GREMLIN Database
YKOX - Uncharacterized membrane protein YkoX
UniProt: O34908 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 221 (189)
Sequences: 6593 (4677)
Seq/√Len: 340.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
77_L144_V3.4521.00
60_T63_G3.1191.00
199_L203_K2.9181.00
69_S156_L2.9171.00
197_L201_M2.6531.00
200_L204_R2.5361.00
115_H118_F2.5091.00
54_V167_V2.4391.00
73_V152_F2.4321.00
65_V160_F2.4041.00
121_F153_I2.3811.00
117_G146_V2.3481.00
37_S78_T2.2781.00
77_L148_S2.2681.00
143_N146_V2.2161.00
101_K104_A2.1511.00
185_L189_I2.0781.00
67_A71_G2.0481.00
109_D113_K1.9661.00
68_G159_T1.9241.00
61_L164_Y1.8991.00
24_F28_S1.8651.00
65_V163_V1.8391.00
29_Y60_T1.8141.00
84_R141_K1.7721.00
117_G150_Y1.7601.00
164_Y168_K1.7541.00
88_R109_D1.6701.00
61_L65_V1.6651.00
47_L163_V1.6521.00
36_L71_G1.6381.00
61_L163_V1.6311.00
37_S74_A1.5971.00
33_F67_A1.5811.00
50_A64_V1.5801.00
39_E43_A1.5631.00
144_V148_S1.5561.00
32_I68_G1.5461.00
33_F71_G1.5411.00
81_W85_Y1.5291.00
102_P106_D1.5271.00
106_D110_N1.5241.00
198_Y202_K1.5051.00
29_Y63_G1.5001.00
203_K206_K1.4431.00
64_V163_V1.4361.00
118_F122_S1.4331.00
33_F70_L1.4291.00
182_Q186_P1.4001.00
92_E102_P1.4001.00
186_P190_A1.3761.00
177_G181_D1.3581.00
123_G133_I1.3501.00
103_E107_K1.3471.00
27_L31_G1.3421.00
125_F157_P1.3351.00
81_W144_V1.3071.00
73_V155_M1.3001.00
179_I182_Q1.2861.00
198_Y201_M1.2721.00
63_G67_A1.2691.00
29_Y67_A1.2631.00
76_P124_R1.2521.00
54_V61_L1.2491.00
145_W149_L1.2461.00
203_K207_R1.2191.00
18_M22_E1.1781.00
22_E25_K1.1751.00
83_G139_I1.1741.00
62_A164_Y1.1651.00
120_A142_M1.1611.00
196_L200_L1.1601.00
194_L198_Y1.1581.00
200_L203_K1.1561.00
85_Y89_P1.1521.00
66_L70_L1.1511.00
79_L135_I1.1421.00
47_L68_G1.1201.00
62_A66_L1.1131.00
59_M64_V1.1121.00
184_M188_G1.1081.00
55_S167_V1.0931.00
109_D140_A1.0891.00
112_F137_C1.0841.00
204_R207_R1.0831.00
191_I194_L1.0781.00
73_V148_S1.0771.00
183_Y186_P1.0671.00
51_G166_G1.0661.00
65_V164_Y1.0621.00
27_L30_F1.0431.00
181_D185_L1.0341.00
174_K178_S1.0311.00
188_G192_L1.0261.00
47_L51_G1.0251.00
201_M205_K1.0241.00
91_L105_L1.0191.00
44_E130_R1.0011.00
29_Y59_M0.9991.00
69_S159_T0.9991.00
69_S73_V0.9961.00
88_R92_E0.9951.00
180_L183_Y0.9941.00
32_I64_V0.9931.00
22_E26_S0.9831.00
106_D109_D0.9671.00
195_F198_Y0.9531.00
95_G98_L0.9521.00
89_P93_R0.9501.00
151_T155_M0.9471.00
121_F157_P0.9451.00
110_N114_K0.9331.00
70_L74_A0.9311.00
72_G155_M0.9271.00
77_L81_W0.9261.00
145_W148_S0.9181.00
28_S31_G0.9171.00
65_V69_S0.9121.00
134_S151_T0.9101.00
202_K205_K0.9081.00
157_P160_F0.9051.00
95_G100_I0.9031.00
91_L100_I0.8981.00
81_W84_R0.8961.00
68_G163_V0.8911.00
149_L153_I0.8871.00
51_G163_V0.8861.00
94_F97_Y0.8851.00
76_P151_T0.8851.00
62_A65_V0.8841.00
26_S30_F0.8831.00
33_F74_A0.8821.00
175_A178_S0.8811.00
130_R158_I0.8801.00
104_A107_K0.8771.00
90_F94_F0.8731.00
108_S140_A0.8721.00
66_L69_S0.8631.00
55_S171_E0.8611.00
195_F199_L0.8601.00
175_A179_I0.8571.00
63_G66_L0.8501.00
201_M204_R0.8491.00
111_F119_V0.8471.00
160_F164_Y0.8371.00
116_G142_M0.8321.00
36_L159_T0.8301.00
18_M21_I0.8201.00
86_G89_P0.8181.00
52_Y55_S0.8091.00
73_V151_T0.8061.00
119_V122_S0.8051.00
72_G124_R0.7951.00
82_I86_G0.7941.00
148_S152_F0.7931.00
52_Y173_W0.7861.00
193_A197_L0.7861.00
161_V164_Y0.7791.00
174_K177_G0.7781.00
24_F31_G0.7771.00
19_S22_E0.7771.00
51_G64_V0.7761.00
149_L152_F0.7751.00
25_K28_S0.7741.00
40_F124_R0.7641.00
169_L172_N0.7621.00
54_V64_V0.7551.00
165_L168_K0.7491.00
77_L151_T0.7491.00
43_A127_P0.7430.99
49_L180_L0.7400.99
190_A194_L0.7330.99
118_F150_Y0.7320.99
187_I191_I0.7310.99
90_F93_R0.7300.99
169_L173_W0.7240.99
197_L200_L0.7230.99
94_F102_P0.7190.99
76_P144_V0.7170.99
24_F27_L0.7140.99
177_G180_L0.7130.99
176_V179_I0.7100.99
41_I131_T0.7070.99
188_G191_I0.7050.99
43_A151_T0.7050.99
87_G91_L0.7030.99
126_L129_I0.7020.99
23_A28_S0.6980.99
19_S23_A0.6970.99
80_Y144_V0.6920.99
94_F98_L0.6920.99
54_V163_V0.6910.99
32_I50_A0.6890.99
97_Y100_I0.6890.99
172_N175_A0.6860.99
156_L160_F0.6840.99
185_L188_G0.6820.99
79_L131_T0.6820.99
49_L53_W0.6810.99
124_R130_R0.6750.99
202_K206_K0.6750.99
49_L52_Y0.6660.99
192_L196_L0.6660.99
119_V133_I0.6600.99
95_G102_P0.6510.99
21_I53_W0.6510.99
88_R91_L0.6460.99
86_G90_F0.6450.99
109_D141_K0.6440.99
89_P92_E0.6430.99
110_N113_K0.6430.99
94_F100_I0.6410.99
159_T163_V0.6360.98
80_Y138_G0.6270.98
137_C142_M0.6220.98
47_L159_T0.6200.98
167_V171_E0.6180.98
44_E162_Y0.6070.98
36_L68_G0.6070.98
135_I139_I0.6060.98
32_I67_A0.6060.98
107_K110_N0.6050.98
152_F156_L0.6050.98
131_T162_Y0.5960.98
161_V165_L0.5960.98
127_P131_T0.5960.98
105_L112_F0.5940.98
35_A46_V0.5850.97
47_L72_G0.5830.97
178_S182_Q0.5800.97
138_G141_K0.5790.97
112_F119_V0.5730.97
199_L202_K0.5730.97
40_F76_P0.5690.97
80_Y141_K0.5630.97
168_K172_N0.5630.97
147_F151_T0.5630.97
146_V150_Y0.5630.97
48_P52_Y0.5620.97
44_E154_A0.5570.96
23_A27_L0.5540.96
78_T81_W0.5520.96
123_G137_C0.5520.96
198_Y205_K0.5480.96
98_L105_L0.5470.96
118_F136_P0.5460.96
20_W28_S0.5450.96
39_E124_R0.5440.96
193_A200_L0.5400.96
123_G127_P0.5370.96
39_E131_T0.5340.95
35_A41_I0.5330.95
185_L199_L0.5310.95
21_I28_S0.5310.95
36_L154_A0.5280.95
157_P161_V0.5280.95
103_E106_D0.5250.95
111_F115_H0.5250.95
44_E124_R0.5250.95
79_L127_P0.5220.95
182_Q194_L0.5220.95
78_T82_I0.5210.95
179_I183_Y0.5170.95
21_I25_K0.5160.95
130_R155_M0.5160.95
28_S59_M0.5160.95
39_E151_T0.5160.95
23_A31_G0.5160.95
94_F101_K0.5150.95
40_F131_T0.5150.95
72_G131_T0.5140.94
50_A163_V0.5130.94
194_L197_L0.5130.94
119_V154_A0.5110.94
191_I195_F0.5110.94
104_A108_S0.5090.94
120_A137_C0.5070.94
51_G57_G0.5050.94
90_F97_Y0.5040.94
189_I192_L0.5030.94
40_F134_S0.5030.94
74_A78_T0.5010.94
72_G123_G0.5000.94
61_L160_F0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1pw4A 1 0.9367 37.1 0.933 Contact Map
4dx5A 3 0.8009 36.4 0.933 Contact Map
2m20A 2 0.2081 31.6 0.935 Contact Map
2kluA 1 0.2308 30.7 0.935 Contact Map
2cfqA 1 0.8643 27.9 0.937 Contact Map
4ldsA 2 0.8552 27.3 0.937 Contact Map
2l2tA 2 0.1855 27.2 0.937 Contact Map
2rddB 1 0.1674 25.5 0.938 Contact Map
2ks1B 1 0.1991 23.7 0.939 Contact Map
2jwaA 2 0.1991 22.8 0.939 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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