GREMLIN Database
EZRA - Septation ring formation regulator EzrA
UniProt: O34894 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 562 (453)
Sequences: 10215 (9011)
Seq/√Len: 423.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
463_L466_L2.7881.00
398_H401_Y2.6631.00
205_L208_L2.6471.00
426_I429_T2.4981.00
112_L115_A2.4541.00
405_L408_L2.4181.00
442_P445_I2.4151.00
290_I293_V2.3371.00
311_M314_L2.3261.00
256_L259_L2.3081.00
391_I394_V2.2901.00
64_F67_W2.2731.00
491_S494_L2.2371.00
283_L286_I2.1861.00
449_L452_A2.1631.00
477_L480_A2.1451.00
198_L201_Q2.1211.00
363_L366_V2.1151.00
470_M473_A2.0661.00
377_Y380_L2.0451.00
237_Y240_M2.0341.00
356_L359_I2.0321.00
212_I215_V2.0291.00
456_I459_T2.0291.00
384_V387_I1.9631.00
325_K328_T1.9611.00
412_E415_A1.9461.00
484_V487_A1.9381.00
172_L175_I1.9221.00
263_L266_A1.9211.00
105_L108_I1.9161.00
297_L300_E1.9091.00
262_Q267_E1.9081.00
119_I122_I1.8761.00
111_L116_E1.8471.00
339_Y342_T1.8431.00
472_E476_H1.7931.00
79_M82_V1.7891.00
147_Y150_S1.7511.00
126_I129_L1.7371.00
139_E142_Q1.7341.00
300_E304_G1.6991.00
179_I182_F1.6991.00
191_Y194_A1.6961.00
140_I143_V1.6771.00
358_E362_L1.6751.00
332_T335_V1.6741.00
276_I279_A1.6591.00
448_M451_N1.6531.00
57_T60_T1.6511.00
71_W74_I1.6321.00
391_I395_K1.5961.00
349_Q352_F1.5891.00
419_L422_L1.5871.00
332_T336_K1.5701.00
486_R490_E1.5451.00
287_D291_Q1.5421.00
125_E130_V1.5361.00
498_V501_I1.5301.00
480_A484_V1.5261.00
195_R199_L1.5021.00
285_L289_N1.4941.00
383_E388_E1.4941.00
178_G183_E1.4851.00
376_A379_L1.4821.00
229_Q232_K1.4761.00
393_E397_E1.4751.00
255_E260_S1.4751.00
238_G242_E1.4741.00
481_E485_N1.4721.00
197_V202_D1.4681.00
360_G364_S1.4681.00
244_G247_L1.4631.00
355_R360_G1.4631.00
310_K315_I1.4611.00
137_R141_E1.4571.00
254_K258_N1.4461.00
98_F101_A1.4401.00
451_N455_H1.4401.00
86_L89_A1.4371.00
352_F362_L1.4311.00
365_S369_K1.4301.00
85_L90_E1.4291.00
368_D372_A1.4271.00
219_L222_C1.4261.00
430_A434_K1.4221.00
490_E495_V1.4221.00
318_Y321_L1.4201.00
116_E120_E1.4171.00
341_L345_E1.4041.00
353_E357_D1.4011.00
133_E136_S1.3971.00
282_I287_D1.3961.00
231_A234_K1.3881.00
289_N292_S1.3811.00
446_Q450_E1.3701.00
489_R493_E1.3661.00
351_A355_R1.3641.00
457_Q461_N1.3641.00
396_K400_E1.3611.00
271_M274_L1.3601.00
118_S123_L1.3591.00
362_L366_V1.3591.00
478_K481_E1.3581.00
138_E142_Q1.3561.00
196_K200_E1.3501.00
342_T345_E1.3441.00
149_K153_N1.3441.00
324_E329_K1.3341.00
139_E144_R1.3311.00
170_K174_E1.3281.00
425_T430_A1.3251.00
284_Q288_E1.3221.00
88_D92_N1.3191.00
338_S343_A1.3161.00
85_L89_A1.3141.00
209_Q213_D1.3121.00
229_Q234_K1.3081.00
234_K238_G1.3011.00
373_E377_Y1.2971.00
258_N262_Q1.2971.00
123_L127_S1.2941.00
301_V305_Q1.2931.00
289_N294_Y1.2921.00
462_Q467_P1.2871.00
362_L365_S1.2811.00
260_S264_K1.2801.00
165_Y168_L1.2781.00
109_D113_T1.2761.00
251_Q255_E1.2751.00
147_Y151_R1.2721.00
142_Q146_R1.2701.00
204_N209_Q1.2691.00
237_Y241_K1.2621.00
239_E243_K1.2551.00
395_K399_A1.2491.00
57_T61_E1.2471.00
483_I486_R1.2421.00
83_E87_Y1.2391.00
107_H111_L1.2391.00
411_E414_Q1.2381.00
156_A160_L1.2371.00
390_Q395_K1.2351.00
381_V385_A1.2331.00
100_K104_V1.2311.00
110_D114_A1.2261.00
70_E75_V1.2161.00
323_E327_H1.2151.00
199_L202_D1.2141.00
474_G478_K1.2131.00
441_I444_H1.2091.00
106_V109_D1.2091.00
304_G307_V1.2081.00
171_D174_E1.2001.00
114_A118_S1.1961.00
278_E282_I1.1951.00
327_H331_E1.1911.00
385_A389_K1.1901.00
158_S162_G1.1891.00
338_S342_T1.1881.00
367_K371_D1.1871.00
484_V488_S1.1861.00
427_S430_A1.1821.00
417_E421_N1.1821.00
429_T432_L1.1811.00
87_Y90_E1.1781.00
317_A320_K1.1701.00
418_T423_K1.1651.00
231_A235_D1.1651.00
210_S214_D1.1641.00
180_K183_E1.1641.00
183_E187_E1.1621.00
445_I448_M1.1611.00
143_V147_Y1.1611.00
399_A402_R1.1591.00
469_N474_G1.1591.00
448_M453_H1.1591.00
414_Q418_T1.1571.00
146_R151_R1.1521.00
115_A119_I1.1511.00
261_N265_R1.1501.00
392_E395_K1.1501.00
213_D216_P1.1491.00
298_E302_E1.1481.00
362_L367_K1.1431.00
65_E68_R1.1411.00
112_L116_E1.1401.00
298_E301_V1.1401.00
262_Q266_A1.1391.00
59_Q63_F1.1361.00
340_R343_A1.1351.00
211_Y214_D1.1321.00
108_I112_L1.1311.00
390_Q393_E1.1211.00
401_Y405_L1.1211.00
377_Y381_V1.1191.00
385_A388_E1.1191.00
104_V109_D1.1181.00
290_I294_Y1.1171.00
404_N409_R1.1161.00
386_S390_Q1.1151.00
403_E406_Q1.1151.00
357_D360_G1.1141.00
118_S121_K1.1111.00
458_E462_Q1.1091.00
312_P315_I1.1091.00
364_S367_K1.1061.00
220_A223_K1.1011.00
172_L176_W1.1011.00
379_L383_E1.1001.00
475_A479_Q1.1001.00
439_P442_P1.1001.00
182_F185_E1.0951.00
485_N488_S1.0951.00
384_V388_E1.0941.00
193_T197_V1.0941.00
450_E453_H1.0931.00
376_A381_V1.0931.00
225_T229_Q1.0901.00
228_G232_K1.0901.00
61_E65_E1.0851.00
218_L221_D1.0841.00
428_E432_L1.0831.00
457_Q460_V1.0761.00
199_L203_R1.0741.00
253_D257_E1.0731.00
310_K313_E1.0731.00
415_A419_L1.0711.00
291_Q294_Y1.0701.00
400_E404_N1.0701.00
311_M315_I1.0691.00
490_E493_E1.0671.00
211_Y216_P1.0641.00
369_K372_A1.0641.00
121_K125_E1.0631.00
127_S131_T1.0621.00
129_L133_E1.0621.00
141_E144_R1.0601.00
479_Q483_I1.0591.00
315_I319_D1.0591.00
476_H479_Q1.0591.00
124_R128_D1.0571.00
63_F68_R1.0571.00
144_R148_S1.0551.00
359_I363_L1.0551.00
90_E94_D1.0541.00
81_K85_L1.0521.00
455_H458_E1.0511.00
113_T116_E1.0501.00
72_D76_T1.0501.00
423_K427_S1.0481.00
208_L215_V1.0471.00
226_V229_Q1.0471.00
334_L338_S1.0461.00
493_E497_Q1.0461.00
275_D280_S1.0451.00
304_G308_L1.0451.00
450_E454_H1.0441.00
478_K482_D1.0441.00
280_S284_Q1.0431.00
99_K103_Q1.0431.00
494_L498_V1.0431.00
293_V300_E1.0411.00
176_W180_K1.0401.00
87_Y91_E1.0401.00
171_D176_W1.0391.00
444_H448_M1.0391.00
403_E407_A1.0381.00
180_K184_E1.0331.00
453_H457_Q1.0321.00
184_E187_E1.0321.00
363_L367_K1.0321.00
491_S495_V1.0311.00
462_Q465_E1.0281.00
238_G241_K1.0281.00
227_P231_A1.0281.00
325_K329_K1.0271.00
215_V219_L1.0271.00
321_L325_K1.0241.00
264_K268_H1.0231.00
437_N441_I1.0211.00
330_A334_L1.0201.00
455_H460_V1.0181.00
485_N489_R1.0161.00
184_E188_G1.0161.00
106_V110_D1.0151.00
160_L164_L1.0051.00
303_A306_S1.0041.00
476_H481_E1.0041.00
66_K70_E1.0031.00
218_L223_K0.9971.00
326_E329_K0.9961.00
354_K358_E0.9961.00
111_L114_A0.9941.00
324_E327_H0.9921.00
331_E336_K0.9921.00
296_Q301_V0.9921.00
439_P443_S0.9901.00
190_N193_T0.9871.00
410_K414_Q0.9841.00
281_A285_L0.9831.00
292_S296_Q0.9811.00
419_L423_K0.9751.00
82_V85_L0.9751.00
103_Q107_H0.9741.00
492_E495_V0.9731.00
206_E209_Q0.9711.00
145_E149_K0.9701.00
463_L467_P0.9691.00
175_I179_I0.9671.00
62_E66_K0.9661.00
445_I452_A0.9641.00
245_Y248_E0.9621.00
495_V499_I0.9621.00
259_L262_Q0.9611.00
295_Q299_G0.9611.00
420_S424_K0.9611.00
300_E303_A0.9591.00
355_R358_E0.9521.00
456_I460_V0.9521.00
210_S213_D0.9511.00
296_Q299_G0.9501.00
173_D176_W0.9491.00
406_Q409_R0.9491.00
197_V201_Q0.9471.00
288_E292_S0.9471.00
235_D239_E0.9461.00
350_Q354_K0.9461.00
192_I195_R0.9421.00
113_T117_S0.9411.00
322_K326_E0.9411.00
317_A322_K0.9391.00
257_E261_N0.9381.00
324_E328_T0.9331.00
469_N472_E0.9311.00
204_N207_R0.9301.00
86_L90_E0.9291.00
282_I285_L0.9261.00
115_A122_I0.9261.00
80_P83_E0.9251.00
442_P446_Q0.9231.00
411_E416_R0.9221.00
466_L470_M0.9211.00
146_R150_S0.9201.00
441_I446_Q0.9181.00
157_Y161_Y0.9171.00
488_S492_E0.9171.00
441_I445_I0.9161.00
177_S181_Q0.9141.00
413_L417_E0.9131.00
373_E376_A0.9091.00
328_T332_T0.9091.00
350_Q353_E0.9091.00
169_E173_D0.9081.00
251_Q254_K0.9081.00
374_H378_S0.9081.00
404_N407_A0.9081.00
283_L287_D0.9041.00
382_E386_S0.9031.00
214_D218_L0.9031.00
349_Q353_E0.9011.00
173_D177_S0.9011.00
397_E400_E0.9001.00
244_G248_E0.8991.00
205_L209_Q0.8991.00
85_L88_D0.8991.00
399_A403_E0.8961.00
425_T428_E0.8961.00
128_D132_S0.8951.00
467_P471_E0.8941.00
443_S447_E0.8941.00
197_V200_E0.8941.00
80_P84_E0.8911.00
402_R406_Q0.8861.00
500_L503_K0.8861.00
462_Q466_L0.8851.00
277_D281_A0.8841.00
357_D361_K0.8821.00
295_Q298_E0.8811.00
368_D371_D0.8791.00
157_Y160_L0.8791.00
329_K333_E0.8781.00
387_I391_I0.8771.00
65_E69_E0.8761.00
127_S130_V0.8761.00
56_M60_T0.8731.00
71_W75_V0.8721.00
198_L202_D0.8721.00
196_K199_L0.8701.00
194_A198_L0.8691.00
120_E123_L0.8681.00
471_E474_G0.8681.00
326_E330_A0.8681.00
207_R211_Y0.8671.00
108_I115_A0.8661.00
125_E128_D0.8651.00
447_E451_N0.8631.00
58_G62_E0.8601.00
115_A118_S0.8601.00
195_R198_L0.8591.00
213_D217_K0.8571.00
339_Y343_A0.8511.00
302_E306_S0.8511.00
389_K393_E0.8491.00
185_E188_G0.8481.00
159_H163_E0.8441.00
445_I449_L0.8441.00
164_L167_S0.8431.00
219_L223_K0.8431.00
230_I237_Y0.8421.00
232_K236_G0.8421.00
496_E499_I0.8411.00
264_K267_E0.8361.00
136_S140_I0.8351.00
162_G166_D0.8351.00
378_S381_V0.8341.00
105_L109_D0.8321.00
203_R207_R0.8321.00
438_I441_I0.8311.00
309_S313_E0.8291.00
316_I320_K0.8271.00
511_F514_Q0.8251.00
230_I233_L0.8241.00
392_E396_K0.8231.00
69_E73_E0.8211.00
148_S151_R0.8211.00
55_K59_Q0.8201.00
281_A284_Q0.8181.00
287_D290_I0.8171.00
208_L212_I0.8171.00
475_A478_K0.8161.00
482_D486_R0.8141.00
192_I196_K0.8121.00
95_K99_K0.8111.00
286_I290_I0.8101.00
140_I144_R0.8091.00
135_K139_E0.8071.00
117_S120_E0.8051.00
440_G444_H0.8051.00
89_A92_N0.8021.00
208_L211_Y0.8001.00
454_H458_E0.7991.00
420_S423_K0.7981.00
122_I126_I0.7981.00
320_K324_E0.7971.00
200_E204_N0.7961.00
464_N467_P0.7951.00
99_K102_N0.7951.00
155_L158_S0.7941.00
60_T64_F0.7931.00
236_G239_E0.7931.00
252_L262_Q0.7921.00
299_G303_A0.7881.00
359_I362_L0.7861.00
483_I488_S0.7851.00
58_G61_E0.7781.00
229_Q233_L0.7781.00
177_S180_K0.7771.00
276_I280_S0.7751.00
255_E258_N0.7751.00
263_L267_E0.7731.00
331_E334_L0.7711.00
366_V370_L0.7711.00
216_P220_A0.7691.00
124_R127_S0.7691.00
262_Q265_R0.7671.00
63_F66_K0.7671.00
119_I123_L0.7661.00
308_L312_P0.7661.00
230_I234_K0.7651.00
332_T339_Y0.7641.00
265_R269_V0.7621.00
167_S171_D0.7621.00
178_G181_Q0.7621.00
337_E341_L0.7611.00
279_A282_I0.7601.00
202_D206_E0.7571.00
511_F515_N0.7551.00
190_N194_A0.7541.00
194_A197_V0.7531.00
70_E73_E0.7511.00
163_E167_S0.7501.00
174_E178_G0.7501.00
443_S446_Q0.7491.00
370_L373_E0.7431.00
171_D175_I0.7411.00
313_E317_A0.7411.00
410_K413_L0.7401.00
312_P316_I0.7341.00
310_K314_L0.7321.00
201_Q205_L0.7281.00
418_T421_N0.7271.00
169_E172_L0.7241.00
130_V134_E0.7231.00
56_M61_E0.7211.00
425_T429_T0.7191.00
179_I183_E0.7191.00
407_A411_E0.7191.00
59_Q62_E0.7161.00
416_R420_S0.7151.00
198_L205_L0.7151.00
56_M59_Q0.7121.00
388_E392_E0.7091.00
448_M452_A0.7091.00
217_K221_D0.7091.00
160_L163_E0.7081.00
429_T433_L0.7061.00
305_Q308_L0.7061.00
141_E145_E0.7051.00
111_L115_A0.7041.00
261_N264_K0.7041.00
257_E260_S0.7021.00
284_Q287_D0.7011.00
340_R344_G0.7001.00
191_Y195_R0.7001.00
236_G241_K0.6991.00
421_N425_T0.6971.00
412_E416_R0.6971.00
97_R100_K0.6911.00
148_S152_K0.6901.00
250_I254_K0.6891.00
427_S431_R0.6891.00
492_E496_E0.6881.00
364_S368_D0.6861.00
130_V133_E0.6851.00
299_G302_E0.6831.00
72_D75_V0.6781.00
484_V494_L0.6751.00
79_M83_E0.6751.00
449_L453_H0.6751.00
215_V218_L0.6741.00
104_V107_H0.6741.00
283_L290_I0.6741.00
470_M474_G0.6731.00
131_T135_K0.6701.00
275_D278_E0.6671.00
452_A456_I0.6651.00
146_R149_K0.6651.00
67_W70_E0.6640.99
140_I147_Y0.6620.99
355_R362_L0.6610.99
424_K428_E0.6590.99
117_S121_K0.6570.99
204_N208_L0.6570.99
359_I366_V0.6560.99
73_E78_H0.6550.99
459_T463_L0.6530.99
382_E385_A0.6420.99
133_E137_R0.6400.99
303_A308_L0.6400.99
493_E496_E0.6370.99
413_L416_R0.6360.99
481_E484_V0.6350.99
120_E124_R0.6340.99
129_L132_S0.6340.99
361_K365_S0.6330.99
321_L324_E0.6310.99
502_E506_Q0.6310.99
412_E419_L0.6300.99
111_L118_S0.6290.99
338_S341_L0.6280.99
342_T349_Q0.6280.99
152_K156_A0.6280.99
166_D169_E0.6240.99
391_I398_H0.6240.99
167_S170_K0.6230.99
305_Q309_S0.6230.99
220_A224_Q0.6230.99
465_E469_N0.6210.99
471_E475_A0.6180.99
168_L172_L0.6180.99
451_N454_H0.6180.99
356_L360_G0.6160.99
101_A104_V0.6150.99
61_E64_F0.6140.99
512_R515_N0.6130.99
406_Q410_K0.6080.99
308_L311_M0.6070.99
206_E210_S0.6060.99
383_E386_S0.6050.99
356_L363_L0.6040.99
203_R206_E0.6020.99
296_Q300_E0.6020.99
95_K98_F0.6020.99
395_K398_H0.6020.99
366_V369_K0.6010.99
333_E336_K0.6010.99
319_D322_K0.6000.99
447_E450_E0.5970.99
131_T134_E0.5960.99
349_Q362_L0.5950.99
297_L301_V0.5930.99
252_L256_L0.5920.99
345_E348_K0.5910.99
288_E291_Q0.5890.99
166_D170_K0.5870.99
102_N106_V0.5840.99
301_V304_G0.5830.99
440_G443_S0.5830.99
136_S139_E0.5820.99
240_M243_K0.5800.99
78_H82_V0.5780.99
62_E65_E0.5750.99
477_L484_V0.5740.99
154_L157_Y0.5740.99
233_L236_G0.5730.99
111_L126_I0.5700.98
226_V230_I0.5700.98
157_Y162_G0.5670.98
254_K257_E0.5660.98
110_D113_T0.5660.98
426_I430_A0.5660.98
415_A425_T0.5640.98
391_I405_L0.5640.98
246_K249_H0.5630.98
307_V310_K0.5630.98
98_F102_N0.5620.98
290_I304_G0.5620.98
461_N465_E0.5620.98
319_D323_E0.5610.98
282_I286_I0.5600.98
229_Q236_G0.5590.98
397_E402_R0.5570.98
189_G193_T0.5530.98
294_Y298_E0.5520.98
375_V379_L0.5510.98
259_L263_L0.5510.98
461_N464_N0.5510.98
78_H81_K0.5510.98
108_I111_L0.5490.98
460_V464_N0.5470.98
390_Q394_V0.5470.98
255_E259_L0.5450.98
417_E420_S0.5450.98
442_P449_L0.5440.98
309_S312_P0.5420.98
165_Y169_E0.5400.98
183_E186_T0.5380.98
424_K427_S0.5370.98
214_D217_K0.5360.98
256_L260_S0.5340.98
330_A333_E0.5330.98
397_E401_Y0.5330.98
144_R147_Y0.5320.98
134_E138_E0.5310.98
53_H56_M0.5310.98
452_A459_T0.5290.98
394_V398_H0.5280.97
217_K220_A0.5260.97
85_L93_A0.5250.97
97_R102_N0.5240.97
89_A93_A0.5240.97
452_A455_H0.5240.97
101_A105_L0.5230.97
362_L370_L0.5220.97
378_S382_E0.5210.97
337_E340_R0.5200.97
122_I133_E0.5170.97
162_G165_Y0.5170.97
225_T228_G0.5150.97
100_K103_Q0.5150.97
409_R412_E0.5150.97
277_D280_S0.5140.97
352_F359_I0.5130.97
414_Q417_E0.5120.97
168_L175_I0.5120.97
468_L472_E0.5120.97
211_Y215_V0.5110.97
178_G182_F0.5100.97
112_L122_I0.5100.97
105_L112_L0.5100.97
107_H110_D0.5100.97
164_L169_E0.5090.97
63_F67_W0.5090.97
360_G363_L0.5070.97
476_H480_A0.5070.97
487_A491_S0.5060.97
259_L266_A0.5000.97
480_A483_I0.5000.97
84_E88_D0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4uxvA 1 0.927 100 0.367 Contact Map
1i84S 2 0.2544 99.6 0.654 Contact Map
1c1gA 2 0.5053 99.2 0.72 Contact Map
4uy3A 1 0.3452 99.1 0.738 Contact Map
3r6nA 1 0.7135 97.9 0.818 Contact Map
1hciA 2 0.7473 97.8 0.821 Contact Map
2dfsA 2 0.3132 97.5 0.831 Contact Map
1u4qA 1 0.5 97.4 0.834 Contact Map
3kbtA 1 0.4164 97 0.845 Contact Map
3edvA 2 0.532 96.8 0.85 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0137 seconds.