GREMLIN Database
YOBE - Putative SOS response-associated peptidase YobE
UniProt: O34915 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 219 (202)
Sequences: 3459 (2504)
Seq/√Len: 176.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
101_A130_F4.3461.00
41_I148_C4.2521.00
82_L151_I4.1431.00
43_T56_L3.9851.00
133_L149_T3.9571.00
18_F129_A3.3951.00
98_I175_K3.3911.00
103_S119_R2.8191.00
116_I205_Q2.7111.00
171_T174_N2.6881.00
97_C132_G2.4931.00
79_A151_I2.4561.00
130_F150_I2.3911.00
91_P135_E2.3891.00
45_I54_G2.2221.00
121_K202_E2.1931.00
121_K204_Y2.1241.00
86_P89_R2.0581.00
136_K146_Y1.9541.00
120_I162_I1.9201.00
76_N163_H1.8451.00
106_E163_H1.8291.00
51_N176_K1.8081.00
83_A92_L1.7821.00
98_I129_A1.7721.00
74_M87_S1.7671.00
95_K135_E1.7371.00
104_F159_M1.6881.00
156_S166_M1.6661.00
5_F41_I1.6601.00
77_A149_T1.6461.00
17_Q175_K1.6241.00
129_A175_K1.6191.00
99_I148_C1.5971.00
174_N177_E1.5931.00
10_E13_D1.5891.00
6_T119_R1.5721.00
120_I159_M1.5721.00
61_I145_L1.5611.00
99_I150_I1.5421.00
157_E160_E1.5181.00
110_L114_T1.5181.00
79_A193_L1.5171.00
35_V41_I1.4831.00
32_S39_Q1.4831.00
82_L92_L1.4691.00
9_S102_D1.4671.00
7_L35_V1.4601.00
43_T148_C1.4521.00
196_Y201_M1.4481.00
12_D16_E1.4241.00
83_A190_Q1.3591.00
34_N117_P1.3571.00
122_L126_N1.3541.00
128_F201_M1.3381.00
136_K144_L1.3081.00
5_F101_A1.2991.00
114_T208_S1.2871.00
122_L128_F1.2721.00
108_K118_M1.2631.00
169_I201_M1.2591.00
138_N144_L1.2491.00
153_I195_P1.2331.00
81_T85_K1.2301.00
45_I52_R1.2301.00
99_I132_G1.2121.00
98_I170_L1.2011.00
153_I168_V1.1981.00
119_R204_Y1.1921.00
107_W115_K1.1871.00
158_L199_D1.1681.00
43_T97_C1.1581.00
170_L174_N1.1431.00
118_M205_Q1.1291.00
45_I134_Y1.1151.00
158_L201_M1.1121.00
137_W140_L1.1081.00
131_A168_V1.1071.00
120_I203_A1.0911.00
123_K202_E1.0911.00
80_E165_R1.0911.00
11_F15_I1.0881.00
32_S35_V1.0871.00
95_K134_Y1.0811.00
20_I53_L1.0741.00
81_T88_F1.0691.00
90_K94_S1.0631.00
172_D175_K1.0621.00
128_F175_K1.0471.00
76_N106_E1.0471.00
91_P95_K1.0451.00
90_K93_G1.0441.00
9_S127_L1.0390.99
21_D50_N1.0210.99
198_A201_M1.0090.99
43_T99_I1.0080.99
180_N183_N1.0050.99
3_G75_I0.9980.99
153_I156_S0.9910.99
61_I147_T0.9910.99
47_D50_N0.9900.99
154_K164_D0.9870.99
56_L146_Y0.9720.99
42_L53_L0.9590.99
158_L203_A0.9540.99
153_I166_M0.9530.99
192_L195_P0.9510.99
97_C134_Y0.9510.99
177_E191_S0.9450.99
41_I99_I0.9340.99
157_E161_D0.9290.99
110_L113_K0.9270.99
65_A70_I0.9270.99
38_S72_Y0.9270.99
36_A39_Q0.9090.99
60_L147_T0.9070.99
4_K107_W0.9070.99
5_F42_L0.9010.99
177_E180_N0.8980.99
4_K34_N0.8960.99
61_I74_M0.8960.99
70_I73_K0.8940.98
109_R115_K0.8930.98
108_K115_K0.8930.98
139_T143_N0.8910.98
38_S57_R0.8850.98
122_L171_T0.8850.98
104_F156_S0.8750.98
60_L135_E0.8730.98
67_D71_G0.8720.98
44_I51_N0.8700.98
188_Y191_S0.8660.98
59_G75_I0.8590.98
138_N143_N0.8580.98
107_W117_P0.8570.98
34_N107_W0.8550.98
8_F102_D0.8540.98
158_L161_D0.8420.98
111_D114_T0.8380.98
177_E188_Y0.8340.98
54_G146_Y0.8260.97
110_L116_I0.8260.97
74_M88_F0.8260.97
122_L201_M0.8190.97
150_I167_P0.8120.97
62_P65_A0.8100.97
132_G149_T0.8080.97
104_F161_D0.7960.97
174_N194_L0.7920.97
109_R114_T0.7860.97
151_I168_V0.7840.97
82_L133_L0.7840.97
122_L200_D0.7830.96
2_C76_N0.7800.96
58_W167_P0.7800.96
85_K88_F0.7770.96
61_I67_D0.7760.96
139_T144_L0.7720.96
156_S161_D0.7690.96
58_W96_R0.7620.96
155_P164_D0.7620.96
36_A107_W0.7590.96
92_L189_L0.7580.96
171_T200_D0.7520.96
33_Y117_P0.7440.95
187_D191_S0.7420.95
77_A88_F0.7390.95
94_S135_E0.7390.95
128_F169_I0.7350.95
5_F35_V0.7290.95
3_G37_P0.7250.95
67_D73_K0.7240.95
42_L55_K0.7170.94
138_N142_G0.7160.94
71_G74_M0.7140.94
79_A153_I0.7110.94
121_K125_S0.7100.94
17_Q126_N0.7040.94
2_C163_H0.6990.94
7_L42_L0.6950.93
78_R106_E0.6900.93
63_P135_E0.6900.93
176_K180_N0.6890.93
155_P160_E0.6890.93
196_Y200_D0.6880.93
36_A117_P0.6870.93
137_W145_L0.6840.93
9_S12_D0.6820.93
90_K135_E0.6820.93
81_T84_E0.6790.93
33_Y36_A0.6720.92
5_F36_A0.6720.92
18_F175_K0.6720.92
89_R93_G0.6690.92
174_N192_L0.6670.92
122_L127_L0.6660.92
67_D70_I0.6650.92
132_G150_I0.6650.92
181_P189_L0.6630.92
101_A150_I0.6620.92
9_S13_D0.6570.91
6_T103_S0.6540.91
59_G71_G0.6530.91
34_N103_S0.6510.91
104_F169_I0.6490.91
60_L87_S0.6470.91
40_N55_K0.6460.91
46_N51_N0.6460.91
70_I74_M0.6440.90
5_F99_I0.6430.90
45_I146_Y0.6420.90
103_S121_K0.6400.90
5_F148_C0.6390.90
3_G107_W0.6390.90
19_N176_K0.6340.90
154_K157_E0.6340.90
13_D16_E0.6330.90
106_E165_R0.6320.90
108_K116_I0.6300.89
108_K161_D0.6300.89
37_P75_I0.6270.89
57_R145_L0.6270.89
162_I203_A0.6230.89
151_I193_L0.6230.89
114_T199_D0.6230.89
15_I20_I0.6070.88
189_L193_L0.6060.88
130_F167_P0.6030.87
189_L192_L0.6020.87
22_Q25_P0.6010.87
126_N172_D0.5980.87
5_F100_P0.5980.87
60_L91_P0.5960.87
60_L74_M0.5950.87
183_N188_Y0.5950.87
108_K111_D0.5940.87
156_S198_A0.5930.86
159_M162_I0.5930.86
205_Q208_S0.5910.86
46_N49_S0.5870.86
118_M162_I0.5860.86
12_D21_D0.5860.86
65_A71_G0.5840.86
17_Q172_D0.5830.86
162_I166_M0.5800.85
80_E154_K0.5800.85
61_I64_C0.5790.85
169_I195_P0.5790.85
57_R68_E0.5780.85
104_F158_L0.5760.85
25_P28_E0.5750.85
110_L118_M0.5740.85
2_C106_E0.5730.85
78_R163_H0.5700.84
28_E55_K0.5690.84
63_P90_K0.5680.84
122_L125_S0.5670.84
11_F28_E0.5660.84
22_Q52_R0.5650.84
105_Y117_P0.5630.84
75_I149_T0.5620.83
41_I58_W0.5620.83
68_E145_L0.5600.83
69_K72_Y0.5590.83
155_P158_L0.5580.83
168_V195_P0.5560.83
61_I137_W0.5520.82
44_I100_P0.5490.82
119_R128_F0.5480.82
105_Y165_R0.5470.82
56_L148_C0.5460.82
109_R164_D0.5460.82
98_I128_F0.5440.81
100_P129_A0.5440.81
91_P133_L0.5390.81
4_K37_P0.5380.81
74_M149_T0.5340.80
102_D119_R0.5330.80
14_I18_F0.5320.80
60_L72_Y0.5320.80
8_F12_D0.5280.79
12_D15_I0.5280.79
137_W147_T0.5260.79
20_I51_N0.5250.79
22_Q50_N0.5250.79
49_S98_I0.5220.79
80_E151_I0.5210.79
158_L200_D0.5190.78
38_S75_I0.5160.78
100_P132_G0.5140.78
43_T132_G0.5140.78
62_P66_K0.5130.78
156_S159_M0.5130.78
197_D200_D0.5130.78
102_D127_L0.5110.77
168_V193_L0.5110.77
7_L14_I0.5100.77
123_K199_D0.5100.77
56_L134_Y0.5080.77
65_A72_Y0.5070.77
83_A93_G0.5040.76
156_S195_P0.5020.76
77_A82_L0.5000.76
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2icuA 1 0.9224 100 0.073 Contact Map
2bdvA 1 0.9452 100 0.075 Contact Map
2f20A 1 0.9726 100 0.085 Contact Map
2aegA 1 0.9269 100 0.117 Contact Map
1zn6A 1 0.9041 100 0.12 Contact Map
2gs0B 1 0.0639 17.9 0.955 Contact Map
2b3gB 2 0.1096 8 0.961 Contact Map
2jd3A 2 0.3927 7.7 0.962 Contact Map
3bsuA 1 0.2237 6.4 0.963 Contact Map
2iiiA 2 0.1781 4.1 0.967 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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