GREMLIN Database
ACCA - Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha
UniProt: O34847 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 325 (260)
Sequences: 5072 (2525)
Seq/√Len: 156.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
79_F102_A5.0741.00
71_T98_V3.8541.00
99_G142_L3.7831.00
84_E100_G3.4541.00
97_I139_A3.2981.00
193_C210_G3.0821.00
157_I193_C2.7441.00
147_D188_R2.6591.00
105_H283_D2.5581.00
143_M184_M2.5101.00
239_L242_K2.4271.00
140_L180_N2.4091.00
175_E179_K2.3531.00
214_H262_H2.2611.00
157_I208_G2.2051.00
78_L156_F2.1441.00
79_F111_V2.1351.00
214_H285_T2.1241.00
156_F194_I2.0751.00
102_A111_V2.0211.00
144_K183_E1.9961.00
110_T151_R1.9831.00
262_H288_Q1.9751.00
72_L115_Q1.9711.00
59_R218_N1.9551.00
71_T113_G1.9511.00
28_S31_D1.9511.00
216_L278_Q1.9161.00
71_T196_I1.8851.00
104_F287_K1.8531.00
77_H279_A1.8401.00
238_S241_K1.8401.00
224_I228_G1.8391.00
110_T142_L1.8121.00
109_V154_I1.8071.00
104_F275_V1.8001.00
77_H276_K1.7631.00
215_M219_S1.7581.00
105_H287_K1.7581.00
24_F87_G1.7481.00
140_L183_E1.7331.00
242_K246_T1.7311.00
237_S240_A1.7091.00
154_I194_I1.7001.00
79_F104_F1.7001.00
139_A180_N1.6491.00
70_T115_Q1.6301.00
224_I229_A1.5981.00
200_G220_T1.5861.00
104_F283_D1.5461.00
91_Y134_E1.5431.00
71_T114_H1.5191.00
216_L269_G1.5181.00
58_D265_K1.5061.00
58_D267_V1.5061.00
74_Y196_I1.5031.00
72_L98_V1.4921.00
42_R83_F1.4831.00
35_E38_R1.4791.00
88_D99_G1.4651.00
22_K40_E1.4631.00
150_N189_V1.4551.00
99_G110_T1.4501.00
154_I279_A1.4311.00
27_D31_D1.4271.00
210_G213_L1.4211.00
145_Q151_R1.4161.00
143_M187_L1.4091.00
73_D76_E1.4081.00
262_H285_T1.3721.00
248_K253_D1.3611.00
192_I279_A1.3561.00
104_F276_K1.3521.00
86_H93_D1.3311.00
72_L86_H1.3231.00
110_T145_Q1.3211.00
144_K186_G1.3211.00
208_G213_L1.3141.00
107_L283_D1.3071.00
137_R176_A1.3001.00
167_A170_E1.2851.00
108_P151_R1.2831.00
229_A247_M1.2771.00
237_S241_K1.2751.00
26_Q35_E1.2651.00
91_Y171_R1.2621.00
34_A38_R1.2551.00
103_K108_P1.2551.00
214_H272_H1.2551.00
147_D187_L1.2471.00
55_K58_D1.2431.00
78_L283_D1.2321.00
38_R83_F1.2271.00
101_I110_T1.2271.00
80_T106_G1.2211.00
23_K88_D1.2151.00
65_L272_H1.2041.00
214_H264_I1.2041.00
87_G99_G1.2031.00
226_P245_E1.1971.00
199_G204_A1.1881.00
71_T75_I1.1871.00
101_I151_R1.1861.00
92_G95_E1.1481.00
132_H167_A1.1451.00
277_L281_Y1.1381.00
215_M260_I1.1331.00
32_L36_I1.1251.00
78_L104_F1.1211.00
179_K183_E1.1151.00
155_C184_M1.1121.00
79_F154_I1.1091.00
97_I112_I1.1040.99
59_R252_P1.1030.99
268_K271_A1.0990.99
283_D287_K1.0980.99
236_D240_A1.0970.99
213_L260_I1.0910.99
111_V154_I1.0900.99
206_G213_L1.0900.99
105_H280_S1.0890.99
114_H207_L1.0840.99
134_E171_R1.0780.99
80_T103_K1.0730.99
101_I145_Q1.0700.99
75_I111_V1.0560.99
284_E288_Q1.0550.99
112_I143_M1.0460.99
220_T249_I1.0410.99
32_L35_E1.0390.99
130_M160_K1.0390.99
58_D61_Q1.0350.99
45_K49_D1.0310.99
279_A282_M1.0300.99
29_D33_S1.0280.99
97_I131_P1.0270.99
225_S228_G1.0100.99
34_A37_E0.9930.99
166_R170_E0.9850.99
269_G272_H0.9830.99
195_V208_G0.9820.99
255_K260_I0.9800.99
212_H278_Q0.9790.99
278_Q282_M0.9660.99
245_E258_G0.9630.99
153_I189_V0.9510.98
194_I269_G0.9420.98
285_T288_Q0.9370.98
104_F109_V0.9310.98
255_K262_H0.9240.98
75_I100_G0.9190.98
52_K57_W0.9190.98
242_K245_E0.9140.98
70_T73_D0.9140.98
33_S37_E0.9130.98
26_Q32_L0.9130.98
243_A247_M0.9070.98
114_H131_P0.9040.98
145_Q149_F0.9000.98
31_D35_E0.8990.98
133_P171_R0.8970.98
167_A171_R0.8950.98
101_I149_F0.8860.98
168_A173_Q0.8820.98
78_L279_A0.8820.98
46_L49_D0.8800.98
179_K182_F0.8770.97
95_E118_K0.8750.97
68_R197_G0.8710.97
98_V115_Q0.8640.97
182_F186_G0.8610.97
250_T253_D0.8550.97
262_H272_H0.8510.97
264_I282_M0.8500.97
139_A143_M0.8480.97
57_W60_V0.8480.97
40_E44_A0.8470.97
191_V210_G0.8470.97
194_I282_M0.8460.97
56_P59_R0.8460.97
112_I155_C0.8450.97
260_I263_M0.8440.97
155_C193_C0.8430.97
253_D257_L0.8290.96
200_G206_G0.8290.96
105_H276_K0.8280.96
140_L144_K0.8260.96
73_D118_K0.8210.96
212_H262_H0.8200.96
211_N259_I0.8190.96
229_A246_T0.8170.96
253_D256_E0.8140.96
234_W243_A0.8070.96
230_A234_W0.8070.96
25_T90_A0.8070.96
184_M208_G0.8020.96
153_I187_L0.7930.95
137_R206_G0.7910.95
41_D45_K0.7900.95
20_E24_F0.7890.95
236_D239_L0.7870.95
192_I286_L0.7860.95
184_M191_V0.7860.95
180_N183_E0.7840.95
55_K59_R0.7840.95
227_E231_A0.7830.95
75_I84_E0.7810.95
193_C213_L0.7750.95
153_I208_G0.7720.95
97_I207_L0.7710.95
92_G132_H0.7680.95
265_K268_K0.7670.95
137_R175_E0.7660.94
275_V279_A0.7560.94
226_P249_I0.7500.94
223_V229_A0.7500.94
231_A237_S0.7460.94
97_I114_H0.7450.94
60_V249_I0.7430.94
147_D184_M0.7410.93
57_W61_Q0.7380.93
184_M209_V0.7360.93
210_G260_I0.7360.93
131_P206_G0.7360.93
159_T162_A0.7350.93
75_I79_F0.7330.93
37_E40_E0.7330.93
143_M155_C0.7260.93
143_M153_I0.7260.93
110_T146_A0.7240.93
180_N191_V0.7190.92
164_P202_G0.7180.92
230_A236_D0.7180.92
147_D211_N0.7180.92
59_R217_E0.7170.92
82_F100_G0.7160.92
24_F89_R0.7130.92
83_F103_K0.7100.92
181_L202_G0.7090.92
163_Y167_A0.7060.92
154_I192_I0.7050.92
81_D103_K0.7030.92
116_R160_K0.7020.91
75_I98_V0.6980.91
20_E23_K0.6960.91
71_T115_Q0.6920.91
158_D169_E0.6920.91
104_F286_L0.6900.91
94_D135_G0.6890.91
103_K106_G0.6890.91
92_G134_E0.6800.90
198_E220_T0.6780.90
56_P77_H0.6760.90
156_F196_I0.6680.89
19_A23_K0.6680.89
43_L47_Q0.6670.89
194_I275_V0.6660.89
55_K245_E0.6640.89
96_A132_H0.6610.89
184_M187_L0.6590.89
86_H138_K0.6580.89
23_K26_Q0.6550.88
191_V208_G0.6550.88
54_L77_H0.6530.88
24_F28_S0.6510.88
26_Q31_D0.6500.88
96_A135_G0.6490.88
36_I40_E0.6480.88
131_P135_G0.6480.88
74_Y216_L0.6470.88
57_W241_K0.6460.88
214_H269_G0.6430.87
165_G168_A0.6380.87
200_G222_S0.6380.87
216_L282_M0.6370.87
155_C191_V0.6360.87
25_T32_L0.6350.87
181_L209_V0.6320.87
60_V220_T0.6310.87
278_Q281_Y0.6280.86
158_D196_I0.6270.86
90_A179_K0.6250.86
70_T118_K0.6250.86
33_S36_I0.6250.86
184_M211_N0.6250.86
116_R128_F0.6190.85
226_P247_M0.6130.85
74_Y279_A0.6110.85
86_H89_R0.6090.85
112_I142_L0.6090.85
43_L46_L0.6090.85
200_G207_L0.6090.85
154_I286_L0.6070.84
202_G225_S0.6050.84
30_M34_A0.6040.84
52_K56_P0.6040.84
27_D30_M0.6030.84
154_I275_V0.6030.84
38_R42_R0.6010.84
180_N205_L0.6000.84
96_A131_P0.5990.84
227_E245_E0.5970.83
188_R211_N0.5950.83
187_L191_V0.5920.83
102_A154_I0.5920.83
194_I264_I0.5900.83
192_I278_Q0.5880.82
40_E43_L0.5880.82
31_D34_A0.5870.82
236_D241_K0.5870.82
258_G261_D0.5860.82
265_K281_Y0.5860.82
252_P256_E0.5840.82
213_L221_Y0.5840.82
189_V211_N0.5830.82
44_A48_D0.5830.82
24_F35_E0.5830.82
35_E85_C0.5820.82
111_V156_F0.5800.82
72_L76_E0.5780.81
50_I58_D0.5770.81
180_N184_M0.5760.81
132_H171_R0.5760.81
280_S284_E0.5750.81
50_I54_L0.5740.81
92_G96_A0.5740.81
84_E93_D0.5740.81
23_K27_D0.5740.81
264_I269_G0.5730.81
56_P245_E0.5710.81
183_E186_G0.5700.80
144_K182_F0.5690.80
69_P116_R0.5620.80
276_K280_S0.5600.79
271_A277_L0.5600.79
163_Y224_I0.5590.79
267_V270_G0.5570.79
217_E265_K0.5560.79
252_P263_M0.5560.79
170_E205_L0.5550.79
148_K151_R0.5550.79
114_H196_I0.5550.79
227_E235_K0.5530.78
252_P255_K0.5520.78
24_F32_L0.5500.78
75_I113_G0.5500.78
245_E249_I0.5470.78
48_D286_L0.5440.77
25_T28_S0.5410.77
42_R108_P0.5410.77
162_A206_G0.5410.77
45_K48_D0.5400.77
150_N188_R0.5400.77
85_C101_I0.5380.77
264_I281_Y0.5370.76
37_E41_D0.5330.76
132_H164_P0.5310.76
249_I255_K0.5300.76
84_E87_G0.5290.75
281_Y285_T0.5280.75
42_R46_L0.5270.75
281_Y284_E0.5270.75
141_R202_G0.5270.75
163_Y166_R0.5260.75
34_A41_D0.5250.75
20_E32_L0.5240.75
222_S228_G0.5220.74
244_A248_K0.5210.74
78_L287_K0.5200.74
134_E137_R0.5190.74
277_L280_S0.5190.74
181_L184_M0.5180.74
147_D189_V0.5170.74
144_K148_K0.5160.74
68_R117_G0.5150.73
153_I191_V0.5130.73
73_D77_H0.5120.73
38_R45_K0.5100.73
113_G270_G0.5090.73
36_I39_L0.5090.73
276_K284_E0.5070.72
54_L58_D0.5070.72
191_V211_N0.5060.72
77_H275_V0.5060.72
86_H98_V0.5060.72
27_D34_A0.5020.72
104_F271_A0.5020.72
51_Y62_I0.5010.71
116_R198_E0.5010.71
224_I247_M0.5000.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3n6rB 4 0.8831 100 0.293 Contact Map
1vrgA 4 0.8831 100 0.297 Contact Map
4rcnA 6 0.8 100 0.314 Contact Map
3iavA 4 0.8831 100 0.319 Contact Map
3gf3A 4 0.9354 100 0.32 Contact Map
1pixA 4 0.9415 100 0.321 Contact Map
2bzrA 4 0.8492 100 0.323 Contact Map
1on3A 6 0.8831 100 0.332 Contact Map
1x0uA 5 0.8831 100 0.339 Contact Map
4l6wA 2 0.8431 100 0.341 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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