GREMLIN Database
YTCA - Putative UDP-glucose 6-dehydrogenase YtcA
UniProt: O34862 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 428 (400)
Sequences: 8449 (5087)
Seq/√Len: 254.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
125_E197_A4.9531.00
33_V37_G4.7281.00
347_Y386_F4.2361.00
299_I378_F3.3761.00
2_K25_D3.3581.00
310_K343_D3.3461.00
321_N384_S3.2961.00
310_K345_H3.2001.00
38_Q43_V3.0721.00
300_Q340_L3.0561.00
66_E69_S3.0351.00
144_V180_V2.8621.00
194_T233_D2.6801.00
299_I376_F2.6141.00
312_A374_S2.6051.00
21_S57_R2.5041.00
293_G336_R2.4911.00
313_V334_M2.4751.00
4_C74_C2.4721.00
170_Q176_S2.4591.00
225_E298_K2.4131.00
195_S198_G2.3361.00
279_F286_H2.3231.00
40_K63_F2.3101.00
37_G41_K2.2941.00
129_K143_I2.2351.00
317_S351_A2.2291.00
157_Y161_H2.2041.00
108_R111_K2.1871.00
333_L380_A2.1851.00
230_D233_D2.1261.00
24_H186_H2.1221.00
25_D62_S2.1071.00
395_A401_R2.0851.00
76_V183_I2.0781.00
33_V65_S2.0641.00
101_G130_Q1.9971.00
8_A28_C1.9951.00
25_D60_N1.9731.00
311_A342_C1.9721.00
67_V102_D1.9701.00
366_Q369_D1.9391.00
345_H374_S1.9271.00
206_N238_I1.9181.00
44_I55_I1.8971.00
208_F216_F1.8841.00
34_K37_G1.8821.00
194_T202_I1.8681.00
371_I394_A1.8681.00
177_A193_V1.8671.00
227_Y274_K1.8551.00
142_N171_E1.8521.00
77_I111_K1.8301.00
379_L409_V1.8181.00
86_R90_S1.8071.00
98_S101_G1.7901.00
390_D393_K1.7751.00
368_F393_K1.7671.00
178_A182_S1.7391.00
201_L224_C1.7361.00
272_Q282_R1.7221.00
212_A284_V1.7181.00
32_D35_K1.7011.00
277_E282_R1.6991.00
110_Y142_N1.6971.00
177_A181_K1.6961.00
312_A370_A1.6961.00
97_Q101_G1.6321.00
17_A55_I1.6121.00
37_G40_K1.6101.00
2_K73_E1.6031.00
97_Q126_N1.5911.00
3_I183_I1.5831.00
181_K193_V1.5801.00
294_L298_K1.5771.00
209_F213_K1.5581.00
384_S387_L1.5571.00
112_T179_I1.5431.00
4_C77_I1.5411.00
30_D36_I1.5291.00
282_R286_H1.5251.00
17_A61_L1.4961.00
336_R339_E1.4891.00
316_I346_A1.4751.00
299_I404_I1.4751.00
345_H364_H1.4721.00
18_A21_S1.4711.00
226_A276_T1.4651.00
222_R294_L1.4621.00
19_L183_I1.4621.00
178_A192_I1.4571.00
38_Q45_P1.4481.00
52_S56_L1.4301.00
39_L63_F1.4241.00
169_V177_A1.4221.00
29_T67_V1.4211.00
76_V112_T1.4111.00
223_I278_T1.4081.00
320_P382_E1.4031.00
36_I65_S1.4011.00
17_A54_A1.3981.00
336_R340_L1.3911.00
209_F247_H1.3871.00
225_E294_L1.3861.00
304_E309_K1.3851.00
337_L342_C1.3771.00
107_I111_K1.3651.00
222_R291_Q1.3631.00
34_K38_Q1.3611.00
97_Q127_I1.3471.00
331_V335_E1.3441.00
53_D57_R1.3391.00
70_S73_E1.3351.00
268_Q282_R1.3321.00
253_I406_G1.3271.00
66_E70_S1.3251.00
62_S70_S1.3191.00
18_A160_L1.3151.00
212_A216_F1.2971.00
36_I63_F1.2931.00
142_N176_S1.2861.00
50_G53_D1.2801.00
296_I333_L1.2771.00
233_D236_R1.2761.00
182_S185_K1.2621.00
350_E385_E1.2571.00
129_K133_A1.2491.00
2_K27_I1.2381.00
21_S160_L1.2371.00
280_L283_A1.2351.00
72_E108_R1.2341.00
94_K98_S1.2241.00
312_A377_L1.2191.00
54_A156_L1.2151.00
310_K373_E1.2121.00
154_N157_Y1.2121.00
298_K404_I1.2111.00
76_V179_I1.2081.00
302_F404_I1.2031.00
217_I235_S1.2001.00
169_V176_S1.1981.00
126_N130_Q1.1961.00
222_R226_A1.1881.00
38_Q41_K1.1841.00
202_I237_A1.1831.00
224_C231_I1.1781.00
40_K62_S1.1771.00
296_I336_R1.1741.00
280_L287_I1.1631.00
27_I74_C1.1601.00
403_V410_L1.1591.00
332_R335_E1.1541.00
311_A376_F1.1531.00
270_A273_E1.1511.00
123_T127_I1.1501.00
205_A220_M1.1491.00
212_A280_L1.1461.00
255_Y285_Q1.1411.00
128_A132_I1.1351.00
146_N184_Y1.1351.00
195_S233_D1.1291.00
375_D399_K1.1281.00
179_I182_S1.1281.00
6_V99_V1.1251.00
27_I73_E1.1241.00
279_F290_T1.1131.00
101_G105_E1.1111.00
172_E178_A1.1071.00
371_I377_L1.1031.00
314_L389_F1.1031.00
293_G297_K1.0981.00
312_A345_H1.0941.00
232_S250_Q1.0911.00
113_I131_L1.0821.00
27_I62_S1.0801.00
39_L61_L1.0781.00
100_I104_S1.0771.00
35_K45_P1.0751.00
343_D362_T1.0721.00
73_E108_R1.0661.00
220_M231_I1.0661.00
232_S236_R1.0651.00
27_I64_S1.0631.00
125_E129_K1.0611.00
110_Y140_L1.0611.00
198_G229_S1.0591.00
6_V77_I1.0581.00
242_P247_H1.0551.00
384_S388_A1.0531.00
335_E338_A1.0521.00
69_S72_E1.0521.00
316_I356_H1.0491.00
21_S53_D1.0481.00
142_N170_Q1.0451.00
334_M338_A1.0451.00
181_K185_K1.0381.00
112_T144_V1.0381.00
84_P92_D1.0341.00
101_G131_L1.0341.00
67_V106_A1.0311.00
8_A16_S1.0291.00
185_K190_P1.0281.00
229_S234_I1.0231.00
158_D161_H1.0191.00
36_I40_K1.0151.00
236_R246_K1.0131.00
115_T124_N1.0121.00
379_L403_V1.0071.00
128_A170_Q1.0041.00
98_S102_D1.0001.00
332_R336_R0.9941.00
354_P357_L0.9931.00
300_Q342_C0.9911.00
299_I406_G0.9891.00
167_I180_V0.9851.00
300_Q306_L0.9771.00
325_I356_H0.9721.00
222_R290_T0.9691.00
16_S28_C0.9651.00
181_K192_I0.9631.00
124_N196_L0.9581.00
379_L410_L0.9571.00
224_C234_I0.9571.00
269_F273_E0.9561.00
198_G234_I0.9551.00
75_P111_K0.9531.00
306_L342_C0.9521.00
3_I19_L0.9501.00
393_K396_D0.9491.00
269_F272_Q0.9441.00
309_K375_D0.9441.00
290_T293_G0.9431.00
253_I380_A0.9421.00
176_S180_V0.9421.00
4_C29_T0.9401.00
112_T176_S0.9371.00
297_K301_S0.9351.00
314_L377_L0.9331.00
292_L332_R0.9321.00
125_E196_L0.9321.00
79_I103_L0.9311.00
302_F402_L0.9311.00
107_I141_F0.9291.00
69_S73_E0.9291.00
110_Y141_F0.9281.00
311_A378_F0.9271.00
102_D105_E0.9241.00
29_T70_S0.9231.00
310_K374_S0.9221.00
335_E339_E0.9191.00
16_S61_L0.9141.00
91_A120_P0.9121.00
223_I276_T0.9101.00
211_A285_Q0.9001.00
43_V51_L0.8991.00
171_E176_S0.8981.00
114_I180_V0.8941.00
316_I328_S0.8921.00
376_F402_L0.8911.00
103_L113_I0.8901.00
8_A61_L0.8861.00
364_H370_A0.8851.00
392_K396_D0.8811.00
278_T281_L0.8791.00
97_Q130_Q0.8751.00
62_S69_S0.8741.00
127_I131_L0.8711.00
64_S70_S0.8681.00
298_K301_S0.8671.00
303_F309_K0.8661.00
330_A380_A0.8651.00
54_A57_R0.8610.99
23_G186_H0.8610.99
18_A159_M0.8610.99
126_N129_K0.8600.99
178_A193_V0.8590.99
100_I115_T0.8490.99
75_P179_I0.8480.99
15_L159_M0.8470.99
109_S140_L0.8450.99
4_C27_I0.8440.99
181_K190_P0.8410.99
314_L386_F0.8370.99
79_I96_L0.8370.99
51_L55_I0.8350.99
107_I132_I0.8340.99
76_V114_I0.8310.99
128_A196_L0.8310.99
364_H369_D0.8280.99
29_T64_S0.8270.99
265_Q285_Q0.8260.99
391_W410_L0.8240.99
55_I61_L0.8230.99
3_I24_H0.8220.99
213_K249_L0.8170.99
31_K102_D0.8150.99
255_Y264_L0.8140.99
308_G343_D0.8110.99
345_H373_E0.8090.99
316_I325_I0.8060.99
75_P109_S0.8060.99
177_A192_I0.8050.99
289_D332_R0.8030.99
299_I311_A0.8030.99
299_I337_L0.8020.99
76_V180_V0.8010.99
295_Y406_G0.7970.99
296_I340_L0.7940.99
369_D372_E0.7920.99
4_C71_M0.7920.99
67_V105_E0.7870.99
338_A361_V0.7840.99
382_E407_R0.7820.99
312_A371_I0.7790.99
239_G248_F0.7790.99
223_I267_L0.7790.99
178_A181_K0.7760.99
268_Q285_Q0.7750.99
328_S331_V0.7720.99
345_H362_T0.7710.99
150_L159_M0.7690.99
320_P384_S0.7670.99
91_A266_A0.7660.99
114_I183_I0.7660.99
27_I70_S0.7640.99
100_I128_A0.7630.99
268_Q281_L0.7620.99
163_D242_P0.7610.99
290_T297_K0.7610.99
338_A344_V0.7570.99
346_A363_Q0.7550.99
116_K184_Y0.7550.99
59_G62_S0.7530.99
136_V139_N0.7530.99
100_I130_Q0.7500.99
325_I331_V0.7490.99
295_Y404_I0.7490.99
352_V363_Q0.7470.99
129_K132_I0.7430.99
79_I113_I0.7420.98
192_I240_L0.7410.98
316_I334_M0.7400.98
100_I131_L0.7390.98
325_I351_A0.7390.98
334_M346_A0.7370.98
5_V16_S0.7290.98
190_P240_L0.7270.98
325_I355_E0.7210.98
314_L371_I0.7210.98
151_R154_N0.7200.98
209_F249_L0.7160.98
109_S139_N0.7160.98
104_S131_L0.7150.98
15_L19_L0.7140.98
367_A385_E0.7140.98
103_L106_A0.7120.98
367_A371_I0.7110.98
104_S141_F0.7110.98
144_V169_V0.7100.98
77_I103_L0.7070.98
382_E387_L0.7010.98
231_I235_S0.6950.98
166_V181_K0.6930.98
226_A277_E0.6930.98
71_M77_I0.6930.98
47_Y350_E0.6930.98
377_L386_F0.6930.98
78_F183_I0.6920.98
213_K217_I0.6910.98
25_D73_E0.6900.98
352_V356_H0.6880.98
366_Q393_K0.6870.98
96_L100_I0.6860.98
268_Q272_Q0.6840.97
208_F281_L0.6840.97
29_T65_S0.6840.97
293_G332_R0.6830.97
362_T373_E0.6800.97
29_T102_D0.6790.97
96_L123_T0.6780.97
35_K38_Q0.6770.97
130_Q133_A0.6760.97
6_V67_V0.6760.97
4_C70_S0.6740.97
338_A360_H0.6730.97
198_G233_D0.6700.97
232_S408_N0.6690.97
18_A156_L0.6690.97
100_I127_I0.6690.97
314_L379_L0.6680.97
356_H363_Q0.6670.97
253_I295_Y0.6640.97
168_G177_A0.6630.97
270_A274_K0.6630.97
15_L164_K0.6620.97
104_S113_I0.6620.97
124_N145_S0.6560.97
5_V15_L0.6550.97
10_Y326_R0.6540.97
353_L356_H0.6530.97
8_A30_D0.6530.97
271_A278_T0.6530.97
181_K191_F0.6500.97
220_M267_L0.6480.96
29_T99_V0.6480.96
289_D292_L0.6480.96
72_E106_A0.6470.96
313_V378_F0.6450.96
35_K39_L0.6440.96
264_L285_Q0.6430.96
116_K146_N0.6420.96
69_S106_A0.6420.96
265_Q289_D0.6410.96
115_T127_I0.6410.96
101_G133_A0.6400.96
359_Q362_T0.6400.96
166_V202_I0.6390.96
373_E399_K0.6390.96
136_V140_L0.6390.96
235_S239_G0.6380.96
169_V193_V0.6380.96
170_Q196_L0.6370.96
272_Q277_E0.6370.96
102_D106_A0.6360.96
349_P386_F0.6350.96
219_E287_I0.6340.96
194_T198_G0.6340.96
303_F376_F0.6340.96
49_P54_A0.6330.96
335_E357_L0.6320.96
389_F394_A0.6320.96
171_E178_A0.6310.96
132_I141_F0.6270.96
118_T263_D0.6270.96
391_W403_V0.6270.96
216_F220_M0.6260.96
121_P132_I0.6260.96
235_S250_Q0.6240.96
166_V190_P0.6230.96
361_V364_H0.6210.96
377_L394_A0.6210.96
23_G60_N0.6190.95
211_A255_Y0.6180.95
303_F311_A0.6170.95
85_P265_Q0.6160.95
31_K95_A0.6150.95
118_T259_C0.6150.95
150_L155_A0.6140.95
297_K340_L0.6130.95
77_I106_A0.6090.95
43_V52_S0.6080.95
223_I271_A0.6060.95
222_R276_T0.6060.95
93_T97_Q0.6060.95
283_A286_H0.6060.95
296_I300_Q0.6060.95
152_E318_F0.6030.95
236_R239_G0.6030.95
314_L367_A0.6020.95
6_V71_M0.6010.95
79_I115_T0.6000.95
235_S251_A0.5980.95
165_T202_I0.5980.95
142_N179_I0.5970.94
367_A389_F0.5970.94
312_A366_Q0.5960.94
303_F400_G0.5960.94
392_K395_A0.5960.94
241_D244_I0.5950.94
351_A355_E0.5930.94
133_A141_F0.5920.94
43_V56_L0.5910.94
201_L220_M0.5910.94
180_V184_Y0.5900.94
298_K302_F0.5880.94
338_A343_D0.5880.94
148_E259_C0.5880.94
135_G140_L0.5870.94
30_D65_S0.5850.94
258_S262_K0.5850.94
86_R97_Q0.5850.94
144_V167_I0.5850.94
303_F402_L0.5840.94
8_A39_L0.5840.94
368_F371_I0.5830.94
217_I220_M0.5830.94
291_Q294_L0.5810.94
357_L364_H0.5800.94
239_G244_I0.5780.93
279_F283_A0.5780.93
207_N263_D0.5770.93
83_T117_S0.5760.93
20_A60_N0.5760.93
292_L333_L0.5750.93
44_I52_S0.5750.93
164_K206_N0.5750.93
205_A208_F0.5730.93
292_L329_Q0.5730.93
71_M111_K0.5720.93
96_L115_T0.5690.93
253_I333_L0.5690.93
50_G54_A0.5690.93
164_K184_Y0.5650.93
253_I320_P0.5640.93
264_L281_L0.5630.93
346_A352_V0.5620.93
74_C77_I0.5610.92
296_I306_L0.5610.92
198_G202_I0.5610.92
51_L54_A0.5590.92
366_Q370_A0.5570.92
390_D394_A0.5570.92
169_V196_L0.5560.92
78_F184_Y0.5560.92
278_T282_R0.5550.92
246_K250_Q0.5550.92
325_I330_A0.5550.92
299_I306_L0.5530.92
24_H76_V0.5510.92
222_R225_E0.5500.92
369_D373_E0.5500.92
303_F306_L0.5490.92
113_I141_F0.5480.92
126_N270_A0.5480.92
81_V95_A0.5470.92
67_V71_M0.5460.91
259_C262_K0.5460.91
116_K262_K0.5450.91
391_W394_A0.5430.91
376_F404_I0.5430.91
36_I39_L0.5420.91
226_A274_K0.5420.91
316_I330_A0.5420.91
223_I227_Y0.5410.91
166_V177_A0.5410.91
232_S251_A0.5390.91
114_I144_V0.5380.91
371_I374_S0.5370.91
21_S54_A0.5370.91
337_L344_V0.5360.91
95_A99_V0.5360.91
367_A370_A0.5340.91
272_Q279_F0.5330.90
116_K164_K0.5330.90
221_A291_Q0.5310.90
209_F217_I0.5290.90
280_L284_V0.5280.90
40_K43_V0.5270.90
279_F282_R0.5270.90
215_S280_L0.5260.90
149_F206_N0.5260.90
316_I363_Q0.5260.90
365_S369_D0.5260.90
139_N142_N0.5260.90
220_M224_C0.5250.90
225_E291_Q0.5240.90
62_S73_E0.5230.90
53_D56_L0.5230.90
285_Q289_D0.5220.90
39_L45_P0.5220.90
152_E262_K0.5210.89
159_M187_I0.5200.89
106_A111_K0.5200.89
97_Q131_L0.5200.89
307_Q341_G0.5180.89
387_L409_V0.5180.89
207_N259_C0.5180.89
90_S273_E0.5170.89
138_K169_V0.5170.89
84_P327_N0.5170.89
281_L284_V0.5160.89
50_G156_L0.5160.89
17_A21_S0.5150.89
302_F376_F0.5150.89
334_M380_A0.5140.89
172_E177_A0.5130.89
395_A403_V0.5130.89
263_D326_R0.5130.89
47_Y323_D0.5110.89
20_A59_G0.5090.88
276_T287_I0.5090.88
132_I143_I0.5080.88
193_V237_A0.5080.88
116_K152_E0.5080.88
167_I177_A0.5080.88
215_S287_I0.5080.88
107_I136_V0.5070.88
255_Y284_V0.5070.88
295_Y378_F0.5060.88
207_N319_K0.5060.88
347_Y385_E0.5060.88
239_G247_H0.5060.88
5_V19_L0.5050.88
265_Q327_N0.5040.88
306_L309_K0.5040.88
105_E109_S0.5040.88
313_V380_A0.5030.88
158_D162_P0.5010.88
208_F212_A0.5000.87
368_F372_E0.5000.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2y0cA 4 0.9953 100 0.232 Contact Map
2o3jA 4 0.9883 100 0.25 Contact Map
3gg2A 3 0.979 100 0.251 Contact Map
2q3eA 5 1 100 0.251 Contact Map
3g79A 2 0.9813 100 0.264 Contact Map
3ojoA 2 0.9463 100 0.27 Contact Map
4a7pA 2 0.986 100 0.274 Contact Map
3vtfA 2 0.9696 100 0.291 Contact Map
4xr9A 2 0.9883 100 0.296 Contact Map
1mv8A 2 0.9626 100 0.313 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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