GREMLIN Database
OPUCB - Glycine betaine/carnitine/choline transport system permease protein OpuCB
UniProt: O34878 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 217 (190)
Sequences: 93514 (56775)
Seq/√Len: 4118.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
124_E128_L3.3531.00
20_G24_Y3.3431.00
116_K125_Q3.2021.00
101_Y105_K2.6871.00
121_T124_E2.6041.00
115_G125_Q2.5251.00
32_L89_F2.4801.00
17_Y20_G2.3971.00
122_G125_Q2.3521.00
103_G137_I2.2511.00
112_L130_E2.2511.00
123_W127_R2.2501.00
28_I85_I2.1971.00
16_L20_G2.1491.00
176_Q179_Y2.0891.00
46_R112_L2.0261.00
162_G170_I1.9871.00
112_L125_Q1.9821.00
45_T105_K1.9621.00
111_L133_L1.9591.00
24_Y81_K1.9421.00
112_L116_K1.9291.00
120_M124_E1.9231.00
100_T138_I1.8951.00
18_K167_Y1.8901.00
17_Y21_E1.7931.00
24_Y28_I1.7931.00
124_E127_R1.7581.00
84_A156_A1.7401.00
196_Y200_V1.7331.00
115_G120_M1.7261.00
104_I134_A1.7101.00
116_K122_G1.6821.00
40_L97_L1.6781.00
30_V142_I1.6711.00
35_I39_P1.5621.00
96_I145_S1.5421.00
44_L97_L1.5361.00
38_V100_T1.5171.00
21_E24_Y1.5011.00
162_G167_Y1.4941.00
14_E17_Y1.4941.00
109_K112_L1.4761.00
143_R198_L1.4551.00
55_I101_Y1.4441.00
96_I141_G1.4431.00
166_D170_I1.4421.00
37_A96_I1.4291.00
41_G100_T1.4271.00
167_Y170_I1.4261.00
26_S146_T1.3951.00
38_V134_A1.3911.00
45_T104_I1.3831.00
168_I183_G1.3661.00
115_G129_V1.3581.00
29_A149_L1.3401.00
38_V126_I1.3341.00
48_K51_A1.3101.00
175_Y178_E1.2901.00
50_G53_A1.2821.00
64_L69_I1.2601.00
121_T125_Q1.2551.00
34_I142_I1.2461.00
104_I130_E1.2431.00
109_K113_E1.2251.00
140_A144_T1.2211.00
44_L55_I1.1841.00
49_K52_G1.1811.00
153_A157_S1.1391.00
40_L93_V1.1381.00
45_T101_Y1.1251.00
107_V133_L1.1151.00
163_G166_D1.1151.00
32_L85_I1.1111.00
110_N113_E1.1081.00
51_A105_K1.1071.00
49_K53_A1.1001.00
122_G126_I1.0951.00
155_L159_I1.0911.00
53_A56_G1.0871.00
93_V97_L1.0821.00
85_I89_F1.0821.00
41_G45_T1.0751.00
30_V146_T1.0551.00
79_V82_V1.0491.00
131_I138_I1.0461.00
112_L122_G1.0451.00
39_P43_A1.0441.00
31_V35_I1.0441.00
28_I31_V1.0201.00
53_A57_F1.0141.00
29_A33_G1.0121.00
82_V86_V1.0091.00
46_R109_K1.0071.00
33_G145_S0.9991.00
42_V104_I0.9971.00
192_I196_Y0.9901.00
100_T141_G0.9901.00
43_A54_V0.9891.00
162_G166_D0.9861.00
28_I32_L0.9791.00
120_M125_Q0.9761.00
196_Y199_A0.9741.00
41_G104_I0.9691.00
29_A88_L0.9671.00
12_G16_L0.9441.00
38_V138_I0.9421.00
125_Q130_E0.9401.00
135_I139_M0.9391.00
197_V200_V0.9241.00
81_K85_I0.9161.00
81_K161_G0.9151.00
78_G82_V0.9101.00
36_V93_V0.9041.00
133_L136_P0.9041.00
88_L149_L0.8991.00
24_Y82_V0.8971.00
125_Q128_L0.8961.00
166_D169_F0.8921.00
162_G165_G0.8891.00
161_G165_G0.8881.00
36_V89_F0.8781.00
80_G161_G0.8771.00
33_G92_S0.8721.00
16_L19_T0.8711.00
84_A88_L0.8691.00
165_G168_I0.8651.00
73_F87_A0.8651.00
87_A159_I0.8611.00
25_I81_K0.8591.00
51_A55_I0.8551.00
193_I197_V0.8521.00
66_S91_Y0.8491.00
48_K52_G0.8471.00
42_V126_I0.8411.00
156_A163_G0.8411.00
52_G56_G0.8401.00
78_G81_K0.8391.00
165_G169_F0.8361.00
163_G168_I0.8351.00
37_A97_L0.8351.00
24_Y27_L0.8311.00
96_I100_T0.8301.00
23_L27_L0.8281.00
31_V142_I0.8251.00
100_T134_A0.8191.00
99_N141_G0.8101.00
72_F76_L0.8071.00
32_L35_I0.8041.00
197_V201_T0.8021.00
120_M128_L0.7971.00
30_V149_L0.7971.00
19_T23_L0.7891.00
19_T164_L0.7861.00
21_E161_G0.7851.00
167_Y183_G0.7831.00
27_L31_V0.7831.00
44_L101_Y0.7811.00
20_G23_L0.7771.00
82_V85_I0.7761.00
171_G174_L0.7741.00
80_G83_P0.7711.00
152_W155_L0.7691.00
33_G96_I0.7681.00
28_I89_F0.7671.00
29_A89_F0.7661.00
126_I130_E0.7601.00
134_A137_I0.7591.00
52_G55_I0.7591.00
137_I141_G0.7571.00
22_H150_I0.7501.00
58_V97_L0.7491.00
36_V39_P0.7481.00
77_L83_P0.7471.00
22_H164_L0.7381.00
163_G167_Y0.7371.00
34_I100_T0.7351.00
188_T192_I0.7321.00
127_R131_I0.7291.00
178_E181_I0.7201.00
26_S150_I0.7161.00
42_V122_G0.7161.00
41_G97_L0.7131.00
170_I173_N0.7071.00
130_E133_L0.7051.00
100_T137_I0.7011.00
73_F76_L0.7001.00
69_I91_Y0.6991.00
152_W156_A0.6991.00
114_S118_I0.6981.00
69_I73_F0.6941.00
177_P181_I0.6901.00
126_I131_I0.6881.00
109_K116_K0.6881.00
114_S117_G0.6881.00
19_T190_L0.6861.00
21_E81_K0.6831.00
92_S145_S0.6801.00
46_R122_G0.6801.00
127_R130_E0.6781.00
171_G180_I0.6751.00
59_N98_R0.6731.00
145_S149_L0.6711.00
70_L74_I0.6701.00
33_G37_A0.6691.00
103_G134_A0.6691.00
195_D199_A0.6661.00
18_K21_E0.6651.00
29_A85_I0.6651.00
157_S166_D0.6651.00
43_A47_M0.6631.00
191_A195_D0.6601.00
35_I38_V0.6601.00
47_M122_G0.6601.00
37_A100_T0.6571.00
79_V83_P0.6551.00
135_I138_I0.6511.00
59_N62_Q0.6511.00
181_I184_A0.6481.00
87_A155_L0.6481.00
80_G160_G0.6431.00
162_G169_F0.6371.00
13_G17_Y0.6371.00
44_L54_V0.6261.00
111_L129_V0.6251.00
154_T157_S0.6221.00
111_L114_S0.6211.00
153_A169_F0.6191.00
179_Y183_G0.6181.00
66_S154_T0.6181.00
34_I138_I0.6161.00
17_Y24_Y0.6151.00
44_L51_A0.6131.00
57_F61_V0.6101.00
190_L193_I0.6081.00
145_S148_Y0.6041.00
47_M51_A0.6031.00
74_I78_G0.6001.00
26_S30_V0.5981.00
73_F159_I0.5941.00
70_L154_T0.5911.00
25_I88_L0.5891.00
25_I84_A0.5861.00
30_V34_I0.5801.00
107_V134_A0.5681.00
138_I142_I0.5681.00
31_V34_I0.5671.00
148_Y151_G0.5661.00
193_I196_Y0.5661.00
141_G145_S0.5661.00
50_G54_V0.5651.00
83_P87_A0.5621.00
15_L183_G0.5611.00
54_V58_V0.5611.00
108_N111_L0.5601.00
100_T104_I0.5601.00
69_I90_F0.5571.00
46_R130_E0.5561.00
88_L156_A0.5551.00
25_I29_A0.5551.00
125_Q129_V0.5491.00
41_G101_Y0.5491.00
14_E18_K0.5451.00
113_E116_K0.5421.00
64_L68_A0.5411.00
103_G141_G0.5391.00
37_A41_G0.5371.00
14_E167_Y0.5341.00
33_G89_F0.5321.00
13_G16_L0.5301.00
44_L58_V0.5291.00
163_G169_F0.5291.00
42_V46_R0.5261.00
194_I198_L0.5261.00
62_Q94_L0.5231.00
40_L43_A0.5211.00
189_I193_I0.5211.00
177_P180_I0.5201.00
25_I163_G0.5191.00
55_I59_N0.5161.00
181_I185_V0.5101.00
19_T186_P0.5081.00
34_I38_V0.5071.00
175_Y179_Y0.5011.00
33_G149_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2onkC 2 0.9263 100 0.244 Contact Map
3d31C 2 0.9078 100 0.256 Contact Map
4tquM 1 0.9447 100 0.294 Contact Map
3rlfF 1 0.9032 100 0.313 Contact Map
4ymuD 2 0.9447 99.9 0.35 Contact Map
3rlfG 1 0.9724 99.9 0.35 Contact Map
3tuiA 2 0.9263 99.9 0.361 Contact Map
4tquN 1 0.9217 99.9 0.39 Contact Map
3w9iA 3 0.8341 41.9 0.913 Contact Map
4mt1A 3 0.8249 37.1 0.916 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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