GREMLIN Database
DAPEL - N-acetyldiaminopimelate deacetylase
UniProt: O34916 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 374 (350)
Sequences: 29192 (20857)
Seq/√Len: 1114.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
54_K120_L3.4321.00
181_D242_T3.1421.00
181_D244_H2.9151.00
12_D29_Y2.9001.00
31_L35_E2.7811.00
56_N118_D2.6491.00
179_V244_H2.6161.00
187_G195_A2.5911.00
90_N352_N2.5891.00
63_M118_D2.4901.00
201_A277_C2.4801.00
182_L205_L2.4721.00
261_K265_E2.4101.00
183_E242_T2.3901.00
265_E269_K2.3841.00
33_V36_Q2.3541.00
109_H366_T2.3281.00
179_V246_E2.3101.00
183_E278_K2.2921.00
29_Y33_V2.2481.00
306_E367_G2.2471.00
231_T244_H2.2331.00
181_D280_K2.2201.00
34_L53_V2.2121.00
63_M120_L2.2031.00
54_K118_D2.1831.00
202_A243_A2.1651.00
202_A230_I2.1601.00
109_H113_H2.1511.00
179_V282_T2.1101.00
229_T246_E2.0811.00
262_E266_D2.0571.00
202_A245_L2.0561.00
37_Y108_D2.0181.00
204_T207_T2.0031.00
183_E280_K1.9961.00
307_H367_G1.9911.00
16_I29_Y1.9711.00
301_M305_A1.9251.00
203_S206_V1.9121.00
83_F87_H1.8691.00
33_V37_Y1.8291.00
24_F28_Q1.8181.00
205_L268_V1.8081.00
32_N36_Q1.7611.00
134_E138_E1.7521.00
65_A147_P1.7481.00
300_F368_Y1.7421.00
29_Y32_N1.7111.00
9_I33_V1.7071.00
39_Q55_V1.6961.00
203_S207_T1.6861.00
25_K28_Q1.6741.00
82_P350_K1.6741.00
11_R15_R1.6541.00
200_V210_Q1.6451.00
269_K273_I1.6431.00
198_M243_A1.6391.00
196_E201_A1.6181.00
191_Y194_L1.5921.00
31_L51_L1.5911.00
186_G241_E1.5871.00
185_K196_E1.5871.00
28_Q32_N1.5851.00
6_L362_V1.5831.00
263_R266_D1.5761.00
232_G243_A1.5691.00
258_K262_E1.5621.00
256_S259_Q1.5621.00
108_D112_H1.5611.00
27_Q70_I1.5511.00
204_T275_F1.5461.00
135_P138_E1.5431.00
59_A116_K1.5331.00
208_Q267_V1.5321.00
62_K148_D1.5231.00
12_D15_R1.5181.00
367_G370_S1.5141.00
298_E301_M1.4991.00
24_F49_T1.4941.00
8_A12_D1.4891.00
135_P139_S1.4871.00
12_D25_K1.4821.00
12_D16_I1.4761.00
181_D282_T1.4741.00
65_A122_L1.4721.00
30_L70_I1.4611.00
221_D253_S1.4551.00
259_Q263_R1.4511.00
208_Q270_G1.4301.00
40_D56_N1.4211.00
305_A311_T1.4121.00
328_L333_G1.3951.00
182_L202_A1.3931.00
65_A150_I1.3851.00
360_T363_H1.3851.00
39_Q42_I1.3801.00
216_N263_R1.3771.00
102_I361_A1.3751.00
32_N35_E1.3641.00
176_S257_M1.3581.00
55_V111_V1.3561.00
33_V108_D1.3351.00
178_L247_G1.3301.00
204_T274_G1.3281.00
31_L42_I1.3221.00
8_A11_R1.3161.00
35_E42_I1.3101.00
304_V364_V1.3041.00
15_R86_E1.2861.00
307_H363_H1.2821.00
301_M315_A1.2811.00
86_E355_E1.2781.00
180_I245_L1.2771.00
266_D270_G1.2741.00
7_I11_R1.2741.00
262_E265_E1.2741.00
80_G84_A1.2721.00
66_Y369_F1.2681.00
299_E303_F1.2611.00
6_L105_G1.2581.00
272_E279_G1.2561.00
356_N360_T1.2471.00
261_K283_Y1.2431.00
86_E89_G1.2361.00
58_T116_K1.2361.00
212_I263_R1.2331.00
18_E26_T1.2051.00
113_H370_S1.2031.00
105_G108_D1.1921.00
182_L201_A1.1901.00
9_I105_G1.1891.00
359_E363_H1.1871.00
28_Q31_L1.1821.00
98_L353_P1.1771.00
113_H366_T1.1741.00
199_V232_G1.1731.00
268_V279_G1.1681.00
66_Y103_A1.1671.00
199_V230_I1.1671.00
223_A260_V1.1591.00
303_F367_G1.1581.00
9_I29_Y1.1561.00
266_D269_K1.1411.00
207_T211_T1.1401.00
253_S256_S1.1351.00
14_H96_H1.1251.00
13_L26_T1.1211.00
16_I25_K1.1211.00
141_V144_K1.1151.00
294_S298_E1.1131.00
303_F307_H1.1121.00
259_Q262_E1.1021.00
298_E302_S1.1021.00
208_Q211_T1.0961.00
267_V270_G1.0951.00
227_V247_G1.0911.00
14_H93_A1.0911.00
62_K117_H1.0881.00
354_D357_A1.0861.00
20_G129_G1.0811.00
153_L365_M1.0781.00
196_E277_C1.0721.00
87_H90_N1.0691.00
12_D33_V1.0671.00
178_L261_K1.0651.00
89_G356_N1.0551.00
206_V245_L1.0551.00
25_K29_Y1.0541.00
90_N354_D1.0481.00
157_P346_L1.0471.00
31_L45_E1.0471.00
98_L155_I1.0441.00
76_E88_H1.0351.00
204_T211_T1.0261.00
39_Q53_V1.0161.00
37_Y111_V1.0151.00
30_L100_M1.0151.00
107_I121_F1.0141.00
43_E54_K1.0121.00
11_R86_E1.0101.00
265_E281_V1.0101.00
50_G125_P1.0071.00
134_E326_Y1.0041.00
27_Q51_L0.9971.00
63_M148_D0.9971.00
235_A238_I0.9931.00
269_K272_E0.9901.00
200_V206_V0.9901.00
263_R267_V0.9881.00
363_H367_G0.9871.00
366_T370_S0.9831.00
336_F340_A0.9791.00
57_G118_D0.9781.00
81_L84_A0.9771.00
302_S305_A0.9741.00
106_I366_T0.9711.00
55_V115_V0.9711.00
202_A206_V0.9711.00
206_V227_V0.9681.00
98_L358_I0.9671.00
6_L358_I0.9611.00
11_R355_E0.9611.00
64_L149_F0.9601.00
267_V271_I0.9551.00
204_T208_Q0.9491.00
303_F306_E0.9471.00
149_F296_L0.9451.00
70_I123_F0.9411.00
13_L29_Y0.9401.00
209_L264_I0.9391.00
17_P22_Q0.9381.00
40_D54_K0.9371.00
180_I268_V0.9361.00
68_A98_L0.9361.00
305_A310_A0.9361.00
362_V366_T0.9351.00
42_I45_E0.9341.00
261_K285_S0.9311.00
27_Q31_L0.9301.00
230_I243_A0.9281.00
353_P358_I0.9241.00
236_Q246_E0.9221.00
108_D111_V0.9221.00
208_Q271_I0.9211.00
21_F126_A0.9211.00
179_V236_Q0.9171.00
338_L341_D0.9171.00
6_L101_T0.9161.00
357_A360_T0.9141.00
9_I108_D0.9121.00
107_I111_V0.9121.00
299_E368_Y0.9091.00
270_G273_I0.9071.00
270_G274_G0.9061.00
34_L104_L0.9031.00
297_T334_F0.9001.00
302_S306_E0.8941.00
299_E302_S0.8831.00
297_T301_M0.8831.00
300_F334_F0.8811.00
174_N251_T0.8811.00
120_L147_P0.8781.00
308_Q311_T0.8761.00
271_I274_G0.8761.00
43_E144_K0.8741.00
180_I205_L0.8731.00
200_V203_S0.8651.00
168_S298_E0.8651.00
340_A353_P0.8621.00
109_H363_H0.8611.00
143_K330_K0.8581.00
52_F120_L0.8581.00
176_S261_K0.8531.00
344_H350_K0.8531.00
183_E241_E0.8481.00
144_K147_P0.8451.00
293_T296_L0.8421.00
40_D43_E0.8391.00
199_V243_A0.8391.00
345_G348_H0.8361.00
39_Q107_I0.8351.00
106_I365_M0.8311.00
204_T210_Q0.8301.00
82_P87_H0.8291.00
251_T257_M0.8291.00
42_I53_V0.8291.00
103_A121_F0.8281.00
206_V230_I0.8241.00
295_G298_E0.8211.00
258_K261_K0.8201.00
150_I331_Y0.8181.00
214_S217_T0.8181.00
26_T70_I0.8151.00
207_T210_Q0.8151.00
109_H362_V0.8151.00
18_E99_H0.8081.00
254_E258_K0.8071.00
68_A100_M0.8061.00
285_S288_H0.8051.00
33_V104_L0.8001.00
12_D32_N0.7981.00
57_G60_P0.7981.00
231_T234_S0.7961.00
295_G299_E0.7931.00
266_D273_I0.7921.00
162_G167_K0.7871.00
55_V107_I0.7851.00
21_F129_G0.7841.00
89_G354_D0.7831.00
209_L225_I0.7821.00
200_V211_T0.7801.00
102_I106_I0.7791.00
151_T368_Y0.7791.00
152_A335_M0.7771.00
177_E248_T0.7761.00
326_Y330_K0.7761.00
109_H112_H0.7741.00
358_I362_V0.7721.00
140_D143_K0.7691.00
117_H148_D0.7681.00
324_F333_G0.7671.00
37_Y104_L0.7661.00
255_E259_Q0.7661.00
227_V245_L0.7631.00
27_Q49_T0.7621.00
9_I101_T0.7611.00
102_I362_V0.7601.00
9_I12_D0.7581.00
178_L264_I0.7581.00
162_G314_E0.7541.00
356_N359_E0.7541.00
340_A357_A0.7521.00
196_E276_R0.7521.00
70_I100_M0.7511.00
133_A137_L0.7501.00
300_F336_F0.7491.00
185_K348_H0.7461.00
46_K49_T0.7441.00
10_R91_M0.7431.00
163_T314_E0.7421.00
225_I249_I0.7371.00
164_I167_K0.7361.00
217_T223_A0.7321.00
168_S294_S0.7321.00
326_Y329_K0.7301.00
182_L245_L0.7291.00
66_Y106_I0.7261.00
64_L369_F0.7201.00
63_M117_H0.7201.00
271_I275_F0.7191.00
7_I86_E0.7181.00
249_I260_V0.7181.00
257_M261_K0.7171.00
30_L123_F0.7111.00
304_V307_H0.7051.00
13_L100_M0.7051.00
193_H196_E0.7031.00
167_K317_E0.7031.00
106_I362_V0.7011.00
101_T105_G0.7011.00
58_T114_P0.7011.00
60_P118_D0.7001.00
162_G168_S0.7001.00
179_V284_P0.6991.00
151_T296_L0.6991.00
43_E52_F0.6981.00
229_T244_H0.6961.00
105_G109_H0.6931.00
187_G239_I0.6931.00
344_H348_H0.6931.00
102_I365_M0.6881.00
205_L245_L0.6851.00
364_V368_Y0.6811.00
165_A168_S0.6791.00
336_F364_V0.6781.00
66_Y151_T0.6751.00
177_E236_Q0.6721.00
300_F364_V0.6711.00
39_Q111_V0.6701.00
303_F368_Y0.6691.00
19_L74_S0.6691.00
79_T84_A0.6661.00
9_I13_L0.6661.00
105_G362_V0.6651.00
30_L51_L0.6641.00
51_L123_F0.6631.00
19_L22_Q0.6621.00
217_T220_L0.6611.00
201_A275_F0.6601.00
82_P85_S0.6601.00
126_A129_G0.6601.00
231_T246_E0.6591.00
322_E335_M0.6581.00
36_Q108_D0.6571.00
11_R14_H0.6521.00
283_Y286_V0.6491.00
100_M103_A0.6481.00
286_V289_Q0.6471.00
43_E46_K0.6471.00
67_R122_L0.6431.00
231_T242_T0.6371.00
180_I281_V0.6361.00
258_K285_S0.6351.00
204_T271_I0.6351.00
310_A313_I0.6271.00
92_H352_N0.6271.00
254_E329_K0.6261.00
30_L104_L0.6261.00
55_V121_F0.6261.00
182_L198_M0.6251.00
334_F337_W0.6251.00
7_I359_E0.6241.00
56_N60_P0.6221.00
106_I110_F0.6221.00
142_L331_Y0.6211.00
355_E359_E0.6211.00
87_H92_H0.6181.00
34_L39_Q0.6181.00
100_M123_F0.6151.00
39_Q121_F0.6141.00
197_D240_A0.6121.00
296_L334_F0.6121.00
91_M94_C0.6111.00
81_L85_S0.6111.00
48_R135_P0.6081.00
156_A337_W0.6081.00
200_V204_T0.6081.00
77_E80_G0.6081.00
200_V207_T0.6031.00
72_A94_C0.6021.00
363_H366_T0.6021.00
101_T104_L0.6021.00
338_L361_A0.6001.00
126_A131_G0.5991.00
81_L352_N0.5901.00
189_A226_T0.5901.00
102_I153_L0.5891.00
189_A228_G0.5881.00
103_A153_L0.5881.00
16_I26_T0.5871.00
303_F364_V0.5871.00
42_I51_L0.5861.00
150_I333_G0.5851.00
233_G242_T0.5841.00
272_E277_C0.5821.00
61_E118_D0.5821.00
152_A324_F0.5801.00
337_W340_A0.5771.00
150_I327_M0.5761.00
293_T298_E0.5751.00
7_I355_E0.5741.00
162_G165_A0.5741.00
218_D221_D0.5741.00
91_M355_E0.5731.00
25_K32_N0.5711.00
210_Q275_F0.5711.00
251_T260_V0.5711.00
120_L144_K0.5711.00
136_M141_V0.5701.00
180_I247_G0.5691.00
359_E362_V0.5691.00
173_A224_V0.5681.00
61_E117_H0.5681.00
138_E330_K0.5671.00
9_I104_L0.5671.00
164_I168_S0.5671.00
122_L136_M0.5661.00
291_Y294_S0.5651.00
205_L271_I0.5651.00
133_A136_M0.5621.00
205_L267_V0.5581.00
19_L90_N0.5571.00
182_L277_C0.5561.00
79_T83_F0.5551.00
132_G139_S0.5541.00
54_K63_M0.5541.00
272_E278_K0.5541.00
11_R91_M0.5541.00
307_H364_V0.5541.00
308_Q364_V0.5541.00
336_F339_G0.5541.00
178_L283_Y0.5531.00
203_S210_Q0.5521.00
193_H218_D0.5521.00
201_A204_T0.5521.00
10_R101_T0.5491.00
345_G352_N0.5481.00
180_I279_G0.5481.00
102_I105_G0.5451.00
198_M240_A0.5451.00
137_L330_K0.5451.00
128_E347_H0.5451.00
43_E141_V0.5441.00
331_Y334_F0.5431.00
50_G136_M0.5411.00
247_G264_I0.5401.00
178_L281_V0.5371.00
75_I93_A0.5361.00
304_V309_L0.5361.00
13_L101_T0.5351.00
296_L299_E0.5351.00
262_E269_K0.5351.00
100_M104_L0.5351.00
131_G135_P0.5341.00
58_T61_E0.5331.00
209_L227_V0.5331.00
38_P42_I0.5321.00
9_I37_Y0.5301.00
35_E40_D0.5301.00
27_Q45_E0.5301.00
174_N289_Q0.5291.00
268_V281_V0.5261.00
58_T118_D0.5251.00
59_A118_D0.5241.00
47_W139_S0.5221.00
254_E288_H0.5211.00
201_A271_I0.5191.00
265_E283_Y0.5161.00
62_K149_F0.5141.00
219_P222_S0.5141.00
304_V313_I0.5141.00
198_M239_I0.5141.00
338_L353_P0.5131.00
162_G166_T0.5131.00
177_E246_E0.5121.00
23_E27_Q0.5121.00
199_V203_S0.5111.00
221_D256_S0.5101.00
217_T221_D0.5091.00
180_I264_I0.5081.00
16_I87_H0.5081.00
13_L30_L0.5071.00
122_L327_M0.5071.00
153_L338_L0.5061.00
249_I264_I0.5061.00
175_T248_T0.5051.00
182_L268_V0.5041.00
52_F122_L0.5041.00
304_V308_Q0.5031.00
132_G136_M0.5021.00
214_S218_D0.5021.00
24_F27_Q0.5021.00
345_G350_K0.5001.00
255_E258_K0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ewtA 4 0.9813 100 0.232 Contact Map
1ysjA 2 0.9385 100 0.239 Contact Map
3io1A 4 0.9011 100 0.24 Contact Map
1xmbA 1 0.9385 100 0.244 Contact Map
3pfoA 2 0.9519 100 0.251 Contact Map
4pqaA 2 0.9572 100 0.269 Contact Map
3iszA 2 0.9465 100 0.279 Contact Map
3gb0A 2 0.9358 100 0.291 Contact Map
3rzaA 2 0.9305 100 0.292 Contact Map
3tx8A 2 0.9278 100 0.293 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0116 seconds.