GREMLIN Database
YTRC - Probable ABC transporter permease YtrC
UniProt: O34898 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 328 (312)
Sequences: 572 (475)
Seq/√Len: 26.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
102_F252_G6.3221.00
10_E105_K3.8921.00
114_V147_I3.8691.00
109_G154_F3.7081.00
106_F155_S3.6251.00
82_E259_L3.3621.00
306_G310_G3.3291.00
244_M248_F3.2281.00
278_Q319_Y3.1111.00
26_V120_G3.0911.00
161_G170_Q3.0771.00
219_N222_P3.0611.00
286_I289_F2.9371.00
78_F154_F2.8121.00
103_Q249_Y2.7911.00
277_V283_A2.7471.00
83_R161_G2.7371.00
88_M261_S2.5950.99
154_F164_T2.4560.99
99_S253_F2.4120.99
92_L256_F2.3900.99
148_V245_S2.3680.99
183_L283_A2.3230.98
301_I305_L2.2590.98
119_I122_L2.2470.98
99_S257_K2.2280.98
98_R101_I2.1920.98
289_F306_G2.1870.98
92_L261_S2.1700.97
97_N257_K2.1550.97
110_G114_V2.1020.97
176_S283_A2.0820.97
176_S277_V1.9920.96
92_L101_I1.9870.96
81_M116_S1.9800.96
165_G265_G1.8850.94
102_F164_T1.8240.93
284_F288_G1.8010.93
79_L158_M1.7990.93
82_E105_K1.7720.92
75_A289_F1.7670.92
180_L283_A1.7390.91
83_R170_Q1.7300.91
222_P225_Y1.7230.91
81_M259_L1.6860.90
80_G170_Q1.6680.90
82_E264_N1.6590.89
183_L187_L1.6480.89
216_N222_P1.6440.89
259_L264_N1.6130.88
156_L184_I1.6010.88
89_D93_S1.5980.87
283_A322_I1.5780.87
9_R82_E1.5760.87
169_A195_V1.5740.87
7_L108_L1.5740.87
259_L319_Y1.5680.86
21_S25_L1.5570.86
175_F314_G1.5470.86
251_I258_K1.5010.84
92_L319_Y1.4840.83
89_D267_F1.4840.83
94_L101_I1.4830.83
12_K15_Q1.4600.82
68_W276_P1.4580.82
106_F154_F1.4080.80
218_S222_P1.3960.79
160_A164_T1.3950.79
165_G262_E1.3870.79
299_S304_I1.3610.77
90_F196_F1.3560.77
163_L173_T1.3550.77
82_E108_L1.3520.77
110_G151_F1.3460.76
155_S245_S1.3440.76
318_S322_I1.3350.76
221_V224_S1.3260.75
74_L113_I1.3230.75
285_G311_A1.3160.75
9_R264_N1.3110.75
169_A265_G1.3000.74
280_L284_F1.2980.74
180_L184_I1.2920.73
145_G238_L1.2920.73
14_N78_F1.2860.73
22_I119_I1.2830.73
111_F119_I1.2800.73
27_L305_L1.2710.72
113_I150_S1.2670.72
9_R13_Q1.2400.70
169_A267_F1.2360.70
91_I259_L1.2330.70
82_E161_G1.2330.70
159_A248_F1.2320.70
310_G314_G1.2270.69
172_L176_S1.2260.69
11_W19_L1.2230.69
163_L255_S1.2160.69
133_P137_Y1.2050.68
82_E91_I1.2050.68
317_V321_S1.1880.67
74_L102_F1.1860.67
48_D144_I1.1810.66
81_M92_L1.1780.66
87_T91_I1.1770.66
92_L116_S1.1730.66
79_L161_G1.1720.66
9_R91_I1.1700.66
81_M91_I1.1630.65
101_I105_K1.1570.65
101_I256_F1.1560.65
174_A181_P1.1430.64
121_F143_S1.1430.64
302_G306_G1.1380.64
281_V306_G1.1340.63
88_M92_L1.1310.63
82_E267_F1.1190.62
52_C249_Y1.1170.62
134_E137_Y1.1160.62
5_G14_N1.1140.62
283_A286_I1.1130.62
6_L91_I1.0920.60
188_P192_L1.0900.60
83_R264_N1.0870.60
27_L31_L1.0810.59
320_F324_K1.0800.59
47_Q73_I1.0710.59
123_L185_I1.0670.58
314_G318_S1.0640.58
221_V271_N1.0620.58
30_P314_G1.0620.58
26_V313_A1.0580.58
82_E87_T1.0570.58
80_G106_F1.0550.58
19_L73_I1.0550.58
38_L168_F1.0480.57
23_A61_S1.0460.57
89_D259_L1.0420.57
170_Q306_G1.0410.57
15_Q89_D1.0340.56
66_I151_F1.0330.56
42_G168_F1.0330.56
105_K108_L1.0320.56
264_N319_Y1.0230.55
305_L309_I1.0210.55
246_M304_I1.0170.55
159_A255_S1.0090.54
163_L274_D1.0090.54
214_A217_L1.0060.54
180_L277_V1.0060.54
263_R274_D1.0040.54
8_Y11_W0.9990.53
78_F181_P0.9940.53
193_E282_M0.9890.53
80_G167_A0.9860.52
144_I246_M0.9860.52
16_V178_A0.9800.52
280_L314_G0.9750.52
85_K89_D0.9730.51
13_Q89_D0.9700.51
284_F287_L0.9690.51
72_V308_I0.9670.51
216_N219_N0.9670.51
9_R14_N0.9660.51
222_P229_E0.9600.50
41_Q73_I0.9550.50
24_F114_V0.9550.50
6_L83_R0.9450.49
191_N195_V0.9440.49
24_F100_Q0.9430.49
176_S179_I0.9370.49
6_L101_I0.9360.49
150_S163_L0.9310.48
198_A320_F0.9260.48
117_Q143_S0.9250.48
187_L315_F0.9250.48
159_A256_F0.9240.48
176_S273_L0.9230.48
38_L53_D0.9140.47
126_L132_N0.9140.47
97_N253_F0.9130.47
277_V281_V0.9130.47
20_L139_F0.9090.47
215_S218_S0.9070.46
97_N152_M0.9040.46
142_S198_A0.9040.46
11_W279_I0.9040.46
37_Y131_Y0.9020.46
214_A221_V0.8990.46
75_A157_V0.8910.45
23_A260_P0.8890.45
94_L259_L0.8870.45
144_I148_V0.8860.45
34_V252_G0.8860.45
92_L259_L0.8840.45
33_I124_A0.8820.45
76_V227_V0.8810.45
179_I313_A0.8800.44
90_F108_L0.8770.44
144_I251_I0.8760.44
141_H250_L0.8760.44
199_N279_I0.8700.44
259_L267_F0.8650.43
114_V136_V0.8630.43
79_L162_A0.8600.43
80_G83_R0.8550.43
198_A315_F0.8550.43
6_L155_S0.8530.42
75_A153_A0.8520.42
246_M257_K0.8510.42
263_R266_H0.8510.42
8_Y29_N0.8490.42
83_R259_L0.8490.42
284_F314_G0.8430.42
313_A321_S0.8420.42
289_F303_Y0.8380.41
42_G247_L0.8360.41
105_K285_G0.8320.41
239_L312_V0.8280.41
259_L269_L0.8280.41
69_V221_V0.8260.41
78_F113_I0.8240.40
157_V174_A0.8240.40
287_L293_G0.8240.40
281_V285_G0.8240.40
257_K261_S0.8230.40
6_L105_K0.8200.40
187_L288_G0.8190.40
172_L280_L0.8170.40
144_I301_I0.8170.40
147_I242_A0.8120.40
225_Y228_N0.8100.39
109_G256_F0.8060.39
79_L83_R0.8050.39
15_Q18_I0.8050.39
163_L273_L0.8050.39
180_L324_K0.8020.39
95_P116_S0.8010.39
163_L169_A0.8000.39
16_V109_G0.7980.39
39_S246_M0.7960.38
9_R89_D0.7950.38
243_V250_L0.7940.38
98_R256_F0.7890.38
268_F274_D0.7880.38
78_F86_G0.7870.38
40_Y85_K0.7860.38
183_L288_G0.7830.37
58_Y65_D0.7800.37
46_R49_P0.7750.37
71_G75_A0.7740.37
23_A111_F0.7690.36
23_A287_L0.7670.36
271_N300_I0.7660.36
260_P263_R0.7660.36
12_K271_N0.7650.36
4_R83_R0.7610.36
286_I315_F0.7570.36
105_K264_N0.7570.36
96_Y238_L0.7510.35
288_G306_G0.7450.35
6_L96_Y0.7420.35
7_L11_W0.7410.35
102_F226_V0.7390.34
322_I325_K0.7380.34
83_R281_V0.7380.34
198_A241_P0.7350.34
150_S325_K0.7330.34
242_A311_A0.7320.34
122_L246_M0.7290.34
10_E108_L0.7260.34
244_M295_Y0.7260.34
94_L277_V0.7250.33
159_A259_L0.7230.33
198_A324_K0.7220.33
176_S284_F0.7220.33
24_F254_I0.7210.33
71_G98_R0.7180.33
91_I105_K0.7180.33
13_Q177_A0.7170.33
21_S82_E0.7130.33
52_C126_L0.7080.32
285_G291_L0.7080.32
68_W249_Y0.7070.32
140_E313_A0.7000.32
26_V188_P0.6990.32
82_E96_Y0.6990.32
319_Y323_Y0.6970.32
153_A184_I0.6960.32
25_L117_Q0.6950.31
239_L246_M0.6940.31
101_I325_K0.6940.31
242_A291_L0.6930.31
111_F242_A0.6900.31
15_Q178_A0.6890.31
85_K169_A0.6890.31
243_V247_L0.6880.31
44_L152_M0.6860.31
160_A177_A0.6860.31
81_M270_W0.6860.31
238_L287_L0.6850.31
221_V227_V0.6840.31
82_E319_Y0.6800.31
238_L242_A0.6800.31
73_I182_Y0.6800.31
92_L95_P0.6790.30
151_F312_V0.6780.30
268_F273_L0.6760.30
80_G84_S0.6740.30
9_R267_F0.6730.30
69_V177_A0.6730.30
244_M311_A0.6720.30
292_F306_G0.6700.30
21_S30_P0.6640.29
33_I285_G0.6640.29
9_R83_R0.6630.29
83_R96_Y0.6610.29
39_S47_Q0.6590.29
89_D266_H0.6570.29
83_R105_K0.6550.29
66_I168_F0.6540.29
163_L177_A0.6510.29
26_V296_T0.6500.29
9_R87_T0.6470.28
320_F325_K0.6460.28
114_V221_V0.6440.28
148_V238_L0.6430.28
24_F29_N0.6390.28
94_L228_N0.6380.28
116_S198_A0.6370.28
272_R317_V0.6340.28
121_F142_S0.6330.28
96_Y309_I0.6320.28
87_T180_L0.6320.28
242_A254_I0.6300.27
184_I313_A0.6270.27
43_C126_L0.6270.27
45_D48_D0.6260.27
164_T173_T0.6260.27
78_F109_G0.6240.27
199_N305_L0.6230.27
52_C127_L0.6220.27
283_A287_L0.6210.27
120_G123_L0.6180.27
123_L151_F0.6170.27
223_I243_V0.6160.27
151_F229_E0.6150.27
145_G317_V0.6140.26
142_S154_F0.6130.26
107_W115_L0.6130.26
274_D322_I0.6120.26
170_Q281_V0.6120.26
54_F132_N0.6110.26
64_I218_S0.6100.26
65_D111_F0.6060.26
62_N73_I0.6040.26
111_F235_K0.6040.26
285_G292_F0.6030.26
132_N149_I0.6010.26
234_S324_K0.6010.26
92_L142_S0.5990.26
50_Q62_N0.5970.25
37_Y282_M0.5970.25
177_A183_L0.5940.25
275_R278_Q0.5930.25
46_R111_F0.5920.25
268_F277_V0.5910.25
79_L102_F0.5910.25
72_V109_G0.5900.25
95_P268_F0.5900.25
80_G181_P0.5880.25
315_F324_K0.5880.25
182_Y246_M0.5870.25
83_R92_L0.5870.25
173_T277_V0.5850.25
114_V175_F0.5850.25
264_N269_L0.5810.25
30_P109_G0.5810.25
40_Y97_N0.5800.25
216_N251_I0.5780.24
114_V153_A0.5770.24
34_V219_N0.5750.24
16_V169_A0.5740.24
17_V163_L0.5740.24
191_N251_I0.5720.24
49_P119_I0.5720.24
130_V184_I0.5710.24
175_F277_V0.5710.24
219_N225_Y0.5700.24
79_L259_L0.5660.24
142_S261_S0.5660.24
254_I308_I0.5650.24
241_P277_V0.5640.24
288_G310_G0.5630.24
142_S277_V0.5620.24
98_R155_S0.5610.23
235_K247_L0.5610.23
54_F151_F0.5580.23
158_M178_A0.5580.23
64_I70_P0.5580.23
164_T264_N0.5570.23
117_Q160_A0.5550.23
10_E101_I0.5550.23
149_I307_M0.5540.23
48_D247_L0.5530.23
50_Q53_D0.5520.23
99_S103_Q0.5510.23
88_M259_L0.5510.23
92_L264_N0.5490.23
33_I280_L0.5480.23
11_W114_V0.5480.23
68_W77_C0.5450.23
281_V286_I0.5440.23
145_G157_V0.5430.23
11_W82_E0.5430.23
125_W246_M0.5420.22
285_G322_I0.5420.22
116_S119_I0.5410.22
13_Q181_P0.5400.22
173_T315_F0.5400.22
159_A176_S0.5390.22
102_F106_F0.5390.22
64_I190_G0.5390.22
195_V315_F0.5380.22
71_G160_A0.5370.22
71_G150_S0.5350.22
187_L289_F0.5340.22
152_M191_N0.5320.22
8_Y257_K0.5320.22
78_F105_K0.5320.22
71_G259_L0.5320.22
79_L82_E0.5310.22
73_I111_F0.5310.22
98_R277_V0.5310.22
80_G285_G0.5300.22
70_P153_A0.5280.22
95_P269_L0.5280.22
169_A264_N0.5260.22
132_N137_Y0.5260.22
23_A145_G0.5250.22
298_H311_A0.5240.22
73_I191_N0.5220.21
221_V226_V0.5210.21
188_P224_S0.5210.21
289_F307_M0.5200.21
177_A275_R0.5190.21
129_L242_A0.5190.21
71_G78_F0.5180.21
130_V151_F0.5170.21
84_S87_T0.5160.21
57_N184_I0.5150.21
90_F123_L0.5130.21
193_E300_I0.5130.21
151_F245_S0.5120.21
97_N111_F0.5110.21
27_L67_N0.5100.21
160_A320_F0.5080.21
27_L309_I0.5080.21
9_R104_T0.5080.21
97_N272_R0.5070.21
26_V256_F0.5070.21
195_V304_I0.5060.21
8_Y102_F0.5050.21
262_E265_G0.5050.21
22_I193_E0.5040.21
75_A95_P0.5010.20
239_L257_K0.5000.20
82_E92_L0.5000.20
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2xq2A 2 0.2348 49.5 0.94 Contact Map
4av3A 2 0.2713 12.7 0.956 Contact Map
2mfrA 1 0.1555 12 0.956 Contact Map
4hw9A 3 0.2683 8.1 0.959 Contact Map
3dh4A 3 0.1768 8.1 0.959 Contact Map
3hd7A 1 0.1037 7.9 0.959 Contact Map
1iijA 1 0.1067 6.8 0.961 Contact Map
2kv5A 1 0.1006 5.7 0.962 Contact Map
5ajiA 3 0.2957 5.2 0.963 Contact Map
1v54A 1 0.3201 5.2 0.963 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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