GREMLIN Database
YOLI - Probable tautomerase YolI
UniProt: O34882 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 129 (125)
Sequences: 762 (557)
Seq/√Len: 49.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
10_E47_P5.2091.00
45_Q50_E3.8901.00
63_T102_D3.2221.00
25_H29_V2.6961.00
89_A103_L2.5151.00
84_L88_L2.4391.00
4_L24_A2.2201.00
5_R70_S2.2141.00
88_L105_V2.1771.00
11_G45_Q2.1421.00
6_F24_A2.1091.00
7_D46_H2.0101.00
78_E113_A1.9320.99
98_I103_L1.9300.99
26_Q91_R1.8850.99
3_L42_I1.8550.99
20_L67_V1.8480.99
77_T80_Q1.8360.99
17_L50_E1.7650.99
30_E87_L1.7450.99
22_D39_R1.7450.99
12_R16_S1.7430.99
16_S65_D1.7300.99
86_A90_E1.6730.98
21_L43_V1.6330.98
60_F119_L1.5930.98
14_E49_N1.5720.97
21_L39_R1.5380.97
57_G124_F1.5350.97
21_L41_Q1.5280.97
8_V17_L1.5240.97
87_L91_R1.4970.96
82_E125_L1.4830.96
26_Q30_E1.4770.96
88_L103_L1.4690.96
12_R65_D1.4370.96
75_A109_E1.4310.95
7_D44_H1.4260.95
101_D119_L1.4090.95
110_N114_D1.3450.94
68_I104_M1.3420.94
78_E82_E1.2950.92
23_T96_C1.2640.91
19_L23_T1.2590.91
70_S108_T1.2230.90
23_T27_A1.1930.89
81_K114_D1.1650.88
30_E91_R1.1540.87
56_A61_Q1.1300.86
74_K121_E1.1240.86
31_A87_L1.1120.85
18_Q52_I1.1080.85
53_I66_M1.0620.82
87_L90_E1.0420.81
109_E114_D1.0420.81
6_F43_V1.0350.81
90_E94_K1.0340.80
6_F21_L1.0320.80
74_K112_D1.0270.80
63_T101_D0.9950.78
5_R44_H0.9900.78
7_D42_I0.9870.77
92_L96_C0.9800.77
38_D117_F0.9790.77
17_L45_Q0.9680.76
26_Q36_E0.9530.75
26_Q94_K0.9320.73
72_T85_Y0.9300.73
32_F80_Q0.9220.72
83_K86_A0.9220.72
66_M104_M0.9190.72
54_Q62_R0.9090.71
24_A69_I0.9050.71
33_G80_Q0.8990.70
11_G16_S0.8880.69
23_T95_K0.8860.69
51_L66_M0.8670.68
116_S120_G0.8650.67
34_V84_L0.8610.67
7_D106_S0.8570.67
23_T91_R0.8490.66
93_E99_S0.8470.66
99_S102_D0.8450.66
8_V43_V0.8370.65
37_R54_Q0.8340.65
2_P38_D0.8080.62
25_H41_Q0.8080.62
46_H50_E0.8060.62
93_E100_P0.8050.62
48_A64_K0.8030.62
60_F101_D0.8010.61
89_A105_V0.7970.61
24_A43_V0.7960.61
54_Q57_G0.7950.61
4_L69_I0.7770.59
25_H34_V0.7690.58
10_E45_Q0.7630.58
6_F69_I0.7560.57
90_E100_P0.7460.56
27_A34_V0.7450.56
29_V37_R0.7280.54
69_I75_A0.7240.54
85_Y115_W0.7220.53
37_R52_I0.7150.53
13_D17_L0.7130.53
111_G114_D0.7120.52
49_N53_I0.7040.52
70_S106_S0.7020.51
18_Q22_D0.6970.51
83_K87_L0.6960.51
27_A88_L0.6950.51
14_E47_P0.6930.51
19_L96_C0.6910.50
85_Y107_I0.6860.50
26_Q95_K0.6830.49
17_L20_L0.6800.49
69_I92_L0.6790.49
15_K26_Q0.6760.49
72_T100_P0.6760.49
71_M84_L0.6710.48
91_R94_K0.6670.48
40_Y104_M0.6600.47
19_L95_K0.6510.46
20_L92_L0.6390.45
65_D90_E0.6320.44
16_S96_C0.6300.44
74_K111_G0.6270.44
20_L98_I0.6260.44
3_L73_S0.6250.44
14_E94_K0.6220.43
23_T69_I0.6220.43
14_E83_K0.6160.43
13_D16_S0.6110.42
28_M40_Y0.6110.42
8_V67_V0.6090.42
73_S124_F0.6020.41
21_L52_I0.6000.41
11_G17_L0.5990.41
73_S114_D0.5990.41
4_L75_A0.5980.41
99_S125_L0.5950.41
21_L25_H0.5950.41
112_D124_F0.5940.41
31_A83_K0.5910.40
65_D83_K0.5890.40
57_G73_S0.5840.40
27_A31_A0.5820.39
39_R52_I0.5810.39
39_R55_D0.5750.39
27_A109_E0.5740.39
28_M34_V0.5740.39
21_L40_Y0.5710.38
73_S84_L0.5700.38
61_Q99_S0.5700.38
73_S110_N0.5700.38
62_R92_L0.5680.38
105_V109_E0.5620.37
114_D125_L0.5620.37
27_A91_R0.5490.36
39_R62_R0.5480.36
25_H84_L0.5470.36
73_S117_F0.5430.36
72_T108_T0.5410.35
88_L91_R0.5380.35
73_S106_S0.5380.35
117_F123_Q0.5370.35
79_S90_E0.5330.35
9_I64_K0.5300.34
32_F56_A0.5300.34
71_M76_R0.5300.34
42_I46_H0.5260.34
48_A95_K0.5260.34
58_L124_F0.5260.34
46_H70_S0.5220.34
91_R95_K0.5210.34
10_E50_E0.5210.34
82_E114_D0.5180.33
16_S20_L0.5150.33
21_L73_S0.5150.33
29_V41_Q0.5140.33
95_K100_P0.5120.33
58_L118_G0.5110.33
90_E97_E0.5110.33
28_M80_Q0.5080.32
104_M117_F0.5070.32
42_I85_Y0.5060.32
47_P50_E0.5050.32
15_K30_E0.5000.32
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2aalA 3 0.9922 100 0.412 Contact Map
4lhpA 3 0.9845 100 0.453 Contact Map
3c6vA 3 0.938 99.9 0.478 Contact Map
4jcuA 3 0.938 99.9 0.511 Contact Map
1mwwA 3 0.9225 99.9 0.518 Contact Map
3e6qA 4 0.8837 99.9 0.529 Contact Map
1u9dA 3 0.8295 99.9 0.533 Contact Map
4lkbF 4 0.9225 99.9 0.544 Contact Map
3fwtA 3 0.8682 99.9 0.555 Contact Map
3fwuA 3 0.8605 99.9 0.556 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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