GREMLIN Database
YODP - N-acetyltransferase YodP
UniProt: O34895 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 275 (265)
Sequences: 219 (200)
Seq/√Len: 12.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
162_T169_Y7.6401.00
138_L181_A5.2031.00
125_F204_Y5.1361.00
130_A171_I4.2281.00
72_G270_I3.9840.99
72_G232_L3.5980.99
195_I214_I3.1860.97
192_H230_F3.1340.97
128_R134_D3.0120.96
75_K252_G2.9390.95
128_R173_L2.8540.95
104_Q254_R2.8360.94
231_S244_L2.8120.94
76_G235_A2.7930.94
138_L159_I2.5380.90
21_K49_E2.5300.90
237_S240_M2.4110.88
193_A221_M2.4040.88
128_R191_G2.1530.81
142_Y181_A2.1360.80
182_A217_L2.1060.79
143_K154_F2.0750.78
77_Y83_A2.0700.78
130_A134_D2.0500.77
40_V88_R2.0380.77
74_L77_Y1.9640.74
132_T164_N1.8820.71
158_Y230_F1.8560.70
186_I204_Y1.8040.67
17_D198_C1.8030.67
142_Y197_D1.7920.67
171_I178_L1.7920.67
151_T198_C1.7780.66
54_Y85_V1.7460.65
200_V208_S1.7420.65
54_Y185_E1.7110.63
141_L181_A1.6850.62
198_C210_T1.6570.61
89_Y270_I1.6530.60
163_M169_Y1.6330.59
196_T218_E1.6040.58
130_A181_A1.5920.57
24_R259_C1.5920.57
145_V199_A1.5890.57
24_R210_T1.5870.57
148_T262_A1.5590.56
151_T259_C1.5530.55
198_C259_C1.5400.55
16_H48_A1.5240.54
148_T260_F1.5210.54
187_N190_L1.5180.54
24_R198_C1.4870.52
23_I235_A1.4770.52
214_I244_L1.4740.51
218_E249_Y1.4580.51
74_L83_A1.4480.50
233_A244_L1.4300.49
158_Y162_T1.4080.48
257_N267_N1.4010.48
261_I268_M1.3910.47
130_A173_L1.3910.47
151_T217_L1.3780.47
28_Y59_D1.3780.47
161_K251_Y1.3750.46
85_V185_E1.3630.46
110_I245_Y1.3620.46
24_R54_Y1.3570.46
72_G214_I1.3380.45
12_A182_A1.3270.44
178_L208_S1.3230.44
75_K272_C1.3220.44
210_T244_L1.3200.44
148_T263_E1.3170.44
218_E273_K1.3140.43
17_D259_C1.3080.43
260_F263_E1.3040.43
198_C217_L1.2960.42
134_D173_L1.2820.42
170_Y217_L1.2590.41
186_I226_I1.2500.40
20_N251_Y1.2450.40
72_G85_V1.2340.39
54_Y244_L1.2310.39
18_G47_N1.2290.39
180_S200_V1.2280.39
14_L123_P1.2220.39
50_K258_N1.2220.39
172_M179_I1.2190.39
159_I182_A1.2160.39
85_V230_F1.2010.38
17_D24_R1.1990.38
201_L240_M1.1880.37
15_D259_C1.1840.37
173_L176_D1.1780.37
244_L267_N1.1700.36
17_D151_T1.1670.36
148_T195_I1.1580.36
42_A63_L1.1370.35
27_R231_S1.1350.35
49_E68_F1.1310.35
56_K185_E1.1280.34
149_Y196_T1.1220.34
107_I139_S1.1200.34
213_L255_L1.1110.34
25_V53_V1.1020.33
259_C267_N1.1000.33
125_F209_L1.0980.33
62_I89_Y1.0970.33
53_V63_L1.0970.33
121_S127_M1.0950.33
110_I242_A1.0940.33
12_A35_A1.0930.33
72_G244_L1.0920.33
151_T214_I1.0740.32
64_A166_N1.0730.32
213_L244_L1.0610.31
234_R266_E1.0610.31
49_E86_M1.0590.31
54_Y72_G1.0420.31
239_G242_A1.0340.30
182_A259_C1.0280.30
72_G210_T1.0250.30
24_R267_N1.0230.30
184_A193_A1.0200.30
240_M243_V1.0160.29
199_A261_I1.0160.29
211_S243_V1.0140.29
235_A271_W1.0110.29
196_T233_A1.0030.29
233_A237_S0.9990.29
121_S172_M0.9930.29
137_Q219_K0.9890.28
236_S264_G0.9880.28
193_A229_V0.9850.28
211_S247_S0.9810.28
72_G75_K0.9800.28
48_A244_L0.9650.27
137_Q251_Y0.9550.27
17_D267_N0.9530.27
54_Y233_A0.9500.27
11_T176_D0.9320.26
130_A178_L0.9220.26
39_I51_I0.9180.26
246_H254_R0.9170.25
104_Q251_Y0.9150.25
22_R197_D0.9150.25
142_Y153_V0.9070.25
137_Q177_R0.8980.25
193_A226_I0.8940.25
22_R149_Y0.8830.24
200_V235_A0.8760.24
214_I231_S0.8740.24
77_Y228_H0.8710.24
173_L178_L0.8680.24
45_E91_S0.8660.24
210_T259_C0.8630.23
194_E266_E0.8580.23
97_T267_N0.8560.23
149_Y152_P0.8510.23
24_R151_T0.8480.23
220_E233_A0.8460.23
39_I77_Y0.8420.23
54_Y198_C0.8400.23
72_G88_R0.8390.23
219_K222_A0.8390.23
17_D272_C0.8370.23
87_V190_L0.8370.23
191_G228_H0.8360.22
146_F196_T0.8340.22
68_F172_M0.8330.22
146_F152_P0.8300.22
76_G147_R0.8300.22
130_A267_N0.8290.22
48_A252_G0.8280.22
26_V151_T0.8280.22
232_L268_M0.8260.22
184_A200_V0.8240.22
14_L60_E0.8230.22
63_L214_I0.8210.22
243_V254_R0.8190.22
217_L259_C0.8150.22
185_E230_F0.8140.22
135_M160_E0.8050.21
33_E43_A0.8030.21
54_Y232_L0.8030.21
159_I254_R0.8000.21
39_I139_S0.7890.21
18_G182_A0.7860.21
183_S221_M0.7860.21
15_D151_T0.7830.21
170_Y220_E0.7810.21
16_H75_K0.7810.21
146_F149_Y0.7800.21
54_Y210_T0.7780.20
74_L85_V0.7760.20
184_A221_M0.7750.20
25_V73_Y0.7750.20
172_M209_L0.7750.20
90_L270_I0.7740.20
112_R120_D0.7740.20
23_I169_Y0.7730.20
16_H267_N0.7700.20
196_T249_Y0.7690.20
73_Y176_D0.7680.20
232_L270_I0.7650.20
209_L256_I0.7640.20
88_R232_L0.7640.20
17_D231_S0.7620.20
201_L242_A0.7610.20
15_D56_K0.7600.20
64_A86_M0.7550.20
171_I272_C0.7540.20
107_I141_L0.7540.20
198_C272_C0.7530.20
17_D21_K0.7520.20
151_T210_T0.7500.20
78_Y138_L0.7430.19
142_Y226_I0.7360.19
149_Y268_M0.7300.19
68_F170_Y0.7300.19
35_A38_D0.7290.19
123_P129_K0.7280.19
49_E110_I0.7280.19
184_A217_L0.7230.19
63_L245_Y0.7210.19
206_G274_Q0.7180.19
259_C272_C0.7140.18
88_R159_I0.7070.18
22_R268_M0.7050.18
146_F199_A0.7040.18
89_Y178_L0.7020.18
187_N231_S0.7010.18
126_T226_I0.7010.18
76_G270_I0.6990.18
186_I193_A0.6990.18
15_D52_I0.6990.18
48_A72_G0.6960.18
102_E248_G0.6960.18
155_D186_I0.6940.18
201_L265_L0.6940.18
208_S265_L0.6930.18
69_A95_R0.6890.18
69_A90_L0.6880.18
228_H272_C0.6880.18
56_K267_N0.6860.18
130_A168_V0.6850.18
113_T242_A0.6840.18
136_Y160_E0.6840.18
71_E94_R0.6830.18
52_I268_M0.6810.17
145_V233_A0.6810.17
23_I137_Q0.6800.17
179_I273_K0.6770.17
159_I206_G0.6760.17
74_L230_F0.6750.17
183_S197_D0.6740.17
95_R104_Q0.6740.17
210_T233_A0.6710.17
214_I233_A0.6690.17
135_M139_S0.6680.17
159_I167_T0.6650.17
38_D41_A0.6650.17
195_I210_T0.6640.17
16_H272_C0.6630.17
77_Y265_L0.6620.17
60_E64_A0.6570.17
20_N161_K0.6570.17
198_C232_L0.6560.17
56_K190_L0.6560.17
152_P268_M0.6530.17
56_K259_C0.6490.17
198_C267_N0.6490.17
24_R254_R0.6480.17
35_A55_A0.6480.17
74_L269_N0.6480.17
178_L235_A0.6480.17
17_D56_K0.6470.16
82_S120_D0.6430.16
156_P225_D0.6410.16
50_K71_E0.6400.16
91_S132_T0.6400.16
60_E84_C0.6390.16
102_E105_E0.6370.16
14_L171_I0.6370.16
178_L224_E0.6360.16
52_I195_I0.6310.16
40_V51_I0.6310.16
20_N208_S0.6310.16
55_A238_F0.6250.16
46_E112_R0.6250.16
78_Y134_D0.6220.16
145_V261_I0.6200.16
203_E246_H0.6190.16
89_Y213_L0.6150.16
16_H198_C0.6140.16
83_A262_A0.6120.16
55_A88_R0.6100.15
107_I133_N0.6070.15
92_E179_I0.6060.15
52_I198_C0.6050.15
26_V259_C0.6050.15
174_D204_Y0.6030.15
127_M135_M0.5990.15
133_N179_I0.5990.15
134_D176_D0.5980.15
17_D48_A0.5970.15
145_V249_Y0.5950.15
72_G233_A0.5920.15
65_K124_V0.5910.15
143_K186_I0.5840.15
54_Y237_S0.5840.15
236_S246_H0.5830.15
127_M212_F0.5820.15
201_L237_S0.5720.14
143_K181_A0.5710.14
153_V180_S0.5710.14
246_H270_I0.5710.14
75_K244_L0.5690.14
82_S192_H0.5680.14
161_K165_A0.5680.14
221_M242_A0.5680.14
151_T231_S0.5660.14
77_Y236_S0.5660.14
198_C231_S0.5610.14
168_V224_E0.5610.14
121_S124_V0.5600.14
68_F213_L0.5590.14
102_E108_E0.5570.14
178_L230_F0.5560.14
122_T127_M0.5560.14
61_P206_G0.5530.14
150_P194_E0.5520.14
25_V178_L0.5500.14
45_E166_N0.5500.14
110_I246_H0.5490.14
193_A242_A0.5480.14
72_G83_A0.5460.14
169_Y231_S0.5440.14
27_R190_L0.5430.14
123_P224_E0.5430.14
125_F200_V0.5410.14
180_S210_T0.5390.14
184_A254_R0.5390.14
25_V139_S0.5380.14
176_D200_V0.5370.14
130_A135_M0.5360.14
199_A233_A0.5350.14
139_S156_P0.5350.14
119_N144_K0.5330.14
24_R85_V0.5320.14
76_G89_Y0.5320.14
26_V231_S0.5310.13
162_T166_N0.5290.13
213_L257_N0.5280.13
15_D24_R0.5280.13
241_N269_N0.5280.13
130_A138_L0.5280.13
16_H56_K0.5260.13
91_S219_K0.5260.13
158_Y186_I0.5240.13
86_M154_F0.5230.13
48_A151_T0.5220.13
19_F260_F0.5220.13
169_Y212_F0.5200.13
24_R214_I0.5190.13
89_Y124_V0.5190.13
74_L134_D0.5190.13
210_T217_L0.5190.13
193_A217_L0.5190.13
195_I232_L0.5190.13
235_A239_G0.5180.13
23_I124_V0.5180.13
185_E255_L0.5160.13
106_I109_A0.5150.13
169_Y185_E0.5130.13
23_I118_R0.5120.13
158_Y192_H0.5120.13
149_Y185_E0.5120.13
196_T232_L0.5120.13
166_N228_H0.5110.13
46_E79_L0.5090.13
19_F23_I0.5090.13
151_T267_N0.5080.13
48_A259_C0.5080.13
109_A238_F0.5080.13
20_N87_V0.5060.13
161_K167_T0.5060.13
122_T125_F0.5060.13
229_V272_C0.5050.13
15_D244_L0.5040.13
138_L142_Y0.5040.13
153_V198_C0.5040.13
53_V210_T0.5030.13
41_A44_K0.5010.13
197_D268_M0.5010.13
78_Y166_N0.5000.13
144_K203_E0.5000.13
44_K157_A0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3iwgA 2 0.8582 99.7 0.837 Contact Map
2wpxA 1 0.8364 99.7 0.842 Contact Map
2ob0A 1 0.5491 99.7 0.844 Contact Map
1yr0A 2 0.5527 99.7 0.846 Contact Map
1gheA 1 0.5491 99.6 0.847 Contact Map
4l8aA 1 0.5491 99.6 0.848 Contact Map
2ae6A 4 0.5273 99.6 0.848 Contact Map
3kkwA 1 0.5745 99.6 0.849 Contact Map
3owcA 1 0.5491 99.6 0.849 Contact Map
4mbuA 2 0.5564 99.6 0.849 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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