GREMLIN Database
RSBRB - RsbT co-antagonist protein RsbRB
UniProt: O34860 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 277 (258)
Sequences: 915 (741)
Seq/√Len: 46.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
101_R136_D5.4761.00
14_H17_Q5.3651.00
220_T252_T4.2881.00
9_A13_E3.6481.00
212_L218_V3.5051.00
197_L232_A3.4321.00
20_E24_E3.1421.00
243_S272_A3.1351.00
161_I169_I2.8751.00
184_I189_A2.7691.00
186_T217_V2.5461.00
186_T221_M2.5001.00
170_T177_L2.3241.00
21_E106_K2.2811.00
252_T256_L2.1641.00
176_A205_V2.1231.00
223_A252_T2.0480.99
199_A202_K2.0360.99
184_I192_I2.0290.99
43_T47_K2.0080.99
208_L213_S1.9830.99
220_T256_L1.9550.99
246_R257_G1.9330.99
98_M139_I1.8850.99
176_A200_C1.8700.99
196_T208_L1.8440.99
208_L238_V1.8300.99
220_T257_G1.8040.99
106_K129_D1.7760.98
220_T223_A1.7620.98
14_H107_Y1.7400.98
222_V250_A1.7050.98
56_H60_M1.7020.98
200_C233_L1.6940.98
210_I233_L1.6560.98
146_A149_N1.6560.98
218_V249_I1.6550.98
186_T215_V1.6430.97
230_I242_L1.6280.97
213_S233_L1.6190.97
154_L157_Q1.5980.97
198_Q202_K1.5950.97
215_V249_I1.5650.97
166_S192_I1.5430.96
174_S206_E1.5400.96
220_T224_H1.5290.96
23_I26_M1.5150.96
7_L15_V1.5120.96
102_R133_K1.5120.96
186_T190_K1.5100.96
205_V213_S1.5100.96
173_K270_A1.4960.96
253_A260_F1.4850.95
224_H228_K1.4800.95
219_D222_V1.4350.94
157_Q169_I1.4220.94
21_E25_T1.4200.94
164_L185_D1.4200.94
143_V147_E1.3950.94
245_I250_A1.3900.93
228_K233_L1.3850.93
152_Q156_A1.3800.93
207_H241_T1.3770.93
10_F111_F1.3670.93
215_V252_T1.3560.93
243_S270_A1.3490.92
25_T102_R1.3490.92
15_V19_A1.3460.92
141_T145_H1.3300.92
177_L196_T1.3230.92
76_V138_T1.3180.91
111_F114_E1.3160.91
253_A258_I1.2990.91
172_S243_S1.2930.91
186_T220_T1.2930.91
163_E220_T1.2850.90
178_L213_S1.2840.90
217_V220_T1.2830.90
173_K204_R1.2340.88
209_L243_S1.2290.88
215_V256_L1.2110.88
213_S238_V1.2040.87
135_F139_I1.1980.87
17_Q20_E1.1930.87
239_R264_T1.1910.87
44_E48_E1.1910.87
168_V219_D1.1830.86
109_E126_K1.1750.86
57_L78_E1.1750.86
168_V257_G1.1630.85
206_E210_I1.1630.85
21_E107_Y1.1620.85
219_D250_A1.1600.85
234_N239_R1.1570.85
209_L269_L1.1550.85
213_S272_A1.1480.85
180_L222_V1.1480.85
84_K132_V1.1290.84
108_F173_K1.1200.83
186_T225_Q1.1110.83
158_R231_E1.1070.82
172_S177_L1.1020.82
193_L232_A1.1000.82
59_Y63_L1.0990.82
43_T53_F1.0940.82
186_T222_V1.0880.81
17_Q27_E1.0860.81
13_E24_E1.0840.81
180_L208_L1.0600.79
259_D262_N1.0570.79
42_V52_E1.0530.79
164_L246_R1.0510.79
12_S17_Q1.0510.79
75_W233_L1.0510.79
266_K275_Y1.0500.79
218_V222_V1.0480.79
48_E273_L1.0460.79
249_I252_T1.0400.78
188_R250_A1.0390.78
169_I246_R1.0310.78
189_A225_Q1.0280.77
43_T146_A1.0250.77
14_H44_E1.0200.77
46_L49_Q1.0120.76
160_M169_I1.0040.76
228_K254_V1.0000.75
150_A153_Q0.9900.75
212_L229_L0.9830.74
31_P42_V0.9830.74
9_A12_S0.9810.74
184_I249_I0.9800.74
180_L233_L0.9790.74
105_T128_A0.9760.74
21_E24_E0.9730.73
229_L238_V0.9710.73
11_F47_K0.9670.73
182_G211_D0.9610.72
243_S273_L0.9600.72
10_F28_E0.9580.72
243_S275_Y0.9580.72
23_I28_E0.9540.72
264_T267_T0.9480.71
203_R274_N0.9470.71
10_F31_P0.9470.71
163_E186_T0.9390.71
26_M50_D0.9360.70
109_E114_E0.9360.70
153_Q161_I0.9330.70
212_L243_S0.9180.69
14_H110_K0.9160.69
194_E219_D0.9110.68
11_F18_M0.9110.68
178_L272_A0.9100.68
41_T45_E0.9090.68
58_N61_Y0.9020.67
181_V214_G0.8990.67
213_S229_L0.8960.67
132_V136_D0.8920.67
200_C205_V0.8920.67
16_E21_E0.8860.66
20_E47_K0.8830.66
78_E126_K0.8800.66
209_L242_L0.8790.65
160_M181_V0.8790.65
17_Q21_E0.8750.65
72_F135_F0.8690.65
31_P44_E0.8670.64
91_Q147_E0.8640.64
90_V144_D0.8630.64
21_E110_K0.8610.64
185_D193_L0.8560.63
74_E110_K0.8510.63
96_E99_R0.8510.63
43_T61_Y0.8510.63
115_N118_A0.8450.62
150_A154_L0.8430.62
173_K273_L0.8420.62
231_E273_L0.8410.62
7_L102_R0.8390.62
40_A50_D0.8390.62
10_F18_M0.8370.62
212_L215_V0.8310.61
51_R55_R0.8310.61
217_V252_T0.8260.61
53_F57_L0.8250.60
194_E269_L0.8230.60
107_Y148_M0.8230.60
11_F105_T0.8110.59
176_A233_L0.8100.59
80_T93_V0.8080.59
151_K155_N0.8060.59
148_M152_Q0.8040.58
111_F115_N0.8010.58
227_F249_I0.7970.58
212_L253_A0.7970.58
199_A213_S0.7950.58
104_Y111_F0.7950.58
7_L12_S0.7890.57
27_E30_D0.7890.57
181_V255_Q0.7880.57
12_S62_V0.7820.56
58_N74_E0.7810.56
196_T229_L0.7790.56
159_E187_E0.7790.56
19_A23_I0.7780.56
170_T271_Q0.7750.56
209_L213_S0.7740.56
226_I260_F0.7720.55
220_T247_P0.7710.55
186_T236_I0.7700.55
12_S29_S0.7690.55
93_V142_F0.7680.55
55_R268_N0.7670.55
178_L212_L0.7670.55
163_E189_A0.7660.55
15_V51_R0.7660.55
232_A269_L0.7660.55
227_F253_A0.7650.55
221_M252_T0.7640.55
207_H267_T0.7590.54
50_D60_M0.7590.54
196_T205_V0.7590.54
57_L84_K0.7570.54
237_G244_G0.7560.54
97_F139_I0.7550.54
200_C208_L0.7540.54
176_A271_Q0.7530.54
147_E161_I0.7480.53
252_T257_G0.7480.53
232_A268_N0.7470.53
20_E31_P0.7450.53
189_A220_T0.7450.53
142_F160_M0.7440.53
20_E38_H0.7400.52
189_A221_M0.7380.52
110_K126_K0.7360.52
20_E25_T0.7330.52
94_I139_I0.7330.52
21_E28_E0.7320.51
22_W157_Q0.7300.51
171_L233_L0.7300.51
176_A203_R0.7290.51
223_A258_I0.7270.51
159_E206_E0.7270.51
249_I256_L0.7240.51
199_A203_R0.7220.51
23_I50_D0.7200.50
7_L10_F0.7190.50
23_I43_T0.7190.50
52_E78_E0.7190.50
9_A16_E0.7180.50
68_F202_K0.7160.50
159_E162_L0.7140.50
251_Q254_V0.7120.50
25_T103_L0.7090.49
212_L249_I0.7080.49
196_T216_V0.7070.49
98_M140_Y0.7050.49
249_I257_G0.7040.49
12_S67_Q0.7000.48
136_D142_F0.6990.48
135_F246_R0.6930.48
29_S206_E0.6930.48
53_F56_H0.6900.47
9_A24_E0.6880.47
155_N159_E0.6850.47
242_L272_A0.6850.47
233_L238_V0.6850.47
140_Y200_C0.6780.46
163_E187_E0.6780.46
157_Q163_E0.6760.46
156_A251_Q0.6750.46
175_T228_K0.6750.46
222_V256_L0.6710.45
176_A231_E0.6650.45
12_S59_Y0.6650.45
13_E110_K0.6630.45
39_N42_V0.6600.44
222_V257_G0.6600.44
114_E184_I0.6590.44
46_L61_Y0.6560.44
158_R187_E0.6550.44
220_T258_I0.6540.44
14_H20_E0.6540.44
56_H83_Q0.6530.44
52_E56_H0.6520.44
181_V249_I0.6490.43
161_I164_L0.6480.43
20_E28_E0.6480.43
113_E116_E0.6470.43
15_V31_P0.6460.43
109_E129_D0.6430.43
26_M96_E0.6420.43
215_V222_V0.6360.42
103_L171_L0.6360.42
58_N106_K0.6340.42
221_M246_R0.6320.42
193_L243_S0.6300.42
74_E112_A0.6270.41
19_A26_M0.6250.41
186_T227_F0.6250.41
81_N171_L0.6240.41
78_E152_Q0.6230.41
112_A116_E0.6220.41
219_D223_A0.6200.41
178_L208_L0.6190.40
192_I271_Q0.6170.40
177_L229_L0.6150.40
186_T189_A0.6110.40
184_I251_Q0.6090.40
39_N43_T0.6080.39
49_Q82_D0.6070.39
70_E81_N0.6070.39
90_V171_L0.6030.39
221_M255_Q0.6000.39
54_Y59_Y0.5990.39
16_E20_E0.5970.38
18_M27_E0.5930.38
210_I239_R0.5910.38
61_Y111_F0.5890.38
161_I208_L0.5860.37
165_S220_T0.5820.37
231_E255_Q0.5820.37
195_N243_S0.5810.37
11_F48_E0.5810.37
168_V199_A0.5790.37
113_E180_L0.5790.37
189_A230_I0.5770.37
189_A193_L0.5750.36
20_E23_I0.5740.36
207_H232_A0.5710.36
211_D237_G0.5710.36
196_T200_C0.5690.36
220_T227_F0.5680.36
77_I113_E0.5670.36
124_K128_A0.5660.36
101_R104_Y0.5640.35
15_V55_R0.5620.35
14_H28_E0.5610.35
87_D146_A0.5600.35
163_E227_F0.5570.35
67_Q71_E0.5570.35
211_D244_G0.5560.35
22_W76_V0.5550.35
72_F136_D0.5540.34
23_I79_L0.5540.34
15_V112_A0.5510.34
98_M146_A0.5510.34
182_G237_G0.5500.34
133_K168_V0.5470.34
249_I254_V0.5470.34
177_L184_I0.5450.34
18_M30_D0.5400.33
83_Q92_Y0.5400.33
241_T275_Y0.5360.33
61_Y242_L0.5350.33
182_G244_G0.5350.33
48_E109_E0.5350.33
236_I242_L0.5350.33
18_M28_E0.5320.33
103_L106_K0.5320.33
215_V218_V0.5310.32
174_S205_V0.5300.32
176_A236_I0.5300.32
52_E258_I0.5280.32
227_F238_V0.5280.32
186_T252_T0.5260.32
107_Y111_F0.5250.32
249_I272_A0.5220.32
47_K91_Q0.5210.32
16_E116_E0.5210.32
23_I27_E0.5200.32
51_R63_L0.5180.31
205_V212_L0.5160.31
49_Q79_L0.5160.31
212_L232_A0.5150.31
236_I253_A0.5110.31
251_Q261_S0.5100.31
19_A54_Y0.5100.31
8_Y12_S0.5100.31
16_E28_E0.5090.31
117_S133_K0.5090.31
12_S30_D0.5080.31
106_K115_N0.5030.30
30_D55_R0.5030.30
149_N152_Q0.5010.30
112_A118_A0.5000.30
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zxnA 1 0.4079 99.6 0.752 Contact Map
4dgfA 1 0.4224 99.3 0.803 Contact Map
3ny7A 1 0.4188 99.3 0.803 Contact Map
1h4xA 1 0.4007 99.1 0.815 Contact Map
1th8B 1 0.4043 99.1 0.816 Contact Map
3t6oA 5 0.3971 99.1 0.817 Contact Map
2ka5A 1 0.444 99.1 0.819 Contact Map
4dghA 4 0.4332 99 0.82 Contact Map
3lloA 1 0.4477 99 0.82 Contact Map
2klnA 1 0.426 99 0.822 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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