GREMLIN Database
YFLB - Uncharacterized protein YflB
UniProt: O34887 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 130 (119)
Sequences: 373 (279)
Seq/√Len: 25.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
34_D48_R6.2331.00
46_G49_I3.4811.00
34_D37_A3.3831.00
43_L72_L3.2091.00
16_I21_F3.1231.00
58_D61_A2.8911.00
56_A60_G2.8571.00
61_A64_K2.7871.00
7_V10_D2.2110.97
15_A20_D2.0270.96
14_R69_I1.9810.95
93_Q97_D1.9370.94
57_E60_G1.8410.93
14_R18_D1.8270.92
22_Q27_M1.8150.92
92_K96_L1.8130.92
56_A73_I1.7650.91
21_F76_C1.6560.88
21_F53_A1.6420.87
43_L47_Y1.5920.86
96_L104_G1.5460.84
90_S97_D1.4780.81
115_K119_Y1.4470.80
13_K17_K1.4400.79
47_Y72_L1.4370.79
9_E23_N1.4340.79
21_F27_M1.3870.77
8_S65_E1.3570.75
26_G31_L1.3370.74
71_H74_E1.3320.74
46_G50_L1.3040.72
58_D103_K1.2940.72
90_S93_Q1.2510.69
18_D27_M1.2490.69
4_S90_S1.2030.66
30_P76_C1.1950.65
10_D14_R1.1870.65
7_V11_K1.1560.63
79_E82_R1.1550.63
61_A65_E1.1490.62
39_L57_E1.1420.62
37_A40_P1.1210.60
10_D13_K1.1180.60
60_G64_K1.1170.60
31_L35_D1.1140.60
37_A60_G1.0990.59
47_Y89_K1.0970.59
116_N120_D1.0930.58
33_K37_A1.0840.58
30_P50_L1.0810.57
4_S70_D1.0700.57
91_E95_L1.0420.55
82_R86_I1.0300.54
39_L43_L1.0270.53
8_S12_I1.0260.53
92_K111_S1.0250.53
32_P37_A1.0070.52
31_L38_H1.0060.52
60_G67_M1.0030.52
7_V62_L0.9980.51
15_A96_L0.9830.50
16_I56_A0.9780.50
111_S115_K0.9710.49
8_S45_M0.9610.49
38_H45_M0.9600.49
29_K122_L0.9550.48
2_D5_H0.9480.48
36_A48_R0.9350.47
20_D28_G0.9280.46
62_L95_L0.9270.46
22_Q115_K0.9050.45
119_Y122_L0.8970.44
50_L61_A0.8920.44
81_E87_R0.8910.44
33_K36_A0.8730.42
60_G96_L0.8650.42
66_L89_K0.8510.41
10_D49_I0.8500.41
109_P112_A0.8410.40
49_I83_E0.8410.40
34_D41_E0.8330.39
13_K16_I0.8210.39
38_H63_K0.8200.39
17_K64_K0.8100.38
12_I29_K0.8020.37
21_F24_L0.8000.37
33_K48_R0.7760.36
118_V122_L0.7690.35
55_M69_I0.7590.34
14_R74_E0.7520.34
18_D112_A0.7490.34
38_H44_R0.7440.33
13_K29_K0.7440.33
82_R122_L0.7420.33
14_R123_G0.7380.33
63_K104_G0.7380.33
83_E122_L0.7340.33
113_F116_N0.7330.33
70_D74_E0.7270.32
46_G97_D0.7160.32
80_K102_K0.7060.31
7_V64_K0.7040.31
11_K45_M0.7000.31
55_M93_Q0.6870.30
74_E121_R0.6830.30
88_K116_N0.6830.30
87_R96_L0.6830.30
110_A113_F0.6750.29
107_S110_A0.6750.29
4_S29_K0.6750.29
46_G111_S0.6750.29
14_R121_R0.6700.29
7_V90_S0.6630.28
26_G30_P0.6620.28
34_D73_I0.6600.28
63_K110_A0.6600.28
18_D29_K0.6580.28
35_D52_N0.6580.28
23_N80_K0.6520.28
8_S63_K0.6520.28
20_D117_K0.6480.27
7_V50_L0.6470.27
35_D39_L0.6430.27
64_K106_F0.6380.27
45_M122_L0.6330.27
59_E89_K0.6250.26
34_D39_L0.6220.26
46_G77_Y0.6210.26
10_D77_Y0.6210.26
113_F117_K0.6190.26
37_A48_R0.6180.26
3_F14_R0.6170.26
15_A87_R0.6140.26
83_E86_I0.6140.26
93_Q109_P0.6120.25
37_A44_R0.6110.25
29_K50_L0.6100.25
118_V121_R0.6070.25
25_P28_G0.6060.25
35_D59_E0.6040.25
91_E110_A0.5990.25
68_T84_Q0.5980.25
18_D30_P0.5910.24
5_H93_Q0.5880.24
76_C103_K0.5870.24
23_N48_R0.5850.24
49_I53_A0.5820.24
45_M85_L0.5810.24
23_N27_M0.5750.23
42_S78_D0.5720.23
104_G108_K0.5650.23
34_D59_E0.5650.23
47_Y121_R0.5650.23
85_L113_F0.5620.23
109_P113_F0.5610.23
97_D117_K0.5520.22
58_D108_K0.5510.22
43_L94_L0.5510.22
24_L28_G0.5500.22
20_D67_M0.5490.22
5_H11_K0.5470.22
42_S63_K0.5450.22
74_E119_Y0.5430.22
31_L96_L0.5390.22
38_H85_L0.5330.21
59_E64_K0.5280.21
42_S83_E0.5240.21
24_L53_A0.5210.21
64_K78_D0.5200.21
115_K118_V0.5170.20
4_S45_M0.5160.20
81_E84_Q0.5140.20
4_S7_V0.5120.20
76_C92_K0.5120.20
91_E94_L0.5090.20
9_E105_M0.5090.20
13_K123_G0.5060.20
34_D122_L0.5000.20
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1bh9B 1 0.3308 31.7 0.935 Contact Map
4uxvA 1 0.9077 18.9 0.941 Contact Map
3uo3A 1 0.9615 18.7 0.941 Contact Map
3ca8A 1 0.4538 15.7 0.943 Contact Map
3g06A 1 0.8 10.8 0.947 Contact Map
3nl9A 2 0.4385 10 0.948 Contact Map
2xs1A 1 0.9462 8.7 0.949 Contact Map
1juqA 3 0.3923 8.6 0.95 Contact Map
1g6uA 3 0.3692 7.9 0.95 Contact Map
4h0eA 2 0.4769 7.8 0.951 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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