GREMLIN Database
YKUT - Uncharacterized MscS family protein YkuT
UniProt: O34897 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 267 (240)
Sequences: 11522 (8482)
Seq/√Len: 547.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
255_K259_D3.7811.00
193_D256_N3.4221.00
134_T139_D3.3851.00
143_E153_R3.1411.00
196_I252_K3.0931.00
224_E231_V2.9671.00
257_A260_R2.7821.00
200_Q204_D2.7651.00
257_A261_A2.7111.00
194_E261_A2.6261.00
132_Y139_D2.4951.00
191_N194_E2.4481.00
226_G231_V2.4041.00
197_H201_Q2.3771.00
185_K229_E2.3731.00
206_T249_V2.3651.00
201_Q257_A2.3501.00
223_Q233_R2.3321.00
109_Q113_S2.2911.00
194_E197_H2.1811.00
183_D233_R2.1321.00
183_D231_V2.0331.00
31_F35_S1.9931.00
132_Y141_I1.9471.00
144_Q151_Q1.9331.00
34_R78_F1.9121.00
187_P264_K1.8921.00
186_V195_M1.8681.00
253_E256_N1.8611.00
201_Q205_E1.8511.00
247_E251_R1.8261.00
222_I230_I1.8141.00
196_I200_Q1.8001.00
198_I257_A1.7991.00
185_K231_V1.7761.00
194_E198_I1.7201.00
143_E159_L1.7201.00
199_L254_I1.7101.00
205_E253_E1.6981.00
190_R264_K1.6761.00
124_E148_R1.6731.00
134_T173_H1.6691.00
249_V253_E1.6521.00
134_T171_S1.6271.00
256_N260_R1.6221.00
30_Y78_F1.6151.00
203_C234_V1.6121.00
236_A250_L1.5901.00
198_I261_A1.5771.00
154_S160_H1.5551.00
34_R38_M1.5301.00
202_V257_A1.4871.00
205_E257_A1.4801.00
181_L233_R1.4661.00
110_G113_S1.4601.00
132_Y155_F1.4451.00
134_T137_T1.4441.00
102_L105_G1.4171.00
193_D252_K1.4111.00
150_T164_N1.3901.00
127_L150_T1.3861.00
160_H171_S1.3771.00
74_L78_F1.3711.00
184_I254_I1.3491.00
195_M232_I1.3451.00
258_F263_P1.3431.00
245_R249_V1.3271.00
252_K256_N1.3271.00
206_T253_E1.3261.00
151_Q159_L1.3231.00
133_I142_V1.3071.00
42_K67_L1.3071.00
238_T246_V1.2981.00
202_V253_E1.2961.00
36_L40_I1.2961.00
198_I201_Q1.2891.00
131_D175_R1.2821.00
140_G152_I1.2771.00
213_I216_G1.2761.00
185_K228_S1.2631.00
201_Q204_D1.2481.00
197_H200_Q1.2451.00
185_K226_G1.2131.00
158_T171_S1.2111.00
180_A236_A1.1811.00
166_N169_N1.1771.00
30_Y34_R1.1771.00
242_E245_R1.1751.00
83_L88_Y1.1751.00
82_V86_F1.1661.00
128_D175_R1.1631.00
154_S158_T1.1621.00
188_A225_L1.1561.00
193_D196_I1.1461.00
190_R195_M1.1461.00
201_Q261_A1.1431.00
189_E255_K1.1281.00
186_V190_R1.1151.00
253_E257_A1.1141.00
35_S39_K1.1101.00
23_L30_Y1.1091.00
71_A75_I1.1051.00
183_D224_E1.1001.00
208_A249_V1.0991.00
187_P190_R1.0951.00
96_G99_I1.0881.00
193_D197_H1.0831.00
227_T231_V1.0641.00
159_L175_R1.0631.00
239_E242_E1.0581.00
178_M243_Q1.0531.00
243_Q247_E1.0481.00
135_V167_I1.0461.00
200_Q220_I1.0421.00
192_I232_I1.0301.00
189_E264_K1.0271.00
92_A95_A1.0061.00
108_A116_V0.9991.00
38_M42_K0.9961.00
27_I86_F0.9901.00
20_L23_L0.9851.00
223_Q231_V0.9751.00
179_Q237_K0.9711.00
224_E251_R0.9621.00
23_L38_M0.9601.00
180_A247_E0.9571.00
220_I234_V0.9471.00
157_G237_K0.9461.00
190_R194_E0.9431.00
26_M30_Y0.9381.00
186_V232_I0.9341.00
64_S68_N0.9301.00
149_T161_Y0.9261.00
188_A265_E0.9251.00
42_K71_A0.9161.00
100_V104_V0.9121.00
146_G151_Q0.9101.00
195_M199_L0.9081.00
99_I108_A0.9061.00
94_L98_G0.9051.00
248_R252_K0.9011.00
199_L203_C0.8991.00
185_K227_T0.8981.00
199_L234_V0.8981.00
185_K188_A0.8971.00
203_C207_A0.8931.00
23_L27_I0.8871.00
133_I152_I0.8861.00
250_L254_I0.8821.00
183_D223_Q0.8801.00
208_A242_E0.8781.00
30_Y85_L0.8751.00
221_G248_R0.8711.00
153_R159_L0.8711.00
225_L230_I0.8691.00
38_M71_A0.8641.00
198_I202_V0.8631.00
187_P265_E0.8621.00
27_I31_F0.8601.00
120_F168_T0.8591.00
199_L258_F0.8541.00
107_G112_V0.8521.00
181_L235_I0.8511.00
111_L117_T0.8501.00
186_V258_F0.8471.00
206_T250_L0.8451.00
125_K128_D0.8391.00
124_E149_T0.8381.00
141_I153_R0.8361.00
244_W248_R0.8341.00
78_F82_V0.8331.00
96_G100_V0.8311.00
192_I230_I0.8271.00
203_C236_A0.8251.00
32_I36_L0.8251.00
43_H47_K0.8251.00
113_S165_R0.8231.00
177_T216_G0.8231.00
222_I251_R0.8201.00
200_Q218_N0.8181.00
100_V103_A0.8111.00
142_V152_I0.8101.00
84_D89_D0.8101.00
192_I255_K0.8101.00
192_I196_I0.8081.00
225_L251_R0.8031.00
19_L23_L0.8011.00
138_F160_H0.7991.00
47_K50_E0.7991.00
136_S166_N0.7991.00
42_K46_A0.7991.00
67_L71_A0.7991.00
46_A67_L0.7961.00
212_Q216_G0.7961.00
184_I199_L0.7911.00
117_T168_T0.7901.00
188_A230_I0.7771.00
198_I263_P0.7741.00
23_L34_R0.7661.00
75_I79_F0.7661.00
226_G229_E0.7611.00
46_A50_E0.7491.00
180_A238_T0.7481.00
45_F49_E0.7461.00
212_Q242_E0.7451.00
197_H204_D0.7441.00
182_V236_A0.7441.00
182_V251_R0.7421.00
223_Q247_E0.7411.00
48_F51_Q0.7381.00
41_I44_L0.7371.00
31_F34_R0.7341.00
249_V252_K0.7281.00
123_L126_Q0.7261.00
94_L103_A0.7181.00
156_D179_Q0.7141.00
26_M35_S0.7111.00
97_A101_G0.7071.00
202_V250_L0.7071.00
208_A246_V0.7071.00
35_S38_M0.7061.00
26_M31_F0.7061.00
197_H261_A0.7051.00
204_D214_K0.6981.00
127_L133_I0.6971.00
19_L22_K0.6961.00
127_L167_I0.6921.00
32_I35_S0.6911.00
203_C250_L0.6891.00
153_R157_G0.6891.00
135_V162_I0.6891.00
135_V138_F0.6881.00
22_K26_M0.6881.00
221_G233_R0.6871.00
113_S169_N0.6851.00
44_L48_F0.6831.00
35_S45_F0.6821.00
20_L24_A0.6811.00
76_F80_V0.6801.00
64_S144_Q0.6771.00
258_F265_E0.6751.00
186_V263_P0.6741.00
188_A228_S0.6731.00
234_V254_I0.6731.00
146_G149_T0.6731.00
179_Q235_I0.6721.00
40_I44_L0.6691.00
104_V116_V0.6691.00
27_I82_V0.6681.00
230_I255_K0.6671.00
188_A227_T0.6621.00
225_L255_K0.6591.00
104_V112_V0.6571.00
35_S75_I0.6571.00
45_F48_F0.6541.00
89_D92_A0.6541.00
196_I248_R0.6531.00
114_D165_R0.6521.00
219_V235_I0.6481.00
195_M258_F0.6481.00
30_Y33_V0.6471.00
112_V116_V0.6451.00
27_I30_Y0.6441.00
192_I256_N0.6441.00
61_T122_L0.6441.00
124_E151_Q0.6431.00
208_A245_R0.6411.00
110_G165_R0.6371.00
99_I103_A0.6371.00
96_G101_G0.6361.00
95_A98_G0.6331.00
40_I43_H0.6281.00
191_N256_N0.6251.00
21_I25_I0.6231.00
244_W247_E0.6211.00
228_S265_E0.6211.00
202_V205_E0.6201.00
29_L32_I0.6181.00
109_Q165_R0.6171.00
78_F81_M0.6161.00
68_N71_A0.6151.00
134_T138_F0.6101.00
221_G244_W0.6061.00
214_K217_P0.6041.00
31_F38_M0.6041.00
99_I102_L0.6001.00
184_I234_V0.6001.00
77_I81_M0.5971.00
188_A229_E0.5951.00
81_M85_L0.5951.00
224_E247_E0.5941.00
60_H63_R0.5941.00
111_L168_T0.5931.00
138_F171_S0.5931.00
225_L254_I0.5921.00
117_T165_R0.5901.00
98_G101_G0.5861.00
141_I241_M0.5851.00
23_L82_V0.5830.99
39_K43_H0.5820.99
133_I167_I0.5810.99
139_D173_H0.5800.99
186_V192_I0.5780.99
203_C206_T0.5730.99
151_Q161_Y0.5690.99
46_A49_E0.5680.99
91_S95_A0.5660.99
25_I29_L0.5630.99
28_L39_K0.5600.99
59_A125_K0.5600.99
202_V261_A0.5590.99
127_L170_V0.5550.99
202_V206_T0.5540.99
34_R74_L0.5520.99
28_L32_I0.5510.99
24_A28_L0.5510.99
68_N72_Y0.5480.99
190_R230_I0.5480.99
177_T239_E0.5460.99
189_E259_D0.5440.99
72_Y76_F0.5370.99
45_F50_E0.5370.99
106_F109_Q0.5370.99
185_K230_I0.5360.99
23_L26_M0.5360.99
42_K49_E0.5360.99
141_I155_F0.5350.99
138_F152_I0.5340.99
106_F111_L0.5330.99
200_Q203_C0.5310.99
198_I258_F0.5300.99
60_H64_S0.5300.99
202_V258_F0.5290.99
68_N144_Q0.5280.99
97_A100_V0.5260.99
61_T65_L0.5240.99
180_A243_Q0.5240.99
184_I225_L0.5230.99
258_F261_A0.5220.99
203_C220_I0.5200.99
256_N259_D0.5200.99
106_F110_G0.5190.99
38_M78_F0.5190.99
196_I220_I0.5170.99
194_E201_Q0.5150.99
172_N175_R0.5140.99
162_I167_I0.5120.99
102_L110_G0.5110.99
111_L120_F0.5100.99
63_R67_L0.5100.99
127_L164_N0.5080.99
108_A112_V0.5080.99
196_I232_I0.5050.99
23_L31_F0.5040.99
143_E151_Q0.5040.99
31_F42_K0.5030.99
98_G109_Q0.5020.99
212_Q246_V0.5020.99
101_G107_G0.5020.99
191_N195_M0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
5ajiA 3 0.9326 100 0.163 Contact Map
4hw9A 3 0.8951 100 0.163 Contact Map
3udcA 3 0.9438 100 0.173 Contact Map
1nz9A 1 0.1798 35.3 0.937 Contact Map
2mi6A 1 0.1948 20.7 0.944 Contact Map
2e6zA 1 0.191 19.6 0.944 Contact Map
3mlqE 1 0.1461 17.8 0.945 Contact Map
2mq8A 1 0.3184 14.1 0.948 Contact Map
1j8uA 2 0.3221 13.7 0.948 Contact Map
4p7oA 1 0.3184 12.3 0.949 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0087 seconds.