GREMLIN Database
FTSX - Cell division protein FtsX
UniProt: O34876 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 296 (252)
Sequences: 36245 (30409)
Seq/√Len: 1915.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
60_I64_I3.8681.00
202_I219_F3.7611.00
77_Q81_K2.9281.00
139_A143_E2.9201.00
198_R222_E2.7211.00
17_G20_T2.4461.00
206_K212_N2.3761.00
211_T214_F2.3611.00
231_S275_I2.3271.00
287_L291_R2.2981.00
134_D137_N2.1701.00
31_T233_I2.0741.00
49_N53_N2.0441.00
216_R291_R2.0341.00
135_T139_A1.9761.00
223_G286_S1.9731.00
267_V270_V1.9351.00
27_I31_T1.9141.00
234_P238_V1.8971.00
141_K144_K1.8961.00
136_P139_A1.8701.00
38_G238_V1.8551.00
137_N141_K1.8471.00
59_E63_L1.8281.00
89_V107_D1.8171.00
78_N81_K1.7711.00
60_I66_L1.7531.00
85_G130_T1.7471.00
136_P140_K1.7101.00
60_I63_L1.6771.00
227_G231_S1.6641.00
268_F272_L1.6471.00
227_G282_G1.6431.00
12_S221_L1.6431.00
108_S111_S1.6391.00
198_R201_E1.6391.00
54_A57_Q1.6381.00
140_K143_E1.6371.00
205_M218_P1.6271.00
285_G289_S1.6131.00
205_M210_A1.6071.00
35_I237_L1.6071.00
269_Q273_V1.6051.00
153_Y156_E1.6051.00
141_K145_M1.5671.00
14_K17_G1.5661.00
31_T237_L1.5661.00
214_F217_W1.5481.00
61_K64_I1.5451.00
75_K79_D1.5341.00
87_Q130_T1.5281.00
45_L48_N1.5271.00
15_S222_E1.5261.00
74_D78_N1.4901.00
210_A214_F1.4871.00
240_S244_Y1.4781.00
83_L141_K1.4731.00
129_T138_V1.4621.00
27_I230_G1.4531.00
79_D82_E1.4511.00
140_K144_K1.4361.00
138_V142_I1.4311.00
30_V230_G1.4001.00
201_E205_M1.3921.00
203_E207_L1.3861.00
240_S243_Q1.3811.00
81_K84_K1.3781.00
16_L23_T1.3731.00
170_N174_A1.3581.00
31_T35_I1.3501.00
217_W221_L1.3451.00
213_W217_W1.3441.00
230_G234_P1.3291.00
236_A240_S1.3211.00
87_Q128_K1.3121.00
22_M197_A1.2881.00
75_K78_N1.2841.00
79_D83_L1.2711.00
34_L234_P1.2601.00
125_F129_T1.2551.00
59_E64_I1.2541.00
42_V242_Y1.2541.00
173_I177_I1.2461.00
159_S163_K1.2311.00
238_V242_Y1.2311.00
45_L267_V1.2311.00
59_E62_V1.2191.00
48_N169_R1.2101.00
131_D134_D1.2061.00
139_A153_Y1.2061.00
202_I215_I1.2051.00
232_V236_A1.2031.00
61_K65_D1.2031.00
61_K67_T1.2011.00
85_G141_K1.1991.00
264_N268_F1.1961.00
269_Q272_L1.1941.00
48_N52_T1.1891.00
78_N82_E1.1831.00
49_N52_T1.1831.00
31_T34_L1.1811.00
74_D77_Q1.1741.00
142_I145_M1.1701.00
45_L270_V1.1591.00
77_Q125_F1.1561.00
272_L276_A1.1451.00
54_A58_V1.1451.00
27_I229_F1.1421.00
49_N264_N1.1361.00
223_G227_G1.1351.00
291_R294_L1.1351.00
76_L79_D1.1281.00
38_G274_L1.1271.00
243_Q247_G1.1251.00
35_I241_T1.1161.00
166_G170_N1.1151.00
179_L186_L1.0991.00
290_I294_L1.0981.00
35_I234_P1.0961.00
137_N140_K1.0921.00
45_L49_N1.0861.00
235_I271_S1.0851.00
191_I223_G1.0851.00
79_D84_K1.0841.00
146_D149_Y1.0841.00
244_Y247_G1.0811.00
244_Y248_W1.0781.00
53_N56_K1.0781.00
13_F17_G1.0771.00
236_A239_L1.0721.00
198_R219_F1.0661.00
53_N57_Q1.0631.00
138_V141_K1.0621.00
21_W24_F1.0611.00
19_N197_A1.0611.00
233_I236_A1.0591.00
163_K166_G1.0551.00
184_M285_G1.0491.00
162_F166_G1.0471.00
210_A215_I1.0431.00
33_T176_I1.0381.00
59_E66_L1.0331.00
88_S128_K1.0321.00
154_G158_V1.0191.00
35_I238_V1.0141.00
264_N267_V1.0131.00
188_S192_K0.9951.00
273_V276_A0.9901.00
212_N294_L0.9841.00
242_Y246_I0.9831.00
79_D145_M0.9801.00
23_T226_L0.9751.00
29_A33_T0.9751.00
24_F28_S0.9741.00
227_G278_G0.9701.00
199_R203_E0.9681.00
83_L145_M0.9661.00
153_Y158_V0.9621.00
76_L80_I0.9621.00
271_S275_I0.9561.00
201_E204_I0.9461.00
184_M281_I0.9451.00
37_V41_L0.9451.00
196_F199_R0.9441.00
84_K87_Q0.9411.00
150_K153_Y0.9391.00
206_K215_I0.9381.00
59_E65_D0.9381.00
27_I233_I0.9351.00
154_G157_E0.9261.00
152_T157_E0.9191.00
149_Y153_Y0.9141.00
216_R287_L0.9121.00
133_H138_V0.9111.00
81_K88_S0.9111.00
84_K88_S0.9091.00
266_F271_S0.9081.00
286_S290_I0.9021.00
195_I202_I0.8991.00
29_A186_L0.8991.00
224_L283_V0.8951.00
130_T134_D0.8931.00
148_V151_V0.8901.00
212_N216_R0.8871.00
129_T135_T0.8861.00
231_S278_G0.8851.00
165_V169_R0.8771.00
76_L81_K0.8761.00
52_T56_K0.8711.00
160_R163_K0.8691.00
11_E218_P0.8691.00
19_N22_M0.8571.00
231_S235_I0.8511.00
138_V145_M0.8451.00
60_I65_D0.8411.00
167_V171_I0.8391.00
115_K118_E0.8371.00
126_V129_T0.8361.00
277_I280_V0.8321.00
31_T230_G0.8291.00
280_V284_W0.8281.00
221_L225_L0.8261.00
117_Q120_P0.8221.00
270_V274_L0.8201.00
133_H137_N0.8131.00
194_T222_E0.8111.00
290_I293_F0.8081.00
85_G138_V0.8081.00
221_L224_L0.8011.00
44_M169_R0.8001.00
80_I83_L0.7971.00
235_I275_I0.7971.00
277_I281_I0.7941.00
177_I181_F0.7931.00
186_L205_M0.7901.00
42_V46_N0.7891.00
169_R173_I0.7891.00
125_F128_K0.7861.00
11_E15_S0.7861.00
275_I279_A0.7851.00
48_N51_A0.7831.00
288_T292_K0.7821.00
60_I67_T0.7791.00
189_N193_I0.7761.00
20_T24_F0.7741.00
61_K66_L0.7741.00
204_I207_L0.7721.00
231_S282_G0.7701.00
114_M117_Q0.7671.00
237_L240_S0.7651.00
30_V34_L0.7641.00
156_E159_S0.7601.00
129_T133_H0.7591.00
239_L243_Q0.7581.00
278_G285_G0.7581.00
64_I67_T0.7551.00
123_D126_V0.7511.00
139_A142_I0.7501.00
243_Q246_I0.7461.00
117_Q121_L0.7421.00
26_S190_T0.7311.00
11_E205_M0.7301.00
278_G282_G0.7301.00
194_T198_R0.7291.00
288_T291_R0.7281.00
247_G250_V0.7261.00
195_I293_F0.7231.00
55_E58_V0.7161.00
273_V277_I0.7141.00
130_T133_H0.7141.00
10_R14_K0.7131.00
183_A186_L0.7121.00
239_L266_F0.7081.00
224_L282_G0.7051.00
228_V279_A0.7021.00
200_K204_I0.7001.00
239_L271_S0.6981.00
118_E121_L0.6981.00
15_S201_E0.6971.00
41_L45_L0.6961.00
51_A55_E0.6951.00
274_L278_G0.6951.00
191_I194_T0.6851.00
112_L115_K0.6851.00
39_V238_V0.6841.00
129_T132_P0.6841.00
50_M53_N0.6831.00
25_A29_A0.6811.00
270_V273_V0.6781.00
52_T55_E0.6771.00
179_L183_A0.6761.00
276_A280_V0.6761.00
222_E225_L0.6751.00
152_T156_E0.6751.00
123_D127_V0.6731.00
188_S285_G0.6721.00
155_K159_S0.6671.00
229_F232_V0.6661.00
139_A145_M0.6651.00
151_V154_G0.6581.00
26_S29_A0.6511.00
186_L189_N0.6471.00
20_T23_T0.6411.00
83_L87_Q0.6401.00
223_G282_G0.6381.00
272_L275_I0.6361.00
44_M172_G0.6361.00
12_S218_P0.6341.00
29_A189_N0.6331.00
158_V162_F0.6311.00
15_S198_R0.6311.00
260_L264_N0.6271.00
135_T138_V0.6261.00
117_Q122_N0.6261.00
268_F271_S0.6261.00
190_T194_T0.6221.00
22_M194_T0.6221.00
182_T186_L0.6211.00
50_M54_A0.6181.00
143_E151_V0.6161.00
34_L278_G0.6141.00
116_D119_N0.6121.00
266_F270_V0.6111.00
121_L124_A0.6101.00
21_W25_A0.6091.00
159_S162_F0.6081.00
289_S293_F0.6071.00
111_S114_M0.5971.00
119_N122_N0.5971.00
63_L67_T0.5961.00
83_L138_V0.5931.00
146_D150_K0.5931.00
204_I208_V0.5911.00
33_T36_L0.5901.00
216_R220_F0.5841.00
282_G285_G0.5801.00
26_S223_G0.5791.00
227_G286_S0.5791.00
220_F283_V0.5771.00
195_I219_F0.5711.00
216_R290_I0.5691.00
63_L66_L0.5671.00
264_N269_Q0.5661.00
172_G179_L0.5641.00
85_G88_S0.5601.00
176_I180_V0.5551.00
220_F224_L0.5531.00
30_V187_I0.5521.00
122_N126_V0.5501.00
118_E122_N0.5501.00
213_W216_R0.5501.00
147_H152_T0.5491.00
111_S116_D0.5491.00
85_G134_D0.5471.00
29_A193_I0.5461.00
122_N125_F0.5461.00
276_A279_A0.5451.00
29_A179_L0.5441.00
59_E67_T0.5431.00
38_G42_V0.5421.00
80_I142_I0.5371.00
241_T244_Y0.5371.00
45_L269_Q0.5371.00
15_S22_M0.5371.00
163_K167_V0.5361.00
172_G176_I0.5321.00
43_I245_V0.5301.00
116_D120_P0.5301.00
108_S112_L0.5291.00
83_L86_I0.5281.00
132_P135_T0.5281.00
13_F225_L0.5281.00
202_I206_K0.5271.00
147_H151_V0.5251.00
173_I176_I0.5241.00
218_P221_L0.5231.00
242_Y263_Y0.5231.00
10_R17_G0.5221.00
219_F222_E0.5221.00
167_V170_N0.5211.00
200_K203_E0.5191.00
81_K85_G0.5161.00
112_L116_D0.5161.00
42_V238_V0.5141.00
235_I239_L0.5141.00
39_V241_T0.5141.00
115_K119_N0.5121.00
31_T234_P0.5121.00
129_T134_D0.5101.00
245_V248_W0.5101.00
39_V42_V0.5081.00
44_M48_N0.5061.00
219_F223_G0.5061.00
183_A278_G0.5051.00
108_S116_D0.5041.00
35_I39_V0.5031.00
187_I227_G0.5031.00
231_S279_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4n8nA 1 0.3243 97.4 0.8 Contact Map
4av3A 2 0.348 8.3 0.936 Contact Map
2djwA 6 0.2669 5.6 0.941 Contact Map
2nwlA 3 0.2365 5.5 0.941 Contact Map
2zbcA 6 0.2703 5 0.942 Contact Map
3h90A 3 0.4696 4.7 0.943 Contact Map
2kogA 1 0.1453 4.6 0.943 Contact Map
4pl0A 2 0.2939 4.5 0.943 Contact Map
1kviA 1 0.2635 4.4 0.944 Contact Map
1fvqA 1 0.2432 4.3 0.944 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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