GREMLIN Database
YTIB - Putative carbonic anhydrase YtiB
UniProt: O34872 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 187 (173)
Sequences: 5124 (3303)
Seq/√Len: 251.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
147_V168_G3.8751.00
32_K89_D3.7241.00
34_A79_I2.8771.00
151_V168_G2.8631.00
119_P122_R2.6071.00
144_E179_D2.5561.00
151_V166_V2.4961.00
5_N9_E2.4561.00
65_G101_M2.3021.00
90_E167_H2.2271.00
64_A78_S2.1491.00
143_V170_V2.1121.00
97_H170_V2.0901.00
12_K16_E2.0051.00
12_K177_K1.9711.00
9_E13_T1.8091.00
103_K107_K1.8021.00
80_L84_Y1.7921.00
127_K130_G1.7681.00
169_L178_L1.7601.00
8_L180_L1.7591.00
66_A146_S1.7291.00
98_D174_K1.7251.00
172_D179_D1.7071.00
103_K139_S1.6761.00
34_A88_A1.6591.00
76_M157_H1.6331.00
13_T17_Q1.6281.00
90_E165_P1.6121.00
93_V154_I1.5551.00
158_P161_P1.5501.00
44_V48_P1.5491.00
13_T52_N1.5411.00
144_E170_V1.5111.00
172_D175_T1.5101.00
145_A149_D1.5001.00
119_P123_I1.4921.00
9_E12_K1.4851.00
122_R126_I1.4791.00
29_P41_T1.4661.00
39_M59_K1.4431.00
119_P125_T1.4351.00
145_A148_K1.4301.00
51_M58_V1.4021.00
53_L58_V1.3941.00
120_E124_E1.3731.00
11_N15_T1.3611.00
118_I122_R1.3391.00
118_I123_I1.3251.00
61_I78_S1.2851.00
21_E24_Q1.2711.00
79_I154_I1.2641.00
69_T74_S1.2551.00
81_V85_E1.2501.00
68_V75_I1.2471.00
119_P126_I1.2441.00
118_I126_I1.2371.00
10_F52_N1.2301.00
122_R125_T1.2261.00
128_Y131_V1.2251.00
94_I169_L1.2221.00
35_I94_I1.2071.00
97_H172_D1.1981.00
34_A78_S1.1931.00
83_V160_F1.1881.00
127_K131_V1.1681.00
76_M154_I1.1671.00
33_M92_C1.1631.00
153_V156_H1.1521.00
147_V151_V1.1471.00
66_A95_G1.1471.00
120_E126_I1.1441.00
113_I116_R1.1411.00
155_K166_V1.1371.00
37_S43_L1.1211.00
82_A88_A1.0761.00
29_P100_G1.0751.00
160_F164_V1.0721.00
157_H161_P1.0671.00
92_C169_L1.0601.00
22_K25_T1.0581.00
36_L68_V1.0571.00
34_A91_V1.0441.00
169_L180_L1.0421.00
35_I51_M1.0411.00
120_E123_I1.0391.00
15_T177_K1.0361.00
10_F14_F1.0311.00
83_V164_V1.0221.00
121_E124_E1.0191.00
83_V91_V1.0021.00
117_G123_I0.9991.00
118_I121_E0.9931.00
117_G121_E0.9811.00
87_N163_N0.9811.00
111_E114_K0.9791.00
106_S142_S0.9721.00
97_H173_P0.9621.00
63_S66_A0.9571.00
83_V88_A0.9551.00
51_M94_I0.9541.00
98_D103_K0.9441.00
149_D152_D0.9341.00
117_G120_E0.9221.00
95_G147_V0.9221.00
107_K111_E0.9141.00
148_K181_I0.9121.00
157_H163_N0.9101.00
75_I79_I0.9071.00
10_F13_T0.9041.00
45_E48_P0.9031.00
28_F98_D0.9031.00
111_E115_A0.9021.00
159_L162_E0.8991.00
146_S150_S0.8961.00
134_D137_F0.8921.00
7_I51_M0.8861.00
81_V100_G0.8821.00
102_S143_V0.8771.00
118_I125_T0.8741.00
147_V170_V0.8731.00
140_F143_V0.8670.99
132_D135_Q0.8650.99
140_F144_E0.8630.99
23_Y27_K0.8580.99
154_I166_V0.8570.99
123_I126_I0.8460.99
158_P163_N0.8450.99
160_F163_N0.8440.99
144_E148_K0.8420.99
6_D10_F0.8410.99
114_K120_E0.8390.99
175_T179_D0.8380.99
120_E125_T0.8340.99
37_S94_I0.8310.99
129_S132_D0.8300.99
33_M58_V0.8290.99
95_G146_S0.8240.99
139_S143_V0.8230.99
83_V163_N0.8220.99
45_E49_H0.8170.99
36_L79_I0.8150.99
110_L114_K0.8140.99
148_K168_G0.8080.99
92_C167_H0.8070.99
29_P59_K0.8060.99
107_K135_Q0.7990.99
39_M86_L0.7960.99
35_I58_V0.7900.99
53_L57_D0.7870.99
167_H180_L0.7830.99
130_G133_F0.7790.99
59_K82_A0.7770.99
15_T19_E0.7750.99
136_W140_F0.7730.99
116_R158_P0.7700.99
141_D145_A0.7660.99
68_V150_S0.7660.99
64_A101_M0.7650.99
67_L150_S0.7500.99
69_T75_I0.7490.99
121_E126_I0.7430.98
106_S139_S0.7400.98
44_V50_A0.7380.98
39_M61_I0.7370.98
6_D9_E0.7340.98
135_Q138_K0.7300.98
132_D138_K0.7270.98
51_M169_L0.7260.98
130_G134_D0.7220.98
35_I45_E0.7180.98
136_W141_D0.7140.98
4_L90_E0.7130.98
25_T55_N0.7130.98
117_G122_R0.7090.98
41_T59_K0.7060.98
74_S77_R0.7050.98
119_P124_E0.7040.98
149_D153_V0.7030.98
152_D156_H0.7020.98
44_V60_I0.6990.98
128_Y132_D0.6950.98
61_I75_I0.6920.98
84_Y163_N0.6870.97
64_A100_G0.6840.97
30_D87_N0.6840.97
34_A82_A0.6830.97
152_D155_K0.6700.97
26_S30_D0.6540.97
33_M89_D0.6540.97
11_N178_L0.6520.96
13_T16_E0.6500.96
36_L63_S0.6500.96
17_Q20_Y0.6460.96
102_S105_S0.6370.96
112_K115_A0.6250.96
18_R21_E0.6230.95
67_L146_S0.6170.95
8_L12_K0.6170.95
37_S44_V0.6160.95
102_S142_S0.6110.95
97_H174_K0.6070.95
37_S45_E0.6060.95
63_S74_S0.6050.95
21_E25_T0.6020.95
140_F170_V0.6020.95
84_Y159_L0.6010.94
50_A178_L0.6000.94
48_P53_L0.5990.94
43_L50_A0.5950.94
137_F140_F0.5940.94
158_P162_E0.5930.94
48_P58_V0.5930.94
28_F41_T0.5880.94
151_V155_K0.5860.94
133_F136_W0.5840.94
170_V179_D0.5820.94
103_K106_S0.5800.93
8_L178_L0.5790.93
59_K81_V0.5750.93
84_Y162_E0.5740.93
4_L169_L0.5740.93
39_M64_A0.5740.93
22_K26_S0.5720.93
34_A61_I0.5720.93
124_E127_K0.5680.93
19_E22_K0.5670.93
74_S88_A0.5640.92
23_Y26_S0.5640.92
108_S111_E0.5620.92
33_M90_E0.5570.92
38_C99_C0.5550.92
10_F15_T0.5540.92
82_A86_L0.5530.92
66_A150_S0.5530.92
6_D32_K0.5440.91
100_G104_I0.5430.91
59_K88_A0.5420.91
106_S138_K0.5400.91
121_E125_T0.5370.90
118_I124_E0.5370.90
4_L180_L0.5370.90
54_R57_D0.5370.90
93_V151_V0.5350.90
63_S75_I0.5310.90
68_V153_V0.5310.90
105_S123_I0.5280.90
140_F172_D0.5220.89
56_G86_L0.5190.89
96_H99_C0.5190.89
49_H55_N0.5150.89
7_I33_M0.5150.89
45_E55_N0.5150.89
45_E60_I0.5090.88
138_K142_S0.5070.88
22_K55_N0.5060.88
77_R101_M0.5030.87
125_T129_S0.5030.87
64_A77_R0.5020.87
51_M178_L0.5000.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2w3qA 2 0.9733 100 0.109 Contact Map
1ddzA 2 0.9626 100 0.114 Contact Map
3e3iA 6 0.9412 100 0.116 Contact Map
3qy1A 4 0.9572 100 0.118 Contact Map
4rxyA 4 0.9519 100 0.118 Contact Map
3ucjA 4 0.9626 100 0.124 Contact Map
4o1kA 4 0.9626 100 0.126 Contact Map
1ekjA 5 0.9893 100 0.131 Contact Map
4o1jA 4 0.9626 100 0.132 Contact Map
1ym3A 2 0.9251 100 0.132 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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