GREMLIN Database
TCYK - L-cystine-binding protein TcyK
UniProt: O34852 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 270 (242)
Sequences: 21803 (16027)
Seq/√Len: 1030.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
41_G97_V3.8461.00
149_I192_A3.7251.00
37_T79_T3.7161.00
72_R246_E2.9751.00
177_G186_Q2.4921.00
91_S97_V2.3411.00
157_A176_E2.3381.00
39_T79_T2.3331.00
118_K245_Q2.2991.00
106_K226_Y2.2941.00
37_T77_K2.2711.00
179_G182_E2.2561.00
106_K111_E2.2461.00
157_A161_K2.1891.00
108_K111_E2.1491.00
39_T81_K2.1451.00
252_T255_R2.1191.00
254_K258_L2.0651.00
229_F237_S2.0561.00
70_D78_F2.0561.00
93_G113_K2.0491.00
114_F228_M2.0471.00
53_D59_T2.0231.00
68_E71_K2.0141.00
237_S241_D2.0141.00
147_R174_A2.0041.00
245_Q249_D1.9811.00
115_L237_S1.9621.00
72_R243_A1.9291.00
197_S202_V1.9031.00
118_K241_D1.8951.00
139_G142_D1.8781.00
183_T195_T1.8631.00
229_F240_I1.8281.00
40_V66_I1.7861.00
53_D57_D1.7261.00
138_R142_D1.7251.00
147_R172_E1.7031.00
129_T202_V1.6921.00
186_Q191_R1.6871.00
68_E252_T1.6721.00
101_A227_F1.6531.00
68_E72_R1.5811.00
68_E247_I1.5721.00
117_N241_D1.5631.00
91_S96_K1.5561.00
230_N233_E1.5541.00
83_M91_S1.5521.00
131_L190_G1.5471.00
152_A178_Q1.5271.00
234_Q238_D1.5251.00
238_D242_K1.4741.00
52_I82_T1.4651.00
30_A34_K1.4501.00
123_H224_K1.4461.00
72_R250_D1.4381.00
133_N214_K1.4171.00
115_L232_N1.4161.00
67_K80_F1.4071.00
64_E259_K1.4051.00
89_L114_F1.4011.00
73_L76_Y1.3791.00
88_L100_V1.3721.00
239_D242_K1.3641.00
158_L162_K1.3501.00
132_Q212_K1.3461.00
147_R193_D1.3361.00
69_L243_A1.3251.00
186_Q192_A1.3221.00
63_V67_K1.3111.00
51_F59_T1.3081.00
178_Q182_E1.3051.00
104_M228_M1.2961.00
188_K212_K1.2771.00
199_P203_D1.2711.00
146_K193_D1.2681.00
40_V99_I1.2641.00
159_V163_W1.2611.00
127_K199_P1.2551.00
66_I101_A1.2471.00
187_L213_E1.2391.00
73_L243_A1.2341.00
130_V194_A1.2261.00
161_K176_E1.2251.00
132_Q214_K1.1971.00
44_T82_T1.1961.00
246_E250_D1.1911.00
149_I177_G1.1901.00
150_T157_A1.1891.00
148_V194_A1.1801.00
95_H230_N1.1801.00
126_L156_G1.1601.00
109_E112_K1.1601.00
36_Q76_Y1.1541.00
243_A246_E1.1491.00
90_V93_G1.1461.00
128_I194_A1.1431.00
164_N171_F1.1431.00
83_M97_V1.1361.00
177_G183_T1.1361.00
185_N188_K1.1341.00
100_V104_M1.1341.00
248_I253_L1.1291.00
31_G35_V1.1281.00
21_C24_G1.1261.00
61_Y261_L1.1191.00
62_D121_Y1.1151.00
30_A33_K1.1091.00
239_D243_A1.1041.00
66_I80_F1.0951.00
243_A247_I1.0911.00
187_L195_T1.0861.00
61_Y256_L1.0821.00
130_V216_V1.0751.00
185_N189_S1.0751.00
57_D67_K1.0661.00
187_L192_A1.0641.00
66_I78_F1.0461.00
61_Y257_S1.0441.00
127_K215_T1.0411.00
27_T235_T1.0361.00
115_L231_K1.0311.00
67_K71_K1.0261.00
84_E87_N1.0251.00
151_S154_S1.0211.00
90_V94_Q1.0191.00
65_L247_I1.0121.00
65_L253_L1.0091.00
35_V39_T1.0051.00
115_L234_Q1.0001.00
242_K246_E0.9911.00
40_V78_F0.9901.00
29_G32_Q0.9891.00
99_I240_I0.9851.00
64_E260_W0.9791.00
64_E67_K0.9731.00
59_T64_E0.9651.00
235_T239_D0.9591.00
149_I183_T0.9561.00
76_Y239_D0.9561.00
152_A176_E0.9561.00
99_I229_F0.9521.00
252_T256_L0.9511.00
204_F208_T0.9401.00
174_A177_G0.9381.00
188_K209_S0.9361.00
117_N240_I0.9361.00
247_I252_T0.9351.00
108_K112_K0.9311.00
158_L161_K0.9311.00
69_L240_I0.9271.00
107_S110_R0.9211.00
234_Q237_S0.9191.00
52_I56_G0.9151.00
89_L104_M0.9141.00
93_G114_F0.9071.00
61_Y253_L0.9031.00
255_R258_L0.9011.00
58_L63_V0.9011.00
72_R252_T0.8971.00
118_K248_I0.8961.00
14_L17_V0.8881.00
182_E185_N0.8881.00
241_D245_Q0.8811.00
257_S261_L0.8711.00
116_F228_M0.8651.00
28_T31_G0.8611.00
253_L257_S0.8601.00
241_D244_L0.8601.00
165_E171_F0.8601.00
66_I227_F0.8581.00
17_V20_A0.8541.00
87_N91_S0.8511.00
159_V162_K0.8501.00
85_F88_L0.8471.00
124_F200_F0.8371.00
100_V228_M0.8331.00
18_L21_C0.8321.00
99_I227_F0.8301.00
32_Q36_Q0.8291.00
105_E223_A0.8271.00
44_T58_L0.8241.00
128_I196_I0.8201.00
255_R259_K0.8201.00
47_P51_F0.8141.00
32_Q35_V0.8141.00
38_I99_I0.8121.00
66_I99_I0.8111.00
181_N185_N0.8001.00
174_A186_Q0.7971.00
111_E231_K0.7961.00
125_P199_P0.7961.00
180_A197_S0.7951.00
42_T63_V0.7941.00
52_I58_L0.7941.00
42_T102_H0.7931.00
246_E249_D0.7921.00
27_T30_A0.7911.00
67_K78_F0.7881.00
29_G33_K0.7871.00
247_I250_D0.7871.00
42_T80_F0.7861.00
235_T238_D0.7831.00
33_K36_Q0.7801.00
38_I76_Y0.7781.00
27_T31_G0.7751.00
73_L239_D0.7731.00
19_S22_G0.7711.00
13_S16_T0.7671.00
110_R116_F0.7651.00
32_Q76_Y0.7641.00
106_K119_V0.7641.00
72_R247_I0.7621.00
69_L73_L0.7591.00
141_E144_K0.7531.00
51_F260_W0.7531.00
49_I122_N0.7511.00
68_E243_A0.7501.00
130_V214_K0.7461.00
38_I70_D0.7451.00
70_D74_P0.7421.00
81_K96_K0.7411.00
143_L194_A0.7381.00
92_L100_V0.7351.00
117_N229_F0.7321.00
89_L93_G0.7291.00
127_K217_G0.7271.00
129_T213_E0.7271.00
227_F240_I0.7261.00
254_K257_S0.7231.00
124_F199_P0.7101.00
37_T76_Y0.7091.00
20_A23_A0.7061.00
247_I253_L0.7021.00
162_K165_E0.7001.00
83_M88_L0.7001.00
203_D207_K0.6981.00
209_S212_K0.6971.00
65_L244_L0.6961.00
95_H232_N0.6931.00
69_L101_A0.6931.00
68_E256_L0.6881.00
184_A188_K0.6861.00
247_I251_G0.6851.00
203_D215_T0.6841.00
39_T98_D0.6841.00
242_K245_Q0.6821.00
147_R192_A0.6781.00
149_I186_Q0.6761.00
40_V80_F0.6701.00
137_I142_D0.6681.00
174_A192_A0.6671.00
43_G50_C0.6661.00
85_F104_M0.6651.00
233_E236_L0.6631.00
177_G192_A0.6621.00
92_L97_V0.6621.00
127_K202_V0.6601.00
161_K173_I0.6591.00
136_T214_K0.6571.00
182_E186_Q0.6551.00
106_K116_F0.6511.00
59_T260_W0.6511.00
44_T50_C0.6481.00
87_N90_V0.6471.00
92_L230_N0.6451.00
117_N227_F0.6451.00
131_L212_K0.6441.00
105_E110_R0.6431.00
184_A213_E0.6401.00
116_F226_Y0.6381.00
11_L14_L0.6371.00
238_D241_D0.6361.00
16_T19_S0.6321.00
81_K97_V0.6291.00
251_G255_R0.6261.00
63_V80_F0.6231.00
70_D73_L0.6201.00
10_I13_S0.6191.00
155_N223_A0.6191.00
123_H222_N0.6191.00
41_G88_L0.6181.00
163_W166_D0.6161.00
43_G85_F0.6151.00
219_V222_N0.6111.00
118_K244_L0.6081.00
210_T213_E0.6071.00
115_L233_E0.6051.00
50_C102_H0.6041.00
11_L15_I0.6031.00
42_T58_L0.6021.00
92_L114_F0.6011.00
93_G230_N0.5981.00
14_L18_L0.5971.00
136_T146_K0.5971.00
188_K213_E0.5951.00
17_V21_C0.5921.00
53_D56_G0.5911.00
41_G100_V0.5911.00
117_N244_L0.5891.00
13_S17_V0.5851.00
213_E216_V0.5841.00
245_Q248_I0.5791.00
160_L196_I0.5771.00
46_F103_Q0.5771.00
41_G83_M0.5751.00
125_P221_S0.5741.00
197_S201_A0.5731.00
66_I70_D0.5701.00
85_F110_R0.5671.00
160_L173_I0.5661.00
12_F16_T0.5641.00
104_M114_F0.5641.00
204_F207_K0.5641.00
31_G34_K0.5611.00
202_V206_N0.5601.00
96_K191_R0.5601.00
54_E59_T0.5561.00
126_L196_I0.5541.00
20_A24_G0.5531.00
206_N213_E0.5511.00
174_A191_R0.5501.00
35_V98_D0.5481.00
251_G254_K0.5461.00
33_K239_D0.5461.00
12_F15_I0.5451.00
125_P222_N0.5431.00
69_L227_F0.5421.00
129_T184_A0.5411.00
28_T32_Q0.5401.00
160_L164_N0.5391.00
229_F233_E0.5371.00
166_D171_F0.5371.00
105_E155_N0.5341.00
117_N237_S0.5321.00
71_K252_T0.5321.00
151_S180_A0.5311.00
148_V160_L0.5301.00
128_I143_L0.5271.00
133_N190_G0.5271.00
47_P208_T0.5241.00
202_V215_T0.5241.00
129_T206_N0.5241.00
28_T230_N0.5231.00
70_D76_Y0.5211.00
62_D103_Q0.5211.00
111_E115_L0.5191.00
206_N215_T0.5181.00
43_G102_H0.5181.00
44_T52_I0.5131.00
46_F85_F0.5101.00
29_G76_Y0.5101.00
144_K164_N0.5081.00
88_L91_S0.5081.00
248_I251_G0.5071.00
161_K165_E0.5061.00
152_A157_A0.5051.00
38_I73_L0.5051.00
247_I256_L0.5051.00
129_T215_T0.5021.00
66_I69_L0.5011.00
149_I195_T0.5001.00
150_T176_E0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1xt8A 1 0.8778 100 0.251 Contact Map
2yjpA 1 0.8741 100 0.27 Contact Map
4ohnA 1 0.8926 100 0.273 Contact Map
2ylnA 1 0.863 100 0.275 Contact Map
1pb7A 1 0.9259 100 0.275 Contact Map
3hv1A 2 0.9185 100 0.279 Contact Map
2vhaA 2 0.9111 100 0.28 Contact Map
3kbrA 4 0.837 100 0.283 Contact Map
4ymxA 1 0.8074 100 0.284 Contact Map
2ieeA 1 0.8704 100 0.287 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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