GREMLIN Database
YTFI - Uncharacterized protein YtfI
UniProt: O34917 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 226 (209)
Sequences: 250 (223)
Seq/√Len: 15.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
125_W148_K6.6721.00
127_T148_K5.5221.00
30_H35_D5.1901.00
185_I194_M4.5561.00
20_M44_L3.2890.99
125_W180_T3.2850.99
135_A173_F3.1100.98
129_I190_F2.9750.98
28_Y35_D2.8620.97
66_V140_L2.4000.93
144_V169_V2.3960.93
8_I169_V2.3710.92
125_W169_V2.2680.90
30_H178_S2.2480.90
110_I114_F2.2220.90
119_H162_V2.2060.89
127_T169_V2.1840.89
65_T86_T2.1840.89
110_I203_Y2.1360.88
28_Y37_L2.1220.87
148_K180_T2.1100.87
121_T187_F2.0540.85
114_F193_A2.0380.85
153_A156_Y1.9980.84
42_T123_L1.9510.82
114_F188_F1.8620.79
30_H59_V1.8050.77
165_P189_R1.8030.77
81_G122_K1.6980.72
156_Y161_F1.6900.72
132_Q176_P1.6890.72
185_I191_G1.6840.71
117_H192_H1.6840.71
14_I169_V1.6520.70
185_I193_A1.6300.69
131_I176_P1.6260.69
30_H33_D1.6060.68
185_I202_K1.6040.68
28_Y39_L1.5820.67
101_L118_L1.5410.64
104_V110_I1.5410.64
123_L154_M1.5250.64
165_P191_G1.5020.62
127_T180_T1.4940.62
178_S185_I1.4930.62
9_L15_V1.4760.61
104_V203_Y1.4730.61
47_L51_K1.4230.58
37_L182_F1.4150.58
15_V146_G1.4140.58
108_R158_H1.4140.58
169_V202_K1.4010.57
130_G189_R1.3880.56
89_D120_I1.3680.55
188_F193_A1.3420.53
3_Y153_A1.3080.52
149_G173_F1.2790.50
188_F205_R1.2660.49
8_I194_M1.2470.48
51_K141_T1.2210.47
19_R194_M1.2090.46
138_G173_F1.2030.46
130_G142_G1.1970.45
125_W145_W1.1810.44
47_L196_A1.1730.44
131_I143_A1.1710.44
148_K169_V1.1690.44
127_T145_W1.1640.43
28_Y147_V1.1500.43
90_V126_V1.1440.42
107_L112_A1.1440.42
179_K182_F1.1420.42
180_T193_A1.1390.42
82_K198_F1.1360.42
33_D178_S1.1240.41
45_F203_Y1.1200.41
17_L54_I1.1170.41
130_G149_G1.1120.41
80_S117_H1.1100.40
134_A171_P1.1100.40
49_R163_N1.0790.39
89_D190_F1.0690.38
15_V150_G1.0640.38
140_L160_D1.0590.38
41_I46_G1.0580.38
184_C194_M1.0490.37
110_I188_F1.0450.37
27_E64_G1.0400.37
64_G120_I1.0400.37
186_F202_K1.0340.36
35_D167_Y1.0320.36
29_L71_K1.0300.36
51_K138_G1.0250.36
60_N174_Q1.0200.36
22_I97_I0.9970.34
125_W165_P0.9960.34
52_K75_K0.9920.34
26_L77_K0.9910.34
4_V47_L0.9850.34
60_N111_S0.9710.33
22_I50_I0.9690.33
10_I186_F0.9470.32
126_V168_E0.9460.32
20_M138_G0.9460.32
5_L9_L0.9380.31
104_V114_F0.9330.31
118_L143_A0.9320.31
207_L210_L0.9280.31
149_G169_V0.9180.30
191_G194_M0.9050.30
57_I166_V0.9040.30
141_T182_F0.8990.30
188_F209_V0.8970.29
123_L155_L0.8950.29
35_D57_I0.8840.29
42_T45_F0.8830.29
30_H38_T0.8810.29
3_Y118_L0.8720.28
22_I77_K0.8720.28
125_W171_P0.8710.28
86_T210_L0.8580.28
139_V161_F0.8560.28
138_G208_S0.8520.27
20_M110_I0.8470.27
86_T107_L0.8440.27
30_H34_N0.8440.27
44_L116_A0.8430.27
38_T119_H0.8430.27
62_E175_V0.8390.27
51_K184_C0.8380.27
128_V172_S0.8380.27
5_L146_G0.8360.27
34_N133_D0.8270.26
138_G207_L0.8180.26
14_I205_R0.8100.25
109_K116_A0.8050.25
26_L39_L0.8020.25
8_I15_V0.7970.25
95_N201_V0.7960.25
108_R112_A0.7960.25
71_K170_I0.7940.25
20_M180_T0.7940.25
138_G151_I0.7920.25
128_V179_K0.7910.25
25_A147_V0.7890.25
145_W149_G0.7870.25
40_K51_K0.7840.24
113_S199_K0.7830.24
100_L203_Y0.7760.24
130_G175_V0.7740.24
141_T186_F0.7730.24
106_R109_K0.7720.24
26_L198_F0.7710.24
94_I169_V0.7690.24
21_K190_F0.7670.24
77_K190_F0.7520.23
18_L179_K0.7510.23
37_L188_F0.7480.23
9_L17_L0.7480.23
39_L135_A0.7450.23
46_G153_A0.7450.23
55_P66_V0.7370.22
52_K131_I0.7360.22
11_L139_V0.7340.22
102_H198_F0.7330.22
23_H146_G0.7310.22
124_E166_V0.7310.22
151_I158_H0.7300.22
13_G19_R0.7280.22
42_T47_L0.7230.22
42_T49_R0.7220.22
134_A184_C0.7160.22
184_C192_H0.7150.22
145_W191_G0.7120.21
114_F145_W0.7120.21
17_L44_L0.7120.21
104_V138_G0.7070.21
107_L161_F0.7060.21
131_I134_A0.7050.21
40_K100_L0.7030.21
184_C191_G0.7030.21
71_K118_L0.7030.21
121_T194_M0.7000.21
120_I134_A0.6970.21
81_G105_T0.6930.21
140_L159_L0.6920.21
41_I132_Q0.6920.21
187_F192_H0.6920.21
37_L116_A0.6890.21
6_T169_V0.6880.21
129_I189_R0.6850.20
153_A207_L0.6820.20
124_E139_V0.6810.20
44_L133_D0.6810.20
53_T98_E0.6800.20
139_V163_N0.6800.20
100_L140_L0.6790.20
124_E185_I0.6760.20
43_A203_Y0.6730.20
77_K87_Q0.6730.20
137_T171_P0.6720.20
60_N65_T0.6690.20
123_L173_F0.6690.20
34_N87_Q0.6650.20
45_F91_Q0.6640.20
138_G197_A0.6630.20
82_K189_R0.6630.20
127_T193_A0.6620.20
4_V109_K0.6610.20
203_Y207_L0.6590.20
59_V116_A0.6590.20
4_V91_Q0.6570.19
12_I185_I0.6560.19
24_V147_V0.6540.19
105_T178_S0.6530.19
129_I201_V0.6530.19
39_L52_K0.6520.19
4_V134_A0.6500.19
35_D66_V0.6480.19
35_D55_P0.6470.19
9_L159_L0.6460.19
152_A188_F0.6450.19
173_F203_Y0.6400.19
31_A182_F0.6400.19
70_Q186_F0.6370.19
169_V195_L0.6340.19
14_I41_I0.6320.19
66_V154_M0.6300.19
104_V204_G0.6270.18
7_A129_I0.6260.18
77_K99_M0.6250.18
32_D38_T0.6230.18
16_L54_I0.6220.18
28_Y149_G0.6190.18
100_L200_F0.6170.18
12_I91_Q0.6170.18
30_H56_A0.6150.18
18_L163_N0.6130.18
27_E111_S0.6110.18
32_D119_H0.6080.18
79_S82_K0.6070.18
5_L8_I0.6060.18
133_D162_V0.6040.18
131_I136_V0.6040.18
193_A196_A0.5950.17
16_L108_R0.5950.17
13_G24_V0.5940.17
41_I107_L0.5930.17
116_A146_G0.5900.17
60_N67_D0.5900.17
108_R151_I0.5880.17
95_N151_I0.5880.17
60_N172_S0.5860.17
85_I169_V0.5850.17
100_L187_F0.5810.17
30_H86_T0.5810.17
141_T166_V0.5800.17
74_S113_S0.5800.17
169_V178_S0.5800.17
23_H179_K0.5740.17
22_I131_I0.5720.17
4_V119_H0.5710.17
8_I117_H0.5710.17
63_D206_E0.5700.17
16_L138_G0.5690.17
94_I167_Y0.5690.17
52_K88_N0.5690.17
67_D198_F0.5680.16
90_V201_V0.5680.16
10_I92_Q0.5670.16
147_V173_F0.5670.16
91_Q155_L0.5650.16
73_E197_A0.5580.16
68_I146_G0.5580.16
90_V96_K0.5580.16
117_H120_I0.5560.16
113_S153_A0.5540.16
60_N170_I0.5540.16
74_S147_V0.5540.16
43_A182_F0.5510.16
134_A146_G0.5500.16
21_K187_F0.5450.16
146_G153_A0.5450.16
39_L191_G0.5410.16
20_M82_K0.5370.16
20_M188_F0.5340.15
74_S164_K0.5320.15
17_L31_A0.5320.15
153_A200_F0.5300.15
84_K122_K0.5300.15
152_A167_Y0.5290.15
182_F200_F0.5280.15
33_D57_I0.5220.15
20_M106_R0.5210.15
87_Q206_E0.5210.15
59_V169_V0.5200.15
10_I88_N0.5200.15
139_V186_F0.5180.15
6_T176_P0.5170.15
30_H57_I0.5170.15
6_T11_L0.5130.15
142_G173_F0.5130.15
54_I178_S0.5120.15
30_H93_S0.5120.15
164_K173_F0.5110.15
9_L141_T0.5100.15
39_L50_I0.5090.15
32_D161_F0.5080.15
78_K81_G0.5080.15
21_K54_I0.5050.15
79_S101_L0.5050.15
6_T127_T0.5030.15
40_K66_V0.5000.14
59_V109_K0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2m3eA 1 0.177 9.8 0.958 Contact Map
3wguG 1 0.0929 5.2 0.963 Contact Map
1m56D 1 0.0885 4.9 0.963 Contact Map
2k1aA 1 0.1504 4.7 0.963 Contact Map
1qleD 1 0.0885 4.6 0.964 Contact Map
2mkvA 1 0.1593 4 0.965 Contact Map
4u0qB 1 0 3.1 0.967 Contact Map
2kncA 1 0.1947 3 0.967 Contact Map
4px7A 1 0.3407 2.8 0.967 Contact Map
5a2fA 1 0 2.6 0.968 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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