GREMLIN Database
YODJ - Putative carboxypeptidase YodJ
UniProt: O34866 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 273 (234)
Sequences: 698 (638)
Seq/√Len: 41.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
218_N221_K9.8511.00
226_I245_L5.4001.00
161_F174_K4.5551.00
220_Y257_Q3.7361.00
252_A256_I3.6731.00
154_Y186_Q3.5411.00
225_I256_I3.2421.00
164_E177_V3.1921.00
158_K162_D3.1701.00
133_T250_K3.0501.00
170_E174_K3.0171.00
255_V259_N2.9311.00
137_A222_Y2.8321.00
248_V256_I2.7221.00
87_L252_A2.7201.00
193_I245_L2.7121.00
232_K265_E2.6761.00
254_K258_D2.6151.00
168_K176_A2.5741.00
160_I164_E2.4751.00
104_D124_R2.4511.00
131_L135_F2.3851.00
174_K179_Y2.3191.00
147_A191_M2.2311.00
206_F209_T2.2251.00
89_L94_Y2.2101.00
134_M245_L2.1300.99
150_G191_M1.9890.99
172_K175_E1.9490.99
143_Y211_D1.9420.99
123_I127_A1.9100.99
215_V245_L1.8800.99
164_E176_A1.8700.98
148_V194_S1.8290.98
161_F170_E1.8100.98
165_V173_A1.7640.98
220_Y254_K1.7580.98
128_A132_K1.7410.98
123_I150_G1.6930.97
250_K254_K1.6540.97
235_I262_T1.6520.97
79_T82_N1.6510.97
108_P132_K1.6450.97
137_A141_E1.6270.96
95_A182_E1.5650.95
185_H241_E1.4950.94
164_E168_K1.4880.94
164_E173_A1.4640.93
134_M193_I1.4610.93
207_G212_G1.4390.93
127_A130_A1.4140.92
176_A266_Y1.3990.92
212_G216_Q1.3590.91
178_A238_Y1.3580.91
200_F205_A1.3300.90
107_I122_Y1.3120.89
92_K238_Y1.2960.88
107_I121_R1.2850.88
235_I265_E1.2850.88
192_D244_H1.2740.87
121_R150_G1.2710.87
176_A239_E1.2700.87
134_M226_I1.2540.87
229_P262_T1.2430.86
161_F165_V1.2420.86
241_E244_H1.2310.86
185_H192_D1.2130.85
256_I261_L1.1990.84
149_S185_H1.1980.84
152_R157_Q1.1970.84
162_D166_S1.1970.84
106_V125_K1.1930.84
185_H244_H1.1900.84
248_V259_N1.1780.83
219_A257_Q1.1770.83
195_S211_D1.1640.82
87_L256_I1.1630.82
123_I128_A1.1610.82
152_R183_S1.1160.79
175_E239_E1.0850.77
160_I168_K1.0740.77
119_Q122_Y1.0720.77
175_E233_E1.0610.76
252_A255_V1.0470.75
252_A267_F1.0460.75
208_S212_G1.0400.74
179_Y182_E1.0390.74
125_K129_D1.0390.74
212_G240_Y1.0320.74
38_T46_Q1.0310.74
261_L266_Y1.0170.73
227_R264_E1.0150.73
228_Y242_P1.0120.72
169_G173_A1.0110.72
87_L267_F1.0100.72
226_I242_P1.0080.72
169_G238_Y1.0040.72
104_D125_K1.0030.72
83_P97_P0.9960.71
248_V263_L0.9960.71
261_L269_K0.9940.71
214_W218_N0.9930.71
145_L206_F0.9710.69
130_A133_T0.9700.69
252_A261_L0.9560.68
147_A150_G0.9560.68
85_N124_R0.9520.68
177_V238_Y0.9510.67
216_Q245_L0.9510.67
161_F179_Y0.9290.66
152_R241_E0.9250.65
56_T67_Y0.9120.64
32_Q40_E0.9070.64
220_Y228_Y0.9060.64
63_L67_Y0.9050.64
43_Q48_T0.8960.63
207_G230_K0.8940.63
90_V187_T0.8930.63
164_E175_E0.8920.62
39_A49_A0.8890.62
207_G226_I0.8890.62
89_L267_F0.8890.62
39_A43_Q0.8870.62
152_R185_H0.8840.62
149_S152_R0.8830.62
192_D241_E0.8750.61
132_K136_D0.8750.61
66_Q70_D0.8740.61
193_I226_I0.8730.61
32_Q35_T0.8540.59
198_N205_A0.8490.59
80_I88_A0.8490.59
183_S241_E0.8460.58
80_I267_F0.8360.57
157_Q241_E0.8350.57
40_E43_Q0.8250.56
198_N203_N0.8210.56
124_R127_A0.8210.56
144_E196_R0.8190.56
40_E47_K0.8140.55
256_I267_F0.8080.55
173_A180_P0.7990.54
154_Y169_G0.7940.54
256_I259_N0.7890.53
128_A147_A0.7890.53
102_P124_R0.7880.53
96_L187_T0.7880.53
209_T212_G0.7870.53
184_E244_H0.7870.53
60_E65_S0.7860.53
168_K172_K0.7830.53
108_P119_Q0.7770.52
90_V183_S0.7770.52
254_K257_Q0.7760.52
100_Y154_Y0.7730.52
202_L212_G0.7730.52
121_R226_I0.7680.51
105_L124_R0.7630.51
200_F203_N0.7610.50
63_L71_I0.7550.50
139_K210_A0.7520.50
91_N227_R0.7500.49
36_K39_A0.7430.49
101_E151_Y0.7410.49
162_D213_K0.7370.48
35_T38_T0.7290.47
94_Y222_Y0.7290.47
227_R236_T0.7290.47
135_F145_L0.7280.47
107_I117_K0.7270.47
157_Q181_G0.7270.47
90_V242_P0.7220.47
61_F64_E0.7210.47
96_L100_Y0.7210.47
91_N184_E0.7160.46
31_A34_D0.7150.46
165_V189_L0.7130.46
85_N126_E0.7110.46
149_S241_E0.7090.46
87_L251_K0.7080.46
184_E189_L0.7070.45
178_A186_Q0.6950.44
32_Q36_K0.6920.44
126_E169_G0.6910.44
173_A179_Y0.6910.44
35_T47_K0.6910.44
132_K135_F0.6910.44
126_E130_A0.6900.44
102_P186_Q0.6860.43
56_T66_Q0.6830.43
76_G81_Q0.6830.43
102_P105_L0.6820.43
257_Q261_L0.6810.43
106_V128_A0.6790.43
143_Y242_P0.6770.43
147_A156_R0.6770.43
256_I263_L0.6760.43
53_K58_N0.6740.42
126_E129_D0.6720.42
177_V228_Y0.6720.42
96_L228_Y0.6690.42
81_Q151_Y0.6690.42
172_K208_S0.6670.42
93_Q237_K0.6670.42
55_N66_Q0.6630.41
131_L191_M0.6630.41
31_A36_K0.6610.41
86_I124_R0.6610.41
85_N127_A0.6580.41
146_A200_F0.6580.41
45_E62_S0.6560.41
42_K45_E0.6550.41
146_A194_S0.6530.40
136_D140_K0.6520.40
180_P241_E0.6510.40
138_A145_L0.6500.40
163_N266_Y0.6500.40
68_F71_I0.6500.40
207_G240_Y0.6490.40
134_M161_F0.6480.40
108_P147_A0.6480.40
56_T60_E0.6450.40
88_A162_D0.6440.40
226_I240_Y0.6430.40
121_R191_M0.6410.39
116_E121_R0.6410.39
38_T45_E0.6410.39
137_A143_Y0.6390.39
54_S62_S0.6380.39
229_P232_K0.6380.39
33_K213_K0.6370.39
202_L266_Y0.6340.39
40_E49_A0.6340.39
140_K158_K0.6340.39
134_M137_A0.6340.39
65_S234_D0.6320.39
168_K239_E0.6280.38
42_K55_N0.6250.38
149_S192_D0.6250.38
225_I267_F0.6220.38
39_A45_E0.6210.38
163_N166_S0.6190.37
205_A208_S0.6190.37
87_L263_L0.6180.37
150_G168_K0.6140.37
177_V219_A0.6140.37
238_Y262_T0.6140.37
35_T41_T0.6140.37
54_S58_N0.6120.37
127_A191_M0.6110.37
86_I105_L0.6100.37
38_T48_T0.6100.37
85_N169_G0.6100.37
69_N99_N0.6090.37
220_Y258_D0.6090.37
98_G154_Y0.6080.36
108_P121_R0.6040.36
35_T45_E0.6030.36
107_I118_I0.5990.36
36_K42_K0.5980.36
34_D40_E0.5960.35
107_I226_I0.5960.35
39_A52_K0.5950.35
35_T40_E0.5910.35
255_V260_D0.5900.35
35_T39_A0.5870.35
37_T46_Q0.5850.35
216_Q231_N0.5850.35
185_H190_A0.5830.34
149_S177_V0.5830.34
83_P86_I0.5820.34
169_G186_Q0.5820.34
160_I167_L0.5790.34
34_D42_K0.5780.34
28_N32_Q0.5780.34
185_H243_W0.5770.34
103_S129_D0.5770.34
40_E46_Q0.5760.34
57_Q65_S0.5760.34
178_A241_E0.5730.34
88_A100_Y0.5730.34
135_F193_I0.5720.33
34_D47_K0.5720.33
100_Y105_L0.5720.33
152_R243_W0.5690.33
263_L268_E0.5680.33
33_K39_A0.5670.33
105_L128_A0.5660.33
62_S166_S0.5640.33
224_F228_Y0.5640.33
33_K53_K0.5640.33
140_K217_D0.5640.33
174_K186_Q0.5630.33
118_I173_A0.5600.32
29_G38_T0.5560.32
250_K253_A0.5550.32
134_M214_W0.5530.32
37_T48_T0.5530.32
221_K254_K0.5530.32
192_D243_W0.5520.32
92_K186_Q0.5500.32
156_R190_A0.5490.32
102_P178_A0.5470.31
96_L102_P0.5470.31
215_V226_I0.5450.31
189_L244_H0.5450.31
56_T61_F0.5440.31
56_T62_S0.5420.31
218_N222_Y0.5410.31
51_S59_S0.5390.31
225_I261_L0.5390.31
143_Y233_E0.5390.31
183_S243_W0.5370.31
169_G178_A0.5360.30
133_T162_D0.5340.30
225_I228_Y0.5320.30
30_D41_T0.5310.30
31_A40_E0.5300.30
61_F69_N0.5300.30
89_L252_A0.5280.30
59_S65_S0.5270.30
54_S59_S0.5270.30
157_Q183_S0.5250.30
126_E190_A0.5250.30
31_A39_A0.5240.30
144_E267_F0.5230.29
238_Y241_E0.5220.29
215_V256_I0.5210.29
30_D34_D0.5200.29
30_D33_K0.5190.29
55_N65_S0.5190.29
84_E256_I0.5170.29
66_Q69_N0.5160.29
158_K180_P0.5160.29
47_K55_N0.5120.29
229_P240_Y0.5110.29
29_G32_Q0.5090.28
31_A37_T0.5080.28
31_A47_K0.5070.28
177_V186_Q0.5070.28
37_T42_K0.5060.28
64_E71_I0.5060.28
135_F206_F0.5060.28
205_A239_E0.5060.28
108_P135_F0.5050.28
138_A195_S0.5050.28
147_A198_N0.5050.28
130_A206_F0.5030.28
101_E104_D0.5020.28
118_I156_R0.5010.28
45_E48_T0.5000.28
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ox3A 1 0.7839 100 0.321 Contact Map
4mphA 2 0.674 100 0.341 Contact Map
4muqA 1 0.7179 100 0.364 Contact Map
4murA 2 0.6703 100 0.371 Contact Map
4nt9B 3 0.663 100 0.377 Contact Map
1r44A 1 0.6557 100 0.665 Contact Map
2vo9A 1 0.5165 99.8 0.761 Contact Map
2mxzA 1 0.4615 99.3 0.84 Contact Map
2ibgE 1 0.5165 96.7 0.92 Contact Map
3n1gB 1 0.5421 95.2 0.929 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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