FTSX - BACSU - GREMLIN Contacts

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FTSX - Cell division protein FtsX

UniProt:	O34876	Sequences: MIKILGRHLRESFKSLGRNTWMTFASISAVTVTLILVGVFLVIMLNLNNMATNAEKQVEIKVLIDLTADQKAQDKLQNDIKELKGIQSVTFSSKEKELDQLVDSFGDSGKSLTMKDQENPLNDAFVVKTTDPHDTPNVAKKIEKMDHVYKVTYGKEEVSRLFKVVGVSRNIGIALIIGLVFTAMFLISNTIKITIFARRKEIEIMKLVGATNWFIRWPFFLEGLLLGVFGSVIPIALVLSTYQYVIGWVVPKVQGSFVSLLPYNPFVFQVSLVLIAIGAVIGVWGSLTSIRKFLRV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	296 (252)
Sequences:	36245 (30409)
Seq/√Len:	1915.6

ECOLI - FTSX LOLE LOLC YBBP MACB
BACSU - FTSX YTRF YKNZ YCLI YVRN YXDM
HALSA - Q9HT02 Q9HR95
SULSO - Q7LXM6 Q97Z54 Q97XD5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
60_I	64_I	3.868	1.00
202_I	219_F	3.761	1.00
77_Q	81_K	2.928	1.00
139_A	143_E	2.920	1.00
198_R	222_E	2.721	1.00
17_G	20_T	2.446	1.00
206_K	212_N	2.376	1.00
211_T	214_F	2.361	1.00
231_S	275_I	2.327	1.00
287_L	291_R	2.298	1.00
134_D	137_N	2.170	1.00
31_T	233_I	2.074	1.00
49_N	53_N	2.044	1.00
216_R	291_R	2.034	1.00
135_T	139_A	1.976	1.00
223_G	286_S	1.973	1.00
267_V	270_V	1.935	1.00
27_I	31_T	1.914	1.00
234_P	238_V	1.897	1.00
141_K	144_K	1.896	1.00
136_P	139_A	1.870	1.00
38_G	238_V	1.855	1.00
137_N	141_K	1.847	1.00
59_E	63_L	1.828	1.00
89_V	107_D	1.817	1.00
78_N	81_K	1.771	1.00
60_I	66_L	1.753	1.00
85_G	130_T	1.747	1.00
136_P	140_K	1.710	1.00
60_I	63_L	1.677	1.00
227_G	231_S	1.664	1.00
268_F	272_L	1.647	1.00
227_G	282_G	1.643	1.00
12_S	221_L	1.643	1.00
108_S	111_S	1.639	1.00
198_R	201_E	1.639	1.00
54_A	57_Q	1.638	1.00
140_K	143_E	1.637	1.00
205_M	218_P	1.627	1.00
285_G	289_S	1.613	1.00
205_M	210_A	1.607	1.00
35_I	237_L	1.607	1.00
269_Q	273_V	1.605	1.00
153_Y	156_E	1.605	1.00
141_K	145_M	1.567	1.00
14_K	17_G	1.566	1.00
31_T	237_L	1.566	1.00
214_F	217_W	1.548	1.00
61_K	64_I	1.545	1.00
75_K	79_D	1.534	1.00
87_Q	130_T	1.528	1.00
45_L	48_N	1.527	1.00
15_S	222_E	1.526	1.00
74_D	78_N	1.490	1.00
210_A	214_F	1.487	1.00
240_S	244_Y	1.478	1.00
83_L	141_K	1.473	1.00
129_T	138_V	1.462	1.00
27_I	230_G	1.453	1.00
79_D	82_E	1.451	1.00
140_K	144_K	1.436	1.00
138_V	142_I	1.431	1.00
30_V	230_G	1.400	1.00
201_E	205_M	1.392	1.00
203_E	207_L	1.386	1.00
240_S	243_Q	1.381	1.00
81_K	84_K	1.378	1.00
16_L	23_T	1.373	1.00
170_N	174_A	1.358	1.00
31_T	35_I	1.350	1.00
217_W	221_L	1.345	1.00
213_W	217_W	1.344	1.00
230_G	234_P	1.329	1.00
236_A	240_S	1.321	1.00
87_Q	128_K	1.312	1.00
22_M	197_A	1.288	1.00
75_K	78_N	1.284	1.00
79_D	83_L	1.271	1.00
34_L	234_P	1.260	1.00
125_F	129_T	1.255	1.00
59_E	64_I	1.254	1.00
42_V	242_Y	1.254	1.00
173_I	177_I	1.246	1.00
159_S	163_K	1.231	1.00
238_V	242_Y	1.231	1.00
45_L	267_V	1.231	1.00
59_E	62_V	1.219	1.00
48_N	169_R	1.210	1.00
131_D	134_D	1.206	1.00
139_A	153_Y	1.206	1.00
202_I	215_I	1.205	1.00
232_V	236_A	1.203	1.00
61_K	65_D	1.203	1.00
61_K	67_T	1.201	1.00
85_G	141_K	1.199	1.00
264_N	268_F	1.196	1.00
269_Q	272_L	1.194	1.00
48_N	52_T	1.189	1.00
78_N	82_E	1.183	1.00
49_N	52_T	1.183	1.00
31_T	34_L	1.181	1.00
74_D	77_Q	1.174	1.00
142_I	145_M	1.170	1.00
45_L	270_V	1.159	1.00
77_Q	125_F	1.156	1.00
272_L	276_A	1.145	1.00
54_A	58_V	1.145	1.00
27_I	229_F	1.142	1.00
49_N	264_N	1.136	1.00
223_G	227_G	1.135	1.00
291_R	294_L	1.135	1.00
76_L	79_D	1.128	1.00
38_G	274_L	1.127	1.00
243_Q	247_G	1.125	1.00
35_I	241_T	1.116	1.00
166_G	170_N	1.115	1.00
179_L	186_L	1.099	1.00
290_I	294_L	1.098	1.00
35_I	234_P	1.096	1.00
137_N	140_K	1.092	1.00
45_L	49_N	1.086	1.00
235_I	271_S	1.085	1.00
191_I	223_G	1.085	1.00
79_D	84_K	1.084	1.00
146_D	149_Y	1.084	1.00
244_Y	247_G	1.081	1.00
244_Y	248_W	1.078	1.00
53_N	56_K	1.078	1.00
13_F	17_G	1.077	1.00
236_A	239_L	1.072	1.00
198_R	219_F	1.066	1.00
53_N	57_Q	1.063	1.00
138_V	141_K	1.062	1.00
21_W	24_F	1.061	1.00
19_N	197_A	1.061	1.00
233_I	236_A	1.059	1.00
163_K	166_G	1.055	1.00
184_M	285_G	1.049	1.00
162_F	166_G	1.047	1.00
210_A	215_I	1.043	1.00
33_T	176_I	1.038	1.00
59_E	66_L	1.033	1.00
88_S	128_K	1.032	1.00
154_G	158_V	1.019	1.00
35_I	238_V	1.014	1.00
264_N	267_V	1.013	1.00
188_S	192_K	0.995	1.00
273_V	276_A	0.990	1.00
212_N	294_L	0.984	1.00
242_Y	246_I	0.983	1.00
79_D	145_M	0.980	1.00
23_T	226_L	0.975	1.00
29_A	33_T	0.975	1.00
24_F	28_S	0.974	1.00
227_G	278_G	0.970	1.00
199_R	203_E	0.968	1.00
83_L	145_M	0.966	1.00
153_Y	158_V	0.962	1.00
76_L	80_I	0.962	1.00
271_S	275_I	0.956	1.00
201_E	204_I	0.946	1.00
184_M	281_I	0.945	1.00
37_V	41_L	0.945	1.00
196_F	199_R	0.944	1.00
84_K	87_Q	0.941	1.00
150_K	153_Y	0.939	1.00
206_K	215_I	0.938	1.00
59_E	65_D	0.938	1.00
27_I	233_I	0.935	1.00
154_G	157_E	0.926	1.00
152_T	157_E	0.919	1.00
149_Y	153_Y	0.914	1.00
216_R	287_L	0.912	1.00
133_H	138_V	0.911	1.00
81_K	88_S	0.911	1.00
84_K	88_S	0.909	1.00
266_F	271_S	0.908	1.00
286_S	290_I	0.902	1.00
195_I	202_I	0.899	1.00
29_A	186_L	0.899	1.00
224_L	283_V	0.895	1.00
130_T	134_D	0.893	1.00
148_V	151_V	0.890	1.00
212_N	216_R	0.887	1.00
129_T	135_T	0.886	1.00
231_S	278_G	0.885	1.00
165_V	169_R	0.877	1.00
76_L	81_K	0.876	1.00
52_T	56_K	0.871	1.00
160_R	163_K	0.869	1.00
11_E	218_P	0.869	1.00
19_N	22_M	0.857	1.00
231_S	235_I	0.851	1.00
138_V	145_M	0.845	1.00
60_I	65_D	0.841	1.00
167_V	171_I	0.839	1.00
115_K	118_E	0.837	1.00
126_V	129_T	0.836	1.00
277_I	280_V	0.832	1.00
31_T	230_G	0.829	1.00
280_V	284_W	0.828	1.00
221_L	225_L	0.826	1.00
117_Q	120_P	0.822	1.00
270_V	274_L	0.820	1.00
133_H	137_N	0.813	1.00
194_T	222_E	0.811	1.00
290_I	293_F	0.808	1.00
85_G	138_V	0.808	1.00
221_L	224_L	0.801	1.00
44_M	169_R	0.800	1.00
80_I	83_L	0.797	1.00
235_I	275_I	0.797	1.00
277_I	281_I	0.794	1.00
177_I	181_F	0.793	1.00
186_L	205_M	0.790	1.00
42_V	46_N	0.789	1.00
169_R	173_I	0.789	1.00
125_F	128_K	0.786	1.00
11_E	15_S	0.786	1.00
275_I	279_A	0.785	1.00
48_N	51_A	0.783	1.00
288_T	292_K	0.782	1.00
60_I	67_T	0.779	1.00
189_N	193_I	0.776	1.00
20_T	24_F	0.774	1.00
61_K	66_L	0.774	1.00
204_I	207_L	0.772	1.00
231_S	282_G	0.770	1.00
114_M	117_Q	0.767	1.00
237_L	240_S	0.765	1.00
30_V	34_L	0.764	1.00
156_E	159_S	0.760	1.00
129_T	133_H	0.759	1.00
239_L	243_Q	0.758	1.00
278_G	285_G	0.758	1.00
64_I	67_T	0.755	1.00
123_D	126_V	0.751	1.00
139_A	142_I	0.750	1.00
243_Q	246_I	0.746	1.00
117_Q	121_L	0.742	1.00
26_S	190_T	0.731	1.00
11_E	205_M	0.730	1.00
278_G	282_G	0.730	1.00
194_T	198_R	0.729	1.00
288_T	291_R	0.728	1.00
247_G	250_V	0.726	1.00
195_I	293_F	0.723	1.00
55_E	58_V	0.716	1.00
273_V	277_I	0.714	1.00
130_T	133_H	0.714	1.00
10_R	14_K	0.713	1.00
183_A	186_L	0.712	1.00
239_L	266_F	0.708	1.00
224_L	282_G	0.705	1.00
228_V	279_A	0.702	1.00
200_K	204_I	0.700	1.00
239_L	271_S	0.698	1.00
118_E	121_L	0.698	1.00
15_S	201_E	0.697	1.00
41_L	45_L	0.696	1.00
51_A	55_E	0.695	1.00
274_L	278_G	0.695	1.00
191_I	194_T	0.685	1.00
112_L	115_K	0.685	1.00
39_V	238_V	0.684	1.00
129_T	132_P	0.684	1.00
50_M	53_N	0.683	1.00
25_A	29_A	0.681	1.00
270_V	273_V	0.678	1.00
52_T	55_E	0.677	1.00
179_L	183_A	0.676	1.00
276_A	280_V	0.676	1.00
222_E	225_L	0.675	1.00
152_T	156_E	0.675	1.00
123_D	127_V	0.673	1.00
188_S	285_G	0.672	1.00
155_K	159_S	0.667	1.00
229_F	232_V	0.666	1.00
139_A	145_M	0.665	1.00
151_V	154_G	0.658	1.00
26_S	29_A	0.651	1.00
186_L	189_N	0.647	1.00
20_T	23_T	0.641	1.00
83_L	87_Q	0.640	1.00
223_G	282_G	0.638	1.00
272_L	275_I	0.636	1.00
44_M	172_G	0.636	1.00
12_S	218_P	0.634	1.00
29_A	189_N	0.633	1.00
158_V	162_F	0.631	1.00
15_S	198_R	0.631	1.00
260_L	264_N	0.627	1.00
135_T	138_V	0.626	1.00
117_Q	122_N	0.626	1.00
268_F	271_S	0.626	1.00
190_T	194_T	0.622	1.00
22_M	194_T	0.622	1.00
182_T	186_L	0.621	1.00
50_M	54_A	0.618	1.00
143_E	151_V	0.616	1.00
34_L	278_G	0.614	1.00
116_D	119_N	0.612	1.00
266_F	270_V	0.611	1.00
121_L	124_A	0.610	1.00
21_W	25_A	0.609	1.00
159_S	162_F	0.608	1.00
289_S	293_F	0.607	1.00
111_S	114_M	0.597	1.00
119_N	122_N	0.597	1.00
63_L	67_T	0.596	1.00
83_L	138_V	0.593	1.00
146_D	150_K	0.593	1.00
204_I	208_V	0.591	1.00
33_T	36_L	0.590	1.00
216_R	220_F	0.584	1.00
282_G	285_G	0.580	1.00
26_S	223_G	0.579	1.00
227_G	286_S	0.579	1.00
220_F	283_V	0.577	1.00
195_I	219_F	0.571	1.00
216_R	290_I	0.569	1.00
63_L	66_L	0.567	1.00
264_N	269_Q	0.566	1.00
172_G	179_L	0.564	1.00
85_G	88_S	0.560	1.00
176_I	180_V	0.555	1.00
220_F	224_L	0.553	1.00
30_V	187_I	0.552	1.00
122_N	126_V	0.550	1.00
118_E	122_N	0.550	1.00
213_W	216_R	0.550	1.00
147_H	152_T	0.549	1.00
111_S	116_D	0.549	1.00
85_G	134_D	0.547	1.00
29_A	193_I	0.546	1.00
122_N	125_F	0.546	1.00
276_A	279_A	0.545	1.00
29_A	179_L	0.544	1.00
59_E	67_T	0.543	1.00
38_G	42_V	0.542	1.00
80_I	142_I	0.537	1.00
241_T	244_Y	0.537	1.00
45_L	269_Q	0.537	1.00
15_S	22_M	0.537	1.00
163_K	167_V	0.536	1.00
172_G	176_I	0.532	1.00
43_I	245_V	0.530	1.00
116_D	120_P	0.530	1.00
108_S	112_L	0.529	1.00
83_L	86_I	0.528	1.00
132_P	135_T	0.528	1.00
13_F	225_L	0.528	1.00
202_I	206_K	0.527	1.00
147_H	151_V	0.525	1.00
173_I	176_I	0.524	1.00
218_P	221_L	0.523	1.00
242_Y	263_Y	0.523	1.00
10_R	17_G	0.522	1.00
219_F	222_E	0.522	1.00
167_V	170_N	0.521	1.00
200_K	203_E	0.519	1.00
81_K	85_G	0.516	1.00
112_L	116_D	0.516	1.00
42_V	238_V	0.514	1.00
235_I	239_L	0.514	1.00
39_V	241_T	0.514	1.00
115_K	119_N	0.512	1.00
31_T	234_P	0.512	1.00
129_T	134_D	0.510	1.00
245_V	248_W	0.510	1.00
39_V	42_V	0.508	1.00
44_M	48_N	0.506	1.00
219_F	223_G	0.506	1.00
183_A	278_G	0.505	1.00
108_S	116_D	0.504	1.00
35_I	39_V	0.503	1.00
187_I	227_G	0.503	1.00
231_S	279_A	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4n8nA	1	0.3243	97.4	0.8	Contact Map
4av3A	2	0.348	8.3	0.936	Contact Map
2djwA	6	0.2669	5.6	0.941	Contact Map
2nwlA	3	0.2365	5.5	0.941	Contact Map
2zbcA	6	0.2703	5	0.942	Contact Map
3h90A	3	0.4696	4.7	0.943	Contact Map
2kogA	1	0.1453	4.6	0.943	Contact Map
4pl0A	2	0.2939	4.5	0.943	Contact Map
1kviA	1	0.2635	4.4	0.944	Contact Map
1fvqA	1	0.2432	4.3	0.944	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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