GREMLIN Database
YNGF - Putative enoyl-CoA hydratase/isomerase YngF
UniProt: O34893 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 260 (247)
Sequences: 30254 (19775)
Seq/√Len: 1258.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
126_E184_A3.1591.00
129_V167_R3.1441.00
181_H191_K3.0551.00
124_A179_V2.9131.00
102_A119_C2.7791.00
191_K194_E2.7771.00
16_L193_E2.5931.00
44_E97_P2.4901.00
127_A185_P2.4761.00
41_Q92_L2.4571.00
166_R198_A2.3081.00
6_L20_N2.2891.00
25_A60_K2.2721.00
221_D224_T2.2241.00
172_E175_E2.2051.00
169_T172_E2.1611.00
160_E166_R2.1231.00
157_K176_I2.0411.00
126_E171_H2.0151.00
136_G202_N2.0071.00
16_L55_T1.9911.00
25_A61_A1.9561.00
162_I210_A1.9521.00
103_A192_A1.9111.00
244_E253_R1.8991.00
187_D190_P1.8941.00
7_F15_A1.8841.00
13_H50_R1.8681.00
109_L131_G1.8631.00
37_Q92_L1.8531.00
31_E35_N1.8211.00
18_T57_T1.8161.00
20_N57_T1.8131.00
103_A189_M1.8091.00
123_I183_T1.7981.00
247_Q251_E1.7771.00
15_A43_I1.7651.00
159_K215_N1.7351.00
10_K15_A1.7321.00
160_E180_E1.7321.00
18_T55_T1.7281.00
193_E197_A1.6961.00
10_K46_N1.6821.00
172_E176_I1.6401.00
52_V96_L1.6341.00
8_T11_N1.6131.00
15_A49_I1.5701.00
120_D211_K1.5691.00
34_R85_L1.5671.00
155_R159_K1.5661.00
123_I195_L1.5421.00
171_H175_E1.5411.00
126_E185_P1.5211.00
125_T185_P1.5191.00
160_E181_H1.5041.00
124_A130_L1.5001.00
42_E46_N1.4861.00
43_I52_V1.4841.00
187_D191_K1.4741.00
44_E92_L1.4691.00
159_K214_I1.4571.00
116_A122_R1.4521.00
183_T191_K1.4451.00
122_R156_G1.4361.00
12_E197_A1.4301.00
122_R152_L1.4271.00
17_I39_I1.4241.00
51_C196_A1.4181.00
11_N193_E1.3991.00
91_A223_A1.3831.00
55_T105_N1.3801.00
174_K182_V1.3761.00
7_F43_I1.3651.00
159_K163_Y1.3631.00
91_A95_A1.3591.00
104_I116_A1.3481.00
105_N127_A1.3451.00
94_D148_R1.3361.00
105_N125_T1.3321.00
11_N197_A1.3251.00
93_L100_V1.3191.00
40_I96_L1.3181.00
6_L57_T1.3171.00
157_K160_E1.3121.00
104_I108_A1.2981.00
166_R172_E1.2961.00
113_L132_L1.2951.00
60_K105_N1.2911.00
30_A70_E1.2881.00
37_Q41_Q1.2851.00
161_F168_V1.2671.00
11_N16_L1.2551.00
75_K78_Q1.2441.00
209_Q235_Q1.2381.00
29_S32_M1.2271.00
131_G167_R1.2221.00
21_R24_A1.2031.00
16_L189_M1.2021.00
44_E96_L1.1911.00
107_S129_V1.1851.00
19_L32_M1.1811.00
55_T189_M1.1791.00
156_G180_E1.1771.00
135_T165_G1.1771.00
37_Q88_R1.1751.00
157_K172_E1.1741.00
212_F216_K1.1691.00
202_N207_V1.1571.00
242_R246_L1.1561.00
35_N39_I1.1501.00
188_L192_A1.1471.00
61_A107_S1.1451.00
189_M193_E1.1321.00
220_T224_T1.1281.00
125_T188_L1.1221.00
24_A69_K1.1181.00
8_T18_T1.1111.00
170_A182_V1.0861.00
189_M192_A1.0851.00
168_V176_I1.0821.00
220_T228_I1.0751.00
19_L63_C1.0751.00
154_G157_K1.0701.00
63_C112_G1.0551.00
95_A223_A1.0381.00
35_N38_M1.0251.00
8_T16_L1.0131.00
52_V98_Q1.0111.00
100_V119_C1.0081.00
216_K228_I1.0071.00
86_I143_A1.0061.00
30_A34_R1.0041.00
38_M42_E0.9991.00
121_L195_L0.9931.00
58_G105_N0.9901.00
184_A187_D0.9861.00
21_R67_D0.9861.00
205_I241_D0.9811.00
6_L18_T0.9591.00
153_I157_K0.9451.00
7_F10_K0.9441.00
196_A200_S0.9441.00
114_E145_G0.9381.00
39_I42_E0.9231.00
174_K179_V0.9231.00
53_I192_A0.9211.00
152_L156_G0.9191.00
55_T103_A0.9121.00
113_L130_L0.9121.00
10_K48_N0.9101.00
171_H174_K0.9091.00
126_E182_V0.9041.00
146_T229_E0.9001.00
16_L53_I0.8981.00
97_P208_R0.8971.00
129_V169_T0.8951.00
204_P208_R0.8921.00
190_P194_E0.8901.00
52_V100_V0.8901.00
147_Q225_G0.8881.00
193_E196_A0.8851.00
49_I98_Q0.8841.00
105_N188_L0.8831.00
243_R247_Q0.8821.00
47_S98_Q0.8791.00
135_T210_A0.8771.00
224_T227_A0.8771.00
212_F232_A0.8761.00
14_M51_C0.8691.00
80_L84_S0.8691.00
104_I130_L0.8601.00
155_R218_L0.8561.00
103_A188_L0.8561.00
199_I207_V0.8461.00
33_L89_T0.8451.00
10_K42_E0.8421.00
104_I122_R0.8381.00
228_I231_K0.8371.00
25_A64_A0.8331.00
121_L180_E0.8261.00
140_I236_T0.8211.00
125_T186_C0.8201.00
194_E198_A0.8171.00
209_Q232_A0.8041.00
37_Q85_L0.8021.00
40_I93_L0.7961.00
213_A232_A0.7951.00
105_N185_P0.7941.00
153_I161_F0.7831.00
162_I214_I0.7821.00
41_Q45_F0.7821.00
174_K181_H0.7821.00
114_E134_E0.7801.00
109_L167_R0.7791.00
161_F176_I0.7771.00
43_I49_I0.7751.00
149_L153_I0.7711.00
41_Q88_R0.7631.00
69_K250_Q0.7591.00
191_K195_L0.7581.00
209_Q212_F0.7551.00
209_Q236_T0.7541.00
44_E98_Q0.7531.00
17_I52_V0.7511.00
30_A85_L0.7481.00
37_Q89_T0.7451.00
46_N49_I0.7451.00
54_L119_C0.7431.00
34_R38_M0.7431.00
77_D81_E0.7421.00
10_K13_H0.7371.00
190_P193_E0.7351.00
181_H195_L0.7341.00
136_G167_R0.7331.00
110_G133_P0.7321.00
97_P212_F0.7301.00
29_S70_E0.7281.00
170_A179_V0.7281.00
21_R29_S0.7271.00
203_G241_D0.7251.00
192_A196_A0.7231.00
147_Q150_P0.7221.00
228_I232_A0.7221.00
240_K243_R0.7161.00
160_E164_T0.7151.00
96_L100_V0.7131.00
80_L231_K0.7111.00
222_L226_L0.7111.00
173_A178_L0.7111.00
61_A105_N0.7101.00
183_T188_L0.7071.00
246_L250_Q0.7041.00
28_L32_M0.7041.00
50_R204_P0.7031.00
194_E197_A0.7021.00
127_A170_A0.7001.00
90_A118_A0.6991.00
232_A235_Q0.6951.00
227_A231_K0.6941.00
154_G158_A0.6921.00
198_A202_N0.6911.00
117_L178_L0.6911.00
134_E142_G0.6911.00
104_I128_A0.6901.00
10_K49_I0.6831.00
25_A107_S0.6801.00
84_S88_R0.6791.00
7_F42_E0.6761.00
216_K220_T0.6751.00
14_M53_I0.6731.00
7_F39_I0.6711.00
205_I239_T0.6651.00
179_V182_V0.6641.00
123_I181_H0.6601.00
53_I193_E0.6591.00
21_R27_A0.6551.00
123_I192_A0.6541.00
140_I213_A0.6521.00
13_H48_N0.6521.00
5_I39_I0.6521.00
230_Q234_E0.6521.00
231_K235_Q0.6511.00
197_A201_A0.6501.00
130_L179_V0.6461.00
46_N98_Q0.6451.00
53_I103_A0.6421.00
155_R215_N0.6421.00
43_I98_Q0.6411.00
96_L99_P0.6401.00
134_E141_P0.6401.00
164_T195_L0.6381.00
204_P207_V0.6371.00
54_L100_V0.6361.00
124_A128_A0.6331.00
84_S230_Q0.6301.00
223_A227_A0.6291.00
39_I43_I0.6291.00
101_I196_A0.6291.00
109_L133_P0.6271.00
31_E34_R0.6261.00
32_M35_N0.6241.00
76_E235_Q0.6231.00
155_R214_I0.6221.00
213_A228_I0.6181.00
102_A122_R0.6141.00
72_I247_Q0.6131.00
134_E233_Y0.6111.00
157_K174_K0.6111.00
36_L89_T0.6061.00
131_G165_G0.6031.00
195_L198_A0.6021.00
141_P210_A0.6011.00
244_E251_E0.6011.00
123_I191_K0.5991.00
114_E142_G0.5991.00
164_T199_I0.5991.00
244_E248_A0.5961.00
41_Q44_E0.5951.00
66_A71_R0.5941.00
153_I158_A0.5901.00
123_I188_L0.5891.00
51_C101_I0.5891.00
38_M41_Q0.5871.00
171_H182_V0.5861.00
88_R91_A0.5851.00
244_E247_Q0.5851.00
241_D245_G0.5811.00
245_G248_A0.5741.00
50_R200_S0.5741.00
14_M193_E0.5731.00
24_A67_D0.5731.00
160_E172_E0.5721.00
163_Y207_V0.5711.00
80_L234_E0.5691.00
132_L162_I0.5681.00
105_N128_A0.5671.00
247_Q250_Q0.5651.00
14_M196_A0.5651.00
168_V173_A0.5631.00
169_T175_E0.5621.00
152_L180_E0.5611.00
17_I40_I0.5611.00
107_S167_R0.5591.00
146_T225_G0.5531.00
153_I176_I0.5511.00
17_I54_L0.5501.00
210_A213_A0.5471.00
139_I242_R0.5461.00
114_E144_G0.5451.00
40_I92_L0.5451.00
51_C200_S0.5441.00
121_L199_I0.5431.00
170_A174_K0.5431.00
116_A119_C0.5421.00
125_T128_A0.5381.00
31_E70_E0.5371.00
205_I236_T0.5371.00
240_K244_E0.5361.00
159_K211_K0.5331.00
118_A148_R0.5271.00
150_P153_I0.5261.00
187_D194_E0.5251.00
147_Q151_R0.5251.00
58_G61_A0.5251.00
88_R92_L0.5231.00
49_I52_V0.5231.00
166_R181_H0.5211.00
40_I100_V0.5201.00
103_A196_A0.5191.00
150_P217_G0.5191.00
164_T198_A0.5181.00
113_L178_L0.5181.00
114_E132_L0.5171.00
53_I189_M0.5161.00
220_T225_G0.5131.00
157_K175_E0.5121.00
78_Q81_E0.5111.00
110_G132_L0.5101.00
68_L137_L0.5101.00
29_S67_D0.5081.00
18_T189_M0.5071.00
33_L37_Q0.5071.00
173_A179_V0.5061.00
7_F17_I0.5061.00
17_I43_I0.5061.00
135_T202_N0.5051.00
40_I52_V0.5041.00
134_E144_G0.5011.00
111_G143_A0.5001.00
28_L111_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4jfcA 3 0.9769 100 0.082 Contact Map
2ppyA 6 0.9923 100 0.086 Contact Map
3qxzA 3 0.9885 100 0.087 Contact Map
2ej5A 3 0.9654 100 0.087 Contact Map
3kqfA 3 0.9923 100 0.087 Contact Map
1nzyA 4 0.9923 100 0.087 Contact Map
3sllA 6 0.9769 100 0.089 Contact Map
4olqA 3 0.9846 100 0.089 Contact Map
4lk5A 3 0.9577 100 0.092 Contact Map
3swxA 3 0.9846 100 0.092 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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