K0.5860.48
90_T111_A0.5850.48
60_A100_G0.5820.48
156_R184_F0.5810.47
155_V196_V0.5780.47
113_R117_N0.5780.47
116_G121_G0.5770.47
23_A29_D0.5770.47
176_M208_D0.5760.47
178_K184_F0.5760.47
130_V159_K0.5740.47
90_T103_G0.5670.46
73_A94_T0.5650.46
206_V209_T0.5630.45
86_K215_E0.5620.45
29_D207_K0.5610.45
21_P163_M0.5590.45
117_N120_D0.5580.45
38_T150_W0.5540.44
65_D122_K0.5540.44
15_T19_F0.5500.44
35_A123_I0.5480.44
222_Y226_G0.5480.44
147_S190_G0.5460.43
18_C24_S0.5450.43
13_L17_F0.5380.43
26_A29_D0.5370.42
150_W185_V0.5360.42
162_V194_L0.5350.42
57_E91_V0.5330.42
81_E112_F0.5330.42
95_D144_E0.5320.42
147_S150_W0.5320.42
142_I151_A0.5310.42
13_L20_S0.5310.42
128_R153_I0.5310.42
78_S131_K0.5280.41
17_F25_A0.5280.41
199_T207_K0.5230.41
39_G106_D0.5220.41
225_P229_Q0.5200.40
12_V21_P0.5200.40
34_Y102_R0.5180.40
196_V212_K0.5160.40
35_A82_V0.5150.40
199_T206_V0.5140.40
43_S101_A0.5110.39
143_K154_Q0.5080.39
23_A28_D0.5070.39
41_G53_P0.5060.39
39_G43_S0.5060.39
27_Y128_R0.5060.39
131_K159_K0.5040.39
21_P27_Y0.5000.38
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3d30A 1 0.8621 100 0.218 Contact Map
4jcwA 2 0.8405 100 0.237 Contact Map
2hczX 1 0.9052 100 0.237 Contact Map
1n10A 1 0.875 100 0.27 Contact Map
1wc2A 1 0.5733 99.9 0.617 Contact Map
4pmkA 1 0.4871 99.9 0.676 Contact Map
4jp6A 1 0.4698 99.9 0.68 Contact Map
3ft1A 1 0.4052 99.8 0.687 Contact Map
4avrA 2 0.3879 99.8 0.705 Contact Map
2jnzA 1 0.4397 99.7 0.74 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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