GREMLIN Database
HMGCL - Hydroxymethylglutaryl-CoA lyase YngG
UniProt: O34873 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 299 (275)
Sequences: 10426 (5403)
Seq/√Len: 325.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
189_E225_M3.2301.00
132_Q172_S3.1551.00
88_E130_D2.8631.00
107_T151_E2.8501.00
206_L222_A2.7761.00
39_R272_K2.7411.00
189_E224_Q2.5691.00
164_E198_R2.5491.00
116_S119_E2.4681.00
125_K129_N2.3041.00
193_E225_M2.2821.00
221_T224_Q2.2671.00
106_E117_T2.1981.00
36_Q279_W2.1811.00
115_K123_I2.1521.00
156_I194_A2.0981.00
26_A29_D2.0601.00
48_T62_A2.0561.00
272_K275_S1.9681.00
269_K272_K1.9521.00
196_L228_T1.9411.00
163_S174_L1.9371.00
219_M255_I1.9041.00
158_Q161_R1.9031.00
193_E197_A1.8871.00
186_A224_Q1.8751.00
125_K169_F1.8671.00
31_I68_G1.8611.00
165_A168_E1.8491.00
196_L204_I1.8391.00
164_E168_E1.8351.00
223_L230_F1.8211.00
125_K165_A1.8051.00
194_A198_R1.8041.00
36_Q276_A1.7891.00
160_I194_A1.7281.00
84_Q126_Q1.7261.00
122_H126_Q1.7151.00
6_K265_K1.6881.00
220_V258_M1.6871.00
188_V208_F1.6771.00
137_T172_S1.6591.00
122_H125_K1.6581.00
189_E193_E1.6531.00
129_N133_K1.6531.00
221_T225_M1.6491.00
50_F78_A1.6431.00
118_S161_R1.6411.00
161_R165_A1.6251.00
64_D68_G1.6181.00
219_M230_F1.6021.00
91_L134_A1.5721.00
27_T61_D1.5681.00
131_A138_T1.5631.00
186_A190_T1.5521.00
208_F219_M1.5391.00
36_Q275_S1.5331.00
260_E265_K1.5101.00
256_V268_V1.4971.00
124_L162_L1.4971.00
192_L206_L1.4931.00
130_D133_K1.4881.00
85_R88_E1.4861.00
189_E221_T1.4701.00
36_Q39_R1.4541.00
188_V206_L1.4531.00
213_G254_D1.4521.00
164_E199_F1.4501.00
232_G252_T1.4461.00
223_L259_L1.4441.00
88_E92_E1.4281.00
167_F200_P1.4241.00
160_I198_R1.4121.00
128_N138_T1.3941.00
118_S122_H1.3921.00
157_E161_R1.3851.00
279_W283_K1.3841.00
277_A288_L1.3831.00
29_D283_K1.3821.00
104_A154_V1.3691.00
219_M250_A1.3611.00
206_L230_F1.3531.00
115_K119_E1.3521.00
130_D134_A1.3511.00
8_T44_Y1.3261.00
109_N120_S1.3151.00
63_I67_K1.2901.00
104_A142_L1.2861.00
40_T276_A1.2821.00
106_E155_P1.2821.00
84_Q130_D1.2811.00
183_A188_V1.2671.00
31_I65_V1.2661.00
235_G277_A1.2571.00
87_L134_A1.2561.00
157_E194_A1.2341.00
35_N70_D1.2251.00
33_W280_I1.2231.00
16_D249_N1.2081.00
119_E122_H1.2031.00
208_F222_A1.2001.00
81_V86_G1.1971.00
112_N149_P1.1931.00
190_T194_A1.1901.00
164_E167_F1.1841.00
84_Q88_E1.1841.00
107_T111_K1.1841.00
276_A279_W1.1831.00
194_A197_A1.1801.00
206_L227_I1.1791.00
256_V273_L1.1761.00
32_T36_Q1.1731.00
274_L278_K1.1711.00
156_I190_T1.1711.00
257_Y270_L1.1701.00
192_L204_I1.1671.00
91_L136_L1.1481.00
228_T264_I1.1471.00
87_L127_V1.1421.00
25_I284_M1.1331.00
64_D67_K1.1301.00
109_N117_T1.1191.00
153_D187_Q1.1151.00
14_P34_I1.1151.00
35_N68_G1.1141.00
163_S199_F1.1091.00
188_V222_A1.1051.00
140_A166_L1.1001.00
176_L195_L1.0981.00
42_L268_V1.0951.00
155_P158_Q1.0891.00
7_V264_I1.0861.00
38_S72_E1.0851.00
167_F202_N1.0831.00
260_E266_T1.0791.00
163_S195_L1.0481.00
250_A255_I1.0441.00
125_K168_E1.0421.00
35_N72_E1.0421.00
32_T282_E1.0411.00
103_S108_H1.0401.00
117_T158_Q1.0381.00
38_S71_R1.0371.00
232_G255_I1.0361.00
161_R164_E1.0331.00
54_K60_R1.0281.00
7_V223_L1.0271.00
104_A162_L1.0221.00
165_A169_F1.0211.00
102_M109_N1.0191.00
37_L45_I1.0181.00
36_Q272_K1.0161.00
126_Q129_N1.0131.00
103_S106_E1.0101.00
121_L162_L1.0091.00
124_L166_L0.9991.00
68_G71_R0.9961.00
176_L191_V0.9941.00
184_N187_Q0.9901.00
60_R63_I0.9891.00
192_L227_I0.9611.00
12_V249_N0.9591.00
18_L25_I0.9581.00
44_Y137_T0.9511.00
27_T31_I0.9451.00
223_L264_I0.9451.00
76_T79_A0.9441.00
216_L255_I0.9401.00
115_K120_S0.9381.00
140_A171_I0.9371.00
9_I256_V0.9361.00
60_R64_D0.9341.00
32_T279_W0.9341.00
6_K267_N0.9331.00
35_N38_S0.9311.00
110_R114_N0.9301.00
89_N92_E0.9281.00
14_P45_I0.9261.00
110_R116_S0.9261.00
8_T229_V0.9211.00
61_D64_D0.9161.00
216_L258_M0.9161.00
147_G182_A0.9151.00
255_I259_L0.9071.00
215_A250_A0.9071.00
128_N169_F0.8981.00
148_C151_E0.8941.00
192_L225_M0.8911.00
12_V46_E0.8901.00
220_V262_M0.8881.00
278_K282_E0.8881.00
160_I164_E0.8881.00
199_F202_N0.8861.00
29_D32_T0.8841.00
251_A254_D0.8831.00
121_L165_A0.8791.00
160_I195_L0.8781.00
87_L91_L0.8771.00
140_A162_L0.8671.00
196_L201_A0.8671.00
210_D213_G0.8661.00
147_G154_V0.8641.00
63_I89_N0.8621.00
10_K229_V0.8601.00
234_A280_I0.8581.00
105_S136_L0.8561.00
79_A82_P0.8511.00
87_L130_D0.8491.00
234_A276_A0.8461.00
137_T173_E0.8401.00
156_I191_V0.8401.00
27_T64_D0.8331.00
260_E270_L0.8271.00
187_Q190_T0.8261.00
142_L162_L0.8241.00
97_E137_T0.8231.00
186_A221_T0.8191.00
220_V224_Q0.8181.00
57_P61_D0.8171.00
7_V259_L0.8171.00
25_I283_K0.8131.00
39_R72_E0.8081.00
204_I227_I0.8041.00
210_D215_A0.7961.00
88_E134_A0.7941.00
173_E229_V0.7901.00
65_V68_G0.7891.00
126_Q130_D0.7871.00
85_R89_N0.7861.00
48_T66_A0.7851.00
178_D218_N0.7851.00
6_K43_S0.7851.00
148_C163_S0.7811.00
106_E110_R0.7781.00
160_I199_F0.7771.00
230_F259_L0.7751.00
164_E200_P0.7731.00
167_F174_L0.7701.00
184_N262_M0.7691.00
275_S279_W0.7611.00
8_T43_S0.7570.99
31_I35_N0.7550.99
192_L222_A0.7550.99
11_E252_T0.7520.99
43_S267_N0.7470.99
62_A66_A0.7450.99
142_L163_S0.7430.99
156_I160_I0.7410.99
191_V194_A0.7400.99
28_E32_T0.7390.99
129_N169_F0.7340.99
9_I232_G0.7340.99
230_F255_I0.7340.99
139_R173_E0.7330.99
256_V270_L0.7330.99
48_T59_L0.7280.99
196_L225_M0.7270.99
117_T161_R0.7270.99
187_Q191_V0.7260.99
167_F199_F0.7250.99
39_R275_S0.7250.99
186_A189_E0.7210.99
121_L169_F0.7180.99
151_E154_V0.7160.99
123_I126_Q0.7110.99
35_N39_R0.7090.99
8_T173_E0.7080.99
216_L254_D0.7040.99
223_L255_I0.7030.99
145_V177_G0.7020.99
47_I77_Y0.7010.99
152_K183_A0.7000.99
258_M262_M0.6980.99
195_L199_F0.6970.99
205_A229_V0.6940.99
117_T155_P0.6900.99
233_S248_G0.6890.99
190_T193_E0.6890.99
44_Y78_A0.6880.99
99_C175_S0.6870.99
28_E68_G0.6840.99
191_V195_L0.6830.99
237_L286_K0.6820.99
32_T35_N0.6820.99
99_C102_M0.6810.99
192_L196_L0.6800.99
95_I136_L0.6770.99
175_S205_A0.6760.99
10_K44_Y0.6750.99
224_Q262_M0.6740.99
51_V85_R0.6720.99
200_P203_Q0.6700.99
33_W234_A0.6700.99
216_L219_M0.6670.99
121_L161_R0.6640.99
33_W37_L0.6590.99
102_M124_L0.6580.99
9_I252_T0.6580.99
163_S176_L0.6550.99
157_E198_R0.6540.98
71_R96_N0.6490.98
25_I30_K0.6480.98
167_F203_Q0.6460.98
63_I92_E0.6460.98
69_I72_E0.6430.98
91_L96_N0.6420.98
278_K281_E0.6330.98
91_L135_N0.6330.98
105_S154_V0.6320.98
237_L284_M0.6320.98
199_F204_I0.6310.98
183_A187_Q0.6300.98
38_S70_D0.6290.98
213_G251_A0.6280.98
7_V228_T0.6280.98
203_Q228_T0.6280.98
211_T246_S0.6260.98
42_L252_T0.6250.98
217_A221_T0.6250.98
281_E287_P0.6220.98
40_T273_L0.6220.98
69_I73_K0.6210.98
101_F177_G0.6200.98
32_T275_S0.6190.98
34_I58_A0.6160.98
71_R77_Y0.6120.98
27_T30_K0.6120.98
20_N23_V0.6110.98
166_L171_I0.6110.98
76_T81_V0.6090.98
195_L204_I0.6060.98
91_L130_D0.6060.98
80_L90_A0.6050.98
58_A61_D0.6030.97
49_S53_P0.6000.97
186_A262_M0.5990.97
109_N154_V0.5980.97
157_E160_I0.5960.97
188_V218_N0.5960.97
9_I266_T0.5900.97
44_Y97_E0.5900.97
82_P127_V0.5890.97
178_D181_G0.5870.97
57_P60_R0.5850.97
20_N286_K0.5840.97
70_D73_K0.5820.97
35_N71_R0.5810.97
113_I120_S0.5790.97
152_K191_V0.5780.97
183_A191_V0.5720.97
81_V98_A0.5720.97
119_E123_I0.5710.96
50_F62_A0.5700.96
59_L89_N0.5670.96
172_S203_Q0.5660.96
216_L250_A0.5660.96
275_S278_K0.5660.96
254_D257_Y0.5650.96
270_L274_L0.5650.96
223_L228_T0.5630.96
145_V176_L0.5620.96
147_G153_D0.5610.96
66_A69_I0.5590.96
77_Y80_L0.5560.96
53_P57_P0.5550.96
34_I45_I0.5490.96
77_Y81_V0.5480.96
17_G233_S0.5460.95
76_T137_T0.5440.95
162_L165_A0.5440.95
34_I69_I0.5430.95
185_P217_A0.5410.95
106_E109_N0.5380.95
38_S69_I0.5380.95
122_H165_A0.5360.95
80_L86_G0.5340.95
87_L98_A0.5340.95
105_S108_H0.5340.95
259_L266_T0.5330.95
58_A62_A0.5330.95
278_K288_L0.5310.95
109_N115_K0.5310.95
59_L62_A0.5310.95
279_W282_E0.5310.95
276_A280_I0.5290.95
211_T245_G0.5290.95
19_Q245_G0.5280.95
125_K166_L0.5270.95
12_V233_S0.5260.95
79_A95_I0.5250.94
280_I284_M0.5240.94
90_A98_A0.5230.94
82_P86_G0.5190.94
80_L83_N0.5190.94
20_N237_L0.5180.94
219_M249_N0.5180.94
260_E267_N0.5170.94
210_D216_L0.5170.94
40_T272_K0.5170.94
12_V16_D0.5170.94
100_V127_V0.5160.94
129_N132_Q0.5160.94
147_G177_G0.5150.94
32_T283_K0.5140.94
252_T273_L0.5130.94
34_I47_I0.5090.94
176_L192_L0.5080.93
10_K99_C0.5070.93
6_K264_I0.5060.93
67_K107_T0.5040.93
54_K59_L0.5020.93
9_I42_L0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ftpA 3 1 100 0.083 Contact Map
1ydoA 3 0.9967 100 0.085 Contact Map
2cw6A 5 0.99 100 0.11 Contact Map
1ydnA 1 0.9465 100 0.113 Contact Map
3bleA 2 0.9465 100 0.183 Contact Map
4ov4A 2 0.9465 100 0.185 Contact Map
3rmjA 2 0.9365 100 0.194 Contact Map
2ztjA 2 0.903 100 0.204 Contact Map
3ivsA 2 0.8997 100 0.207 Contact Map
3eegA 2 0.8729 100 0.215 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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