GREMLIN Database
YTCB - Uncharacterized UDP-glucose epimerase YtcB
UniProt: O34886 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 316 (286)
Sequences: 60188 (41727)
Seq/√Len: 2467.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
8_A30_G3.4361.00
224_G241_I2.8841.00
19_E223_K2.7761.00
237_E285_K2.7731.00
255_L299_K2.7081.00
69_A115_E2.6921.00
297_S300_D2.6591.00
258_D299_K2.4721.00
77_V229_L2.4031.00
100_A104_Q2.3991.00
6_T80_H2.3081.00
284_S288_Q2.2811.00
31_I61_E2.2661.00
120_T170_P2.2541.00
287_K293_D2.2521.00
80_H123_F2.2351.00
124_A225_I2.2321.00
180_Y301_G2.2111.00
5_V17_C2.2041.00
79_F229_L2.1071.00
223_K295_A2.0531.00
4_L75_V2.0421.00
19_E226_T2.0061.00
29_I57_T1.8941.00
250_L254_S1.8931.00
223_K227_A1.8871.00
24_K230_G1.8871.00
29_I75_V1.8361.00
259_I303_T1.8261.00
219_S304_N1.8141.00
176_F225_I1.8001.00
248_S251_K1.7761.00
93_N97_P1.7641.00
27_N57_T1.7481.00
255_L258_D1.7431.00
19_E24_K1.7361.00
16_L79_F1.7311.00
160_C171_I1.7311.00
16_L222_V1.7301.00
138_S141_T1.7271.00
64_L100_A1.7261.00
174_L228_V1.6731.00
125_S129_V1.6601.00
217_Y304_N1.6391.00
244_A287_K1.6351.00
130_Y240_N1.6311.00
34_F58_F1.6301.00
29_I59_I1.6121.00
80_H106_L1.6041.00
66_A111_E1.6011.00
251_K254_S1.6011.00
12_I179_V1.5981.00
16_L81_L1.5641.00
286_A290_L1.5631.00
107_Q111_E1.5581.00
139_E285_K1.5551.00
69_A112_A1.5511.00
195_K199_Q1.5461.00
174_L225_I1.5261.00
107_Q159_L1.5241.00
255_L259_I1.5181.00
303_T307_A1.5171.00
76_D119_Q1.5101.00
79_F225_I1.4851.00
78_I113_C1.4791.00
149_Y153_K1.4721.00
19_E22_K1.4721.00
202_P267_H1.4541.00
104_Q107_Q1.4491.00
217_Y301_G1.4441.00
99_A155_T1.4421.00
283_I287_K1.4371.00
102_N152_T1.4341.00
19_E222_V1.4331.00
109_L121_F1.4271.00
96_H100_A1.4061.00
218_I222_V1.4031.00
81_L124_A1.3941.00
176_F221_C1.3751.00
177_F281_A1.3681.00
26_H230_G1.3671.00
226_T230_G1.3651.00
17_C30_G1.3641.00
120_T172_V1.3581.00
18_E183_R1.3561.00
66_A108_R1.3551.00
69_A116_H1.3301.00
300_D303_T1.3251.00
154_L158_K1.3221.00
143_L154_L1.3191.00
124_A176_F1.3051.00
227_A231_K1.3011.00
216_T221_C1.3011.00
138_S282_D1.3011.00
9_A32_D1.2961.00
196_Q201_K1.2931.00
72_L78_I1.2861.00
106_L156_G1.2851.00
250_L268_F1.2831.00
114_R167_F1.2801.00
111_E114_R1.2751.00
110_L163_Y1.2751.00
214_D244_A1.2741.00
158_K161_H1.2691.00
300_D304_N1.2591.00
3_I26_H1.2501.00
283_I294_P1.2441.00
20_L226_T1.2171.00
111_E115_E1.2161.00
175_R238_T1.2091.00
8_A17_C1.2081.00
63_L105_A1.2001.00
21_L56_F1.1721.00
161_H238_T1.1691.00
113_C121_F1.1691.00
223_K292_Y1.1501.00
123_F156_G1.1501.00
157_E175_R1.1451.00
212_S246_R1.1281.00
29_I73_E1.1261.00
175_R240_N1.1241.00
11_F181_G1.1241.00
224_G286_A1.1191.00
24_K226_T1.1111.00
63_L82_A1.1101.00
161_H173_I1.1101.00
113_C118_I1.1061.00
81_L225_I1.1051.00
217_Y220_D1.0971.00
123_F160_C1.0921.00
18_E22_K1.0881.00
151_V155_T1.0841.00
140_N285_K1.0841.00
204_T267_H1.0811.00
180_Y217_Y1.0781.00
66_A69_A1.0761.00
247_A298_L1.0721.00
220_D243_G1.0711.00
14_S183_R1.0621.00
31_I68_L1.0521.00
30_G56_F1.0491.00
112_A116_H1.0491.00
15_H219_S1.0491.00
72_L75_V1.0461.00
110_L121_F1.0441.00
257_E263_K1.0361.00
4_L31_I1.0341.00
210_Q250_L1.0341.00
19_E219_S1.0321.00
6_T82_A1.0251.00
101_H105_A1.0221.00
122_V174_L1.0221.00
57_T73_E1.0191.00
269_S272_I1.0191.00
110_L159_L1.0031.00
125_S157_E0.9931.00
159_L162_V0.9891.00
299_K303_T0.9871.00
11_F218_I0.9851.00
21_L55_R0.9821.00
164_K171_I0.9811.00
227_A290_L0.9811.00
26_H76_D0.9781.00
3_I20_L0.9771.00
29_I74_G0.9741.00
239_V285_K0.9721.00
137_V141_T0.9701.00
161_H171_I0.9671.00
123_F173_I0.9661.00
135_G138_S0.9651.00
259_I306_I0.9631.00
179_V221_C0.9611.00
114_R169_I0.9591.00
246_R278_N0.9521.00
59_I71_L0.9511.00
16_L20_L0.9491.00
254_S257_E0.9441.00
259_I302_L0.9421.00
67_D70_S0.9411.00
84_I101_H0.9411.00
3_I77_V0.9331.00
224_G292_Y0.9331.00
121_F160_C0.9271.00
179_V216_T0.9251.00
170_P235_I0.9211.00
110_L160_C0.9201.00
108_R111_E0.9181.00
162_V166_S0.9121.00
242_G281_A0.9121.00
260_S306_I0.9061.00
68_L112_A0.9061.00
98_Y152_T0.9031.00
161_H165_Q0.9001.00
241_I286_A0.8961.00
228_V290_L0.8951.00
104_Q108_R0.8951.00
174_L241_I0.8941.00
189_A193_L0.8901.00
202_P265_T0.8901.00
21_L28_V0.8891.00
72_L116_H0.8881.00
15_H218_I0.8861.00
33_D62_N0.8861.00
228_V286_A0.8851.00
285_K288_Q0.8841.00
172_V228_V0.8801.00
145_P150_G0.8791.00
31_I71_L0.8751.00
212_S248_S0.8741.00
270_D273_A0.8741.00
173_I238_T0.8711.00
72_L112_A0.8641.00
195_K198_L0.8611.00
17_C28_V0.8561.00
246_R280_W0.8551.00
234_L237_E0.8511.00
99_A103_I0.8451.00
247_A251_K0.8421.00
247_A252_V0.8381.00
242_G283_I0.8341.00
210_Q248_S0.8331.00
127_S177_F0.8321.00
35_I60_K0.8301.00
25_K28_V0.8301.00
304_N307_A0.8271.00
66_A115_E0.8221.00
15_H19_E0.8181.00
105_A108_R0.8181.00
188_M191_H0.8171.00
135_G141_T0.8151.00
129_V157_E0.8141.00
72_L113_C0.8131.00
177_F242_G0.8121.00
6_T109_L0.8101.00
192_R196_Q0.8081.00
4_L61_E0.8071.00
99_A152_T0.8071.00
227_A291_H0.8051.00
257_E262_R0.8041.00
15_H18_E0.8001.00
12_I221_C0.7931.00
89_S93_N0.7931.00
3_I79_F0.7921.00
244_A283_I0.7901.00
15_H222_V0.7891.00
64_L101_H0.7871.00
259_I299_K0.7861.00
62_N65_T0.7821.00
34_F60_K0.7741.00
209_G250_L0.7731.00
254_S258_D0.7711.00
257_E264_A0.7701.00
112_A115_E0.7701.00
99_A104_Q0.7691.00
91_W148_P0.7651.00
155_T158_K0.7651.00
84_I102_N0.7651.00
139_E286_A0.7631.00
119_Q170_P0.7591.00
108_R112_A0.7571.00
245_E297_S0.7541.00
16_L225_I0.7521.00
163_Y167_F0.7501.00
32_D58_F0.7501.00
212_S278_N0.7491.00
3_I229_L0.7481.00
227_A230_G0.7471.00
103_I155_T0.7471.00
114_R168_G0.7391.00
192_R195_K0.7391.00
4_L78_I0.7371.00
106_L110_L0.7321.00
78_I109_L0.7261.00
156_G160_C0.7231.00
227_A292_Y0.7201.00
284_S287_K0.7181.00
68_L108_R0.7161.00
139_E240_N0.7151.00
223_K226_T0.7151.00
231_K234_L0.7131.00
20_L229_L0.7121.00
111_E163_Y0.7111.00
78_I121_F0.7011.00
182_P304_N0.6991.00
133_K137_V0.6961.00
106_L160_C0.6951.00
182_P217_Y0.6941.00
77_V120_T0.6941.00
252_V298_L0.6941.00
197_H257_E0.6931.00
80_H109_L0.6901.00
71_L75_V0.6901.00
97_P100_A0.6861.00
214_D243_G0.6841.00
84_I98_Y0.6661.00
83_A102_N0.6651.00
65_T68_L0.6621.00
255_L298_L0.6611.00
102_N149_Y0.6591.00
52_P56_F0.6561.00
245_E299_K0.6561.00
193_L196_Q0.6561.00
220_D295_A0.6551.00
126_T129_V0.6541.00
84_I97_P0.6541.00
53_E56_F0.6541.00
97_P101_H0.6521.00
158_K162_V0.6491.00
14_S18_E0.6491.00
251_K255_L0.6491.00
222_V226_T0.6461.00
194_I256_I0.6421.00
145_P154_L0.6401.00
29_I71_L0.6361.00
147_S150_G0.6361.00
99_A151_V0.6361.00
128_S150_G0.6351.00
59_I73_E0.6341.00
239_V286_A0.6321.00
129_V143_L0.6321.00
114_R163_Y0.6311.00
27_N55_R0.6311.00
178_T213_R0.6291.00
155_T159_L0.6291.00
127_S281_A0.6271.00
134_Q141_T0.6271.00
151_V158_K0.6271.00
287_K294_P0.6251.00
126_T153_K0.6251.00
160_C173_I0.6241.00
194_I198_L0.6241.00
211_Q249_V0.6241.00
266_L269_S0.6221.00
180_Y243_G0.6211.00
174_L224_G0.6181.00
106_L123_F0.6141.00
120_T232_P0.6111.00
214_D246_R0.6101.00
221_C241_I0.6051.00
152_T156_G0.6031.00
70_S73_E0.6031.00
77_V122_V0.6031.00
171_I236_G0.6021.00
26_H77_V0.6001.00
151_V162_V0.6001.00
136_K282_D0.6001.00
259_I307_A0.5991.00
77_V119_Q0.5991.00
9_A34_F0.5971.00
194_I306_I0.5961.00
255_L302_L0.5961.00
122_V229_L0.5951.00
124_A174_L0.5931.00
220_D223_K0.5911.00
235_I239_V0.5911.00
93_N96_H0.5901.00
276_P279_T0.5861.00
182_P185_R0.5851.00
122_V228_V0.5851.00
253_V257_E0.5811.00
193_L197_H0.5801.00
9_A33_D0.5761.00
81_L176_F0.5741.00
5_V20_L0.5721.00
4_L72_L0.5701.00
4_L71_L0.5701.00
20_L79_F0.5701.00
267_H270_D0.5681.00
269_S273_A0.5671.00
295_A300_D0.5661.00
149_Y152_T0.5651.00
226_T229_L0.5631.00
232_P235_I0.5581.00
79_F226_T0.5541.00
197_H256_I0.5541.00
5_V30_G0.5541.00
200_Q203_L0.5531.00
148_P151_V0.5531.00
159_L163_Y0.5521.00
32_D36_G0.5501.00
184_Q187_D0.5501.00
80_H121_F0.5491.00
200_Q262_R0.5471.00
205_I268_F0.5471.00
176_F179_V0.5461.00
257_E260_S0.5451.00
110_L114_R0.5451.00
212_S280_W0.5451.00
25_K55_R0.5431.00
197_H203_L0.5421.00
148_P152_T0.5421.00
143_L158_K0.5381.00
61_E71_L0.5381.00
182_P219_S0.5381.00
15_H183_R0.5321.00
301_G304_N0.5321.00
78_I118_I0.5311.00
177_F214_D0.5301.00
136_K280_W0.5291.00
172_V237_E0.5271.00
204_T269_S0.5261.00
256_I306_I0.5261.00
113_C116_H0.5241.00
184_Q188_M0.5231.00
18_E219_S0.5231.00
263_K266_L0.5221.00
178_T215_F0.5221.00
26_H226_T0.5211.00
153_K156_G0.5201.00
213_R249_V0.5191.00
16_L226_T0.5181.00
131_G144_S0.5171.00
256_I302_L0.5161.00
181_G218_I0.5161.00
247_A255_L0.5151.00
11_F15_H0.5141.00
31_I59_I0.5131.00
143_L238_T0.5111.00
217_Y305_E0.5101.00
68_L72_L0.5101.00
196_Q204_T0.5101.00
7_G10_G0.5071.00
85_P188_M0.5051.00
17_C21_L0.5041.00
283_I292_Y0.5041.00
196_Q200_Q0.5031.00
231_K239_V0.5021.00
138_S284_S0.5011.00
208_D277_S0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1sb8A 2 0.9715 100 0.155 Contact Map
3rufA 2 0.9747 100 0.161 Contact Map
1orrA 3 0.9684 100 0.174 Contact Map
2q1sA 2 0.9335 100 0.177 Contact Map
3m2pA 2 0.9241 100 0.178 Contact Map
1rkxA 3 0.962 100 0.178 Contact Map
2hunA 2 0.9778 100 0.179 Contact Map
1rpnA 4 0.9747 100 0.181 Contact Map
1oc2A 2 0.9778 100 0.182 Contact Map
4wkgA 5 0.9652 100 0.183 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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