GREMLIN Database
YKOG - Uncharacterized transcriptional regulatory protein YkoG
UniProt: O34903 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 228 (207)
Sequences: 79943 (56836)
Seq/√Len: 3950.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
16_A32_I3.7541.00
16_A34_H3.3041.00
20_Q32_I3.2621.00
9_V39_G2.8091.00
40_L68_R2.7091.00
37_T59_G2.5871.00
31_T48_Y2.5371.00
36_G60_L2.4681.00
44_A72_T2.3961.00
35_N59_G2.3621.00
60_L68_R2.3611.00
5_H31_T2.2431.00
5_H29_S2.1291.00
22_E108_I2.1121.00
33_K42_A2.0721.00
20_Q24_E2.0521.00
26_E112_L2.0171.00
56_M84_R1.9441.00
34_H38_E1.9261.00
90_K110_E1.8801.00
53_L65_V1.8751.00
194_N197_D1.8451.00
31_T42_A1.8211.00
66_L78_V1.7921.00
7_L33_K1.7781.00
35_N38_E1.7731.00
80_L93_G1.7521.00
68_R72_T1.7091.00
159_R162_D1.6931.00
70_R99_N1.6751.00
80_L98_A1.6671.00
67_R96_I1.6401.00
42_A46_G1.6381.00
31_T46_G1.6351.00
87_I107_E1.6171.00
36_G65_V1.6101.00
60_L64_E1.5851.00
177_R197_D1.5761.00
100_D114_R1.5601.00
61_S64_E1.5561.00
4_G119_L1.5531.00
42_A45_E1.5151.00
166_Y183_S1.5011.00
68_R71_K1.4831.00
43_A69_L1.4821.00
165_V169_K1.4781.00
23_L115_I1.4671.00
84_R89_D1.4421.00
199_Y202_Y1.4331.00
66_L80_L1.4291.00
137_D150_G1.4181.00
51_V76_T1.4171.00
175_L183_S1.4021.00
37_T60_L1.3791.00
64_E67_R1.3721.00
50_L115_I1.3571.00
40_L65_V1.3551.00
176_T179_Q1.3401.00
13_E34_H1.3341.00
42_A48_Y1.3261.00
99_N121_Q1.3001.00
79_I118_A1.2941.00
10_E16_A1.2881.00
55_V63_L1.2741.00
11_D54_D1.2701.00
5_H46_G1.2601.00
99_N118_A1.2511.00
63_L93_G1.2391.00
53_L66_L1.2391.00
41_D45_E1.2371.00
73_D76_T1.2331.00
40_L60_L1.2291.00
166_Y170_H1.2271.00
9_V57_L1.2171.00
28_Y116_R1.2131.00
38_E41_D1.2101.00
55_V80_L1.1961.00
146_E153_E1.1891.00
6_I28_Y1.1701.00
7_L48_Y1.1661.00
200_I204_R1.1661.00
37_T41_D1.1621.00
160_E206_K1.1611.00
141_N144_T1.1591.00
33_K39_G1.1591.00
38_E42_A1.1581.00
92_T96_I1.1581.00
86_S89_D1.1521.00
112_L116_R1.1451.00
7_L39_G1.1181.00
139_R148_R1.1111.00
63_L92_T1.1061.00
209_Y218_T1.1051.00
26_E116_R1.0921.00
87_I91_V1.0921.00
179_Q183_S1.0651.00
198_V201_R1.0641.00
27_G116_R1.0501.00
39_G65_V1.0431.00
95_D116_R1.0331.00
33_K38_E1.0271.00
7_L42_A1.0261.00
4_G28_Y1.0241.00
113_A117_A1.0161.00
50_L119_L1.0151.00
195_V199_Y1.0131.00
91_V95_D1.0071.00
40_L44_A1.0041.00
17_R32_I0.9941.00
39_G43_A0.9911.00
166_Y175_L0.9911.00
110_E113_A0.9911.00
67_R92_T0.9891.00
162_D165_V0.9871.00
140_V168_L0.9861.00
8_I19_L0.9831.00
161_F165_V0.9791.00
51_V69_L0.9771.00
88_P92_T0.9751.00
13_E17_R0.9751.00
20_Q30_V0.9721.00
194_N198_V0.9581.00
53_L78_V0.9571.00
90_K103_T0.9541.00
178_E193_T0.9531.00
14_K18_V0.9511.00
7_L43_A0.9401.00
9_V33_K0.9321.00
63_L96_I0.9301.00
175_L179_Q0.9281.00
148_R153_E0.9251.00
159_R185_W0.9211.00
55_V61_S0.9181.00
19_L81_L0.9151.00
66_L98_A0.9071.00
9_V51_V0.9021.00
64_E68_R0.9021.00
41_D44_A0.9011.00
142_E165_V0.9011.00
66_L96_I0.8961.00
132_F139_R0.8931.00
53_L80_L0.8901.00
51_V78_V0.8881.00
5_H49_S0.8821.00
92_T95_D0.8791.00
87_I90_K0.8781.00
52_L111_L0.8771.00
13_E16_A0.8761.00
8_I30_V0.8741.00
209_Y214_Q0.8741.00
17_R20_Q0.8591.00
79_I114_R0.8571.00
55_V89_D0.8571.00
118_A121_Q0.8501.00
28_Y112_L0.8421.00
158_P162_D0.8411.00
85_D103_T0.8361.00
21_L25_Y0.8341.00
140_V161_F0.8301.00
5_H48_Y0.8291.00
208_D214_Q0.8281.00
77_P99_N0.8191.00
65_V69_L0.8181.00
57_L65_V0.8171.00
163_L167_M0.8171.00
202_Y205_K0.8091.00
43_A73_D0.8071.00
110_E114_R0.8041.00
67_R71_K0.8001.00
194_N201_R0.7951.00
108_I112_L0.7881.00
193_T197_D0.7881.00
148_R151_D0.7871.00
178_E182_S0.7831.00
43_A76_T0.7831.00
91_V109_E0.7821.00
15_I106_F0.7811.00
43_A48_Y0.7751.00
166_Y180_I0.7731.00
19_L111_L0.7721.00
36_G40_L0.7701.00
60_L65_V0.7691.00
55_V84_R0.7631.00
89_D92_T0.7631.00
52_L115_I0.7601.00
107_E110_E0.7591.00
117_A120_R0.7531.00
145_R162_D0.7481.00
52_L81_L0.7431.00
56_M83_A0.7411.00
9_V65_V0.7331.00
88_P109_E0.7291.00
179_Q182_S0.7231.00
81_L106_F0.7211.00
17_R21_L0.7181.00
201_R205_K0.7161.00
157_T206_K0.7161.00
36_G59_G0.7151.00
4_G123_G0.7061.00
141_N146_E0.7021.00
106_F111_L0.6961.00
94_L114_R0.6911.00
119_L122_N0.6901.00
177_R193_T0.6881.00
44_A68_R0.6861.00
36_G57_L0.6841.00
40_L43_A0.6831.00
166_Y169_K0.6811.00
69_L78_V0.6781.00
18_V22_E0.6771.00
93_G98_A0.6711.00
22_E112_L0.6701.00
211_Y214_Q0.6631.00
198_V202_Y0.6621.00
8_I32_I0.6611.00
117_A122_N0.6601.00
114_R118_A0.6591.00
122_N126_T0.6591.00
16_A20_Q0.6581.00
138_L149_R0.6561.00
169_K183_S0.6561.00
109_E113_A0.6541.00
10_E57_L0.6491.00
95_D113_A0.6471.00
52_L79_I0.6451.00
69_L74_S0.6441.00
8_I20_Q0.6441.00
182_S185_W0.6431.00
100_D117_A0.6411.00
70_R77_P0.6411.00
77_P121_Q0.6411.00
204_R209_Y0.6401.00
79_I100_D0.6351.00
191_G196_V0.6351.00
47_G73_D0.6311.00
43_A51_V0.6281.00
6_I23_L0.6271.00
6_I50_L0.6251.00
145_R161_F0.6251.00
24_E30_V0.6211.00
77_P119_L0.6211.00
137_D149_R0.6201.00
149_R152_K0.6191.00
213_K216_I0.6181.00
169_K175_L0.6141.00
40_L72_T0.6141.00
208_D213_K0.6121.00
90_K107_E0.6091.00
12_E15_I0.6081.00
4_G49_S0.6081.00
23_L28_Y0.6061.00
12_E83_A0.6041.00
44_A73_D0.6031.00
11_D82_T0.6001.00
15_I18_V0.5981.00
106_F110_E0.5951.00
87_I109_E0.5921.00
113_A116_R0.5921.00
55_V93_G0.5921.00
75_Q125_K0.5881.00
63_L89_D0.5851.00
54_D104_K0.5821.00
70_R76_T0.5791.00
53_L57_L0.5791.00
66_L70_R0.5771.00
131_T143_K0.5731.00
116_R120_R0.5721.00
75_Q124_T0.5721.00
82_T90_K0.5711.00
195_V200_I0.5691.00
162_D166_Y0.5651.00
181_L185_W0.5631.00
22_E26_E0.5611.00
192_D195_V0.5611.00
82_T104_K0.5591.00
77_P122_N0.5531.00
53_L69_L0.5531.00
208_D211_Y0.5521.00
140_V165_V0.5521.00
197_D200_I0.5491.00
167_M200_I0.5461.00
77_P125_K0.5461.00
38_E59_G0.5431.00
164_L167_M0.5411.00
88_P91_V0.5401.00
132_F141_N0.5391.00
43_A65_V0.5381.00
214_Q217_H0.5351.00
8_I16_A0.5321.00
213_K217_H0.5311.00
91_V94_L0.5311.00
82_T101_Y0.5291.00
11_D57_L0.5291.00
149_R208_D0.5271.00
69_L76_T0.5231.00
18_V21_L0.5231.00
128_D131_T0.5221.00
191_G195_V0.5211.00
135_Y168_L0.5151.00
149_R209_Y0.5141.00
35_N57_L0.5131.00
157_T160_E0.5131.00
83_A105_P0.5101.00
177_R181_L0.5071.00
153_E218_T0.5061.00
24_E29_S0.5051.00
159_R199_Y0.5051.00
133_L142_E0.5031.00
6_I115_I0.5001.00
135_Y138_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ys7A 2 0.9868 100 0.168 Contact Map
3r0jA 2 0.9693 100 0.183 Contact Map
1kgsA 1 0.9561 100 0.198 Contact Map
2gwrA 1 0.9693 100 0.202 Contact Map
4b09A 2 0.9167 100 0.206 Contact Map
2oqrA 2 0.9825 100 0.207 Contact Map
4kfcA 2 0.9781 100 0.226 Contact Map
2hqrA 2 0.943 100 0.232 Contact Map
3q9sA 1 0.9211 100 0.237 Contact Map
1p2fA 1 0.9474 100 0.248 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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