GREMLIN Database
YOAM - Putative SOS response-associated peptidase YoaM
UniProt: O34906 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 227 (206)
Sequences: 3368 (2404)
Seq/√Len: 167.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
101_A130_F4.2681.00
82_I151_I4.2251.00
41_I148_C4.2031.00
43_A56_L3.9401.00
133_L149_T3.8021.00
98_I175_E3.4711.00
18_F129_A3.4341.00
103_S119_R2.7581.00
171_A174_H2.6611.00
116_I205_Q2.6191.00
97_C132_G2.3931.00
91_P135_E2.3791.00
79_A151_I2.3731.00
45_I54_G2.3201.00
121_K202_E2.1921.00
130_F150_I2.1711.00
121_K204_Y2.1551.00
86_P89_R2.0231.00
136_K146_Y1.9931.00
98_I129_A1.9161.00
120_I162_I1.9051.00
76_N163_H1.8801.00
83_T92_L1.8731.00
51_N176_K1.8271.00
106_E163_H1.8241.00
17_Q175_E1.7911.00
95_K135_E1.7421.00
74_M87_A1.6751.00
156_N166_M1.6511.00
104_F159_M1.6471.00
99_I148_C1.6431.00
129_A175_E1.6401.00
35_V41_I1.6271.00
157_E160_K1.6141.00
77_A149_T1.6101.00
5_F41_I1.6011.00
207_S211_N1.5851.00
174_H177_E1.5831.00
10_A13_D1.5711.00
61_I145_L1.5551.00
32_S39_Q1.5531.00
110_L114_T1.5531.00
196_Y201_M1.5431.00
9_S102_D1.5381.00
120_I159_M1.5361.00
6_T119_R1.5141.00
82_I92_L1.4841.00
12_D16_D1.4811.00
43_A148_C1.4811.00
99_I150_I1.4671.00
128_F201_M1.4011.00
79_A193_L1.3921.00
7_L35_V1.3921.00
122_L126_A1.3821.00
83_T190_Q1.3601.00
136_K144_P1.3521.00
34_N117_P1.3271.00
81_T85_K1.3251.00
169_I201_M1.3081.00
153_T195_P1.2921.00
5_F101_A1.2721.00
45_I52_R1.2721.00
114_T208_S1.2711.00
32_S35_V1.2671.00
138_S144_P1.2491.00
20_I53_L1.2271.00
158_F199_D1.2111.00
172_H175_E1.2101.00
208_S211_N1.1951.00
108_K118_M1.1931.00
43_A97_C1.1831.00
118_M205_Q1.1721.00
107_W115_K1.1691.00
122_L128_F1.1641.00
119_R204_Y1.1521.00
90_R93_V1.1511.00
120_I203_A1.1361.00
3_G75_I1.1301.00
45_I134_Y1.1271.00
95_K134_Y1.1251.00
21_D50_N1.0991.00
131_A168_V1.0921.00
76_N106_E1.0861.00
170_L174_H1.0811.00
80_E165_R1.0771.00
153_T168_V1.0761.00
140_H143_Y1.0751.00
158_F201_M1.0731.00
99_I132_G1.0711.00
43_A99_I1.0620.99
47_D50_N1.0550.99
9_S127_L1.0540.99
42_L53_L1.0430.99
91_P95_K1.0320.99
128_F175_E1.0310.99
11_F15_I1.0310.99
139_T143_Y1.0270.99
65_A70_I1.0230.99
123_K202_E1.0030.99
56_L146_Y1.0020.99
198_A201_M0.9960.99
98_I170_L0.9910.99
192_L195_P0.9890.99
153_T156_N0.9860.99
8_Y102_D0.9770.99
158_F203_A0.9760.99
180_N183_N0.9710.99
70_I73_K0.9580.99
81_T88_F0.9490.99
41_I99_I0.9490.99
157_E161_D0.9470.99
153_T166_M0.9450.99
111_D114_T0.9420.99
154_E164_D0.9380.99
38_S72_Y0.9370.99
177_E191_S0.9320.99
122_L171_A0.9280.99
4_R34_N0.9260.99
44_I51_N0.9160.98
110_L113_K0.9120.98
61_I74_M0.9110.98
54_G146_Y0.9110.98
108_K115_K0.9090.98
177_E188_Y0.9090.98
109_R115_K0.9070.98
97_C134_Y0.8960.98
60_L147_T0.8890.98
132_G149_T0.8810.98
2_C76_N0.8720.98
158_F161_D0.8700.98
38_S57_R0.8700.98
207_S210_V0.8640.98
85_K88_F0.8550.98
61_I147_T0.8470.97
104_F156_N0.8440.97
90_R94_S0.8360.97
59_G75_I0.8350.97
34_N107_W0.8340.97
110_L116_I0.8310.97
74_M88_F0.8310.97
4_R107_W0.8300.97
60_L135_E0.8280.97
150_I167_P0.8270.97
138_S143_Y0.8270.97
67_D71_G0.8260.97
122_L201_M0.8200.97
36_A39_Q0.8200.97
36_A210_V0.8120.97
177_E180_N0.8100.97
188_Y191_S0.7940.96
107_W117_P0.7920.96
82_I133_L0.7900.96
5_F42_L0.7900.96
121_K125_S0.7880.96
122_L200_D0.7840.96
77_A88_F0.7820.96
137_W140_H0.7800.96
171_A200_D0.7740.96
109_R114_T0.7730.96
104_F161_D0.7720.96
2_C163_H0.7680.95
63_P135_E0.7650.95
139_T144_P0.7640.95
63_P90_R0.7610.95
45_I146_Y0.7570.95
67_D73_K0.7550.95
174_H194_L0.7550.95
89_R93_V0.7510.95
58_W96_R0.7500.95
79_A153_T0.7500.95
46_N51_N0.7490.95
15_I22_Q0.7440.95
90_R135_E0.7300.94
7_L42_L0.7290.94
58_W167_P0.7210.94
33_Y210_V0.7200.94
156_N161_D0.7170.94
151_I168_V0.7160.93
169_I195_P0.7140.93
40_N55_K0.7090.93
137_W145_L0.7080.93
61_I67_D0.7060.93
18_F175_E0.7040.93
155_P160_K0.7030.93
92_L189_L0.7030.93
206_V210_V0.7020.93
36_A107_W0.7000.93
155_P164_D0.7000.93
5_F100_P0.6970.93
3_G37_P0.6970.93
176_K180_N0.6960.92
183_N188_Y0.6940.92
17_Q126_A0.6940.92
101_A150_I0.6910.92
5_F35_V0.6880.92
168_V195_P0.6880.92
42_L55_K0.6830.92
128_F169_I0.6810.92
138_S142_G0.6810.92
78_R106_E0.6810.92
60_L74_M0.6760.91
71_G74_M0.6740.91
6_T103_S0.6700.91
81_T84_E0.6620.90
15_I20_I0.6620.90
154_E157_E0.6620.90
174_H192_L0.6600.90
106_E165_R0.6550.90
44_I100_P0.6550.90
56_L148_C0.6540.90
67_D70_I0.6540.90
155_P158_F0.6520.90
5_F99_I0.6520.90
104_F169_I0.6500.90
187_D191_S0.6470.89
2_C106_E0.6460.89
118_M162_I0.6450.89
13_D16_D0.6410.89
34_N210_V0.6370.89
181_P189_L0.6350.89
41_I58_W0.6330.88
196_Y200_D0.6320.88
33_Y117_P0.6310.88
108_K161_D0.6300.88
9_S13_D0.6270.88
57_R145_L0.6260.88
103_S121_K0.6250.88
57_R68_E0.6240.88
126_A172_H0.6240.88
108_K111_D0.6210.88
122_L127_L0.6200.87
29_Y42_L0.6180.87
9_S12_D0.6150.87
114_T199_D0.6130.87
28_E55_K0.6120.87
46_N49_S0.6090.86
5_F148_C0.6070.86
156_N198_A0.6050.86
22_Q25_P0.6050.86
189_L192_L0.6020.86
75_I149_T0.6010.86
34_N103_S0.5990.86
130_F167_P0.5980.85
5_F36_A0.5940.85
36_A117_P0.5920.85
104_F158_F0.5920.85
37_P75_I0.5880.85
3_G107_W0.5870.84
74_M149_T0.5820.84
151_I193_L0.5800.84
60_L87_A0.5800.84
5_F132_G0.5730.83
12_D21_D0.5710.83
60_L72_Y0.5710.83
189_L193_L0.5690.83
122_L125_S0.5640.82
22_Q50_N0.5630.82
158_F200_D0.5610.82
68_E145_L0.5600.82
69_K72_Y0.5600.82
80_E154_E0.5590.81
154_E160_K0.5590.81
205_Q208_S0.5550.81
137_W147_T0.5550.81
105_Y165_R0.5520.81
72_Y87_A0.5500.80
59_G71_G0.5500.80
131_A149_T0.5500.80
162_I203_A0.5500.80
49_S98_I0.5490.80
131_A170_L0.5470.80
79_A168_V0.5470.80
6_T102_D0.5440.80
105_Y117_P0.5420.79
61_I64_W0.5410.79
162_I166_M0.5410.79
96_R181_P0.5390.79
78_R163_H0.5370.79
70_I74_M0.5370.79
156_N195_P0.5350.79
102_D119_R0.5350.79
130_F169_I0.5340.78
85_K89_R0.5310.78
99_I130_F0.5300.78
17_Q172_H0.5300.78
65_A71_G0.5290.78
50_N54_G0.5280.78
14_I18_F0.5280.78
43_A132_G0.5260.77
100_P132_G0.5260.77
102_D127_L0.5250.77
110_L118_M0.5230.77
77_A165_R0.5210.77
94_S135_E0.5200.77
154_E173_D0.5200.77
83_T93_V0.5170.76
168_V196_Y0.5130.76
61_I137_W0.5130.76
6_T11_F0.5120.76
9_S14_I0.5120.76
109_R164_D0.5090.75
132_G150_I0.5080.75
50_N144_P0.5050.75
108_K116_I0.5040.74
197_D200_D0.5030.74
183_N189_L0.5010.74
60_L77_A0.5000.74
63_P66_K0.5000.74
4_R37_P0.5000.74
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2icuA 1 0.9119 100 0.085 Contact Map
2bdvA 1 0.9119 100 0.087 Contact Map
2f20A 1 0.9692 100 0.097 Contact Map
2aegA 1 0.8943 100 0.139 Contact Map
1zn6A 1 0.8722 100 0.154 Contact Map
2gs0B 1 0.0617 17.7 0.955 Contact Map
2b3gB 2 0.1057 9.2 0.961 Contact Map
3bsuA 1 0.2159 6.1 0.964 Contact Map
2iiiA 2 0.1718 4.5 0.966 Contact Map
3bbnP 1 0.3216 4.2 0.966 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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