GREMLIN Database
ARLY - Argininosuccinate lyase
UniProt: O34858 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 461 (406)
Sequences: 10986 (5623)
Seq/√Len: 279.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
46_K56_E3.7681.00
39_L64_N3.2811.00
47_K211_Y3.2331.00
43_A60_R3.2101.00
355_V358_Q3.1371.00
126_G187_M3.0611.00
394_T398_R2.9571.00
302_D331_T2.8631.00
43_A215_L2.8241.00
417_F420_D2.7351.00
33_E123_N2.7291.00
133_E180_K2.6991.00
246_M299_V2.6931.00
357_K361_K2.6461.00
65_T95_E2.6271.00
136_Q177_E2.6251.00
138_A343_T2.6021.00
138_A347_Q2.5511.00
125_V238_F2.5501.00
129_I184_Q2.5451.00
295_K338_S2.4921.00
29_N333_K2.4631.00
165_F351_V2.4311.00
189_R237_E2.4111.00
211_Y214_E2.3811.00
52_T55_E2.3761.00
129_I180_K2.3161.00
131_L340_Q2.3141.00
142_K145_A2.2861.00
122_K191_N2.2501.00
243_S303_M2.2391.00
46_K53_A2.2061.00
134_A343_T2.2001.00
394_T409_E2.1531.00
191_N219_D2.1291.00
148_E353_K2.1181.00
270_D350_T2.1111.00
343_T347_Q2.0771.00
53_A57_L2.0311.00
133_E184_Q2.0271.00
298_R327_G1.9601.00
141_E347_Q1.9531.00
400_I408_G1.9361.00
136_Q180_K1.9261.00
131_L336_E1.8891.00
355_V359_A1.8741.00
185_D189_R1.8541.00
210_D214_E1.8471.00
357_K428_Y1.8441.00
180_K184_Q1.8431.00
211_Y215_L1.8411.00
141_E145_A1.8261.00
57_L61_E1.8161.00
138_A346_I1.8101.00
253_S292_I1.8091.00
247_M300_Y1.8061.00
403_S422_Y1.7971.00
358_Q362_Q1.7941.00
132_I245_L1.7921.00
268_E352_N1.7791.00
182_R237_E1.7511.00
36_T123_N1.7411.00
39_L60_R1.7231.00
193_S213_A1.7101.00
140_I177_E1.7101.00
185_D188_K1.6911.00
222_Y228_G1.6791.00
146_N149_T1.6791.00
418_E422_Y1.6611.00
426_D429_Y1.6571.00
249_L292_I1.6551.00
179_D248_H1.6291.00
56_E60_R1.5881.00
136_Q173_F1.5871.00
353_K357_K1.5681.00
178_R227_D1.5591.00
407_F418_E1.5541.00
387_V390_K1.5331.00
55_E102_K1.5221.00
420_D423_T1.5111.00
43_A211_Y1.5091.00
236_L310_M1.5081.00
253_S342_F1.5041.00
131_L343_T1.4841.00
400_I405_M1.4761.00
243_S307_F1.4691.00
292_I342_F1.4671.00
238_F332_V1.4541.00
121_L328_M1.4521.00
298_R330_D1.4511.00
97_G100_G1.4411.00
305_G323_E1.4291.00
143_A173_F1.4171.00
197_C228_G1.4101.00
35_I88_I1.4081.00
142_K146_N1.4061.00
44_M211_Y1.3921.00
178_R233_D1.3861.00
232_R321_L1.3821.00
188_K219_D1.3721.00
186_S241_N1.3611.00
407_F422_Y1.3561.00
401_Y404_D1.3521.00
352_N355_V1.3471.00
124_H336_E1.3401.00
181_E189_R1.3391.00
136_Q176_L1.3311.00
289_A345_M1.3281.00
268_E350_T1.3241.00
258_L314_P1.3211.00
32_A36_T1.3191.00
91_M95_E1.2981.00
354_D358_Q1.2961.00
387_V415_T1.2951.00
270_D348_T1.2941.00
134_A347_Q1.2911.00
39_L67_L1.2851.00
39_L43_A1.2801.00
106_G208_D1.2761.00
129_I187_M1.2691.00
169_L172_Y1.2661.00
29_N124_H1.2661.00
14_E17_V1.2651.00
165_F169_L1.2611.00
121_L238_F1.2591.00
400_I404_D1.2551.00
240_S244_M1.2551.00
140_I144_E1.2501.00
58_K99_L1.2451.00
252_F342_F1.2421.00
135_F343_T1.2411.00
34_D112_Q1.2401.00
394_T405_M1.2371.00
236_L244_M1.2321.00
239_L306_L1.2311.00
50_I105_T1.2151.00
58_K61_E1.2141.00
127_H336_E1.2131.00
88_I92_L1.2081.00
172_Y316_A1.2071.00
304_M308_T1.2021.00
144_E147_V1.1991.00
138_A141_E1.1921.00
239_L328_M1.1891.00
149_T353_K1.1761.00
373_Y424_V1.1751.00
292_I338_S1.1741.00
69_K95_E1.1701.00
301_G305_G1.1661.00
132_I176_L1.1521.00
306_L328_M1.1471.00
245_L339_L1.1461.00
300_Y308_T1.1371.00
42_A51_L1.1371.00
245_L335_V1.1341.00
146_N353_K1.1301.00
246_M335_V1.1261.00
35_I66_L1.1211.00
64_N68_Q1.1181.00
165_F356_M1.1181.00
213_A219_D1.1171.00
24_I330_D1.1161.00
135_F176_L1.1141.00
398_R405_M1.1101.00
373_Y420_D1.1101.00
239_L331_T1.1061.00
93_I100_G1.1021.00
235_I328_M1.1011.00
140_I173_F1.1001.00
135_F346_I1.0961.00
183_F245_L1.0951.00
403_S407_F1.0931.00
92_L103_L1.0931.00
40_A215_L1.0831.00
265_K355_V1.0831.00
256_I289_A1.0801.00
32_A67_L1.0731.00
47_K215_L1.0731.00
159_R263_E1.0701.00
139_L252_F1.0651.00
129_I133_E1.0651.00
37_G112_Q1.0641.00
131_L134_A1.0631.00
147_V166_A1.0621.00
170_L224_N1.0621.00
134_A340_Q1.0581.00
99_L102_K1.0571.00
53_A56_E1.0561.00
35_I67_L1.0541.00
299_V335_V1.0521.00
148_E166_A1.0521.00
61_E65_T1.0501.00
241_N245_L1.0461.00
128_I335_V1.0451.00
296_T300_Y1.0421.00
151_L356_M1.0411.00
57_L60_R1.0381.00
250_S293_R1.0381.00
133_E137_S1.0371.00
298_R326_E1.0361.00
117_M325_K1.0331.00
91_M94_D1.0281.00
162_P360_T1.0211.00
172_Y252_F1.0211.00
65_T70_A1.0201.00
159_R262_Q1.0181.00
142_K169_L1.0161.00
370_L406_P1.0161.00
69_K91_M1.0131.00
60_R64_N1.0121.00
124_H127_H1.0071.00
238_F328_M1.0061.00
32_A123_N1.0041.00
81_Y90_K1.0021.00
181_E188_K1.0021.00
115_T193_S0.9981.00
33_E119_L0.9901.00
14_E18_D0.9871.00
122_K218_F0.9871.00
125_V187_M0.9861.00
122_K126_G0.9831.00
198_G279_M0.9821.00
374_L388_V0.9811.00
163_I200_L0.9811.00
142_K346_I0.9811.00
106_G207_I0.9811.00
150_I431_V0.9771.00
122_K187_M0.9761.00
64_N67_L0.9751.00
117_M235_I0.9741.00
28_Q32_A0.9711.00
67_L70_A0.9711.00
147_V164_S0.9651.00
149_T356_M0.9651.00
185_D237_E0.9641.00
98_P101_G0.9611.00
46_K57_L0.9611.00
305_G327_G0.9601.00
164_S431_V0.9591.00
132_I180_K0.9591.00
117_M328_M0.9571.00
273_Y344_G0.9571.00
393_Y397_E0.9501.00
32_A71_E0.9501.00
58_K62_G0.9501.00
50_I208_D0.9441.00
174_W178_R0.9391.00
125_V183_F0.9391.00
181_E185_D0.9381.00
36_T215_L0.9371.00
187_M191_N0.9291.00
298_R334_T0.9281.00
156_H290_E0.9261.00
249_L342_F0.9181.00
62_G65_T0.9171.00
394_T397_E0.9161.00
73_G94_D0.9131.00
124_H332_V0.9131.00
34_D37_G0.9121.00
193_S212_S0.9091.00
256_I349_M0.9091.00
153_G163_I0.9081.00
240_S303_M0.9081.00
247_M310_M0.9081.00
37_G115_T0.9071.00
395_C405_M0.9071.00
249_L339_L0.9031.00
326_E330_D0.9031.00
302_D330_D0.9021.00
44_M48_C0.8951.00
390_K409_E0.8931.00
136_Q140_I0.8891.00
270_D352_N0.8881.00
28_Q72_E0.8881.00
62_G96_I0.8881.00
269_L349_M0.8871.00
239_L303_M0.8861.00
145_A350_T0.8851.00
54_E57_L0.8841.00
29_N123_N0.8821.00
68_Q72_E0.8801.00
265_K352_N0.8781.00
191_N218_F0.8721.00
81_Y87_N0.8721.00
154_Y159_R0.8681.00
419_E423_T0.8681.00
33_E120_Y0.8651.00
212_S216_L0.8641.00
163_I226_L0.8621.00
72_E76_E0.8621.00
242_S335_V0.8611.00
48_C208_D0.8581.00
139_L169_L0.8571.00
404_D408_G0.8571.00
68_Q71_E0.8571.00
139_L346_I0.8551.00
403_S418_E0.8531.00
258_L264_F0.8521.00
303_M307_F0.8491.00
149_T351_V0.8481.00
406_P409_E0.8471.00
291_L341_I0.8441.00
47_K53_A0.8441.00
71_E95_E0.8421.00
394_T408_G0.8411.00
174_W223_E0.8411.00
209_R213_A0.8391.00
150_I360_T0.8371.00
65_T69_K0.8351.00
157_L258_L0.8331.00
143_A170_L0.8321.00
173_F177_E0.8271.00
360_T427_P0.8271.00
139_L173_F0.8261.00
137_S141_E0.8180.99
65_T71_E0.8170.99
250_S311_K0.8130.99
67_L71_E0.8130.99
43_A56_E0.8120.99
54_E58_K0.8080.99
231_D248_H0.8060.99
391_L405_M0.8050.99
421_I425_L0.8030.99
374_L387_V0.8030.99
167_H225_S0.8010.99
138_A142_K0.8000.99
394_T400_I0.7970.99
34_D88_I0.7960.99
32_A72_E0.7940.99
145_A353_K0.7930.99
36_T67_L0.7910.99
168_H259_W0.7830.99
400_I409_E0.7830.99
148_E428_Y0.7820.99
297_G305_G0.7790.99
209_R212_S0.7760.99
36_T212_S0.7740.99
361_K403_S0.7740.99
188_K191_N0.7700.99
42_A56_E0.7700.99
41_H107_R0.7680.99
178_R192_K0.7670.99
176_L339_L0.7630.99
157_L261_S0.7630.99
146_N351_V0.7620.99
47_K208_D0.7610.99
237_E240_S0.7610.99
209_R221_I0.7590.99
194_P228_G0.7580.99
309_I323_E0.7570.99
135_F339_L0.7530.99
391_L402_L0.7510.99
192_K234_F0.7510.99
46_K51_L0.7490.99
212_S215_L0.7450.99
58_K96_I0.7410.99
69_K74_A0.7390.99
43_A47_K0.7390.99
247_M307_F0.7380.99
420_D424_V0.7350.99
298_R302_D0.7340.99
300_Y304_M0.7330.99
75_L87_N0.7260.99
17_V22_A0.7200.99
152_P365_S0.7190.99
154_Y263_E0.7180.99
391_L406_P0.7180.99
386_E390_K0.7170.99
151_L168_H0.7170.99
230_S316_A0.7150.99
300_Y307_F0.7140.99
193_S221_I0.7130.99
233_D248_H0.7090.99
125_V186_S0.7090.99
50_I106_G0.7080.99
238_F242_S0.7080.99
30_L113_V0.7070.98
351_V356_M0.7070.98
139_L176_L0.7070.98
132_I339_L0.7040.98
361_K401_Y0.7020.98
369_E430_A0.7010.98
17_V288_M0.7000.98
192_K222_Y0.6990.98
175_M231_D0.6960.98
398_R409_E0.6950.98
21_G319_K0.6940.98
171_A251_R0.6940.98
176_L179_D0.6930.98
253_S289_A0.6900.98
58_K98_P0.6900.98
128_I332_V0.6890.98
175_M248_H0.6890.98
354_D357_K0.6880.98
15_K19_E0.6870.98
227_D233_D0.6840.98
226_L316_A0.6830.98
235_I306_L0.6830.98
51_L105_T0.6820.98
195_L212_S0.6820.98
90_K94_D0.6820.98
390_K394_T0.6810.98
40_A43_A0.6800.98
48_C211_Y0.6780.98
339_L343_T0.6760.98
236_L306_L0.6760.98
262_Q265_K0.6750.98
39_L56_E0.6740.98
118_H234_F0.6730.98
182_R233_D0.6720.98
304_M307_F0.6720.98
55_E99_L0.6710.98
24_I326_E0.6710.98
428_Y432_E0.6690.98
159_R363_D0.6670.98
69_K72_E0.6660.98
137_S140_I0.6660.98
299_V331_T0.6650.98
267_I349_M0.6640.98
42_A59_I0.6620.98
405_M409_E0.6620.98
341_I344_G0.6610.98
141_E144_E0.6590.98
254_E293_R0.6580.98
133_E136_Q0.6570.98
127_H131_L0.6560.98
149_T164_S0.6540.97
370_L421_I0.6530.97
133_E177_E0.6520.97
146_N165_F0.6500.97
134_A138_A0.6490.97
179_D244_M0.6480.97
144_E148_E0.6470.97
169_L356_M0.6470.97
149_T357_K0.6470.97
191_N213_A0.6470.97
66_L70_A0.6450.97
122_K219_D0.6440.97
345_M349_M0.6430.97
96_I103_L0.6410.97
227_D248_H0.6400.97
221_I225_S0.6400.97
186_S190_I0.6380.97
152_P360_T0.6380.97
297_G308_T0.6370.97
266_F359_A0.6370.97
59_I92_L0.6360.97
25_S124_H0.6360.97
259_W315_L0.6350.97
26_F326_E0.6340.97
151_L163_I0.6340.97
188_K192_K0.6320.97
63_L66_L0.6320.97
295_K334_T0.6310.97
143_A147_V0.6310.97
42_A60_R0.6300.97
261_S264_F0.6270.97
121_L332_V0.6240.97
297_G309_I0.6240.97
39_L63_L0.6230.97
256_I342_F0.6210.97
181_E184_Q0.6210.97
128_I242_S0.6210.97
181_E192_K0.6180.96
182_R189_R0.6170.96
120_Y332_V0.6160.96
416_L424_V0.6160.96
46_K60_R0.6160.96
182_R185_D0.6150.96
236_L307_F0.6150.96
120_Y329_F0.6120.96
213_A216_L0.6120.96
131_L339_L0.6100.96
126_G184_Q0.6100.96
423_T429_Y0.6080.96
39_L215_L0.6050.96
252_F346_I0.6040.96
63_L92_L0.6020.96
70_A73_G0.6010.96
273_Y348_T0.6000.96
179_D182_R0.6000.96
125_V129_I0.6000.96
360_T365_S0.5980.96
176_L249_L0.5940.96
243_S247_M0.5940.96
328_M332_V0.5930.96
236_L240_S0.5920.96
405_M408_G0.5910.95
423_T426_D0.5910.95
164_S432_E0.5910.95
359_A362_Q0.5900.95
172_Y175_M0.5900.95
42_A103_L0.5900.95
69_K73_G0.5900.95
388_V392_V0.5890.95
125_V190_I0.5890.95
59_I96_I0.5870.95
96_I99_L0.5860.95
142_K349_M0.5850.95
366_N430_A0.5840.95
288_M345_M0.5830.95
327_G330_D0.5820.95
140_I143_A0.5820.95
22_A25_S0.5800.95
126_G191_N0.5770.95
400_I406_P0.5740.95
154_Y264_F0.5720.95
71_E74_A0.5720.95
330_D334_T0.5710.95
174_W177_E0.5710.95
250_S308_T0.5700.95
126_G218_F0.5700.95
253_S293_R0.5680.94
293_R320_D0.5680.94
292_I345_M0.5680.94
37_G116_D0.5680.94
416_L420_D0.5670.94
81_Y86_L0.5660.94
55_E58_K0.5650.94
130_E134_A0.5650.94
175_M230_S0.5650.94
132_I183_F0.5640.94
299_V334_T0.5630.94
150_I427_P0.5620.94
362_Q401_Y0.5610.94
95_E99_L0.5610.94
353_K356_M0.5610.94
31_V70_A0.5600.94
88_I116_D0.5600.94
186_S238_F0.5590.94
36_T40_A0.5580.94
396_I399_G0.5580.94
168_H255_E0.5570.94
301_G304_M0.5570.94
129_I241_N0.5550.94
129_I132_I0.5550.94
174_W224_N0.5540.94
51_L55_E0.5540.94
21_G291_L0.5540.94
169_L349_M0.5530.94
297_G311_K0.5520.94
20_F338_S0.5520.94
20_F292_I0.5500.93
364_F402_L0.5500.93
66_L69_K0.5480.93
109_R194_P0.5480.93
414_S417_F0.5470.93
24_I29_N0.5450.93
176_L245_L0.5450.93
364_F395_C0.5450.93
177_E181_E0.5440.93
429_Y432_E0.5440.93
308_T312_G0.5430.93
156_H319_K0.5430.93
75_L91_M0.5420.93
404_D418_E0.5410.93
33_E36_T0.5410.93
37_G195_L0.5410.93
213_A218_F0.5400.93
183_F241_N0.5380.93
163_I167_H0.5360.93
168_H316_A0.5350.92
52_T56_E0.5350.92
15_K18_D0.5330.92
36_T216_L0.5320.92
240_S243_S0.5310.92
310_M321_L0.5310.92
151_L259_W0.5310.92
59_I99_L0.5300.92
29_N127_H0.5300.92
123_N126_G0.5290.92
390_K397_E0.5280.92
258_L261_S0.5270.92
182_R244_M0.5270.92
178_R237_E0.5250.92
258_L315_L0.5240.92
41_H212_S0.5240.92
292_I296_T0.5240.92
366_N425_L0.5230.92
274_A287_D0.5220.92
195_L221_I0.5220.92
210_D213_A0.5220.92
237_E244_M0.5210.91
152_P359_A0.5200.91
186_S237_E0.5190.91
367_A388_V0.5190.91
391_L409_E0.5180.91
242_S245_L0.5170.91
66_L72_E0.5170.91
146_N166_A0.5140.91
395_C400_I0.5120.91
19_E337_G0.5120.91
179_D241_N0.5110.91
121_L190_I0.5110.91
244_M248_H0.5110.91
178_R189_R0.5100.91
240_S307_F0.5070.90
94_D97_G0.5070.90
271_D284_K0.5060.90
260_C269_L0.5060.90
77_F84_I0.5060.90
233_D237_E0.5060.90
135_F138_A0.5050.90
194_P229_V0.5040.90
387_V416_L0.5030.90
184_Q188_K0.5020.90
149_T165_F0.5010.90
419_E422_Y0.5010.90
51_L56_E0.5000.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2e9fA 4 0.9718 100 0.122 Contact Map
1tj7A 4 0.9848 100 0.132 Contact Map
1k7wA 4 0.974 100 0.136 Contact Map
1q5nA 4 0.9024 100 0.212 Contact Map
1re5A 4 0.9414 100 0.212 Contact Map
1c3cA 4 0.9046 100 0.23 Contact Map
3c8tA 4 0.9046 100 0.237 Contact Map
2pfmA 4 0.9197 100 0.244 Contact Map
4eeiA 4 0.8959 100 0.252 Contact Map
3r6qA 4 0.9154 100 0.257 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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