GREMLIN Database
LDC - Probable murein peptide carboxypeptidase
UniProt: O34851 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 319 (293)
Sequences: 2949 (2282)
Seq/√Len: 133.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
183_E298_A4.6731.00
18_D82_K3.9711.00
21_G75_M3.8561.00
19_T47_Q3.5781.00
26_A93_T3.3991.00
56_N67_E3.2681.00
64_Q67_E3.1111.00
207_R238_D3.0361.00
19_T49_K2.8651.00
49_K78_D2.8281.00
183_E296_K2.8151.00
65_D95_R2.7941.00
24_A87_A2.7251.00
46_L161_Q2.5831.00
20_V46_L2.3781.00
22_V87_A2.3551.00
231_K271_S2.2021.00
208_G240_A2.1971.00
38_L42_E2.1951.00
69_L99_G2.1841.00
73_H104_L2.1791.00
181_K300_N2.1581.00
181_K298_A2.1511.00
186_L291_V2.0861.00
70_A74_E2.0781.00
185_E209_K2.0631.00
83_A111_I2.0561.00
210_L297_A2.0271.00
49_K81_V2.0071.00
203_E235_K1.9771.00
241_G299_M1.9741.00
53_A71_D1.9731.00
53_A56_N1.8751.00
12_K82_K1.8621.00
179_P302_A1.8541.00
211_L239_A1.8461.00
242_I274_R1.8441.00
42_E47_Q1.8171.00
39_L43_E1.7971.00
79_D108_H1.7911.00
149_H287_P1.7761.00
69_L73_H1.7711.00
21_G81_V1.7611.00
239_A242_I1.7601.00
44_L157_K1.7511.00
213_I244_V1.7351.00
50_L54_L1.7241.00
243_L280_F1.7151.00
37_A139_L1.7101.00
154_A158_Q1.7061.00
157_K161_Q1.6561.00
23_I75_M1.6311.00
38_L50_L1.6221.00
39_L42_E1.6161.00
73_H77_R1.5971.00
186_L297_A1.5911.00
19_T80_E1.5791.00
66_D99_G1.5521.00
132_V295_A1.5471.00
243_L299_M1.5431.00
77_R104_L1.5401.00
52_K74_E1.5281.00
212_F293_I1.5261.00
72_L76_F1.4861.00
19_T81_V1.4841.00
38_L48_V1.4751.00
82_K108_H1.4631.00
24_A54_L1.4341.00
151_L289_I1.4311.00
236_L274_R1.4101.00
206_T235_K1.4061.00
46_L157_K1.3951.00
185_E296_K1.3881.00
198_L233_G1.3861.00
211_L236_L1.3811.00
242_I269_I1.3791.00
66_D70_A1.3721.00
135_H190_N1.3591.00
228_N268_Y1.3481.00
122_H133_T1.3461.00
212_F291_V1.3371.00
31_P35_D1.3281.00
11_P132_V1.3241.00
85_L113_W1.3061.00
21_G49_K1.3011.00
126_H293_I1.2661.00
76_F105_I1.2661.00
239_A274_R1.2641.00
102_F124_A1.2571.00
93_T121_L1.2561.00
134_F290_A1.2521.00
76_F131_L1.2421.00
135_H288_S1.2381.00
300_N303_E1.2271.00
262_E278_R1.2271.00
98_A232_M1.2271.00
246_D281_K1.2221.00
25_P118_I1.2141.00
111_I134_F1.2041.00
35_D38_L1.1920.99
53_A67_E1.1920.99
158_Q162_E1.1870.99
182_A241_G1.1860.99
122_H135_H1.1850.99
220_P264_V1.1770.99
51_G71_D1.1730.99
15_N18_D1.1640.99
40_F44_L1.1540.99
202_F232_M1.1520.99
260_S263_Q1.1360.99
21_G51_G1.1330.99
198_L203_E1.1300.99
122_H293_I1.1290.99
95_R224_D1.1250.99
244_V247_F1.1190.99
188_G212_F1.1100.99
125_I129_T1.1090.99
42_E48_V1.1040.99
156_Y160_F1.0970.99
22_V139_L1.0950.99
195_T198_L1.0870.99
50_L55_K1.0860.99
76_F108_H1.0760.99
113_W290_A1.0760.99
113_W136_G1.0700.99
215_D247_F1.0630.99
97_A120_F1.0510.99
122_H126_H1.0490.99
218_E222_Q1.0460.99
86_C118_I1.0460.99
298_A307_V1.0450.99
35_D39_L1.0430.99
23_I100_I1.0400.99
67_E70_A1.0370.99
128_N201_P1.0360.99
155_S290_A1.0300.98
194_L213_I1.0270.98
212_F282_I1.0230.98
246_D285_C1.0140.98
218_E225_R1.0130.98
44_L153_K1.0080.98
112_F125_I1.0060.98
123_T194_L1.0000.98
105_I129_T0.9980.98
120_F193_L0.9910.98
20_V83_A0.9840.98
300_N306_A0.9840.98
154_A157_K0.9760.98
20_V48_V0.9740.98
138_M141_T0.9730.98
57_Q63_G0.9650.98
233_G236_L0.9610.98
277_L301_T0.9590.98
203_E206_T0.9580.98
206_T238_D0.9520.97
103_S106_R0.9470.97
198_L229_Q0.9430.97
73_H100_I0.9410.97
282_I291_V0.9370.97
223_I261_L0.9370.97
51_G75_M0.9320.97
112_F118_I0.9320.97
198_L230_L0.9310.97
210_L241_G0.9220.97
176_E301_T0.9210.97
125_I133_T0.9210.97
187_V209_K0.9150.97
19_T48_V0.9130.97
47_Q80_E0.9070.97
132_V292_P0.9040.97
190_N247_F0.9030.96
69_L96_I0.9000.96
235_K238_D0.8880.96
22_V38_L0.8880.96
49_K80_E0.8860.96
30_D33_K0.8850.96
69_L100_I0.8820.96
196_S229_Q0.8790.96
242_I276_A0.8750.96
88_C92_G0.8700.96
269_I276_A0.8660.96
92_G224_D0.8650.96
277_L299_M0.8630.95
181_K302_A0.8610.95
228_N267_D0.8590.95
187_V204_I0.8590.95
98_A202_F0.8580.95
91_F221_Y0.8580.95
26_A118_I0.8550.95
192_S215_D0.8530.95
12_K15_N0.8520.95
206_T209_K0.8500.95
218_E226_M0.8490.95
94_G193_L0.8470.95
88_C138_M0.8450.95
52_K70_A0.8440.95
126_H187_V0.8370.95
41_L85_L0.8360.95
166_T173_P0.8360.95
44_L161_Q0.8350.95
29_P87_A0.8340.95
73_H101_D0.8310.94
94_G232_M0.8310.94
72_L100_I0.8300.94
58_H64_Q0.8280.94
297_A308_I0.8230.94
23_I71_D0.8220.94
219_E222_Q0.8220.94
159_L290_A0.8210.94
73_H102_F0.8200.94
180_G301_T0.8200.94
34_L38_L0.8200.94
269_I272_A0.8200.94
200_T229_Q0.8190.94
37_A41_L0.8180.94
195_T226_M0.8150.94
101_D105_I0.8070.94
150_P154_A0.8050.93
76_F112_F0.8020.93
195_T229_Q0.8010.93
191_L230_L0.7990.93
65_D224_D0.7990.93
244_V278_R0.7970.93
35_D42_E0.7960.93
158_Q163_T0.7950.93
36_T39_L0.7940.93
155_S159_L0.7930.93
11_P111_I0.7920.93
65_D69_L0.7920.93
100_I105_I0.7920.93
241_G301_T0.7910.93
78_D110_K0.7900.93
153_K157_K0.7890.93
115_Y288_S0.7890.93
19_T82_K0.7860.93
124_A202_F0.7850.93
205_D209_K0.7840.93
193_L196_S0.7840.93
23_I84_V0.7830.92
115_Y141_T0.7810.92
120_F197_T0.7810.92
246_D279_G0.7770.92
192_S196_S0.7760.92
94_G196_S0.7750.92
14_L18_D0.7710.92
59_G63_G0.7680.92
182_A299_M0.7670.92
191_L226_M0.7640.92
109_P131_L0.7600.91
231_K268_Y0.7600.91
92_G95_R0.7590.91
178_V182_A0.7530.91
168_T171_L0.7460.91
35_D55_K0.7440.90
155_S158_Q0.7410.90
218_E221_Y0.7370.90
191_L223_I0.7360.90
102_F129_T0.7350.90
25_P121_L0.7330.90
173_P176_E0.7330.90
231_K267_D0.7330.90
61_L92_G0.7290.90
50_L53_A0.7280.89
38_L139_L0.7230.89
61_L65_D0.7210.89
191_L218_E0.7200.89
27_S88_C0.7190.89
126_H133_T0.7180.89
94_G228_N0.7180.89
75_M81_V0.7170.89
299_M308_I0.7150.89
159_L162_E0.7140.89
104_L108_H0.7140.89
86_C112_F0.7130.88
65_D92_G0.7100.88
25_P72_L0.7080.88
213_I242_I0.7070.88
231_K237_T0.7070.88
20_V85_L0.7060.88
72_L96_I0.7060.88
115_Y135_H0.7030.88
31_P55_K0.7020.88
292_P295_A0.7000.88
152_T287_P0.6970.87
105_I125_I0.6950.87
93_T120_F0.6920.87
72_L112_F0.6910.87
213_I227_L0.6900.87
262_E266_E0.6890.87
215_D218_E0.6870.87
185_E208_G0.6870.87
54_L87_A0.6860.87
34_L50_L0.6850.86
268_Y271_S0.6840.86
177_L180_G0.6810.86
223_I250_C0.6770.86
205_D238_D0.6770.86
231_K272_A0.6750.86
37_A144_G0.6730.85
157_K160_F0.6730.85
300_N307_V0.6720.85
19_T78_D0.6710.85
228_N232_M0.6680.85
229_Q233_G0.6670.85
230_L235_K0.6640.85
300_N304_K0.6620.85
97_A124_A0.6610.84
221_Y224_D0.6610.84
41_L48_V0.6600.84
97_A202_F0.6590.84
91_F218_E0.6580.84
118_I121_L0.6560.84
301_T306_A0.6540.84
22_V50_L0.6530.84
192_S222_Q0.6520.84
111_I132_V0.6480.83
227_L268_Y0.6480.83
171_L175_T0.6470.83
15_N82_K0.6460.83
178_V274_R0.6450.83
192_S226_M0.6450.83
223_I226_M0.6430.83
98_A231_K0.6420.83
266_E270_I0.6420.83
217_D249_N0.6390.82
16_K157_K0.6380.82
124_A129_T0.6370.82
200_T232_M0.6350.82
32_K36_T0.6350.82
16_K47_Q0.6330.82
111_I290_A0.6310.82
126_H294_G0.6290.81
220_P250_C0.6260.81
105_I131_L0.6250.81
133_T293_I0.6240.81
21_G78_D0.6220.81
214_E245_C0.6220.81
74_E78_D0.6220.81
247_F261_L0.6190.80
86_C93_T0.6160.80
192_S216_I0.6160.80
211_L235_K0.6160.80
222_Q226_M0.6130.80
101_D109_P0.6100.79
204_I235_K0.6100.79
93_T118_I0.6080.79
231_K236_L0.6060.79
102_F105_I0.6000.78
61_L95_R0.5980.78
103_S107_K0.5960.78
20_V161_Q0.5960.78
133_T307_V0.5960.78
262_E279_G0.5940.78
24_A62_A0.5930.77
194_L230_L0.5910.77
191_L224_D0.5900.77
244_V269_I0.5860.77
111_I160_F0.5850.77
237_T272_A0.5850.77
93_T112_F0.5840.76
73_H105_I0.5830.76
224_D268_Y0.5830.76
14_L17_G0.5800.76
113_W156_Y0.5800.76
123_T204_I0.5800.76
27_S217_D0.5760.75
23_I51_G0.5750.75
92_G216_I0.5750.75
303_E307_V0.5740.75
155_S289_I0.5690.75
65_D96_I0.5690.75
88_C216_I0.5690.75
263_Q266_E0.5680.74
169_E172_S0.5680.74
134_F292_P0.5670.74
29_P34_L0.5670.74
179_P301_T0.5660.74
92_G215_D0.5640.74
139_L144_G0.5620.74
36_T40_F0.5610.74
24_A246_D0.5600.73
235_K239_A0.5590.73
13_A163_T0.5580.73
78_D81_V0.5560.73
96_I100_I0.5560.73
300_N305_T0.5540.73
168_T175_T0.5530.72
166_T175_T0.5530.72
22_V37_A0.5510.72
224_D267_D0.5480.72
14_L111_I0.5480.72
299_M302_A0.5470.72
266_E276_A0.5450.71
252_P258_S0.5450.71
91_F224_D0.5450.71
190_N226_M0.5440.71
36_T146_D0.5430.71
124_A200_T0.5410.71
59_G259_L0.5410.71
191_L251_V0.5400.71
73_H99_G0.5400.71
182_A301_T0.5400.71
126_H209_K0.5400.71
17_G83_A0.5360.70
74_E77_R0.5310.69
92_G221_Y0.5300.69
34_L55_K0.5290.69
119_T189_G0.5290.69
52_K67_E0.5280.69
106_R129_T0.5280.69
113_W134_F0.5240.68
173_P179_P0.5230.68
221_Y226_M0.5230.68
190_N215_D0.5220.68
259_L267_D0.5210.68
51_G54_L0.5200.68
94_G229_Q0.5190.68
123_T293_I0.5180.68
179_P304_K0.5160.67
137_P290_A0.5160.67
96_I99_G0.5150.67
123_T187_V0.5150.67
63_G68_R0.5140.67
182_A210_L0.5130.67
196_S225_R0.5130.67
86_C138_M0.5130.67
95_R218_E0.5130.67
296_K308_I0.5110.67
167_Y172_S0.5090.66
175_T262_E0.5090.66
103_S207_R0.5080.66
213_I232_M0.5080.66
148_V151_L0.5060.66
216_I222_Q0.5060.66
119_T230_L0.5060.66
175_T278_R0.5040.65
18_D83_A0.5030.65
56_N62_A0.5020.65
65_D221_Y0.5010.65
228_N265_L0.5000.65
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tlaA 2 0.9561 100 0.079 Contact Map
4jvoA 2 0.9561 100 0.095 Contact Map
4e5sA 2 0.9436 100 0.104 Contact Map
4injA 2 0.9404 100 0.113 Contact Map
1zl0A 1 0.9373 100 0.124 Contact Map
4eysA 3 0.906 100 0.168 Contact Map
3g23A 2 0.8276 100 0.196 Contact Map
2csuA 2 0.4671 89.1 0.948 Contact Map
4yleA 1 0.4922 88.1 0.948 Contact Map
3gbvA 2 0.5235 85 0.951 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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