GREMLIN Database
PKSD - Polyketide biosynthesis acyltransferase homolog PksD
UniProt: O34877 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 324 (287)
Sequences: 15407 (11387)
Seq/√Len: 672.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
158_E203_S3.7371.00
254_M257_E3.2491.00
138_L181_M3.0331.00
178_R193_L2.5491.00
38_D48_S2.4761.00
83_K86_E2.4491.00
113_D116_D2.3881.00
9_F82_Y2.3461.00
247_N251_K2.3241.00
256_R260_R2.3131.00
143_K146_L2.3071.00
130_N211_A2.2721.00
123_E126_I2.2451.00
82_Y108_V2.2131.00
150_H187_K2.2101.00
206_D250_R2.1101.00
144_P148_N2.0851.00
213_A243_N2.0451.00
75_F117_M1.9541.00
6_V267_T1.9491.00
51_E55_H1.8981.00
86_E91_Y1.8681.00
171_S202_S1.8611.00
24_F35_L1.8591.00
173_E204_L1.8451.00
68_L129_Q1.8271.00
231_S258_A1.8241.00
170_I180_I1.8211.00
181_M193_L1.8041.00
37_M114_A1.7891.00
111_V224_P1.7881.00
156_N173_E1.7871.00
34_M76_M1.7821.00
213_A246_W1.7791.00
174_E193_L1.7551.00
33_S83_K1.7441.00
243_N247_N1.7441.00
29_V87_D1.7371.00
123_E215_F1.7011.00
33_S36_E1.7001.00
136_K177_I1.6921.00
183_D187_K1.6771.00
94_Y267_T1.6681.00
173_E176_H1.6661.00
66_S129_Q1.6591.00
181_M185_K1.6531.00
235_S261_Y1.6351.00
34_M53_I1.6291.00
157_S180_I1.6291.00
107_A117_M1.6271.00
174_E178_R1.6121.00
8_M283_V1.6001.00
79_Y107_A1.5791.00
263_E287_I1.5761.00
96_L258_A1.5721.00
78_E104_A1.5511.00
229_V236_C1.5491.00
229_V261_Y1.5431.00
27_N84_V1.5391.00
120_C216_L1.5341.00
150_H184_L1.5331.00
36_E115_E1.5311.00
146_L149_D1.5241.00
31_R35_L1.5141.00
138_L177_I1.5141.00
181_M191_C1.5091.00
40_I115_E1.4881.00
40_I118_L1.4871.00
136_K174_E1.4851.00
261_Y265_Q1.4841.00
156_N176_H1.4831.00
6_V262_L1.4761.00
5_L93_D1.4651.00
259_I283_V1.4651.00
15_Q19_M1.4521.00
160_I171_S1.4491.00
95_V226_I1.4331.00
38_D50_V1.4211.00
142_D189_I1.4131.00
7_F92_P1.4111.00
122_L126_I1.4061.00
21_K25_K1.4031.00
20_G77_I1.3951.00
148_N152_Q1.3901.00
146_L187_K1.3831.00
213_A217_R1.3741.00
48_S51_E1.3711.00
216_L221_F1.3621.00
211_A214_E1.3561.00
4_P93_D1.3501.00
144_P254_M1.3411.00
34_M80_S1.3351.00
35_L50_V1.3321.00
144_P162_I1.3311.00
9_F108_V1.3291.00
229_V265_Q1.3001.00
96_L262_L1.2951.00
229_V258_A1.2921.00
153_L183_D1.2881.00
227_P236_C1.2861.00
140_I147_L1.2751.00
50_V54_Y1.2701.00
178_R182_E1.2701.00
162_I256_R1.2661.00
184_L189_I1.2501.00
5_L269_K1.2341.00
209_E213_A1.2251.00
21_K54_Y1.2231.00
178_R181_M1.2141.00
162_I168_F1.1861.00
142_D147_L1.1841.00
183_D186_E1.1741.00
136_K193_L1.1741.00
259_I286_L1.1711.00
7_F273_L1.1701.00
211_A215_F1.1581.00
36_E83_K1.1521.00
182_E185_K1.1471.00
214_E217_R1.1451.00
94_Y262_L1.1421.00
215_F218_S1.1291.00
27_N88_R1.1281.00
24_F54_Y1.1251.00
63_P66_S1.1171.00
206_D209_E1.1141.00
150_H183_D1.1081.00
4_P268_C1.1031.00
127_I211_A1.0991.00
79_Y104_A1.0991.00
37_M76_M1.0941.00
209_E250_R1.0931.00
270_F283_V1.0901.00
85_L297_S1.0871.00
126_I130_N1.0861.00
141_L190_L1.0851.00
182_E186_E1.0821.00
7_F82_Y1.0821.00
32_Q36_E1.0761.00
140_I184_L1.0761.00
32_Q35_L1.0751.00
164_Y282_F1.0701.00
208_A249_V1.0681.00
123_E127_I1.0661.00
209_E246_W1.0581.00
8_M96_L1.0571.00
138_L191_C1.0551.00
159_L168_F1.0491.00
127_I208_A1.0481.00
149_D153_L1.0461.00
158_E202_S1.0401.00
162_I252_P1.0401.00
261_Y264_S1.0391.00
127_I215_F1.0381.00
179_K183_D1.0381.00
8_M270_F1.0351.00
68_L125_A1.0341.00
159_L162_I1.0311.00
140_I170_I1.0291.00
22_E26_E1.0281.00
212_Y249_V1.0231.00
37_M118_L1.0221.00
6_V270_F1.0191.00
63_P69_F1.0141.00
162_I257_E1.0101.00
85_L273_L1.0031.00
61_S65_D0.9941.00
228_I240_M0.9861.00
147_L168_F0.9851.00
177_I193_L0.9831.00
146_L189_I0.9831.00
28_T32_Q0.9821.00
18_H21_K0.9761.00
134_K174_E0.9741.00
29_V33_S0.9731.00
231_S248_A0.9721.00
149_D152_Q0.9701.00
33_S80_S0.9701.00
95_V228_I0.9681.00
236_C261_Y0.9631.00
82_Y86_E0.9621.00
150_H180_I0.9611.00
162_I254_M0.9601.00
30_F80_S0.9591.00
7_F90_I0.9551.00
98_S163_N0.9501.00
119_D218_S0.9461.00
138_L193_L0.9321.00
103_F121_I0.9301.00
25_K54_Y0.9291.00
95_V108_V0.9271.00
75_F79_Y0.9271.00
179_K182_E0.9251.00
176_H179_K0.9191.00
260_R264_S0.9141.00
210_S213_A0.9121.00
232_L251_K0.9121.00
65_D195_P0.9111.00
157_S176_H0.8951.00
94_Y265_Q0.8941.00
263_E270_F0.8931.00
106_A245_F0.8931.00
75_F107_A0.8921.00
153_L187_K0.8901.00
68_L126_I0.8881.00
94_Y229_V0.8871.00
166_S285_Q0.8861.00
83_K107_A0.8861.00
10_S78_E0.8851.00
100_L121_I0.8801.00
116_D119_D0.8681.00
165_D286_L0.8621.00
47_T69_F0.8611.00
206_D246_W0.8591.00
141_L166_S0.8571.00
164_Y285_Q0.8571.00
144_P168_F0.8561.00
6_V94_Y0.8541.00
84_V87_D0.8471.00
210_S214_E0.8461.00
84_V88_R0.8401.00
206_D210_S0.8351.00
256_R286_L0.8311.00
102_E231_S0.8311.00
112_S221_F0.8291.00
34_M50_V0.8281.00
53_I77_I0.8251.00
237_L240_M0.8191.00
75_F121_I0.8191.00
217_R242_E0.8091.00
36_E40_I0.8081.00
121_I125_A0.8001.00
255_F283_V0.8001.00
147_L170_I0.7951.00
52_E69_F0.7951.00
263_E268_C0.7931.00
20_G30_F0.7901.00
52_E63_P0.7831.00
145_Q148_N0.7831.00
119_D123_E0.7831.00
185_K191_C0.7821.00
111_V221_F0.7781.00
24_F31_R0.7781.00
180_I184_L0.7781.00
33_S37_M0.7771.00
260_R286_L0.7761.00
67_I200_F0.7761.00
112_S120_C0.7751.00
233_T247_N0.7721.00
83_K114_A0.7711.00
120_C219_K0.7681.00
119_D215_F0.7651.00
146_L166_S0.7641.00
110_G225_S0.7581.00
35_L39_A0.7561.00
29_V32_Q0.7541.00
74_I78_E0.7521.00
147_L151_P0.7521.00
30_F33_S0.7521.00
52_E55_H0.7521.00
142_D146_L0.7481.00
283_V294_R0.7481.00
138_L170_I0.7471.00
234_G257_E0.7461.00
154_F176_H0.7421.00
30_F77_I0.7401.00
196_V200_F0.7371.00
260_R290_D0.7361.00
233_T237_L0.7341.00
257_E260_R0.7311.00
14_S74_I0.7291.00
263_E290_D0.7281.00
113_D222_Q0.7221.00
234_G258_A0.7191.00
38_D49_I0.7171.00
116_D222_Q0.7151.00
91_Y225_S0.7131.00
103_F216_L0.7111.00
144_P257_E0.7101.00
49_I76_M0.7031.00
230_S244_F0.7021.00
141_L189_I0.6991.00
116_D219_K0.6961.00
68_L72_P0.6941.00
62_D65_D0.6941.00
12_Q196_V0.6931.00
96_L255_F0.6931.00
259_I270_F0.6931.00
214_E218_S0.6901.00
228_I237_L0.6881.00
205_I249_V0.6871.00
5_L271_I0.6861.00
79_Y108_V0.6831.00
229_V262_L0.6801.00
31_R50_V0.6791.00
24_F34_M0.6761.00
40_I119_D0.6721.00
107_A114_A0.6711.00
281_A284_K0.6681.00
149_D187_K0.6681.00
260_R263_E0.6631.00
130_N208_A0.6621.00
203_S206_D0.6621.00
75_F104_A0.6541.00
143_K166_S0.6541.00
233_T244_F0.6491.00
277_G281_A0.6491.00
75_F118_L0.6481.00
232_L247_N0.6451.00
6_V268_C0.6441.00
200_F249_V0.6411.00
76_M118_L0.6411.00
100_L200_F0.6381.00
230_S237_L0.6361.00
270_F290_D0.6361.00
140_I191_C0.6351.00
81_L273_L0.6331.00
10_S274_G0.6311.00
36_E114_A0.6311.00
79_Y83_K0.6301.00
128_I205_I0.6271.00
28_T31_R0.6271.00
94_Y236_C0.6261.00
131_S205_I0.6261.00
230_S233_T0.6251.00
263_E288_P0.6231.00
70_S74_I0.6221.00
103_F219_K0.6201.00
154_F180_I0.6171.00
56_P63_P0.6151.00
258_A261_Y0.6141.00
114_A118_L0.6141.00
134_K173_E0.6121.00
146_L150_H0.6121.00
228_I239_V0.6121.00
156_N203_S0.6111.00
120_C212_Y0.6081.00
157_S170_I0.6081.00
154_F183_D0.6051.00
156_N179_K0.6041.00
127_I130_N0.6021.00
151_P159_L0.6021.00
165_D256_R0.6011.00
65_D70_S0.5991.00
208_A212_Y0.5991.00
235_S257_E0.5981.00
107_A112_S0.5941.00
139_A167_H0.5941.00
143_K147_L0.5931.00
71_H124_Q0.5931.00
102_E230_S0.5911.00
175_D178_R0.5901.00
33_S114_A0.5901.00
12_Q71_H0.5881.00
192_Q195_P0.5881.00
25_K31_R0.5851.00
98_S253_M0.5841.00
145_Q149_D0.5831.00
128_I198_Y0.5821.00
55_H62_D0.5811.00
147_L184_L0.5811.00
148_N162_I0.5801.00
24_F50_V0.5801.00
204_L207_P0.5791.00
30_F84_V0.5791.00
80_S84_V0.5781.00
79_Y118_L0.5781.00
207_P210_S0.5771.00
106_A111_V0.5761.00
170_I177_I0.5751.00
29_V84_V0.5751.00
35_L38_D0.5731.00
78_E273_L0.5721.00
246_W250_R0.5691.00
262_L267_T0.5681.00
33_S79_Y0.5661.00
33_S107_A0.5661.00
155_G173_E0.5661.00
272_D279_L0.5661.00
112_S117_M0.5651.00
115_E119_D0.5631.00
215_F219_K0.5601.00
104_A107_A0.5591.00
236_C265_Q0.5581.00
49_I73_A0.5571.00
232_L244_F0.5571.00
134_K207_P0.5561.00
148_N252_P0.5551.00
36_E39_A0.5551.00
12_Q200_F0.5521.00
144_P159_L0.5521.00
92_P226_I0.5511.00
72_P125_A0.5501.00
164_Y167_H0.5501.00
209_E247_N0.5491.00
288_P291_S0.5481.00
29_V83_K0.5481.00
82_Y273_L0.5481.00
86_E225_S0.5461.00
137_M196_V0.5441.00
51_E56_P0.5441.00
221_F242_E0.5411.00
232_L248_A0.5391.00
184_L187_K0.5371.00
69_F72_P0.5331.00
222_Q225_S0.5311.00
118_L122_L0.5311.00
136_K178_R0.5281.00
92_P95_V0.5271.00
12_Q128_I0.5271.00
4_P267_T0.5261.00
123_E211_A0.5250.99
113_D220_S0.5250.99
47_T52_E0.5230.99
210_S246_W0.5200.99
137_M171_S0.5190.99
52_E62_D0.5190.99
109_S228_I0.5190.99
161_S169_V0.5140.99
112_S116_D0.5140.99
10_S276_S0.5120.99
75_F114_A0.5100.99
157_S177_I0.5080.99
208_A211_A0.5080.99
22_E25_K0.5060.99
199_A205_I0.5060.99
293_D296_C0.5050.99
131_S208_A0.5040.99
280_A296_C0.5040.99
281_A285_Q0.5030.99
199_A204_L0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4mz0A 2 0.966 100 0.044 Contact Map
2qo3A 2 0.9938 100 0.045 Contact Map
2hg4A 2 0.9846 100 0.059 Contact Map
4rl1A 1 0.9599 100 0.063 Contact Map
4qbuA 1 0.9846 100 0.072 Contact Map
3tzyA 1 0.9846 100 0.079 Contact Map
3ptwA 1 0.9506 100 0.093 Contact Map
2vz8A 2 0.9691 100 0.102 Contact Map
3hhdA 2 0.9691 100 0.116 Contact Map
3g87A 1 0.8642 100 0.127 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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