GREMLIN Database
PDUO - Cob(I)yrinic acid a,c-diamide adenosyltransferase
UniProt: O34899 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 193 (175)
Sequences: 2452 (1584)
Seq/√Len: 119.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
36_L129_T4.1051.00
136_V153_L3.7711.00
23_D141_K3.0781.00
28_E135_R2.8281.00
4_Y98_D2.7781.00
14_G19_R2.7411.00
39_F124_I2.5611.00
40_I60_L2.5391.00
43_A122_L2.4311.00
23_D138_A2.4011.00
87_E91_S2.3771.00
44_L57_T2.3471.00
46_E117_K2.3011.00
39_F128_I2.2551.00
27_V30_Y2.1461.00
16_V75_A2.1431.00
59_E96_R2.0851.00
66_E152_Y2.0151.00
40_I160_F2.0031.00
59_E159_Y1.9481.00
166_V170_R1.8921.00
32_T135_R1.8461.00
21_D141_K1.8391.00
159_Y163_A1.8141.00
66_E89_S1.7901.00
87_E148_T1.7801.00
117_K121_L1.7661.00
7_T14_G1.7511.00
59_E100_Y1.7101.00
128_I131_R1.6891.00
28_E32_T1.6801.00
23_D137_V1.6691.00
92_F96_R1.6541.00
103_E170_R1.6321.00
119_A168_N1.6201.00
125_A160_F1.6131.00
96_R99_A1.5711.00
73_D146_H1.5701.00
68_F71_G1.5681.00
100_Y159_Y1.5591.00
122_L167_V1.5481.00
3_L162_A1.5371.00
24_S143_E1.5171.00
39_F125_A1.4661.00
168_N175_D1.4441.00
4_Y94_E1.4091.00
135_R138_A1.3971.00
90_V148_T1.3941.00
35_E131_R1.3831.00
91_S95_T1.3631.00
139_L143_E1.3421.00
116_S171_S1.3421.00
56_L163_A1.3381.00
74_L136_V1.3371.00
56_L167_V1.3051.00
37_N68_F1.2961.00
13_T27_V1.2881.00
20_T24_S1.2671.00
42_L124_I1.2350.99
46_E121_L1.2330.99
101_T162_A1.2240.99
38_S127_T1.2170.99
42_L121_L1.1930.99
62_T92_F1.1920.99
87_E151_R1.1870.99
85_L89_S1.1800.99
12_Q21_D1.1620.99
104_A162_A1.1460.99
55_D99_A1.1370.99
30_Y74_L1.1350.99
43_A125_A1.1290.99
121_L124_I1.1250.99
100_Y166_V1.1240.99
4_Y97_I1.1180.99
39_F121_L1.1030.99
116_S168_N1.0970.99
29_S136_V1.0960.99
45_A117_K1.0960.99
108_K177_E1.0850.98
45_A120_S1.0790.98
43_A167_V1.0580.98
21_D24_S1.0510.98
96_R159_Y1.0390.98
55_D170_R1.0310.98
66_E92_F1.0210.98
7_T19_R1.0200.98
47_L118_C1.0160.98
7_T12_Q1.0130.98
39_F43_A1.0100.98
118_C167_V0.9980.97
63_I152_Y0.9840.97
140_M150_L0.9760.97
97_I162_A0.9720.97
45_A121_L0.9680.97
148_T151_R0.9570.97
76_I79_E0.9560.97
32_T131_R0.9540.96
73_D84_K0.9490.96
105_P169_A0.9440.96
26_R143_E0.9360.96
109_K177_E0.9280.96
16_V76_I0.9190.96
28_E138_A0.9140.96
15_L20_T0.9020.95
44_L61_L0.9000.95
110_F161_F0.8940.95
70_C149_V0.8890.95
57_T61_L0.8790.94
54_E58_A0.8790.94
37_N64_Q0.8770.94
34_D126_R0.8730.94
37_N71_G0.8690.94
119_A175_D0.8670.94
14_G18_G0.8620.94
24_S142_S0.8610.94
59_E99_A0.8610.94
33_I67_L0.8540.94
136_V149_V0.8510.93
169_A174_G0.8500.93
41_G64_Q0.8480.93
32_T132_A0.8360.93
115_G168_N0.8140.92
132_A153_L0.8110.92
65_H69_D0.7970.91
88_E91_S0.7960.91
25_L135_R0.7940.91
42_L117_K0.7900.91
33_I70_C0.7800.90
90_V151_R0.7780.90
129_T160_F0.7760.90
13_T20_T0.7750.90
61_L176_V0.7720.90
62_T66_E0.7710.90
99_A103_E0.7690.89
86_T89_S0.7680.89
100_Y163_A0.7580.89
10_K14_G0.7560.89
32_T128_I0.7560.89
96_R100_Y0.7550.89
94_E98_D0.7480.88
104_A107_L0.7480.88
60_L122_L0.7460.88
138_A142_S0.7460.88
30_Y127_T0.7410.88
36_L125_A0.7380.87
10_K147_E0.7360.87
140_M145_I0.7340.87
7_T10_K0.7280.87
124_I128_I0.7250.87
43_A121_L0.7210.86
59_E92_F0.7210.86
62_T96_R0.7170.86
25_L142_S0.7170.86
6_K91_S0.7160.86
158_D165_R0.7150.86
101_T104_A0.7070.85
94_E97_I0.6990.84
29_S135_R0.6990.84
116_S173_I0.6940.84
26_R30_Y0.6920.84
42_L46_E0.6900.84
113_P126_R0.6880.84
72_G76_I0.6850.83
114_G120_S0.6840.83
111_I161_F0.6830.83
140_M144_E0.6760.82
20_T27_V0.6740.82
122_L163_A0.6740.82
177_E180_R0.6720.82
2_K6_K0.6680.82
136_V150_L0.6620.81
121_L125_A0.6550.80
109_K180_R0.6530.80
111_I164_A0.6490.80
119_A164_A0.6450.79
33_I153_L0.6440.79
137_V150_L0.6400.79
29_S33_I0.6370.79
41_G71_G0.6360.78
63_I156_L0.6330.78
116_S119_A0.6300.78
112_L115_G0.6280.78
35_E128_I0.6280.78
95_T99_A0.6270.77
107_L161_F0.6260.77
146_H149_V0.6240.77
29_S139_L0.6220.77
38_S164_A0.6220.77
137_V140_M0.6200.77
36_L39_F0.6190.77
69_D178_Y0.6180.76
47_L167_V0.6170.76
64_Q71_G0.6150.76
3_L104_A0.6140.76
65_H178_Y0.6140.76
103_E166_V0.6120.76
13_T26_R0.6110.76
116_S175_D0.6100.76
21_D137_V0.6080.75
71_G115_G0.6010.74
10_K19_R0.6010.74
37_N115_G0.5970.74
25_L29_S0.5950.74
2_K7_T0.5930.74
8_G11_G0.5920.73
161_F168_N0.5900.73
99_A102_A0.5880.73
56_L100_Y0.5880.73
15_L26_R0.5850.73
123_H164_A0.5850.73
2_K98_D0.5820.72
33_I136_V0.5810.72
104_A109_K0.5780.72
33_I132_A0.5780.72
25_L138_A0.5700.71
30_Y98_D0.5690.70
6_K87_E0.5690.70
37_N113_P0.5690.70
55_D103_E0.5690.70
78_T144_E0.5640.70
129_T156_L0.5630.70
169_A173_I0.5590.69
123_H165_R0.5580.69
63_I100_Y0.5570.69
6_K151_R0.5560.69
32_T134_R0.5560.69
85_L148_T0.5540.68
78_T81_K0.5470.67
111_I165_R0.5410.67
49_G54_E0.5390.66
73_D83_Y0.5390.66
86_T92_F0.5390.66
61_L65_H0.5370.66
139_L144_E0.5360.66
68_F178_Y0.5350.66
31_G34_D0.5350.66
36_L43_A0.5340.66
49_G117_K0.5320.65
56_L166_V0.5310.65
117_K120_S0.5260.64
3_L158_D0.5260.64
114_G175_D0.5260.64
171_S174_G0.5240.64
147_E151_R0.5240.64
132_A139_L0.5210.64
25_L139_L0.5200.64
65_H68_F0.5190.63
29_S132_A0.5190.63
92_F95_T0.5180.63
62_T102_A0.5130.63
116_S174_G0.5110.62
139_L145_I0.5080.62
104_A178_Y0.5070.62
111_I175_D0.5060.62
55_D58_A0.5050.61
98_D158_D0.5050.61
119_A122_L0.5050.61
4_Y90_V0.5050.61
118_C121_L0.5040.61
38_S42_L0.5030.61
20_T30_Y0.5020.61
33_I74_L0.5000.61
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1rtyA 3 0.9016 100 0.064 Contact Map
3ke4A 3 0.8912 100 0.077 Contact Map
2ah6A 3 0.8497 100 0.077 Contact Map
2nt8A 3 0.9171 100 0.091 Contact Map
3ci3A 3 0.9534 100 0.094 Contact Map
2idxA 3 0.9171 100 0.115 Contact Map
2zhyA 3 0.8808 100 0.116 Contact Map
2g2dA 3 0.7979 100 0.125 Contact Map
1wy1A 3 0.7565 100 0.131 Contact Map
1wozA 3 0.8187 100 0.138 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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