GREMLIN Database
YKUE - Uncharacterized metallophosphoesterase YkuE
UniProt: O34870 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 286 (262)
Sequences: 4177 (3213)
Seq/√Len: 198.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
62_Q95_T5.2861.00
93_V199_L3.9311.00
59_K281_T3.6151.00
48_S195_F3.3581.00
58_F122_F3.2831.00
45_T283_K3.2521.00
92_I118_L2.9671.00
246_E260_R2.7851.00
87_S279_V2.7491.00
61_V279_V2.7381.00
45_T281_T2.7111.00
151_T158_Q2.4631.00
125_L170_I2.4481.00
43_E281_T2.4251.00
250_Q255_H2.4111.00
257_Y278_T2.3881.00
142_K154_R2.3831.00
61_V84_I2.3051.00
154_R174_D2.2801.00
248_M255_H2.2711.00
126_C152_V2.2291.00
161_S167_K2.1871.00
61_V89_P2.0931.00
64_S259_N2.0451.00
78_K117_K2.0241.00
59_K279_V2.0191.00
171_A196_S1.9501.00
56_D283_K1.9301.00
63_F84_I1.9071.00
60_I91_L1.8711.00
217_Q254_T1.8701.00
62_Q218_L1.8681.00
83_T87_S1.8571.00
124_K150_F1.8141.00
94_F98_I1.8051.00
44_H257_Y1.8021.00
43_E87_S1.7881.00
93_V218_L1.7761.00
159_T169_E1.7641.00
249_Y258_V1.7461.00
169_E194_L1.6921.00
50_L215_N1.6561.00
128_Y142_K1.6411.00
218_L280_F1.6251.00
81_I85_N1.6211.00
182_D185_G1.6211.00
38_M274_K1.6091.00
157_Y189_R1.6081.00
169_E196_S1.6041.00
54_G166_S1.5801.00
200_V219_S1.5721.00
57_G281_T1.5631.00
85_N121_P1.5271.00
151_T156_G1.5181.00
61_V87_S1.5151.00
159_T167_K1.5091.00
170_I197_I1.5091.00
78_K82_L1.4941.00
125_L158_Q1.4931.00
47_K283_K1.4811.00
191_S194_L1.4751.00
250_Q253_S1.4471.00
157_Y169_E1.4231.00
62_Q259_N1.4151.00
51_I282_L1.4031.00
44_H278_T1.3991.00
93_V170_I1.3871.00
187_L214_V1.3821.00
95_T199_L1.3751.00
95_T218_L1.3721.00
161_S165_G1.3621.00
144_L147_A1.3491.00
48_S51_I1.3301.00
43_E279_V1.3261.00
244_Y249_Y1.3141.00
64_S95_T1.3111.00
63_F66_A1.3091.00
55_F168_I1.2911.00
206_A256_I1.2881.00
34_L38_M1.2781.00
175_D202_E1.2731.00
42_T260_R1.2711.00
206_A251_T1.2661.00
57_G283_K1.2601.00
52_P55_F1.2311.00
157_Y171_A1.2301.00
159_T194_L1.2291.00
95_T259_N1.2241.00
206_A254_T1.2221.00
60_I282_L1.2221.00
173_L200_V1.2181.00
59_K87_S1.2131.00
248_M257_Y1.2041.00
171_A214_V1.2011.00
142_K146_T1.1911.00
259_N278_T1.1861.00
80_V262_L1.1611.00
78_K114_L1.1551.00
31_A35_E1.1491.00
143_S147_A1.1351.00
91_L125_L1.1341.00
139_A143_S1.1321.00
83_T86_E1.1201.00
183_Y198_L1.1141.00
41_T87_S1.1071.00
198_L214_V1.1041.00
94_F150_F1.1041.00
41_T277_I1.1031.00
40_E274_K1.1011.00
257_Y280_F1.1001.00
63_F94_F1.0991.00
42_T276_E1.0971.00
171_A187_L1.0821.00
160_L170_I1.0521.00
155_N174_D1.0511.00
167_K194_L1.0471.00
88_K121_P1.0421.00
133_H174_D1.0401.00
143_S146_T1.0391.00
120_A123_G1.0341.00
92_I120_A1.0241.00
177_M202_E1.0081.00
186_T189_R1.0061.00
168_I195_F1.0051.00
30_Y34_L1.0011.00
176_L202_E1.0001.00
116_R148_G0.9961.00
157_Y186_T0.9941.00
37_H69_S0.9931.00
142_K152_V0.9911.00
67_H223_H0.9881.00
84_I118_L0.9851.00
126_C145_M0.9831.00
31_A271_F0.9801.00
44_H248_M0.9750.99
91_L160_L0.9740.99
55_F166_S0.9720.99
137_G140_V0.9690.99
81_I114_L0.9680.99
62_Q280_F0.9650.99
60_I93_V0.9650.99
245_T249_Y0.9620.99
169_E190_L0.9580.99
82_L117_K0.9560.99
112_I147_A0.9510.99
249_Y256_I0.9470.99
62_Q93_V0.9460.99
196_S214_V0.9450.99
66_A262_L0.9430.99
85_N120_A0.9430.99
46_I248_M0.9400.99
228_Q273_A0.9390.99
55_F58_F0.9370.99
146_T152_V0.9360.99
126_C150_F0.9330.99
112_I144_L0.9310.99
224_G260_R0.9250.99
47_K255_H0.9210.99
68_L77_L0.9200.99
83_T277_I0.9170.99
39_I83_T0.9100.99
171_A186_T0.9050.99
169_E191_S0.9020.99
145_M150_F0.8960.99
42_T278_T0.8900.99
44_H280_F0.8860.99
260_R273_A0.8850.99
32_R36_P0.8840.99
114_L117_K0.8810.99
120_A124_K0.8750.99
32_R35_E0.8740.99
95_T127_I0.8730.99
200_V205_A0.8670.99
157_Y190_L0.8660.99
230_P233_G0.8590.99
198_L209_T0.8580.99
161_S164_D0.8570.99
27_G31_A0.8540.99
119_N123_G0.8510.99
187_L190_L0.8500.99
190_L196_S0.8460.99
76_D80_V0.8370.98
207_L243_V0.8300.98
62_Q257_Y0.8290.98
85_N119_N0.8270.98
224_G245_T0.8250.98
31_A36_P0.8120.98
244_Y256_I0.8100.98
216_L280_F0.8080.98
94_F124_K0.8070.98
31_A34_L0.8040.98
141_Y145_M0.7990.98
197_I216_L0.7980.98
130_N223_H0.7960.98
132_D141_Y0.7950.98
237_T242_K0.7940.98
92_I124_K0.7940.98
36_P264_M0.7900.98
224_G274_K0.7890.98
69_S100_D0.7800.98
263_G270_R0.7770.97
98_I145_M0.7760.97
171_A190_L0.7760.97
46_I216_L0.7730.97
130_N221_H0.7720.97
41_T279_V0.7700.97
67_H131_H0.7690.97
72_F76_D0.7690.97
112_I148_G0.7680.97
131_H223_H0.7680.97
224_G246_E0.7670.97
246_E278_T0.7660.97
52_P57_G0.7640.97
228_Q246_E0.7520.97
113_P116_R0.7510.97
182_D186_T0.7480.97
210_T251_T0.7480.97
79_T83_T0.7480.97
61_V277_I0.7450.97
66_A80_V0.7440.97
184_E188_S0.7400.97
183_Y214_V0.7390.97
207_L211_D0.7340.96
139_A142_K0.7330.96
153_Y156_G0.7310.96
29_G33_Y0.7290.96
33_Y36_P0.7290.96
48_S215_N0.7280.96
207_L244_Y0.7220.96
234_P237_T0.7190.96
202_E222_T0.7100.96
85_N117_K0.7080.96
128_Y138_T0.7060.96
230_P272_L0.7040.95
217_Q256_I0.7040.95
185_G188_S0.7030.95
42_T257_Y0.6990.95
260_R275_P0.6960.95
72_F75_E0.6950.95
199_L218_L0.6920.95
128_Y132_D0.6910.95
144_L148_G0.6890.95
60_I280_F0.6880.95
68_L111_V0.6860.95
100_D265_T0.6860.95
219_S256_I0.6850.95
66_A94_F0.6830.95
62_Q278_T0.6800.95
173_L205_A0.6790.95
35_E275_P0.6780.94
206_A217_Q0.6780.94
146_T154_R0.6770.94
98_I126_C0.6760.94
32_R271_F0.6760.94
74_L114_L0.6760.94
35_E38_M0.6700.94
116_R149_G0.6690.94
67_H130_N0.6650.94
33_Y37_H0.6640.94
74_L78_K0.6630.94
26_G30_Y0.6630.94
22_L26_G0.6620.94
146_T156_G0.6610.94
128_Y141_Y0.6600.94
80_V84_I0.6580.94
155_N173_L0.6580.94
51_I195_F0.6560.93
174_D179_G0.6550.93
99_I269_L0.6550.93
158_Q170_I0.6540.93
195_F215_N0.6520.93
198_L217_Q0.6520.93
54_G57_G0.6510.93
82_L86_E0.6480.93
250_Q254_T0.6480.93
184_E211_D0.6450.93
145_M152_V0.6440.93
48_S216_L0.6440.93
97_D223_H0.6400.93
110_A113_P0.6380.92
48_S255_H0.6370.92
39_I262_L0.6360.92
128_Y174_D0.6360.92
224_G273_A0.6340.92
85_N92_I0.6300.92
94_F115_L0.6290.92
228_Q232_Y0.6290.92
251_T254_T0.6260.92
81_I87_S0.6240.92
55_F282_L0.6230.92
36_P39_I0.6200.91
246_E259_N0.6200.91
71_Y264_M0.6190.91
42_T246_E0.6170.91
74_L113_P0.6160.91
230_P260_R0.6160.91
209_T217_Q0.6130.91
72_F77_L0.6120.91
171_A198_L0.6110.91
66_A76_D0.6100.91
16_A19_A0.6100.91
94_F126_C0.6100.91
81_I118_L0.6090.91
38_M271_F0.6060.90
28_Y32_R0.6050.90
46_I280_F0.6040.90
173_L186_T0.6020.90
19_A23_T0.5980.90
67_H97_D0.5960.90
30_Y36_P0.5960.90
54_G165_G0.5950.90
203_P221_H0.5950.90
207_L251_T0.5930.90
184_E212_Y0.5900.89
58_F160_L0.5890.89
264_M268_P0.5880.89
228_Q245_T0.5880.89
19_A27_G0.5880.89
111_V115_L0.5850.89
197_I218_L0.5810.89
260_R276_E0.5790.88
134_G265_T0.5780.88
41_T83_T0.5780.88
140_V143_S0.5780.88
214_V217_Q0.5770.88
87_S277_I0.5760.88
138_T142_K0.5710.88
227_I267_L0.5690.88
48_S282_L0.5680.87
133_H138_T0.5680.87
89_P279_V0.5670.87
206_A244_Y0.5650.87
28_Y271_F0.5630.87
260_R278_T0.5630.87
173_L176_L0.5620.87
243_V251_T0.5620.87
112_I116_R0.5600.87
230_P234_P0.5580.87
237_T245_T0.5570.86
85_N122_F0.5570.86
72_F123_G0.5550.86
205_A208_K0.5520.86
161_S166_S0.5520.86
178_L202_E0.5520.86
176_L205_A0.5500.86
79_T82_L0.5480.86
204_D241_G0.5470.85
125_L151_T0.5470.85
82_L85_N0.5470.85
109_Q113_P0.5470.85
60_I197_I0.5440.85
16_A22_L0.5430.85
127_I199_L0.5410.85
61_V95_T0.5380.84
145_M148_G0.5370.84
54_G164_D0.5340.84
66_A72_F0.5340.84
72_F80_V0.5340.84
34_L275_P0.5300.84
228_Q234_P0.5280.83
35_E274_K0.5260.83
53_H166_S0.5240.83
264_M269_L0.5230.83
53_H164_D0.5210.83
155_N186_T0.5190.82
216_L282_L0.5190.82
71_Y262_L0.5190.82
195_F216_L0.5190.82
164_D167_K0.5170.82
117_K120_A0.5170.82
134_G266_R0.5170.82
58_F90_D0.5160.82
170_I199_L0.5160.82
200_V217_Q0.5160.82
176_L181_P0.5150.82
49_S253_S0.5150.82
155_N175_D0.5150.82
222_T245_T0.5150.82
35_E271_F0.5140.82
156_G189_R0.5130.82
176_L204_D0.5110.81
63_F95_T0.5110.81
52_P282_L0.5080.81
20_G24_A0.5080.81
208_K211_D0.5080.81
175_D226_Q0.5070.81
185_G189_R0.5060.81
245_T282_L0.5050.81
114_L123_G0.5040.80
196_S215_N0.5030.80
134_G259_N0.5020.80
202_E265_T0.5020.80
46_I255_H0.5000.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4fbkA 2 0.9091 100 0.646 Contact Map
3rl5A 1 0.7902 100 0.648 Contact Map
4fbwA 2 0.7937 100 0.652 Contact Map
3t1iA 2 0.8112 99.9 0.679 Contact Map
4ykeA 2 0.8112 99.9 0.689 Contact Map
1ii7A 2 0.7832 99.9 0.692 Contact Map
4nzvA 1 0.8357 99.9 0.704 Contact Map
3av0A 1 0.7867 99.9 0.704 Contact Map
2wdcA 1 0.7902 99.9 0.705 Contact Map
3thoB 2 0.7902 99.9 0.705 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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