GREMLIN Database
YTMO - Uncharacterized protein YtmO
UniProt: O34846 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 334 (296)
Sequences: 16569 (10632)
Seq/√Len: 618.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
231_K289_E5.4151.00
30_Q66_S3.4631.00
31_M323_Q2.9971.00
231_K286_T2.8441.00
132_D182_K2.7931.00
71_R103_D2.7881.00
31_M34_E2.7061.00
293_E296_R2.6731.00
33_E69_K2.6611.00
201_K205_R2.4911.00
178_I206_A2.4591.00
230_T233_E2.4501.00
231_K235_E2.4281.00
64_A98_A2.4271.00
60_L72_L2.4121.00
286_T289_E2.4101.00
228_A233_E2.2841.00
205_R209_A2.2801.00
200_L204_R2.2351.00
136_E183_L2.2341.00
177_A202_E2.1681.00
30_Q34_E2.1631.00
323_Q327_D2.1481.00
202_E206_A2.1311.00
197_E201_K2.0931.00
207_F217_A2.0841.00
26_V30_Q2.0751.00
232_E236_K2.0671.00
23_Q99_P2.0651.00
35_C326_S2.0481.00
29_A63_L2.0221.00
200_L219_F2.0171.00
229_H328_A2.0101.00
95_S100_G1.9471.00
41_W73_A1.9371.00
91_F102_I1.9351.00
27_K30_Q1.9201.00
296_R300_T1.9171.00
143_R164_K1.9151.00
64_A72_L1.8671.00
40_F70_I1.8531.00
181_A206_A1.8461.00
55_A90_Q1.8351.00
239_V243_S1.8341.00
283_I290_V1.8151.00
178_I209_A1.7701.00
26_V66_S1.7521.00
197_E300_T1.7291.00
139_T164_K1.7171.00
114_Q118_D1.7121.00
198_E201_K1.6691.00
91_F104_L1.6641.00
29_A40_F1.6641.00
202_E205_R1.6411.00
206_A209_A1.6231.00
171_G187_F1.6151.00
136_E140_H1.6021.00
289_E292_E1.5861.00
63_L72_L1.5831.00
31_M35_C1.5711.00
227_A290_V1.5631.00
288_E292_E1.5531.00
139_T183_L1.5001.00
29_A67_T1.4971.00
17_T20_D1.4851.00
26_V62_Y1.4681.00
221_L303_I1.4581.00
291_A295_T1.4551.00
233_E237_H1.4551.00
295_T298_S1.4411.00
33_E67_T1.4291.00
207_F212_P1.4291.00
178_I182_K1.4091.00
34_E68_R1.4001.00
324_L328_A1.3921.00
42_V60_L1.3881.00
147_P150_H1.3771.00
140_H144_D1.3751.00
139_T167_I1.3621.00
140_H145_D1.3611.00
23_Q27_K1.3601.00
62_Y97_L1.3461.00
218_E304_N1.3231.00
62_Y65_A1.3171.00
132_D183_L1.3141.00
55_A58_V1.2951.00
82_Y90_Q1.2861.00
87_V134_K1.2851.00
227_A287_K1.2821.00
236_K239_V1.2771.00
73_A103_D1.2691.00
20_D24_H1.2681.00
255_N259_R1.2681.00
254_V257_G1.2661.00
289_E293_E1.2641.00
136_E149_T1.2621.00
168_F220_H1.2601.00
287_K324_L1.2551.00
292_E296_R1.2451.00
135_L183_L1.2291.00
33_E68_R1.2251.00
226_F237_H1.2161.00
233_E236_K1.2161.00
228_A234_A1.2151.00
168_F186_S1.2091.00
54_S93_L1.2031.00
181_A210_H1.1911.00
178_I210_H1.1771.00
132_D136_E1.1731.00
174_T202_E1.1631.00
139_T185_I1.1611.00
236_K240_S1.1581.00
35_C322_Y1.1571.00
27_K31_M1.1421.00
285_G290_V1.1421.00
94_L102_I1.1411.00
60_L74_S1.1381.00
207_F214_G1.1361.00
175_E178_I1.1361.00
238_I242_E1.1321.00
29_A70_I1.1301.00
106_V135_L1.1261.00
104_L138_L1.1261.00
182_K210_H1.1221.00
138_L142_V1.1191.00
256_V259_R1.1021.00
126_K129_R1.0951.00
42_V63_L1.0941.00
227_A324_L1.0921.00
260_E263_E1.0851.00
86_K90_Q1.0821.00
129_R175_E1.0801.00
113_F116_S1.0721.00
218_E305_D1.0671.00
178_I202_E1.0661.00
229_H233_E1.0651.00
57_E90_Q1.0631.00
99_P160_Q1.0621.00
58_V61_G1.0561.00
235_E239_V1.0531.00
34_E323_Q1.0481.00
62_Y66_S1.0401.00
206_A210_H1.0381.00
30_Q68_R1.0341.00
152_Y155_L1.0191.00
255_N258_S1.0141.00
24_H27_K1.0131.00
95_S161_V1.0071.00
58_V94_L1.0051.00
27_K315_A1.0031.00
37_Y326_S1.0021.00
232_E235_E1.0001.00
198_E202_E0.9971.00
76_G170_L0.9951.00
283_I293_E0.9911.00
177_A206_A0.9861.00
308_I325_L0.9821.00
32_A322_Y0.9741.00
193_I196_E0.9731.00
180_A187_F0.9721.00
225_V308_I0.9631.00
254_V259_R0.9611.00
95_S163_R0.9541.00
223_P283_I0.9511.00
179_S183_L0.9511.00
137_E140_H0.9511.00
322_Y326_S0.9491.00
111_G116_S0.9481.00
132_D179_S0.9481.00
139_T143_R0.9481.00
39_R73_A0.9471.00
130_Q133_E0.9471.00
112_G116_S0.9451.00
19_A23_Q0.9431.00
57_E77_V0.9391.00
188_V220_H0.9341.00
321_S324_L0.9301.00
228_A237_H0.9281.00
24_H315_A0.9231.00
126_K130_Q0.9221.00
123_E126_K0.9151.00
230_T234_A0.9151.00
134_K138_L0.9121.00
79_L87_V0.9111.00
270_T273_Y0.9061.00
133_E137_E0.9061.00
249_K253_K0.9041.00
204_R208_D0.9021.00
84_S137_E0.9011.00
238_I284_A0.8941.00
200_L203_A0.8811.00
197_E301_Y0.8731.00
207_F210_H0.8721.00
146_F149_T0.8701.00
27_K34_E0.8691.00
64_A102_I0.8671.00
295_T300_T0.8671.00
23_Q26_V0.8641.00
158_R161_V0.8591.00
177_A181_A0.8581.00
130_Q134_K0.8551.00
235_E279_K0.8541.00
292_E295_T0.8541.00
142_V165_P0.8501.00
137_E149_T0.8481.00
108_K127_P0.8411.00
22_L97_L0.8401.00
61_G65_A0.8391.00
237_H324_L0.8381.00
229_H324_L0.8291.00
39_R305_D0.8281.00
208_D214_G0.8271.00
187_F203_A0.8261.00
240_S244_I0.8261.00
76_G107_G0.8261.00
95_S164_K0.8231.00
223_P294_L0.8211.00
237_H240_S0.8181.00
146_F150_H0.8171.00
200_L301_Y0.8171.00
148_D152_Y0.8161.00
79_L134_K0.8111.00
60_L64_A0.8101.00
204_R219_F0.8071.00
34_E327_D0.8061.00
96_A163_R0.7991.00
46_H89_E0.7931.00
225_V325_L0.7911.00
153_A158_R0.7901.00
310_T325_L0.7881.00
181_A207_F0.7871.00
141_F147_P0.7821.00
169_L180_A0.7791.00
242_E245_K0.7771.00
207_F215_S0.7761.00
146_F154_A0.7761.00
96_A160_Q0.7751.00
132_D175_E0.7731.00
240_S243_S0.7701.00
258_S261_Q0.7701.00
22_L62_Y0.7701.00
274_D278_Q0.7691.00
146_F152_Y0.7671.00
21_T24_H0.7631.00
60_L102_I0.7631.00
239_V242_E0.7571.00
250_D253_K0.7561.00
177_A187_F0.7551.00
26_V63_L0.7541.00
136_E182_K0.7511.00
114_Q124_Y0.7491.00
257_G260_E0.7471.00
60_L94_L0.7471.00
64_A94_L0.7451.00
65_A98_A0.7441.00
41_W75_G0.7441.00
219_F303_I0.7441.00
263_E270_T0.7421.00
140_H147_P0.7411.00
253_K257_G0.7401.00
189_F199_V0.7351.00
152_Y157_P0.7331.00
203_A217_A0.7321.00
23_Q68_R0.7291.00
128_V175_E0.7281.00
95_S162_D0.7271.00
78_M111_G0.7271.00
204_R207_F0.7251.00
310_T322_Y0.7241.00
125_K175_E0.7221.00
91_F142_V0.7191.00
247_V250_D0.7181.00
203_A207_F0.7171.00
103_D168_F0.7141.00
161_V164_K0.7141.00
235_E238_I0.7091.00
44_E82_Y0.7081.00
115_L118_D0.7081.00
169_L176_S0.7081.00
274_D277_V0.7071.00
169_L184_G0.7011.00
87_V138_L0.6951.00
171_G176_S0.6901.00
61_G94_L0.6891.00
201_K302_K0.6871.00
76_G87_V0.6871.00
169_L179_S0.6861.00
38_H69_K0.6841.00
23_Q65_A0.6841.00
73_A168_F0.6821.00
225_V283_I0.6801.00
248_L253_K0.6791.00
74_S102_I0.6771.00
220_H305_D0.6761.00
174_T178_I0.6731.00
92_H155_L0.6711.00
84_S134_K0.6701.00
151_R154_A0.6701.00
207_F216_E0.6681.00
259_R263_E0.6651.00
153_A161_V0.6651.00
24_H28_L0.6641.00
57_E91_F0.6641.00
28_L322_Y0.6631.00
40_F63_L0.6591.00
178_I205_R0.6581.00
71_R166_G0.6561.00
298_S303_I0.6551.00
140_H143_R0.6551.00
39_R307_V0.6551.00
140_H149_T0.6551.00
212_P215_S0.6511.00
254_V258_S0.6501.00
157_P161_V0.6491.00
153_A156_R0.6491.00
235_E284_A0.6481.00
31_M326_S0.6481.00
153_A157_P0.6471.00
106_V138_L0.6471.00
246_V250_D0.6451.00
133_E136_E0.6441.00
72_L98_A0.6421.00
83_S86_K0.6371.00
95_S98_A0.6361.00
157_P160_Q0.6361.00
92_H157_P0.6351.00
85_Y141_F0.6351.00
67_T101_R0.6321.00
26_V29_A0.6321.00
82_Y86_K0.6291.00
288_E291_A0.6261.00
175_E179_S0.6241.00
228_A231_K0.6241.00
26_V65_A0.6231.00
205_R208_D0.6231.00
229_H287_K0.6231.00
32_A70_I0.6221.00
182_K209_A0.6221.00
231_K234_A0.6221.00
273_Y276_I0.6221.00
204_R214_G0.6171.00
201_K204_R0.6171.00
148_D151_R0.6171.00
152_Y161_V0.6161.00
18_A21_T0.6141.00
108_K131_F0.6141.00
244_I247_V0.6131.00
174_T206_A0.6131.00
38_H71_R0.6131.00
92_H142_V0.6101.00
42_V59_L0.6101.00
276_I280_T0.6081.00
182_K206_A0.6071.00
59_L93_L0.6031.00
136_E139_T0.6021.00
61_G98_A0.6011.00
257_G261_Q0.6001.00
135_L169_L0.6001.00
105_G170_L0.5991.00
222_A307_V0.5991.00
155_L158_R0.5971.00
22_L26_V0.5921.00
204_R304_N0.5921.00
192_F196_E0.5901.00
67_T70_I0.5901.00
168_F218_E0.5861.00
287_K328_A0.5851.00
114_Q117_T0.5851.00
294_L306_F0.5851.00
166_G218_E0.5841.00
294_L308_I0.5831.00
95_S165_P0.5811.00
287_K291_A0.5811.00
210_H214_G0.5761.00
227_A325_L0.5731.00
33_E70_I0.5691.00
20_D23_Q0.5671.00
117_T124_Y0.5651.00
216_E304_N0.5651.00
246_V249_K0.5641.00
82_Y87_V0.5621.00
92_H160_Q0.5611.00
106_V167_I0.5611.00
221_L297_L0.5571.00
128_V179_S0.5551.00
152_Y156_R0.5541.00
95_S159_P0.5521.00
203_A219_F0.5521.00
61_G64_A0.5511.00
198_E205_R0.5501.00
84_S138_L0.5480.99
172_G191_Y0.5430.99
288_E328_A0.5420.99
177_A203_A0.5420.99
172_G199_V0.5410.99
88_A142_V0.5400.99
83_S122_A0.5400.99
214_G217_A0.5380.99
194_N296_R0.5380.99
219_F304_N0.5370.99
71_R161_V0.5330.99
56_P74_S0.5310.99
154_A157_P0.5310.99
310_T321_S0.5280.99
98_A102_I0.5280.99
243_S247_V0.5270.99
191_Y194_N0.5260.99
227_A286_T0.5250.99
25_T28_L0.5230.99
223_P306_F0.5220.99
58_V93_L0.5220.99
199_V202_E0.5200.99
250_D271_E0.5190.99
249_K252_R0.5190.99
228_A324_L0.5190.99
275_I278_Q0.5190.99
293_E297_L0.5170.99
137_E147_P0.5170.99
45_H116_S0.5160.99
92_H96_A0.5160.99
122_A130_Q0.5160.99
79_L106_V0.5150.99
113_F117_T0.5150.99
277_V280_T0.5150.99
297_L301_Y0.5140.99
62_Y98_A0.5120.99
230_T236_K0.5110.99
39_R71_R0.5110.99
156_R161_V0.5100.99
106_V169_L0.5100.99
152_Y158_R0.5080.99
176_S179_S0.5080.99
204_R215_S0.5060.99
225_V290_V0.5050.99
118_D151_R0.5040.99
168_F305_D0.5040.99
253_K259_R0.5030.99
34_E69_K0.5030.99
135_L179_S0.5020.99
131_F169_L0.5010.99
135_L139_T0.5010.99
247_V252_R0.5010.99
224_A309_F0.5000.99
75_G188_V0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1lucA 1 0.9401 100 0.173 Contact Map
2wgkA 2 0.979 100 0.184 Contact Map
1lucB 1 0.9311 100 0.197 Contact Map
2i7gA 2 0.9611 100 0.205 Contact Map
4us5A 3 0.9611 100 0.225 Contact Map
3raoA 2 0.9611 100 0.237 Contact Map
1ezwA 3 0.9431 100 0.238 Contact Map
3c8nA 2 0.9401 100 0.238 Contact Map
1rhcA 2 0.9341 100 0.24 Contact Map
1z69A 4 0.9311 100 0.246 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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