GREMLIN Database
YOAC - Putative sugar kinase YoaC
UniProt: O34861 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 487 (462)
Sequences: 12519 (8549)
Seq/√Len: 397.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
110_W142_Q3.8121.00
191_E201_P3.7581.00
23_S27_S3.4681.00
19_V62_L3.3831.00
113_G142_Q3.3431.00
380_K384_D2.9481.00
183_D186_Q2.8241.00
411_Q415_D2.7911.00
387_T419_K2.7741.00
123_S190_S2.7721.00
97_F147_L2.7361.00
325_L366_H2.7021.00
34_E61_N2.6991.00
352_F367_F2.6871.00
182_F207_L2.6821.00
168_I206_P2.6411.00
41_E99_G2.6191.00
396_Y422_Y2.6031.00
32_E65_R2.5771.00
209_R212_T2.5671.00
34_E65_R2.5171.00
98_L144_Q2.5051.00
92_Q152_A2.4891.00
448_E451_A2.4771.00
56_W164_Q2.4541.00
462_Q465_L2.4391.00
53_Q164_Q2.4371.00
91_D150_K2.4091.00
21_V66_A2.3711.00
447_E451_A2.3351.00
314_T317_V2.2591.00
183_D190_S2.2451.00
194_C201_P2.1641.00
191_E195_D2.1491.00
188_T201_P2.1181.00
10_F59_V2.1121.00
20_A432_V2.1071.00
237_G242_L2.0951.00
162_T236_G2.0901.00
153_S169_L2.0841.00
324_A365_A2.0621.00
218_A221_Y2.0431.00
330_H366_H2.0221.00
301_N371_A1.9871.00
119_E122_S1.9861.00
5_K76_I1.9851.00
53_Q95_N1.9711.00
65_R69_R1.9671.00
262_T298_T1.9281.00
39_S54_V1.9281.00
363_K366_H1.9221.00
16_N33_R1.9201.00
44_Y47_S1.9201.00
317_V320_E1.8981.00
399_V410_T1.8921.00
332_C352_F1.8851.00
387_T393_E1.8721.00
7_Y440_N1.8671.00
8_L63_A1.8521.00
6_G29_L1.8421.00
219_N229_I1.8281.00
12_I17_A1.8261.00
8_L19_V1.8061.00
166_S233_V1.8011.00
415_D465_L1.7721.00
305_L371_A1.7651.00
380_K468_Y1.7621.00
380_K469_E1.7521.00
138_Y142_Q1.7401.00
91_D95_N1.7351.00
123_S192_E1.7251.00
234_I442_T1.7201.00
119_E192_E1.7171.00
208_V212_T1.7151.00
94_G163_Y1.6931.00
89_L140_L1.6871.00
6_G21_V1.6651.00
119_E123_S1.6651.00
170_T208_V1.6541.00
112_A116_D1.6521.00
213_A216_T1.6301.00
328_E331_A1.6211.00
109_E113_G1.5991.00
213_A234_I1.5941.00
303_Q307_Q1.5931.00
420_K460_D1.5421.00
5_K74_D1.5281.00
88_V157_I1.5261.00
349_R359_S1.5241.00
21_V70_S1.5211.00
321_E324_A1.5131.00
89_L203_I1.5061.00
66_A70_S1.5051.00
472_K476_R1.4861.00
7_Y445_L1.4801.00
321_E365_A1.4751.00
24_V445_L1.4641.00
118_E122_S1.4621.00
56_W60_M1.4571.00
458_P461_C1.4551.00
146_S149_E1.4541.00
322_I408_A1.4441.00
384_D387_T1.4371.00
162_T214_I1.4371.00
30_T69_R1.4251.00
53_Q57_K1.4201.00
369_R373_E1.4191.00
51_S54_V1.4181.00
32_E62_L1.4091.00
139_G143_R1.4031.00
313_E317_V1.4031.00
321_E364_R1.3971.00
32_E66_A1.3901.00
407_K423_V1.3881.00
228_S231_A1.3871.00
440_N446_T1.3741.00
30_T66_A1.3721.00
254_I396_Y1.3641.00
318_M368_V1.3631.00
200_S203_I1.3591.00
67_L72_D1.3531.00
380_K472_K1.3511.00
90_I155_T1.3491.00
396_Y420_K1.3461.00
10_F63_A1.3451.00
320_E324_A1.3441.00
77_G439_C1.3441.00
408_A412_Y1.3371.00
173_P187_N1.3371.00
331_A470_E1.3351.00
319_E323_S1.3301.00
461_C464_E1.3161.00
30_T70_S1.3151.00
216_T230_N1.3141.00
376_A412_Y1.3141.00
84_R238_G1.3091.00
166_S215_G1.3061.00
160_W164_Q1.2931.00
468_Y472_K1.2901.00
376_A416_L1.2861.00
295_P378_S1.2791.00
376_A413_I1.2781.00
119_E196_I1.2771.00
332_C336_L1.2611.00
17_A59_V1.2571.00
194_C204_L1.2541.00
71_C74_D1.2371.00
252_E269_E1.2371.00
57_K61_N1.2341.00
108_R112_A1.2331.00
473_Q477_F1.2271.00
110_W138_Y1.2261.00
41_E54_V1.2241.00
208_V214_I1.2241.00
418_Q469_E1.2151.00
213_A232_K1.2121.00
415_D462_Q1.2051.00
353_L478_F1.2051.00
134_A197_F1.2011.00
405_Q428_H1.1941.00
332_C371_A1.1921.00
17_A58_Q1.1881.00
319_E407_K1.1871.00
49_Y99_G1.1871.00
464_E467_L1.1861.00
237_G438_I1.1851.00
192_E195_D1.1851.00
141_K148_W1.1841.00
380_K417_L1.1761.00
120_I128_P1.1751.00
162_T170_T1.1741.00
168_I208_V1.1711.00
94_G169_L1.1711.00
251_L254_I1.1691.00
51_S99_G1.1681.00
358_L362_L1.1671.00
144_Q147_L1.1651.00
412_Y416_L1.1621.00
32_E69_R1.1581.00
297_I301_N1.1561.00
89_L151_T1.1521.00
255_V394_R1.1481.00
10_F19_V1.1471.00
309_F367_F1.1411.00
319_E406_S1.1391.00
151_T203_I1.1311.00
297_I300_L1.1271.00
61_N65_R1.1261.00
173_P207_L1.1251.00
112_A115_P1.1241.00
146_S150_K1.1241.00
279_W282_C1.1161.00
22_V28_V1.1161.00
362_L366_H1.1111.00
317_V321_E1.1091.00
441_E452_N1.1091.00
111_E128_P1.1031.00
5_K24_V1.1031.00
213_A442_T1.1021.00
155_T169_L1.0991.00
170_T214_I1.0991.00
384_D472_K1.0921.00
6_G74_D1.0911.00
398_W422_Y1.0901.00
77_G443_F1.0881.00
316_E319_E1.0821.00
109_E112_A1.0811.00
332_C370_A1.0801.00
148_W151_T1.0781.00
301_N332_C1.0771.00
89_L137_L1.0751.00
59_V161_V1.0741.00
7_Y443_F1.0731.00
320_E323_S1.0721.00
22_V436_A1.0611.00
270_D286_Q1.0591.00
67_L70_S1.0581.00
106_R139_G1.0541.00
173_P182_F1.0441.00
65_R68_S1.0431.00
98_L147_L1.0381.00
321_E368_V1.0371.00
251_L450_S1.0351.00
55_L157_I1.0341.00
254_I398_W1.0241.00
80_S162_T1.0231.00
52_P88_V1.0211.00
418_Q465_L1.0191.00
110_W113_G1.0111.00
137_L154_F1.0101.00
383_F417_L1.0061.00
279_W284_T1.0051.00
40_T50_F1.0011.00
59_V63_A0.9941.00
194_C199_F0.9941.00
375_I403_G0.9931.00
54_V57_K0.9931.00
377_F416_L0.9911.00
110_W143_R0.9891.00
269_E288_H0.9861.00
274_T277_K0.9851.00
38_Y58_Q0.9821.00
469_E473_Q0.9801.00
120_I180_L0.9791.00
134_A180_L0.9771.00
216_T232_K0.9751.00
163_Y169_L0.9721.00
28_V31_V0.9711.00
473_Q476_R0.9711.00
470_E473_Q0.9691.00
369_R408_A0.9681.00
64_K68_S0.9601.00
446_T452_N0.9581.00
187_N209_R0.9571.00
7_Y77_G0.9561.00
77_G234_I0.9541.00
78_L231_A0.9511.00
471_W474_T0.9491.00
145_P149_E0.9491.00
48_R103_I0.9491.00
325_L330_H0.9451.00
19_V66_A0.9441.00
81_T431_S0.9441.00
89_L154_F0.9441.00
95_N164_Q0.9421.00
279_W283_H0.9411.00
450_S453_V0.9381.00
403_G409_L0.9381.00
21_V75_I0.9331.00
147_L150_K0.9321.00
437_V452_N0.9321.00
281_N284_T0.9301.00
255_V266_K0.9301.00
182_F186_Q0.9291.00
410_T459_K0.9251.00
22_V433_V0.9251.00
76_I443_F0.9231.00
234_I443_F0.9221.00
151_T154_F0.9211.00
440_N445_L0.9181.00
323_S408_A0.9161.00
8_L21_V0.9151.00
251_L453_V0.9151.00
380_K416_L0.9131.00
159_D171_Y0.9041.00
23_S29_L0.9021.00
377_F471_W0.9001.00
140_L147_L0.8971.00
315_Y318_M0.8961.00
350_G358_L0.8951.00
167_G218_A0.8921.00
264_I383_F0.8921.00
471_W475_Q0.8911.00
466_A470_E0.8901.00
8_L75_I0.8901.00
80_S161_V0.8871.00
60_M64_K0.8861.00
358_L367_F0.8861.00
173_P209_R0.8821.00
325_L328_E0.8811.00
397_V417_L0.8791.00
251_L454_R0.8771.00
122_S185_K0.8761.00
208_V235_A0.8751.00
98_L140_L0.8751.00
441_E449_M0.8751.00
67_L75_I0.8741.00
455_V458_P0.8741.00
352_F371_A0.8731.00
79_T234_I0.8711.00
134_A181_L0.8701.00
80_S165_L0.8691.00
417_L420_K0.8681.00
138_Y141_K0.8661.00
441_E448_E0.8651.00
171_Y176_A0.8651.00
384_D388_E0.8651.00
467_L471_W0.8621.00
312_N318_M0.8621.00
274_T278_A0.8611.00
75_I231_A0.8601.00
253_D395_D0.8591.00
467_L470_E0.8571.00
87_I154_F0.8561.00
468_Y471_W0.8561.00
12_I161_V0.8541.00
267_I288_H0.8511.00
262_T379_I0.8511.00
460_D465_L0.8501.00
474_T477_F0.8461.00
310_Y364_R0.8461.00
322_I369_R0.8461.00
73_I228_S0.8451.00
407_K459_K0.8431.00
420_K457_E0.8401.00
90_I94_G0.8401.00
273_D277_K0.8381.00
266_K386_L0.8341.00
263_P294_N0.8331.00
122_S273_D0.8321.00
188_T206_P0.8321.00
316_E320_E0.8311.00
189_W204_L0.8291.00
187_N287_G0.8291.00
170_T206_P0.8291.00
217_I231_A0.8291.00
34_E62_L0.8271.00
85_Q178_E0.8241.00
37_E306_K0.8221.00
115_P128_P0.8221.00
256_I413_I0.8221.00
105_N129_T0.8211.00
113_G116_D0.8201.00
372_L412_Y0.8181.00
152_A202_S0.8181.00
109_E143_R0.8131.00
451_A454_R0.8131.00
111_E130_A0.8101.00
243_A400_C0.8081.00
54_V58_Q0.8081.00
37_E303_Q0.8081.00
137_L181_L0.8061.00
111_E135_L0.8041.00
84_R175_Q0.8031.00
383_F387_T0.8021.00
188_T191_E0.8011.00
171_Y205_P0.8011.00
182_F187_N0.7961.00
84_R292_E0.7941.00
113_G138_Y0.7921.00
328_E373_E0.7921.00
399_V423_V0.7891.00
351_G478_F0.7871.00
306_K315_Y0.7861.00
97_F150_K0.7861.00
348_T351_G0.7861.00
463_I466_A0.7851.00
399_V413_I0.7821.00
470_E474_T0.7801.00
219_N230_N0.7801.00
156_S179_T0.7791.00
240_T263_P0.7791.00
177_T282_C0.7781.00
404_F428_H0.7771.00
440_N444_Q0.7751.00
171_Y207_L0.7751.00
251_L395_D0.7751.00
76_I445_L0.7751.00
158_S236_G0.7741.00
280_L283_H0.7741.00
258_S413_I0.7711.00
63_A67_L0.7701.00
327_K467_L0.7681.00
216_T229_I0.7661.00
60_M221_Y0.7661.00
176_A189_W0.7651.00
325_L329_D0.7651.00
174_S284_T0.7601.00
273_D276_H0.7601.00
466_A469_E0.7601.00
304_K307_Q0.7591.00
313_E364_R0.7571.00
9_V79_T0.7571.00
322_I368_V0.7551.00
385_I388_E0.7551.00
109_E142_Q0.7551.00
325_L365_A0.7551.00
52_P99_G0.7551.00
249_A254_I0.7541.00
12_I59_V0.7531.00
91_D97_F0.7521.00
192_E196_I0.7471.00
247_T400_C0.7471.00
138_Y198_G0.7451.00
89_L97_F0.7411.00
319_E408_A0.7411.00
298_T375_I0.7411.00
323_S411_Q0.7381.00
376_A409_L0.7341.00
268_T291_V0.7341.00
372_L406_S0.7321.00
43_L47_S0.7321.00
102_N261_T0.7311.00
92_Q150_K0.7311.00
404_F410_T0.7301.00
14_T101_P0.7301.00
59_V62_L0.7301.00
381_W476_R0.7281.00
78_L217_I0.7271.00
34_E58_Q0.7271.00
305_L367_F0.7261.00
90_I169_L0.7251.00
217_I228_S0.7241.00
123_S183_D0.7231.00
227_L230_N0.7231.00
243_A431_S0.7221.00
305_L368_V0.7211.00
280_L284_T0.7211.00
77_G232_K0.7111.00
469_E472_K0.7111.00
399_V421_V0.7111.00
57_K60_M0.7081.00
460_D463_I0.7071.00
31_V429_Q0.7051.00
326_A329_D0.7051.00
60_M164_Q0.7031.00
448_E452_N0.7031.00
53_Q160_W0.7021.00
255_V397_V0.7021.00
72_D75_I0.7001.00
91_D152_A0.6971.00
174_S237_G0.6971.00
303_Q315_Y0.6961.00
112_A347_L0.6931.00
38_Y50_F0.6921.00
377_F468_Y0.6911.00
53_Q96_P0.6911.00
217_I227_L0.6901.00
293_T382_N0.6891.00
120_I193_M0.6871.00
124_T193_M0.6871.00
229_I232_K0.6860.99
323_S407_K0.6840.99
12_I58_Q0.6840.99
406_S409_L0.6840.99
385_I389_V0.6790.99
63_A66_A0.6790.99
162_T166_S0.6790.99
94_G152_A0.6790.99
239_D260_T0.6780.99
183_D188_T0.6780.99
397_V419_K0.6770.99
20_A28_V0.6760.99
216_T219_N0.6750.99
7_Y76_I0.6750.99
210_A236_G0.6750.99
327_K330_H0.6730.99
87_I133_S0.6720.99
149_E153_S0.6720.99
114_I197_F0.6700.99
322_I325_L0.6700.99
214_I235_A0.6690.99
160_W163_Y0.6680.99
227_L231_A0.6680.99
53_Q99_G0.6670.99
327_K331_A0.6670.99
381_W472_K0.6660.99
257_V379_I0.6660.99
49_Y106_R0.6640.99
61_N64_K0.6640.99
82_S175_Q0.6640.99
100_L106_R0.6630.99
411_Q459_K0.6620.99
418_Q463_I0.6620.99
90_I160_W0.6610.99
190_S193_M0.6590.99
449_M452_N0.6570.99
118_E121_Y0.6540.99
328_E369_R0.6540.99
90_I153_S0.6520.99
384_D476_R0.6500.99
295_P382_N0.6490.99
373_E412_Y0.6470.99
262_T413_I0.6460.99
24_V76_I0.6460.99
221_Y230_N0.6460.99
335_A339_Y0.6450.99
407_K411_Q0.6450.99
472_K475_Q0.6440.99
437_V441_E0.6430.99
397_V421_V0.6430.99
138_Y197_F0.6420.99
22_V432_V0.6420.99
465_L468_Y0.6390.99
141_K198_G0.6360.99
60_M63_A0.6350.99
90_I163_Y0.6350.99
395_D419_K0.6340.99
321_E325_L0.6340.99
246_S430_A0.6310.99
265_T290_L0.6290.99
326_A330_H0.6280.99
302_Y319_E0.6270.99
396_Y419_K0.6260.99
6_G70_S0.6260.99
82_S157_I0.6240.99
369_R412_Y0.6230.99
56_W221_Y0.6230.99
305_L309_F0.6220.99
158_S175_Q0.6220.99
319_E322_I0.6210.99
394_R419_K0.6190.99
185_K271_H0.6190.99
193_M197_F0.6180.99
174_S210_A0.6180.99
357_P362_L0.6160.99
359_S362_L0.6140.99
181_L204_L0.6120.99
100_L140_L0.6120.99
150_K153_S0.6110.99
410_T423_V0.6110.99
244_V283_H0.6080.99
213_A443_F0.6070.99
39_S51_S0.6070.99
343_E381_W0.6060.99
135_L180_L0.6050.99
51_S57_K0.6050.99
53_Q56_W0.6050.99
83_Q102_N0.6020.99
461_C475_Q0.6020.99
187_N282_C0.6020.99
448_E454_R0.6000.99
311_P364_R0.6000.99
238_G241_Q0.6000.99
137_L203_I0.5990.99
138_Y148_W0.5980.99
343_E348_T0.5980.99
281_N290_L0.5970.99
232_K443_F0.5940.99
107_G135_L0.5920.99
331_A369_R0.5920.99
290_L294_N0.5910.99
375_I409_L0.5910.99
262_T295_P0.5900.98
114_I135_L0.5900.98
7_Y446_T0.5900.98
195_D200_S0.5880.98
148_W152_A0.5880.98
179_T189_W0.5840.98
345_N348_T0.5830.98
49_Y98_L0.5830.98
6_G73_I0.5820.98
128_P180_L0.5820.98
373_E377_F0.5810.98
245_K437_V0.5810.98
299_G303_Q0.5800.98
108_R130_A0.5800.98
256_I264_I0.5800.98
221_Y227_L0.5770.98
257_V413_I0.5770.98
450_S454_R0.5760.98
296_G340_L0.5760.98
441_E446_T0.5730.98
75_I227_L0.5730.98
78_L233_V0.5730.98
159_D169_L0.5720.98
415_D459_K0.5720.98
84_R178_E0.5720.98
15_G18_R0.5710.98
126_R132_F0.5700.98
276_H389_V0.5700.98
333_V351_G0.5670.98
211_G442_T0.5670.98
132_F178_E0.5670.98
206_P212_T0.5670.98
254_I395_D0.5660.98
185_K273_D0.5650.98
248_G453_V0.5650.98
298_T301_N0.5630.98
460_D464_E0.5630.98
7_Y24_V0.5630.98
88_V96_P0.5620.98
423_V459_K0.5610.98
266_K394_R0.5610.98
273_D278_A0.5590.98
218_A230_N0.5590.98
85_Q102_N0.5580.98
322_I372_L0.5580.98
315_Y319_E0.5580.98
173_P210_A0.5570.98
404_F423_V0.5560.98
411_Q414_A0.5540.98
319_E372_L0.5530.98
441_E444_Q0.5520.98
407_K457_E0.5520.98
245_K284_T0.5520.98
29_L33_R0.5500.98
423_V456_I0.5490.98
303_Q306_K0.5460.98
94_G153_S0.5450.97
300_L303_Q0.5450.97
96_P99_G0.5440.97
456_I461_C0.5440.97
193_M196_I0.5420.97
155_T163_Y0.5420.97
310_Y313_E0.5420.97
199_F204_L0.5420.97
50_F101_P0.5420.97
413_I417_L0.5410.97
211_G441_E0.5380.97
433_V437_V0.5380.97
210_A237_G0.5370.97
14_T102_N0.5370.97
244_V265_T0.5370.97
48_R101_P0.5370.97
20_A433_V0.5360.97
332_C374_E0.5360.97
325_L369_R0.5360.97
195_D201_P0.5350.97
167_G220_E0.5340.97
326_A369_R0.5340.97
330_H361_H0.5330.97
106_R143_R0.5320.97
449_M453_V0.5320.97
95_N150_K0.5310.97
377_F380_K0.5300.97
278_A282_C0.5300.97
327_K369_R0.5300.97
156_S175_Q0.5290.97
437_V449_M0.5280.97
357_P360_A0.5260.97
62_L66_A0.5260.97
336_L358_L0.5250.97
5_K445_L0.5250.97
130_A346_A0.5250.97
395_D420_K0.5240.97
86_G101_P0.5240.97
308_I363_K0.5230.97
272_G275_K0.5220.97
117_W121_Y0.5220.97
273_D280_L0.5220.97
407_K456_I0.5210.97
318_M408_A0.5210.97
334_A374_E0.5210.97
432_V435_A0.5210.97
120_I197_F0.5210.97
414_A421_V0.5210.97
377_F467_L0.5210.97
379_I413_I0.5190.97
195_D198_G0.5190.97
387_T391_P0.5190.97
97_F151_T0.5180.97
24_V440_N0.5180.97
264_I382_N0.5170.97
47_S106_R0.5170.97
27_S425_E0.5160.97
198_G201_P0.5150.96
217_I226_G0.5140.96
216_T231_A0.5140.96
185_K188_T0.5140.96
305_L310_Y0.5120.96
448_E453_V0.5110.96
81_T435_A0.5100.96
85_Q261_T0.5090.96
282_C289_W0.5070.96
260_T300_L0.5070.96
83_Q238_G0.5030.96
174_S241_Q0.5030.96
294_N340_L0.5030.96
239_D259_G0.5030.96
258_S403_G0.5020.96
158_S171_Y0.5020.96
446_T451_A0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ll3A 2 0.9774 100 0.154 Contact Map
3qdkA 2 0.9733 100 0.159 Contact Map
2itmA 2 0.9528 100 0.161 Contact Map
3ifrA 2 0.9671 100 0.17 Contact Map
3hz6A 1 0.9713 100 0.171 Contact Map
3h3nX 3 0.9774 100 0.177 Contact Map
3ezwA 3 0.9774 100 0.18 Contact Map
3wxlA 2 0.9836 100 0.182 Contact Map
3g25A 3 0.9754 100 0.183 Contact Map
2w40A 3 0.9733 100 0.187 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0136 seconds.