GREMLIN Database
KU - Non-homologous end joining protein Ku
UniProt: O34859 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 311 (274)
Sequences: 1606 (993)
Seq/√Len: 60.0

  • BACSU - KU
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
146_A214_I4.6871.00
262_D265_S4.1441.00
49_R58_P3.8091.00
145_E148_R3.5371.00
52_H65_C3.2921.00
62_E71_T2.9141.00
65_C68_C2.8801.00
118_E220_K2.7721.00
145_E149_S2.7271.00
35_I130_V2.6571.00
149_S211_I2.6561.00
63_K74_P2.6511.00
290_A293_K2.6431.00
37_L130_V2.6191.00
52_H68_C2.4961.00
285_A288_Q2.4431.00
73_S76_E2.3761.00
53_K76_E2.3341.00
227_E232_Q2.2831.00
289_A292_P2.2041.00
222_E225_K2.1901.00
61_Y77_I2.1661.00
82_E85_K2.1551.00
287_A290_A2.1501.00
204_D208_Q2.1381.00
115_Q152_K2.0681.00
244_N247_T2.0661.00
234_L238_V2.0231.00
288_Q291_E2.0161.00
82_E86_G2.0111.00
111_V157_N2.0081.00
48_L234_L1.9851.00
119_I168_I1.9821.00
286_P289_A1.9731.00
169_L176_I1.9611.00
42_E188_R1.9421.00
281_T284_A1.9271.00
150_T211_I1.9231.00
265_S269_A1.9131.00
53_K92_T1.9121.00
282_P285_A1.8921.00
49_R88_Y1.8241.00
287_A292_P1.8071.00
41_T126_R1.7770.99
46_I235_L1.7760.99
284_A287_A1.7510.99
280_E283_A1.7280.99
57_A67_N1.7210.99
52_H57_A1.7020.99
268_Q272_D1.6820.99
277_P280_E1.6630.99
148_R174_N1.6530.99
261_I264_V1.6520.99
38_Y131_G1.6500.99
57_A65_C1.6360.99
153_I168_I1.5870.99
285_A290_A1.5720.99
278_N281_T1.5700.99
144_R174_N1.5600.99
283_A286_P1.5520.98
52_H55_D1.5410.98
25_S32_N1.5310.98
51_L90_V1.5220.98
155_I168_I1.5130.98
59_I72_L1.5080.98
60_K66_T1.5020.98
112_D225_K1.4980.98
26_I169_L1.4940.98
238_V242_L1.4840.98
51_L78_V1.4820.98
231_R235_L1.4680.98
34_P136_G1.4580.98
112_D219_A1.4500.98
117_Q151_G1.4100.97
64_V68_C1.3930.97
57_A66_T1.3830.97
63_K77_I1.3780.97
208_Q211_I1.3680.97
20_T23_K1.3340.96
46_I187_V1.3320.96
114_V119_I1.3200.96
116_L153_I1.3190.96
50_S59_I1.3160.96
239_N242_L1.3140.96
131_G193_V1.2750.95
158_M178_M1.2720.95
265_S268_Q1.2720.95
91_L99_L1.2570.95
178_M213_L1.2540.94
157_N229_T1.2540.94
243_E246_E1.2500.94
127_S182_H1.2440.94
91_L96_L1.2300.94
28_F143_L1.2260.94
279_R282_P1.2220.94
29_G143_L1.2140.93
140_Y175_C1.2080.93
138_K206_E1.1860.93
100_K233_A1.1860.93
84_V87_K1.1850.93
284_A293_K1.1820.92
240_D244_N1.1810.92
125_N182_H1.1610.92
44_K231_R1.1590.92
168_I181_I1.1320.91
50_S77_I1.1300.91
282_P290_A1.1230.90
258_E261_I1.1040.90
279_R284_A1.1010.90
205_K208_Q1.0990.89
125_N180_S1.0960.89
49_R82_E1.0920.89
96_L234_L1.0900.89
272_D275_R1.0840.89
236_Q240_D1.0770.88
167_A180_S1.0760.88
55_D68_C1.0730.88
43_D125_N1.0670.88
28_F31_V1.0640.88
51_L88_Y1.0640.88
119_I153_I1.0610.88
95_D241_K1.0490.87
50_S61_Y1.0440.87
115_Q118_E1.0400.87
21_M161_R1.0310.86
157_N164_Q1.0290.86
120_D170_R1.0270.86
26_I143_L1.0270.86
154_G200_S1.0260.86
214_I268_Q1.0240.86
51_L56_H1.0210.86
54_E70_K1.0190.86
163_K228_D1.0150.85
286_P291_E1.0100.85
202_V207_L1.0100.85
151_G215_D1.0100.85
280_E293_K1.0080.85
110_I147_L1.0030.85
50_S63_K0.9960.84
94_E97_K0.9960.84
28_F110_I0.9950.84
91_L237_R0.9870.84
101_Q104_E0.9840.83
281_T285_A0.9820.83
284_A289_A0.9810.83
283_A288_Q0.9790.83
91_L95_D0.9720.83
110_I156_A0.9710.83
147_L152_K0.9660.82
36_K133_G0.9650.82
147_L183_Y0.9640.82
55_D66_T0.9610.82
107_A147_L0.9610.82
288_Q293_K0.9590.82
141_T144_R0.9510.81
70_K76_E0.9490.81
31_V185_D0.9470.81
28_F142_L0.9460.81
55_D65_C0.9440.81
276_R279_R0.9410.81
282_P287_A0.9410.81
54_E65_C0.9350.80
167_A178_M0.9260.80
101_Q159_T0.9250.79
158_M167_A0.9210.79
59_I160_I0.9190.79
55_D95_D0.9170.79
235_L239_N0.9100.78
284_A288_Q0.9050.78
264_V271_I0.9020.78
39_A79_K0.8980.77
25_S33_I0.8690.75
29_G142_L0.8660.75
83_Y242_L0.8630.75
233_A236_Q0.8590.74
280_E285_A0.8580.74
163_K170_R0.8490.73
78_V90_V0.8420.73
160_I180_S0.8380.72
154_G252_D0.8350.72
282_P286_P0.8330.72
155_I220_K0.8330.72
64_V69_E0.8310.72
53_K78_V0.8260.71
287_A291_E0.8240.71
141_T145_E0.8180.71
285_A289_A0.8110.70
32_N139_A0.8070.70
112_D226_Y0.8050.69
57_A68_C0.8040.69
80_G83_Y0.8010.69
122_I187_V0.8000.69
21_M39_A0.7980.69
59_I63_K0.7950.68
84_V242_L0.7890.68
48_L91_L0.7850.67
50_S96_L0.7800.67
44_K185_D0.7800.67
279_R292_P0.7730.66
219_A225_K0.7720.66
289_A293_K0.7690.66
272_D282_P0.7690.66
278_N286_P0.7650.65
124_F168_I0.7620.65
114_V155_I0.7620.65
154_G205_K0.7600.65
79_K93_D0.7600.65
52_H66_T0.7590.65
283_A289_A0.7580.65
283_A292_P0.7480.64
240_D247_T0.7480.64
68_C127_S0.7460.63
258_E264_V0.7450.63
41_T169_L0.7440.63
42_E171_V0.7430.63
286_P292_P0.7390.63
75_D87_K0.7380.63
127_S181_I0.7380.63
239_N243_E0.7370.62
234_L237_R0.7370.62
281_T293_K0.7350.62
211_I215_D0.7350.62
205_K216_E0.7340.62
64_V71_T0.7330.62
212_T271_I0.7320.62
286_P290_A0.7310.62
59_I79_K0.7280.62
276_R280_E0.7270.61
169_L254_A0.7250.61
104_E158_M0.7240.61
130_V178_M0.7230.61
285_A291_E0.7220.61
27_S138_K0.7210.61
102_E139_A0.7140.60
278_N283_A0.7110.60
285_A293_K0.7110.60
21_M140_Y0.7070.59
182_H209_T0.7060.59
104_E157_N0.7040.59
94_E284_A0.7030.59
122_I177_V0.6980.58
206_E213_L0.6950.58
282_P288_Q0.6880.57
121_P124_F0.6870.57
279_R288_Q0.6850.57
57_A156_A0.6850.57
88_Y139_A0.6840.57
69_E79_K0.6830.57
37_L160_I0.6800.56
23_K36_K0.6800.56
26_I179_E0.6770.56
83_Y87_K0.6770.56
108_V169_L0.6760.56
165_Q181_I0.6750.56
236_Q288_Q0.6750.56
112_D156_A0.6720.55
273_R276_R0.6710.55
34_P236_Q0.6700.55
230_Y233_A0.6680.55
216_E238_V0.6660.55
95_D233_A0.6630.54
81_Y96_L0.6630.54
95_D237_R0.6580.54
288_Q292_P0.6570.54
165_Q234_L0.6570.54
27_S142_L0.6570.54
102_E106_K0.6560.54
210_A244_N0.6530.53
117_Q173_E0.6530.53
33_I61_Y0.6420.52
170_R187_V0.6400.52
223_P226_Y0.6390.52
140_Y176_I0.6340.51
95_D234_L0.6340.51
276_R282_P0.6330.51
105_E176_I0.6330.51
20_T264_V0.6290.51
68_C159_T0.6290.51
240_D248_A0.6270.50
21_M37_L0.6250.50
274_T278_N0.6230.50
50_S74_P0.6230.50
52_H159_T0.6210.50
23_K180_S0.6210.50
138_K142_L0.6210.50
121_P179_E0.6190.49
37_L86_G0.6180.49
75_D259_D0.6180.49
105_E110_I0.6170.49
32_N95_D0.6170.49
122_I172_Y0.6160.49
110_I154_G0.6150.49
286_P293_K0.6130.49
191_A283_A0.6100.48
192_Q195_G0.6090.48
65_C221_F0.6060.48
279_R286_P0.6050.48
21_M28_F0.6050.48
161_R165_Q0.6030.48
181_I194_P0.6020.48
127_S177_V0.5950.47
21_M193_V0.5950.47
281_T286_P0.5950.47
221_F226_Y0.5940.47
152_K215_D0.5940.47
216_E221_F0.5920.46
23_K158_M0.5910.46
126_R180_S0.5910.46
118_E292_P0.5900.46
285_A292_P0.5890.46
140_Y177_V0.5880.46
158_M162_S0.5880.46
72_L97_K0.5880.46
35_I256_P0.5880.46
280_E286_P0.5870.46
287_A293_K0.5850.46
158_M180_S0.5830.45
75_D224_E0.5800.45
48_L96_L0.5760.45
91_L122_I0.5750.45
281_T289_A0.5730.44
43_D122_I0.5730.44
19_H38_Y0.5710.44
253_K256_P0.5700.44
76_E279_R0.5700.44
280_E289_A0.5690.44
282_P293_K0.5690.44
192_Q256_P0.5680.44
109_E242_L0.5680.44
54_E67_N0.5670.44
140_Y193_V0.5670.44
80_G88_Y0.5660.44
43_D126_R0.5650.43
224_E283_A0.5640.43
26_I263_L0.5620.43
121_P170_R0.5620.43
199_Q252_D0.5610.43
41_T263_L0.5600.43
95_D101_Q0.5600.43
122_I178_M0.5590.43
279_R290_A0.5590.43
189_S224_E0.5580.43
279_R287_A0.5550.42
280_E284_A0.5540.42
43_D86_G0.5540.42
284_A291_E0.5540.42
174_N225_K0.5530.42
185_D231_R0.5510.42
28_F206_E0.5500.42
36_K99_L0.5490.42
80_G146_A0.5490.42
121_P127_S0.5480.42
58_P88_Y0.5470.41
19_H194_P0.5440.41
264_V268_Q0.5440.41
220_K232_Q0.5440.41
42_E189_S0.5440.41
35_I174_N0.5430.41
279_R285_A0.5430.41
83_Y145_E0.5420.41
207_L213_L0.5420.41
136_G225_K0.5410.41
116_L225_K0.5410.41
48_L154_G0.5410.41
230_Y234_L0.5400.41
79_K181_I0.5400.41
106_K241_K0.5370.40
173_E176_I0.5360.40
240_D245_K0.5350.40
36_K119_I0.5350.40
62_E155_I0.5340.40
112_D221_F0.5340.40
205_K217_L0.5320.40
59_I93_D0.5320.40
276_R288_Q0.5300.40
281_T287_A0.5290.40
28_F138_K0.5280.39
119_I135_N0.5280.39
209_T219_A0.5260.39
31_V41_T0.5260.39
177_V252_D0.5240.39
168_I179_E0.5230.39
246_E249_V0.5230.39
23_K134_D0.5220.39
76_E120_D0.5200.39
129_F169_L0.5200.39
96_L230_Y0.5180.38
181_I227_E0.5160.38
213_L270_S0.5140.38
33_I164_Q0.5130.38
284_A290_A0.5130.38
67_N80_G0.5120.38
277_P291_E0.5120.38
85_K108_V0.5110.38
275_R287_A0.5100.38
54_E57_A0.5100.38
58_P179_E0.5100.38
178_M211_I0.5090.37
51_L183_Y0.5090.37
45_D124_F0.5090.37
124_F133_G0.5080.37
246_E252_D0.5080.37
85_K175_C0.5050.37
154_G165_Q0.5050.37
75_D189_S0.5040.37
47_K61_Y0.5030.37
32_N187_V0.5030.37
155_I232_Q0.5020.37
144_R222_E0.5020.37
277_P281_T0.5000.36
263_L267_L0.5000.36
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1jeyA 1 0.8682 100 0.478 Contact Map
1jeyB 1 0.9196 100 0.503 Contact Map
3bvoA 1 0.5434 43.7 0.968 Contact Map
2f2eA 4 0.2637 39.7 0.969 Contact Map
3j7y0 1 0.2476 28.4 0.971 Contact Map
1dl6A 1 0.1672 23.3 0.972 Contact Map
4ce45 1 0.119 19.6 0.973 Contact Map
4gcvA 3 0.283 17.3 0.974 Contact Map
3ga8A 1 0.1897 16.6 0.974 Contact Map
3q87A 1 0.2765 16.5 0.974 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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