ACCA - BACSU - GREMLIN Contacts

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ACCA - Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha

UniProt:	O34847	Sequences: MAPRLEFEKPVIELQTKIAELKKFTQDSDMDLSAEIERLEDRLAKLQDDIYKNLKPWDRVQIARLADRPTTLDYIEHLFTDFFECHGDRAYGDDEAIVGGIAKFHGLPVTVIGHQRGKDTKENLVRNFGMPHPEGYRKALRLMKQADKFNRPIICFIDTKGAYPGRAAEERGQSEAIAKNLFEMAGLRVPVICIVIGEGGSGGALGLGVGNHLHMLENSTYSVISPEGAAALLWKDSSLAKKAAETMKITAPDLKELGIIDHMIKEVKGGAHHDVKLQASYMDETLKQSLKTLLKLSEEELVQQRYEKYKAIGKVSVEDQYIGVN	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	325 (260)
Sequences:	5072 (2525)
Seq/√Len:	156.6

ECOLI - ACCA ACCD
BACSU - ACCA PCCB YNGE ACCD
HALSA - Q9HRN1 Q9HPQ0
SULSO - Q97VY8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
79_F	102_A	5.074	1.00
71_T	98_V	3.854	1.00
99_G	142_L	3.783	1.00
84_E	100_G	3.454	1.00
97_I	139_A	3.298	1.00
193_C	210_G	3.082	1.00
157_I	193_C	2.744	1.00
147_D	188_R	2.659	1.00
105_H	283_D	2.558	1.00
143_M	184_M	2.510	1.00
239_L	242_K	2.427	1.00
140_L	180_N	2.409	1.00
175_E	179_K	2.353	1.00
214_H	262_H	2.261	1.00
157_I	208_G	2.205	1.00
78_L	156_F	2.144	1.00
79_F	111_V	2.135	1.00
214_H	285_T	2.124	1.00
156_F	194_I	2.075	1.00
102_A	111_V	2.021	1.00
144_K	183_E	1.996	1.00
110_T	151_R	1.983	1.00
262_H	288_Q	1.975	1.00
72_L	115_Q	1.971	1.00
59_R	218_N	1.955	1.00
71_T	113_G	1.951	1.00
28_S	31_D	1.951	1.00
216_L	278_Q	1.916	1.00
71_T	196_I	1.885	1.00
104_F	287_K	1.853	1.00
77_H	279_A	1.840	1.00
238_S	241_K	1.840	1.00
224_I	228_G	1.839	1.00
110_T	142_L	1.812	1.00
109_V	154_I	1.807	1.00
104_F	275_V	1.800	1.00
77_H	276_K	1.763	1.00
215_M	219_S	1.758	1.00
105_H	287_K	1.758	1.00
24_F	87_G	1.748	1.00
140_L	183_E	1.733	1.00
242_K	246_T	1.731	1.00
237_S	240_A	1.709	1.00
154_I	194_I	1.700	1.00
79_F	104_F	1.700	1.00
139_A	180_N	1.649	1.00
70_T	115_Q	1.630	1.00
224_I	229_A	1.598	1.00
200_G	220_T	1.586	1.00
104_F	283_D	1.546	1.00
91_Y	134_E	1.543	1.00
71_T	114_H	1.519	1.00
216_L	269_G	1.518	1.00
58_D	265_K	1.506	1.00
58_D	267_V	1.506	1.00
74_Y	196_I	1.503	1.00
72_L	98_V	1.492	1.00
42_R	83_F	1.483	1.00
35_E	38_R	1.479	1.00
88_D	99_G	1.465	1.00
22_K	40_E	1.463	1.00
150_N	189_V	1.455	1.00
99_G	110_T	1.450	1.00
154_I	279_A	1.431	1.00
27_D	31_D	1.427	1.00
210_G	213_L	1.421	1.00
145_Q	151_R	1.416	1.00
143_M	187_L	1.409	1.00
73_D	76_E	1.408	1.00
262_H	285_T	1.372	1.00
248_K	253_D	1.361	1.00
192_I	279_A	1.356	1.00
104_F	276_K	1.352	1.00
86_H	93_D	1.331	1.00
72_L	86_H	1.323	1.00
110_T	145_Q	1.321	1.00
144_K	186_G	1.321	1.00
208_G	213_L	1.314	1.00
107_L	283_D	1.307	1.00
137_R	176_A	1.300	1.00
167_A	170_E	1.285	1.00
108_P	151_R	1.283	1.00
229_A	247_M	1.277	1.00
237_S	241_K	1.275	1.00
26_Q	35_E	1.265	1.00
91_Y	171_R	1.262	1.00
34_A	38_R	1.255	1.00
103_K	108_P	1.255	1.00
214_H	272_H	1.255	1.00
147_D	187_L	1.247	1.00
55_K	58_D	1.243	1.00
78_L	283_D	1.232	1.00
38_R	83_F	1.227	1.00
101_I	110_T	1.227	1.00
80_T	106_G	1.221	1.00
23_K	88_D	1.215	1.00
65_L	272_H	1.204	1.00
214_H	264_I	1.204	1.00
87_G	99_G	1.203	1.00
226_P	245_E	1.197	1.00
199_G	204_A	1.188	1.00
71_T	75_I	1.187	1.00
101_I	151_R	1.186	1.00
92_G	95_E	1.148	1.00
132_H	167_A	1.145	1.00
277_L	281_Y	1.138	1.00
215_M	260_I	1.133	1.00
32_L	36_I	1.125	1.00
78_L	104_F	1.121	1.00
179_K	183_E	1.115	1.00
155_C	184_M	1.112	1.00
79_F	154_I	1.109	1.00
97_I	112_I	1.104	0.99
59_R	252_P	1.103	0.99
268_K	271_A	1.099	0.99
283_D	287_K	1.098	0.99
236_D	240_A	1.097	0.99
213_L	260_I	1.091	0.99
111_V	154_I	1.090	0.99
206_G	213_L	1.090	0.99
105_H	280_S	1.089	0.99
114_H	207_L	1.084	0.99
134_E	171_R	1.078	0.99
80_T	103_K	1.073	0.99
101_I	145_Q	1.070	0.99
75_I	111_V	1.056	0.99
284_E	288_Q	1.055	0.99
112_I	143_M	1.046	0.99
220_T	249_I	1.041	0.99
32_L	35_E	1.039	0.99
130_M	160_K	1.039	0.99
58_D	61_Q	1.035	0.99
45_K	49_D	1.031	0.99
279_A	282_M	1.030	0.99
29_D	33_S	1.028	0.99
97_I	131_P	1.027	0.99
225_S	228_G	1.010	0.99
34_A	37_E	0.993	0.99
166_R	170_E	0.985	0.99
269_G	272_H	0.983	0.99
195_V	208_G	0.982	0.99
255_K	260_I	0.980	0.99
212_H	278_Q	0.979	0.99
278_Q	282_M	0.966	0.99
245_E	258_G	0.963	0.99
153_I	189_V	0.951	0.98
194_I	269_G	0.942	0.98
285_T	288_Q	0.937	0.98
104_F	109_V	0.931	0.98
255_K	262_H	0.924	0.98
75_I	100_G	0.919	0.98
52_K	57_W	0.919	0.98
242_K	245_E	0.914	0.98
70_T	73_D	0.914	0.98
33_S	37_E	0.913	0.98
26_Q	32_L	0.913	0.98
243_A	247_M	0.907	0.98
114_H	131_P	0.904	0.98
145_Q	149_F	0.900	0.98
31_D	35_E	0.899	0.98
133_P	171_R	0.897	0.98
167_A	171_R	0.895	0.98
101_I	149_F	0.886	0.98
168_A	173_Q	0.882	0.98
78_L	279_A	0.882	0.98
46_L	49_D	0.880	0.98
179_K	182_F	0.877	0.97
95_E	118_K	0.875	0.97
68_R	197_G	0.871	0.97
98_V	115_Q	0.864	0.97
182_F	186_G	0.861	0.97
250_T	253_D	0.855	0.97
262_H	272_H	0.851	0.97
264_I	282_M	0.850	0.97
139_A	143_M	0.848	0.97
57_W	60_V	0.848	0.97
40_E	44_A	0.847	0.97
191_V	210_G	0.847	0.97
194_I	282_M	0.846	0.97
56_P	59_R	0.846	0.97
112_I	155_C	0.845	0.97
260_I	263_M	0.844	0.97
155_C	193_C	0.843	0.97
253_D	257_L	0.829	0.96
200_G	206_G	0.829	0.96
105_H	276_K	0.828	0.96
140_L	144_K	0.826	0.96
73_D	118_K	0.821	0.96
212_H	262_H	0.820	0.96
211_N	259_I	0.819	0.96
229_A	246_T	0.817	0.96
253_D	256_E	0.814	0.96
234_W	243_A	0.807	0.96
230_A	234_W	0.807	0.96
25_T	90_A	0.807	0.96
184_M	208_G	0.802	0.96
153_I	187_L	0.793	0.95
137_R	206_G	0.791	0.95
41_D	45_K	0.790	0.95
20_E	24_F	0.789	0.95
236_D	239_L	0.787	0.95
192_I	286_L	0.786	0.95
184_M	191_V	0.786	0.95
180_N	183_E	0.784	0.95
55_K	59_R	0.784	0.95
227_E	231_A	0.783	0.95
75_I	84_E	0.781	0.95
193_C	213_L	0.775	0.95
153_I	208_G	0.772	0.95
97_I	207_L	0.771	0.95
92_G	132_H	0.768	0.95
265_K	268_K	0.767	0.95
137_R	175_E	0.766	0.94
275_V	279_A	0.756	0.94
226_P	249_I	0.750	0.94
223_V	229_A	0.750	0.94
231_A	237_S	0.746	0.94
97_I	114_H	0.745	0.94
60_V	249_I	0.743	0.94
147_D	184_M	0.741	0.93
57_W	61_Q	0.738	0.93
184_M	209_V	0.736	0.93
210_G	260_I	0.736	0.93
131_P	206_G	0.736	0.93
159_T	162_A	0.735	0.93
75_I	79_F	0.733	0.93
37_E	40_E	0.733	0.93
143_M	155_C	0.726	0.93
143_M	153_I	0.726	0.93
110_T	146_A	0.724	0.93
180_N	191_V	0.719	0.92
164_P	202_G	0.718	0.92
230_A	236_D	0.718	0.92
147_D	211_N	0.718	0.92
59_R	217_E	0.717	0.92
82_F	100_G	0.716	0.92
24_F	89_R	0.713	0.92
83_F	103_K	0.710	0.92
181_L	202_G	0.709	0.92
163_Y	167_A	0.706	0.92
154_I	192_I	0.705	0.92
81_D	103_K	0.703	0.92
116_R	160_K	0.702	0.91
75_I	98_V	0.698	0.91
20_E	23_K	0.696	0.91
71_T	115_Q	0.692	0.91
158_D	169_E	0.692	0.91
104_F	286_L	0.690	0.91
94_D	135_G	0.689	0.91
103_K	106_G	0.689	0.91
92_G	134_E	0.680	0.90
198_E	220_T	0.678	0.90
56_P	77_H	0.676	0.90
156_F	196_I	0.668	0.89
19_A	23_K	0.668	0.89
43_L	47_Q	0.667	0.89
194_I	275_V	0.666	0.89
55_K	245_E	0.664	0.89
96_A	132_H	0.661	0.89
184_M	187_L	0.659	0.89
86_H	138_K	0.658	0.89
23_K	26_Q	0.655	0.88
191_V	208_G	0.655	0.88
54_L	77_H	0.653	0.88
24_F	28_S	0.651	0.88
26_Q	31_D	0.650	0.88
96_A	135_G	0.649	0.88
36_I	40_E	0.648	0.88
131_P	135_G	0.648	0.88
74_Y	216_L	0.647	0.88
57_W	241_K	0.646	0.88
214_H	269_G	0.643	0.87
165_G	168_A	0.638	0.87
200_G	222_S	0.638	0.87
216_L	282_M	0.637	0.87
155_C	191_V	0.636	0.87
25_T	32_L	0.635	0.87
181_L	209_V	0.632	0.87
60_V	220_T	0.631	0.87
278_Q	281_Y	0.628	0.86
158_D	196_I	0.627	0.86
90_A	179_K	0.625	0.86
70_T	118_K	0.625	0.86
33_S	36_I	0.625	0.86
184_M	211_N	0.625	0.86
116_R	128_F	0.619	0.85
226_P	247_M	0.613	0.85
74_Y	279_A	0.611	0.85
86_H	89_R	0.609	0.85
112_I	142_L	0.609	0.85
43_L	46_L	0.609	0.85
200_G	207_L	0.609	0.85
154_I	286_L	0.607	0.84
202_G	225_S	0.605	0.84
30_M	34_A	0.604	0.84
52_K	56_P	0.604	0.84
27_D	30_M	0.603	0.84
154_I	275_V	0.603	0.84
38_R	42_R	0.601	0.84
180_N	205_L	0.600	0.84
96_A	131_P	0.599	0.84
227_E	245_E	0.597	0.83
188_R	211_N	0.595	0.83
187_L	191_V	0.592	0.83
102_A	154_I	0.592	0.83
194_I	264_I	0.590	0.83
192_I	278_Q	0.588	0.82
40_E	43_L	0.588	0.82
31_D	34_A	0.587	0.82
236_D	241_K	0.587	0.82
258_G	261_D	0.586	0.82
265_K	281_Y	0.586	0.82
252_P	256_E	0.584	0.82
213_L	221_Y	0.584	0.82
189_V	211_N	0.583	0.82
44_A	48_D	0.583	0.82
24_F	35_E	0.583	0.82
35_E	85_C	0.582	0.82
111_V	156_F	0.580	0.82
72_L	76_E	0.578	0.81
50_I	58_D	0.577	0.81
180_N	184_M	0.576	0.81
132_H	171_R	0.576	0.81
280_S	284_E	0.575	0.81
50_I	54_L	0.574	0.81
92_G	96_A	0.574	0.81
84_E	93_D	0.574	0.81
23_K	27_D	0.574	0.81
264_I	269_G	0.573	0.81
56_P	245_E	0.571	0.81
183_E	186_G	0.570	0.80
144_K	182_F	0.569	0.80
69_P	116_R	0.562	0.80
276_K	280_S	0.560	0.79
271_A	277_L	0.560	0.79
163_Y	224_I	0.559	0.79
267_V	270_G	0.557	0.79
217_E	265_K	0.556	0.79
252_P	263_M	0.556	0.79
170_E	205_L	0.555	0.79
148_K	151_R	0.555	0.79
114_H	196_I	0.555	0.79
227_E	235_K	0.553	0.78
252_P	255_K	0.552	0.78
24_F	32_L	0.550	0.78
75_I	113_G	0.550	0.78
245_E	249_I	0.547	0.78
48_D	286_L	0.544	0.77
25_T	28_S	0.541	0.77
42_R	108_P	0.541	0.77
162_A	206_G	0.541	0.77
45_K	48_D	0.540	0.77
150_N	188_R	0.540	0.77
85_C	101_I	0.538	0.77
264_I	281_Y	0.537	0.76
37_E	41_D	0.533	0.76
132_H	164_P	0.531	0.76
249_I	255_K	0.530	0.76
84_E	87_G	0.529	0.75
281_Y	285_T	0.528	0.75
42_R	46_L	0.527	0.75
281_Y	284_E	0.527	0.75
141_R	202_G	0.527	0.75
163_Y	166_R	0.526	0.75
34_A	41_D	0.525	0.75
20_E	32_L	0.524	0.75
222_S	228_G	0.522	0.74
244_A	248_K	0.521	0.74
78_L	287_K	0.520	0.74
134_E	137_R	0.519	0.74
277_L	280_S	0.519	0.74
181_L	184_M	0.518	0.74
147_D	189_V	0.517	0.74
144_K	148_K	0.516	0.74
68_R	117_G	0.515	0.73
153_I	191_V	0.513	0.73
73_D	77_H	0.512	0.73
38_R	45_K	0.510	0.73
113_G	270_G	0.509	0.73
36_I	39_L	0.509	0.73
276_K	284_E	0.507	0.72
54_L	58_D	0.507	0.72
191_V	211_N	0.506	0.72
77_H	275_V	0.506	0.72
86_H	98_V	0.506	0.72
27_D	34_A	0.502	0.72
104_F	271_A	0.502	0.72
51_Y	62_I	0.501	0.71
116_R	198_E	0.501	0.71
224_I	247_M	0.500	0.71

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3n6rB	4	0.8831	100	0.293	Contact Map
1vrgA	4	0.8831	100	0.297	Contact Map
4rcnA	6	0.8	100	0.314	Contact Map
3iavA	4	0.8831	100	0.319	Contact Map
3gf3A	4	0.9354	100	0.32	Contact Map
1pixA	4	0.9415	100	0.321	Contact Map
2bzrA	4	0.8492	100	0.323	Contact Map
1on3A	6	0.8831	100	0.332	Contact Map
1x0uA	5	0.8831	100	0.339	Contact Map
4l6wA	2	0.8431	100	0.341	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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